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The evaluatıon of lung ınvolvement and functıonal capacıtıes ın patients diagnosed wıth prımary sjogren's syndrome.

Int J Clin Pract 2021 Jul 26:e14635. Epub 2021 Jul 26.

Department of Pulmonology, University of Health Sciences, Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Introduction: Sjögren syndrome is a chronic, systemic, inflammatory disease characterized with lymphocytic infiltration of the exocrine glands, frequently manifested by dryness in the region affected. Although the most common extraglandular involvement in SS is pulmonary involvement. Early diagnosis and treatment is considered to be important. Read More

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Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.

Eur J Pain 2021 Jul 26. Epub 2021 Jul 26.

Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Disrupted pain regulation has been proposed as a component in functional somatic disorders (FSD). The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM). Pressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. Read More

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Comprehensive Molecular Analyses of a Novel Mutational Signature Classification System with Regard to Prognosis, Genomic Alterations, and Immune Landscape in Glioma.

Front Mol Biosci 2021 7;8:682084. Epub 2021 Jul 7.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Glioma is the most common malignant brain tumor with complex carcinogenic process and poor prognosis. The current molecular classification cannot fully elucidate the molecular diversity of glioma. Using broad public datasets, we performed cluster analysis based on the mutational signatures and further investigated the multidimensional heterogeneity of the novel glioma molecular subtypes. Read More

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Molecular gut content analysis indicates the inter- and intra-guild predation patterns of spiders in conventionally managed vegetable fields.

Ecol Evol 2021 Jul 27;11(14):9543-9552. Epub 2021 Jun 27.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry University Fuzhou China.

Inter- and intra-guild interactions are important in the coexistence of predators and their prey, especially in highly disturbed vegetable cropping systems with sporadic food resources. Assessing the dietary range of a predator taxon characterized by diverse foraging behavior using conventional approaches, such as visual observation and conventional molecular approaches for prey detection, has serious logistical problems. In this study, we assessed the prey compositions and compare the dietary spectrum of a functionally diverge group of predators-spiders-to characterize their trophic interactions and assess biological control potential in Brassica vegetable fields. Read More

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Comparison of high-resolution melting analysis with direct sequencing for detection of FLT3-TKD, FLT3-ITD and WT1 mutations in acute myeloid leukemia.

Cancer Treat Res Commun 2021 Jul 11;28:100432. Epub 2021 Jul 11.

Department of Hematology, Faculty of Paramedicine, Aja University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Acute Myeloid Leukemia (AML) is a group of hematologic diseases characterized by a variety of clinically important genetic alterations. Genetic mutations affecting the FMS-like receptor tyrosine kinase-3 (FLT3) and Wilm's tumor (WT-1) genes are associated with poor prognosis in AML. In this work, efficiency of HRM method for detection of FLT3-ITD, FLT3-TKD, and WT-1 mutations was assessed in comparison with direct sequencing. Read More

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Investigating the Viability of Epithelial Cells on Polymer Based Thin-Films.

Polymers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska Ulica 8, SI-2000 Maribor, Slovenia.

The development of novel polymer-based materials opens up possibilities for several novel applications, such as advanced wound dressings, bioinks for 3D biofabrication, drug delivery systems, etc. The aim of this study was to evaluate the viability of vascular and intestinal epithelial cells on different polymers as a selection procedure for more advanced cell-polymer applications. In addition, possible correlations between increased cell viability and material properties were investigated. Read More

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Characterization of laryngeal motor neuron properties in the American bullfrog, Lithobates catesbieanus.

Respir Physiol Neurobiol 2021 Jul 20:103745. Epub 2021 Jul 20.

The University of North Carolina at Greensboro, Department of Biology, United States. Electronic address:

Motoneurons represent the final output from the central respiratory network. American bullfrogs, Lithobates catesbieanus, have provided insight into development and plasticity of the breathing control system, yet cellular aspects of bullfrog motoneurons are not well-described. In this study, we characterized properties of laryngeal motoneurons that produce motor outflow to the glottal dilator, a muscle that gates airflow to the lungs of anurans. Read More

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Neighborhood-level Asian American Populations, Social Determinants of Health, and Health Outcomes in 500 US Cities.

Ethn Dis 2021 15;31(3):433-444. Epub 2021 Jul 15.

Department of Population Health, NYU Grossman School of Medicine, New York, NY.

