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Gut-specific arylphorin mediates midgut regenerative response against cry-induced damage in Achaea janata.

Comp Biochem Physiol B Biochem Mol Biol 2021 Apr 10:110600. Epub 2021 Apr 10.

Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Ghudda, Bathinda 151401, India.

Development of insect resistance to biopesticides is a current and pertinent global issue. Earlier, it was established that lepidopteran larvae can recover from Bt intoxication via a midgut regenerative response and subsequently generate resistance. Molecular aspects of restoration of the midgut integrity following toxin exposure are emerging recently. Read More

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A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma.

Cancer Lett 2021 Apr 10. Epub 2021 Apr 10.

Pediatric Immunotherapy Group, Medical Faculty, Otto-von Guericke University of Magdeburg, Germany; Department of Environmental Immunology, Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany; Städtisches Klinikum Dessau, Academic Hospital of University Brandenburg, Dessau, Germany.

We recently identified Galectin-1 (Gal-1), a β-galactoside-binding lectin, as a novel immune regulator in neuroblastoma (NB). Here, we characterized the tolerogenic function of Gal-1 within the CD8 T cell compartment and further evaluated its relevance as an antigen for effective DNA vaccination against NB in a mouse model. NB cells with Gal-1 knockdown (NXS-2L) exhibited significantly reduced tumor growth compared to NXS-2 NB cells. Read More

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Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation.

Aging (Albany NY) 2021 Apr 13;13. Epub 2021 Apr 13.

Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), Meaux 77100, France.

Parkinson's disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by a loss of dopamine in the substantia nigra pars compacta. Recent findings have shown that oxidative stress and inflammation play key roles in the development of PD. However, therapies remain uncertain and research for new treatment is of the utmost importance. Read More

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Contraction-relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium.

J Gen Physiol 2021 Jul;153(7)

Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH.

The two main phases of the mammalian cardiac cycle are contraction and relaxation; however, whether there is a connection between them in humans is not well understood. Routine exercise has been shown to improve cardiac function, morphology, and molecular signatures. Likewise, the acute and chronic changes that occur in the heart in response to injury, disease, and stress are well characterized, albeit not fully understood. Read More

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Phytochemicals from twigs of and their antioxidation kinetics of oxymyoglobin.

Nat Prod Res 2021 Apr 13:1-5. Epub 2021 Apr 13.

Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

The phytochemical investigation of crude -hexane and ethyl acetate extracts from twigs of (Kurz) led to the isolation of 14 known compounds. Their structures were elucidated by spectroscopic techniques (IR, H NMR, C NMR, and 2D NMR) as well as mass spectrometry. These structures were characterized as -sitosterol (), lupeol (), vanilic acid (), 5,7-dihydroxychromone (), (+)-mellein (), isoliquiritigenin (), 7-hydroxyemodin (), physion (), aromadendrin (), naringenin (), apigenin (), luteolin (), chrysoeriol () and kaempferol (). Read More

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Effect of long noncoding RNAs on epithelial-mesenchymal transition in A549 cells and fibrotic human lungs.

J Cell Biochem 2021 Apr 13. Epub 2021 Apr 13.

Department of Thoracic Surgery, Lung Transplantation Center, Kartal Kosuyolu High Specialty Educational and Research Hospital, Istanbul, Turkey.

Long noncoding RNAs (LncRNAs) regulate epithelial-mesenchymal transition (EMT). EMT involves myofibroblast differentiation and pulmonary fibrosis (PF). We aimed to determine the expression profiles of HOTAIR, CARLo-5, and CD99P1 LncRNAs in EMT-mediated myofibroblast differentiation in A549 cells and fibrotic human lungs and to explain their roles. Read More

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Characterization of an L-α,β-diaminopropionic acid polymer with comb-like structure isolated from a poly(ε-L-lysine)-producing Streptomyces sp.

Appl Microbiol Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Department of Life Science and Biotechnology, Graduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, 564-8680, Japan.

Polymers of basic amino acids function as polycationic compounds under physiological conditions and exhibit intriguing biological properties, such as antimicrobial and antiviral activities, immunopotentiating ability, and DNA-binding activity. Poly(ε-L-lysine) (ε-PL) produced by some strains of Streptomyces spp. is a cationic homopolymer of L-lysine linking between ε-amino and α-carboxylic acid functional groups and has been used as a food preservative based on its biocompatibility and biodegradability. Read More

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Extracellular vesicles derived from umbilical cord mesenchymal stromal cells alleviate pulmonary fibrosis by means of transforming growth factor-β signaling inhibition.

Stem Cell Res Ther 2021 Apr 12;12(1):230. Epub 2021 Apr 12.

China-Japan Union Hospital of Jilin University, 126 Xiantai St., Changchun, 130033, Jilin, China.

Background: Pulmonary fibrosis (PF), the end point of interstitial lung diseases, is characterized by myofibroblast over differentiation and excessive extracellular matrix accumulation, leading to progressive organ dysfunction and usually a terminal outcome. Studies have shown that umbilical cord-derived mesenchymal stromal cells (uMSCs) could alleviate PF; however, the underlying mechanism remains to be elucidated.

Methods: The therapeutic effects of uMSC-derived extracellular vesicles (uMSC-EVs) on PF were evaluated using bleomycin (BLM)-induced mouse models. Read More

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