6,220 results match your criteria characterized extreme


Strong host-specific selection and over-dominance characterize arbuscular mycorrhizal fungal root colonizers of coastal sand dune plants of the Mediterranean region.

FEMS Microbiol Ecol 2021 Jul 28. Epub 2021 Jul 28.

Agricultural University of Athens, Department of Natural Resources and Agricultural Engineering, Athens, Greece.

Sand dunes of the Mediterranean region constitute drought-stressed, low-fertility ecosystems. Arbuscular mycorrhizal fungi (AMF) are regarded as key components of their biota, that contribute to plant host adaptation and fitness. However, AMF community assembly rules in the roots of the psammophilous plants of coastal sand dunes have not been investigated. Read More

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Growth Hormone Receptor (Ghr) 6ω Pseudoexon Activation: A Novel Cause Of Severe Growth Hormone Insensitivity (Ghi).

J Clin Endocrinol Metab 2021 Jul 28. Epub 2021 Jul 28.

Centre for Endocrinology, William Harvey Research Institute: Barts and The London School of Medicine and Dentistry William Harvey Research Institute.

Context: Severe forms of Growth Hormone Insensitivity (GHI) are characterized by extreme short stature, dysmorphism and metabolic anomalies.

Objective: Identification of the genetic cause of growth failure in 3 'classical' GHI subjects.

Design: A novel intronic GHR variant was identified, and in vitro splicing assays confirmed aberrant splicing. Read More

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A Neurodegenerative Phenotype Associated With Sjögren-Larsson Syndrome.

J Child Neurol 2021 Jul 28:8830738211029390. Epub 2021 Jul 28.

Department of Pediatrics, Child Health Research Institute, University of Nebraska Medical Center and Children's Hospital & Medical Center, Omaha, NE, USA.

Sjögren-Larsson syndrome (SLS) is a rare neurologic disorder caused by pathogenic sequence variants in and characterized by ichthyosis, spasticity, intellectual disability, and a crystalline retinopathy. Neurologic symptoms develop in the first 2 years of life. Except for worsening ambulation due to spastic diplegia and contractures, the neurologic disease has been considered static and a neurodegenerative course is distinctly unusual. Read More

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Multi-type Bayesian hierarchical modeling of traffic conflict extremes for crash estimation.

Accid Anal Prev 2021 Jul 23:106309. Epub 2021 Jul 23.

School of Transportation Science and Engineering, Harbin Institute of Technology, China. Electronic address:

Most existing Extreme Value Theory (EVT) models were developed based on the total number of conflicts or a single type of traffic conflict to estimate the corresponding frequency of crashes. Using the total number of conflicts to estimate the total number of crashes may make it difficult to diagnose safety problems as countermeasures are usually related to specific conflict/crash types. Single-type EVT models may help to better explain the mechanism of crash occurrence of a certain type, but they only reflect the partial safety of a road entity. Read More

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Discovery of Fungus-Specific Targets and Inhibitors Using Chemical Phenotyping of Pathogenic Spore Germination.

mBio 2021 Jul 27:e0167221. Epub 2021 Jul 27.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

There is a critical need for new antifungal drugs; however, the lack of available fungus-specific targets is a major hurdle in the development of antifungal therapeutics. Spore germination is a differentiation process absent in humans that could harbor uncharacterized fungus-specific targets. To capitalize on this possibility, we developed novel phenotypic assays to identify and characterize inhibitors of spore germination of the human fungal pathogen Cryptococcus. Read More

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Effects of Intertidal Position on Metabolism and Behavior in the Acorn Barnacle, .

Integr Org Biol 2021 30;3(1):obab010. Epub 2021 Apr 30.

Department of Biological Sciences, Center for Coastal Marine Sciences, California Polytechnic State University, San Luis Obispo, CA 93407, USA.

The intertidal zone is characterized by persistent, tidally-driven fluctuations in both abiotic (e.g., temperature, oxygen, and salinity) and biotic (e. Read More

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Cold Stress in Wheat: Plant Acclimation Responses and Management Strategies.

Front Plant Sci 2021 8;12:676884. Epub 2021 Jul 8.

School of Agronomy, Anhui Agricultural University, Hefei, China.

Unpredicted variability in temperature is associated with frequent extreme low-temperature events. Wheat is a leading crop in fulfilling global food requirements. Climate-driven temperature extremes influence the vegetative and reproductive growth of wheat, followed by a decrease in yield. Read More

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Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China.

J Ethnobiol Ethnomed 2021 Jul 23;17(1):46. Epub 2021 Jul 23.

Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

Background: Douyu Village, inhabited by the Lhoba people, is situated within the Eastern Himalayas, in southeastern Tibet, China. The village is located among high mountains and valleys, which feature complex terrain with cold and dry climates and distinctive vegetation types and species. The Lhoba people in this village are isolated from other groups in China. Read More

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Comparative Study on Temperature Response of Hydropower Development in the Dry-Hot Valley.

Geohealth 2021 Jul 1;5(7):e2021GH000438. Epub 2021 Jul 1.

School of Geology and Geomatics Tianjin Chengjian University Tianjin China.

Due to the specific hydrothermal conditions of dry-hot valleys, temperature changes caused by the development of large-scale hydropower projects may be more extreme than they are in other regions. In this study, we analyzed these temperature changes at four hydropower stations in both dry-hot and non-dry-hot valleys. Based on the calculated relative temperatures of the downstream river and the areas surrounding the reservoirs, we employed two indices to quantify the influence of the reservoirs on the temperatures of these two regions: the downstream river temperature change and the reservoir effect change intensity. Read More

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n. sp., a Secondarily Oligomerized Parabirojimid Hypotrich (Ciliophora, Spirotrichea) From Hypersaline Costal Water in Korea.

Front Microbiol 2021 5;12:691361. Epub 2021 Jul 5.

Department of Biology, Gangneung-Wonju National University, Gangneung, South Korea.

n. sp. was discovered in a hypersaline marine sample from Jeju Island, Korea. Read More

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Death Zone Weather Extremes Mountaineers Have Experienced in Successful Ascents.

Front Physiol 2021 5;12:696335. Epub 2021 Jul 5.

Department of Nutritional Biochemistry, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.

Background: Few data are available on mountaineers' survival prospects in extreme weather above 8000 m (the Death Zone). We aimed to assess Death Zone weather extremes experienced in climbing-season ascents of Everest and K2, all winter ascents of 8000 m peaks (8K) in the Himalayas and Karakoram, environmental records of human survival, and weather extremes experienced with and without oxygen support.

Materials And Methods: We analyzed 528 ascents of 8K peaks: 423 non-winter ascents without supplemental oxygen (Everest-210, K2-213), 76 ascents in winter without oxygen, and 29 in winter with oxygen. Read More

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PEGylated Graphene Oxide Carried OH-CATH30 to Accelerate the Healing of Infected Skin Wounds.

Int J Nanomedicine 2021 13;16:4769-4780. Epub 2021 Jul 13.

School of Pharmacy, Weifang Medical University, Weifang, Shandong, 261053, People's Republic of China.

Background: The treatment of ()-infected wounds is difficult. It causes extreme pain to tens of thousands of patients and increases the cost of medical care. The antimicrobial peptide OH-CATH30 (OH30) has a good killing activity against and can play a role in accelerating wound healing and immune regulation. Read More

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Design of experiments applied to stress testing of pharmaceutical products: a case study of Albendazole.

Eur J Pharm Sci 2021 Jul 17:105939. Epub 2021 Jul 17.

Department of Chemistry, Federal University of São Carlos, 13565-905, São Carlos, São Paulo, Brazil. Electronic address:

Forced degradation tests are studies used to assess the stability of active pharmaceutical ingredients (APIs) and their formulations. These tests are performed submitting the API under extreme conditions in order to know the main degradation products in a short period of time. The results of these studies are used to assess the degradation susceptibility of APIs and to validate chromatographic analytical methods. Read More

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A multi-proxy record of hurricanes, tsunami, and post-disturbance ecosystem changes from coastal southern Baja California.

Sci Total Environ 2021 Jul 14;796:149011. Epub 2021 Jul 14.

Indiana Geological and Water Survey, Indiana University, 420 N Walnut St., Bloomington, IN 47404, USA.

Tsunamis and hurricanes are two earth surface processes that can dramatically impact coastal landforms and ecosystems. This study uses a combination of palynological, grain-size, X-ray fluorescence, and loss-on-ignition analyses, short-lived isotopic and radiocarbon dating, and statistical analysis to differentiate the tsunami and hurricane deposits, establish a Late-Holocene record of extreme events, and document the landscape and vegetation transformation in response to disturbance events and environmental changes from a small coastal lagoon in Baja California, Mexico. Prior to ~530 cal yr BP, Playa Los Cocos was occupied by a short-hydroperiod tidal marsh bounded by desert vegetation on the surrounding hillslopes. Read More

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Arsenic-Doped SnSe Thin Films Prepared by Pulsed Laser Deposition.

ACS Omega 2021 Jul 30;6(27):17483-17491. Epub 2021 Jun 30.