Introduction: The US Asian American (AA) population is projected to double by 2050, reaching ~43 million, and currently resides primarily in urban areas. Despite this, the geographic distribution of AA subgroup populations in US cities is not well-characterized, and social determinants of health (SDH) and health measures in places with significant AA/AA subgroup populations have not been described. Our research aimed to: 1) map the geographic distribution of AAs and AA subgroups at the city- and neighborhood- (census tract) level in 500 large US cities (population ≥66,000); 2) characterize SDH and health outcomes in places with significant AA or AA subgroup populations; and 3) compare SDH and health outcomes in places with significant AA or AA subgroup populations to SDH and health outcomes in places with significant non-Hispanic White (NHW) populations. Read More

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Effects of Sex and Estrous Cycle on the Time-Course of Incubation of Cue-Induced Craving Following Extended-Access Cocaine Self-Administration.

eNeuro 2021 Jul 21. Epub 2021 Jul 21.

Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, NJ

Cocaine addiction is a devastating public health epidemic that continues to grow. Studies focused on identifying biological factors influencing cocaine craving and relapse vulnerability are necessary in order to promote abstinence in recovering drug users. Sex and ovarian hormones are known to influence cocaine addiction liability and relapse vulnerability in both humans and rodents. Read More

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Assessing Prepulse Inhibition of Startle in Mice.

Bio Protoc 2018 Apr 5;8(7):e2789. Epub 2018 Apr 5.

INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.

Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce 'core' symptoms of complex human disorders such as schizophrenia. Despite this challenge, however, it is still conceivable to use animal models designed to reproduce some of the disease's 'endo-phenotypes'. Read More

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Maternal Rat Metabolomics: Amniotic Fluid and Placental Metabolic Profiling Workflows.

J Proteome Res 2021 Jul 20. Epub 2021 Jul 20.

UMR 1253 iBrain, Université de Tours, Inserm, Tours 37000, France.

Studying the metabolome of specific gestational compartments is of growing interest in the context of fetus developmental disorders. However, the metabolomes of the placenta and amniotic fluid (AF) are poorly characterized. Therefore, we present the validation of a fingerprinting methodology. Read More

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A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma.

BMC Cancer 2021 Jul 19;21(1):831. Epub 2021 Jul 19.

Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, People's Republic of China, 515041.

Background: Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical value of ferroptosis, an iron-dependent regulated cell death, is practical and important.

Methods: Prognostic ferroptosis-related differentially expressed genes (DEGs) were identified from the KIRC cohort in the cancer genome atlas (TCGA) database, from which a prognostic signature was established using Lasso-penalized Cox regression analysis. Read More

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Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats.

Clin Toxicol (Phila) 2021 Jul 19:1-8. Epub 2021 Jul 19.

Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.

Context: Diethylene glycol (DEG) is an organic compound found in household products but also as a counterfeit solvent in medicines. DEG poisonings are characterized by acute kidney injury (AKI) and by neurological sequelae such as decreased reflexes or face and limb weakness. Previous studies in male rats have demonstrated that neurotoxic effects develop only with the establishment of AKI, but the dose sensitivity of females to DEG toxicity is unknown. Read More

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Amplification of mutant in a patient with advanced metastatic pancreatic adenocarcinoma detected by liquid biopsy: A case report.

Mol Clin Oncol 2021 Sep 29;15(3):172. Epub 2021 Jun 29.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancer types. Activating oncogenic mutations are commonly observed in PDAC; however, oncogenic amplification is rarely observed, and its significance in prognosis and resistance to therapy remains poorly characterized. The present report describes the case of a 52-year-old male patient diagnosed with advanced PDAC with liver metastasis. Read More

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September 2021

Wild Olive Genotypes as a Valuable Source of Resistance to Defoliating .

Front Plant Sci 2021 1;12:662060. Epub 2021 Jul 1.

Instituto de Recursos Naturales y Agrobiología, Spanish National Research Council (CSIC), Seville, Spain.

Resistance to the defoliating pathotype of has been evaluated in a pool of 68 wild genotypes of olive belonging to the SILVOLIVE collection. Resistance was evaluated by assessing symptom severity using a 0-4 rating scale, estimating the relative area under the disease progress curve (RAUDPC), determining the percentage of dead plants (PDP), and measuring the evolution of morphological parameters in inoculated plants over time. In addition, the density levels of in the stem of root-inoculated genotypes have been quantified by means of quantitative real-time PCR at 35 and 120 days after inoculation (dai). Read More

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Diversity, population structure, and linkage disequilibrium among cowpea accessions.

Plant Genome 2021 Jul 18:e20113. Epub 2021 Jul 18.

Non-timber Forest Products and Orphan Crop Species Unit, Laboratory of Applied Ecology (LEA), University of Abomey-Calavi (UAC), 01 BP: 526 Cotonou, Benin.

