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Malignant pleural mesothelioma: clinical experience and prognostic value of derived neutrophil-to-lymphocyte ratio and PD-L1 expression.

Clin Transl Oncol 2021 Apr 10. Epub 2021 Apr 10.

Medical Oncology Department, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain.

Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, with a poor prognosis. MPM needs to find prognostic factors of survival. We provided the management of patients with MPM and sought to determine whether pre-treatment levels of derived neutrophil-to-lymphocyte ratio (dNLR) as well as PD-L1 expression were reliable prognostic factors of survival. Read More

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Computed tomographic features of coronavirus disease-2019 (COVID-19) pneumonia in three groups of Iranian patients: A single center study.

Radiologia 2021 Mar 14. Epub 2021 Mar 14.

Centro de Investigación de Gastroenterología y Enfermedades Hepáticas, Instituto de Investigación de Gastroenterología y Enfermedades Hepáticas, Universidad de Ciencias Médicas Shahid Beheshti, Teherán, Irán.

Introduction And Objectives: The pivotal role of chest computed tomographic (CT) to diagnosis and prognosis coronavirus disease-2019 (COVID-19) is still an open field to be explored. This study was conducted to assess the CT features in confirmed cases with COVID-19.

Materials And Methods: Retrospectively, initial chest CT data of 363 confirmed cases with COVID-19 were reviewed. Read More

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The incidence of pleural effusion in COVID-19 pneumonia: State-of-the-art review.

Heart Lung 2021 Feb 27;50(4):481-490. Epub 2021 Feb 27.

Department of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY, USA.

Background: COVID-19-related pleural effusions are frequently described during the ongoing pandemic.

Objectives: We described the incidence, characteristics, and outcomes of COVID-19-related pleural effusions based on the current evidence available in the literature.

Methods: We searched MEDLINE, Pubmed, and Google Scholar databases using keywords of "coronavirus disease 2019 (COVID-19)," "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)," "pleural effusion," "pleural fluid," and "pleura" from January 1st, 2020 to January 31st, 2021. Read More

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February 2021

P14/ARF-Positive Malignant Pleural Mesothelioma: A Phenotype With Distinct Immune Microenvironment.

Front Oncol 2021 22;11:653497. Epub 2021 Mar 22.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Introduction: The CDKN2A gene plays a central role in the pathogenesis of malignant pleural mesothelioma (MPM). The gene encodes for two tumor suppressor proteins, p16/INK4A and p14/ARF, frequently lost in MPM tumors. The exact role of p14/ARF in MPM and overall its correlation with the immune microenvironment is unknown. Read More

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Clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection: A multi-center study.

PLoS One 2021 5;16(4):e0249668. Epub 2021 Apr 5.

Department of Respiratory and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Hunan, China.

Objective: To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and therefore contributing to their early identification and prognosis estimation.

Method: 905 COVID-19 patients from 7 different centers were enrolled. The demography data, clinical manifestations, laboratory results, and treatments were collected accordingly for further analyses. Read More

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Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries.

Lancet Respir Med 2021 Mar 31. Epub 2021 Mar 31.

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Background: Lung transplantation is a life-saving treatment for patients with end-stage lung disease; however, it is infrequently considered for patients with acute respiratory distress syndrome (ARDS) attributable to infectious causes. We aimed to describe the course of disease and early post-transplantation outcomes in critically ill patients with COVID-19 who failed to show lung recovery despite optimal medical management and were deemed to be at imminent risk of dying due to pulmonary complications.

Methods: We established a multi-institutional case series that included the first consecutive transplants for severe COVID-19-associated ARDS known to us in the USA, Italy, Austria, and India. Read More

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Lung Transplantation for Pleuroparenchymal Fibroelastosis.

J Clin Med 2021 Mar 1;10(5). Epub 2021 Mar 1.

Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Pleuroparenchymal fibroelastosis (PPFE), a new disease entity associated with interstitial pneumonia, is characterized by fibrosis and elastosis involving the pleura and subpleural lung parenchyma, predominantly in the upper lobe. As the awareness of this disease entity has increased, many studies have revealed the prevalence and incidence, clinical and pathological characteristics, and disease course of PPFE. Patients with PPFE reportedly have several unique clinical characteristics-including an extremely low body mass index with a slender body and chest wall deformity, known as "flat chest". Read More

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Characteristics and Outcome of Severe Pneumonia Admitted to PICU in Shanghai: A Retrospective Cohort Study.

Crit Care Explor 2021 Mar 23;3(3):e0366. Epub 2021 Mar 23.

Department of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: We aimed to describe the characteristics and outcome in children with severe pneumonia in a Chinese PICU.

Design: A retrospective observational study from 2017 to 2019.

Setting: A 36-bed university tertiary PICU at Shanghai Children's Hospital. Read More

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Epidemiology and prognostic factors of pleural empyema.

Thorax 2021 Mar 30. Epub 2021 Mar 30.

Thoracic Surgery, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France.