Department of Graphic Arts and Photophysics, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Czech Republic.

Pulsed UV laser deposition was exploited for the preparation of thin Sn As Se ( = 0, 0.05, 0.5, and 2. Read More

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Imaging from the visible to the longwave infrared wavelengths via an inverse-designed flat lens.

Opt Express 2021 Jun;29(13):20715-20723

It is generally assumed that correcting chromatic aberrations in imaging requires multiple optical elements. Here, we show that by allowing the phase in the image plane to be a free parameter, it is possible to correct chromatic variation of focal length over an extremely large bandwidth, from the visible (Vis) to the longwave infrared (LWIR) wavelengths using a single diffractive surface, i.e. Read More

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Antibacterial and cytotoxic potency of thermophilic Streptomyces werraensis MI-S.24-3 isolated from an Egyptian extreme environment.

Arch Microbiol 2021 Jul 14. Epub 2021 Jul 14.

Colin Ratledge Center for Microbial Lipids, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.

The need for novel and active antibiotics specially from actinomycetes is essential due to new and drug-resistant pathogens. In this study, 87 actinomycetes were isolated, and 18 strains among them characterized as thermophilic actinomycetes. Further fractionation and preliminary antibacterial activities indicated that one strain, coded as MI-S. Read More

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Global reporting of pulmonary embolism-related deaths in the World Health Organization mortality database: Vital registration data from 123 countries.

Res Pract Thromb Haemost 2021 Jul 15;5(5):e12520. Epub 2021 Jun 15.

Center for Thrombosis and Hemostasis University Medical Center Mainz Mainz Germany.

Introduction: Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause-specific mortality in global reports.

Methods: We analyzed global PE-related mortality by focusing on the latest year available for each member state in the World Health Organization (WHO) mortality database, which provides age-sex-specific aggregated mortality data transmitted by national authorities for each underlying cause of death. PE-related deaths were defined by International Classification of Diseases, Tenth Revision codes for acute PE or nonfatal manifestations of venous thromboembolism (VTE). Read More

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Community norms of the Muscle Dysmorphic Disorder Inventory (MDDI) among gender minority populations.

J Eat Disord 2021 Jul 14;9(1):87. Epub 2021 Jul 14.

The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: Representing the pathological extreme pursuit of muscularity, muscle dysmorphia (MD) is characterized by a pervasive belief or fear around insufficient muscularity and an elevated drive for muscularity. Despite evidence of heightened body image-related concerns among gender minority populations, little is known about the degree of MD symptoms among gender minorities, particularly based on Muscle Dysmorphic Disorder Inventory (MDDI) scores. The objective of this study was to assess community norms of the MDDI in gender-expansive people, transgender men, and transgender women. Read More

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Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder.

J Clin Psychol 2021 Jul 14. Epub 2021 Jul 14.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Hikikomori, a severe form of social withdrawal, is a condition characterized by the avoidance of social participation and staying at home for more than 6 months. Hikikomori was initially reported in Japan in the 1990s and is now observed worldwide. Here, we introduce specialized psychodynamic group psychotherapy for persons with hikikomori, and illustrate the case of an adult male with schizoaffective disorder. Read More

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Chemical or genetic alteration of proton motive force results in loss of virulence of , the cause of rice bacterial panicle blight.

Appl Environ Microbiol 2021 Jul 14:AEM0091521. Epub 2021 Jul 14.

Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.

Rice is an important source of food for more than half the world's population. Bacterial panicle blight (BPB) is a disease of rice characterized by grain discoloration or sheath rot caused mainly by . synthesizes toxoflavin, an essential virulence factor, that is required for symptoms of the disease. Read More

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Terminal osseous dysplasia with pigmentary defects and cardiomyopathy caused by a novel FLNA variant.

Am J Med Genet A 2021 Jul 13. Epub 2021 Jul 13.

Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Terminal osseous dysplasia with pigmentary defects (TODPD), also known as digitocutaneous dysplasia, is one of the X-linked filaminopathies caused by a variety of FLNA-variants. TODPD is characterized by skeletal defects, skin fibromata and dysmorphic facial features. So far, only a single recurrent variant (c. Read More

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Occurrence of in Black Pepper ( L.) in the Extreme South of the State of Bahia, Brazil.

Helminthologia 2021 Jun 8;58(2):213-216. Epub 2021 Jun 8.

Federal University of Espirito Santo, Department of Agronomy, Alegre-ES, CEP 29500-000, Brazil.