Cowpea [Vigna unguiculata (L.) Walp] is a globally important food security crop. However, it is susceptible to pest and disease; hence, constant breeding efforts based on its diversity are required for its improvement. Read More

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Lung branching morphogenesis is accompanied by temporal metabolic changes towards a glycolytic preference.

Cell Biosci 2021 Jul 17;11(1):134. Epub 2021 Jul 17.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.

Background: Lung branching morphogenesis is characterized by epithelial-mesenchymal interactions that ultimately define the airway conducting system. Throughout this process, energy and structural macromolecules are necessary to sustain the high proliferative rates. The extensive knowledge of the molecular mechanisms underlying pulmonary development contrasts with the lack of data regarding the embryonic lung metabolic requirements. Read More

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Beyond the classic sensory systems: Characteristics of the sense of time of harbor seals (Phoca vitulina) assessed in a visual temporal discrimination and a bisection task.

Anat Rec (Hoboken) 2021 Jul 16. Epub 2021 Jul 16.

Neuroethology, University of Rostock, Institute for Biosciences, Rostock, Germany.

Beyond the classic sensory systems, the sense of time is most likely involved from foraging to navigation. As a prerequisite for assessing the role time is playing in different behavioral contexts, we further characterized the sense of time of a harbor seal in this study. Supra-second time intervals were presented to the seal in a temporal discrimination and a temporal bisection task. Read More

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Differently PEGylated Polymer Nanoparticles for Pancreatic Cancer Delivery: Using a Novel Near-Infrared Emissive and Biodegradable Polymer as the Fluorescence Tracer.

Front Bioeng Biotechnol 2021 29;9:699610. Epub 2021 Jun 29.

School of Medicine, Jiangsu University, Zhenjiang, China.

In this study, a chemically synthetic polymer, benzo[1,2-:4,5-']difuran(BDF)-based donor-acceptor copolymer PBDFDTBO, was individually coated by amphiphilic poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-PCL) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethylene glycol) (DSPE-PEG or PEG-DSPE), to form stably fluorescent nanoparticles in the near-infrared (NIR) window. The physicochemical properties of the synthesized nanoparticles were characterized and compared, including their size, surface charge, and morphology. In addition, studies were also performed using two pancreatic cancer cell lines, assessing the cell viability of the PBDFDTBO-included PEGylated nanoparticles formulations. Read More

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Assessing the Concordance Between Urogenital and Vaginal Microbiota: Can Urine Specimens Be Used as a Proxy for Vaginal Samples?

Front Cell Infect Microbiol 2021 29;11:671413. Epub 2021 Jun 29.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.

Background: The vaginal microbiota play a key role in defense against reproductive tract infections; however, many population-based women's health studies do not collect vaginal samples. Molecular examinations of urine samples have revealed common vaginal bacteria. We sought to assess the extent that community state type assignments of archived random-catch and clean-catch urine samples agreed with the paired vaginal samples in both reproductive-age and peri/post-menopausal women. Read More

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Assessing prognostic value of early tumor shrinkage and depth of response in first-line therapy for patients with advanced unresectable pancreatic cancer.

BMC Gastroenterol 2021 Jul 15;21(1):294. Epub 2021 Jul 15.

Division of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, China.

Background: The prognostic potential of early tumor shrinkage (ETS) and depth of response (DpR) in pancreatic cancer (PC) is unclear. Here, we recruited 90 patients with recurrent and metastatic PC (RMPC) who had received chemotherapy as first-line therapy to assess the prognostic potential of these markers.

Methods: ETS is characterized as a ≥ 20% depletion in the sum-of-the-longest-diameters (SLD) of measurable tumor lesions at 6-12 weeks than the baseline. Read More

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Assessing the presence of microplastic particles in Tunisian agriculture soils and their potential toxicity effects using Eisenia andrei as bioindicator.

Sci Total Environ 2021 Jul 8;796:148959. Epub 2021 Jul 8.

Laboratory of Agrobiodiversity and Ecotoxicology, Higher Institute of Agronomy Chott-Meriem, Sousse University, Tunisia; Higher Institute of Biotechnology, Monastir University, Tunisia.

In the present study, we investigated microplastics (MPs) in agricultural soils with different agronomic practices (organic farming, soil under greenhouses, soil under mulching and soil irrigated with treated wastewater (TWW)). Plastic particles from each site were collected and characterized by FTIR and Raman microspectroscopy. Plastic particles were then ground and added (size rage under 100 μm) at a concentration of 100 μg kg to soils from organic farming containing Eisenia andrei for 7 and 14 days. Read More

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Face masks as a source of nanoplastics and microplastics in the environment: Quantification, characterization, and potential for bioaccumulation.

Environ Pollut 2021 Jul 8;288:117748. Epub 2021 Jul 8.

Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China. Electronic address:

Billions of disposable face masks are consumed daily due to the COVID-19 pandemic. The role of these masks as a source of nanoplastics (NPs) and microplastics (MPs) in the environment has not been studied in previous studies. We quantified and characterized face mask released particles and evaluated their potential for accumulation in humans and marine organisms. Read More

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An Observational, Longitudinal Study of Cognition in Medical Cannabis Patients over the Course of 12 Months of Treatment: Preliminary Results.

J Int Neuropsychol Soc 2021 07;27(6):648-660

Cognitive and Clinical Neuroimaging Core, McLean Hospital Imaging Center, 115 Mill St, Belmont, MA02478, USA.

Objective: Cannabis use has increased dramatically across the country; however, few studies have assessed the long-term impact of medical cannabis (MC) use on cognition. Studies examining recreational cannabis users generally report cognitive decrements, particularly in those with adolescent onset. As MC patients differ from recreational consumers in motives for use, product selection, and age of onset, we assessed cognitive and clinical measures in well-characterized MC patients over 1 year. Read More

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Community norms of the Muscle Dysmorphic Disorder Inventory (MDDI) among gender minority populations.

J Eat Disord 2021 Jul 14;9(1):87. Epub 2021 Jul 14.

The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: Representing the pathological extreme pursuit of muscularity, muscle dysmorphia (MD) is characterized by a pervasive belief or fear around insufficient muscularity and an elevated drive for muscularity. Despite evidence of heightened body image-related concerns among gender minority populations, little is known about the degree of MD symptoms among gender minorities, particularly based on Muscle Dysmorphic Disorder Inventory (MDDI) scores. The objective of this study was to assess community norms of the MDDI in gender-expansive people, transgender men, and transgender women. Read More

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Pre-Transplant Patient Education in Solid Organ Transplant: A Narrative Review.

Transplantation 2021 Jul 13. Epub 2021 Jul 13.

Multi-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario Canada.

Education for pre-transplant, solid-organ recipient candidates aims to improve knowledge and understanding about the transplant process, outcomes and potential complications to support informed, shared decision-making to reduce fears and anxieties about transplant, inform expectations, and facilitate adjustment to post-transplant life. In this review, we summarize novel pre-transplant initiatives and approaches to educate solid-organ transplant recipient candidates. First, we review approaches that may be common to all solid-organ transplants, then we summarize interventions specific to kidney, liver, lung, and heart transplant. Read More

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Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway.

Stem Cell Res Ther 2021 Jul 13;12(1):392. Epub 2021 Jul 13.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound healing due to its high content of growth factors. However, its application is limited due to the rapid degradation of growth factors. Read More

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Increased integration between default mode and task-relevant networks in children with ADHD is associated with impaired response control.

Dev Cogn Neurosci 2021 Aug 22;50:100980. Epub 2021 Jun 22.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Default mode network (DMN) dysfunction is theorized to play a role in attention lapses and task errors in children with attention-deficit/hyperactivity disorder (ADHD). In ADHD, the DMN is hyperconnected to task-relevant networks, and both increased functional connectivity and reduced activation are related to poor task performance. The current study extends existing literature by considering interactions between the DMN and task-relevant networks from a brain network perspective and by assessing how these interactions relate to response control. Read More

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Evaluation of analgesic and anti-inflammatory activities and molecular docking analysis of steroidal lactones from Datura stramonium L.

Phytomedicine 2021 Jun 2;89:153621. Epub 2021 Jun 2.

Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 203, Haryana, India. Electronic address:

Background: Datura stramonium L. is widely used across the world for its therapeutic potential to treat inflammatory disorders. The current work was designed to isolate and identify steroidal lactones from D. Read More

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Case Report: Acute Eosinophilic Myocarditis With a Low-Flow Heart Failure With Preserved Ejection Fraction Phenotype.

Front Cardiovasc Med 2021 23;8:678973. Epub 2021 Jun 23.

Department of Cardiology, Cardiovascular Center, Showa General Hospital, Tokyo, Japan.

Eosinophilic myocarditis is a rare subtype of myocarditis characterized by myocardial eosinophilic infiltration, and it is potentially fatal if left untreated. Although endomyocardial biopsy (EMB) is a cornerstone for the histological diagnosis of acute eosinophilic myocarditis (AEM), as it is an invasive procedure and has a low diagnostic accuracy, the diagnosis of AEM with hemodynamic instability remains challenging. We describe a case of AEM presenting as low-flow heart failure with preserved ejection fraction (HFpEF), with rapid progression to cardiogenic shock. Read More

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