Samples of black pepper root with the presence of galls from the most southern region of the State of Bahia, Brazil, were characterized biochemically and morphologically using three criteria: i) observation of the anterior region of the males; ii) analysis of female perineal configuration and iii) polyacrylamide gel electrophoresis technique. was found. This is the first report of this pathosystem in the State. Read More

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Parity-time-symmetric rational vector rogue waves of the n-component nonlinear Schrödinger equation.

Chaos 2021 Jun;31(6):063120

Departamento de Física, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Edifício C8, Lisboa 1749-016, Portugal.

Extreme events are investigated in the integrable n-component nonlinear Schrödinger (NLS) equation with focusing nonlinearity. We report novel multi-parametric families of rational vector rogue wave (RW) solutions featuring the parity-time ( PT) symmetry, which are characterized by non-identical boundary conditions for the components that are consistent with the degeneracy of n branches of Benjamin-Feir instability. Explicit examples of PT-symmetric rational vector RWs are presented. Read More

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Climatic displacement exacerbates the negative impact of drought on plant performance and associated arthropod abundance.

Ecology 2021 Jul 8:e03462. Epub 2021 Jul 8.

Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA.

Climate change is acting on species and modifying communities and ecosystems through changes not only with respect to mean abiotic conditions, but also through increases in the frequency and severity of extreme events. Changes in mean aridity associated with climate change can generate ecotype by environment mismatch (i.e. Read More

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Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates.

World J Microbiol Biotechnol 2021 Jul 7;37(8):129. Epub 2021 Jul 7.

Pharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, 751 24, Uppsala, Sweden.

Lichens are symbiotic organisms formed by a fungus and one or more photosynthetic partners which are usually alga or cyanobacterium. Their diverse and scarcely studied metabolites facilitate adaptability to extreme living conditions. We investigated Evernia prunastri (L. Read More

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Unmasking the -Stilbene Phantom State via Vacuum Ultraviolet Time-Resolved Photoelectron Spectroscopy and Multiple Spawning.

J Phys Chem Lett 2021 Jul 7;12(27):6363-6369. Epub 2021 Jul 7.

Department of Chemistry and The PULSE Institute, Stanford University, Stanford, California 94305, United States.

We present the first vacuum ultraviolet time-resolved photoelectron spectroscopy (VUV-TRPES) study of photoisomerization dynamics in the paradigmatic molecule -stilbene. A key reaction intermediate in its dynamics, known as the phantom state, has often been invoked but never directly detected in the gas phase. We report direct spectral signatures of the phantom state in isolated -stilbene, observed and characterized through a combination of VUV-TRPES and multiple spawning (AIMS) nonadiabatic dynamics simulations of the channel-resolved observable. Read More

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Assessing biomass and primary production of microphytobenthos in depositional coastal systems using spectral information.

PLoS One 2021 6;16(7):e0246012. Epub 2021 Jul 6.

Department of Coastal Systems, Royal Netherlands Institute for Sea Research, Den Burg, the Netherlands.

In depositional intertidal coastal systems, primary production is dominated by benthic microalgae (microphytobenthos) inhabiting the mudflats. This benthic productivity is supporting secondary production and supplying important services to humans including food provisioning. Increased frequencies of extreme events in weather (such as heatwaves, storm surges and cloudbursts) are expected to strongly impact the spatiotemporal dynamics of the microphytobenthos and subsequently their contribution to coastal food webs. Read More

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Dentition and feeding in Placodontia: tooth replacement in Henodus chelyops.

BMC Ecol Evol 2021 Jul 5;21(1):136. Epub 2021 Jul 5.

Senckenberg Centre for Human Evolution and Palaeoenvironment (HEP) an der Eberhard-Karls-Universität Tübingen, Sigwartstraße 10, 72076, Tübingen, Germany.

Background: Placodontia is a Triassic sauropterygian reptile group characterized by flat and enlarged crushing teeth adapted to a durophagous diet. The enigmatic placodont Henodus chelyops has numerous autapomorphic character states, including extreme tooth count reduction to only a single pair of palatine and dentary crushing teeth. This renders the species unusual among placodonts and challenges identification of its phylogenetic position. Read More

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Dropped head in systemic sclerosis: a case based review.

Rheumatol Int 2021 Jul 5. Epub 2021 Jul 5.

Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Tokyo, 1528902, Japan.

Dropped head syndrome is a rare disease entity characterized by severe weakness of the cervical para-spinal muscles, resulting in a chin-on-chest deformity. Systemic sclerosis is one of the causes of dropped head syndrome, but its characteristics and prognosis remain unclear due to the extreme rarity of this condition. We present a case of dropped head which occurred in systemic sclerosis. Read More

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