Background: Infection of the pleural cavity invariably leads to hospitalisation, and a fatal outcome is not uncommon. Our aim was to study the epidemiology of pleural empyema on a nationwide basis in the whole population and in three subgroups of patients, namely post-lung resection, associated cancer and those with no surgery and no cancer.

Methods: Data from patients aged ≥18 years hospitalised with a diagnosis of pleural infection in France between January 2013 and December 2017 were retrieved from the medical-administrative national hospitalisation database and retrospectively analysed. Read More

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Clinical and radiological findings for the new multisystem inflammatory syndrome in children associated with COVID-19.

Radiologia 2021 Mar 11. Epub 2021 Mar 11.

Servicio de Radiodiagnóstico, Hospital Arnau de Vilanova de Valencia - Hospital de Llíria, Valencia, España.

The World Health Organization defines the multisystem inflammatory syndrome in children (MIS-C) as a new syndrome reported in patients aged <19 years old who have a history of exposure to SARS-CoV-2. The onset of this syndrome is characterized by persistent fever that is associated with lethargy, abdominal pain, vomiting and/or diarrhea, and, less frequently, rash and conjunctivitis. The course and severity of the signs and symptoms vary; in some children, MIS-C worsens rapidly and can lead to hypotension, cariogenic shock, or even damage to multiple organs. Read More

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Incidence and Management of Effusions Before and After CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Large B Cell Lymphoma.

Transplant Cell Ther 2021 Mar 27;27(3):242.e1-242.e6. Epub 2020 Dec 27.

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida; Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:

In patients with lymphoma, third-space fluid accumulations may develop or worsen during cytokine release syndrome (CRS) associated with chimeric antigen receptor (CAR) T cell therapy. Pre-existing symptomatic pleural effusions were excluded by the ZUMA-1 trial of axicabtagene ciloleucel for large B cell lymphoma (LBCL) and variants. The incidence and management of effusions during CAR T cell therapy for LBCL are unknown. Read More

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Typical CT Features of Intrapulmonary Lymph Nodes: A Review.

Radiol Cardiothorac Imaging 2020 Aug 27;2(4):e190159. Epub 2020 Aug 27.

Diagnostic Image Analysis Group, Department of Radiology, Nuclear Medicine, and Anatomy, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands (A.S., C.J., E.T.S., B.v.G., C.M.S.P., M.P.); Fraunhofer MEVIS, Bremen, Germany (C.J., B.v.G.); and Department of Radiology, Meander Medisch Centrum, Amersfoort, the Netherlands (C.M.S.P.).

Several studies investigated the appearance of intrapulmonary lymph nodes (IPLNs) at CT with pathologic correlation. IPLNs are benign lesions and do not require follow-up after initial detection. There are indications that IPLNs represent a considerable portion of incidentally found pulmonary nodules seen at high-resolution CT. Read More

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Thin-Section Chest CT Imaging of COVID-19 Pneumonia: A Comparison Between Patients with Mild and Severe Disease.

Radiol Cardiothorac Imaging 2020 Apr 23;2(2):e200126. Epub 2020 Apr 23.

Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago Medicine, Chicago, Ill (S.Y.X.).

Purpose: To compare radiologic characteristics of coronavirus disease 2019 (COVID-19) pneumonia at thin-section CT on admission between patients with mild and severe disease.

Materials And Methods: Seventy patients with COVID-19 pneumonia who were admitted to Zhongnan Hospital of Wuhan University between January 20, 2020 and January 27, 2020 were enrolled. On the basis of the World Health Organization guidelines, 50 patients were categorized with the mild form and 20 with the severe form based on clinical conditions. Read More

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Pulmonary Artery Filling Defects in COVID-19 Patients Revealed Using CT Pulmonary Angiography: A Predictable Complication?

Biomed Res Int 2021 10;2021:8851736. Epub 2021 Mar 10.

Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University Hospital "Policlinico" of Bari Medical School, Italy.

Purpose: This study is aimed at assessing the prevalence of pulmonary artery filling defects (PAFDs) consistent with pulmonary artery embolism (PAE) in patients with SARS-CoV-2 infection and at investigating possible radiological or clinical predictors.

Materials And Methods: Computed Tomography Pulmonary Angiographies (CTPAs) from 43 consecutive patients with a confirmed COVID-19 infection were retrospectively reviewed, taking into consideration the revised Geneva score and the D-dimer value for each patient. Filling defects within the pulmonary arteries were recorded along with pleural and parenchymal findings such as ground glass opacities, consolidation, crazy paving, linear consolidation, and pleural effusion. Read More

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Trends in extrapulmonary TB cases at three teaching hospitals in Ghana, 2008-2017.

Public Health Action 2021 Mar;11(1):26-32

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.

Setting: Three teaching hospitals in Ghana.

Objective: To elucidate trends in demographics, clinical characteristics and treatment outcomes in extrapulmonary TB (EPTB) patients.

Design: This was a retrospective study involving the review and comparison of EPTB and pulmonary TB (PTB) data from 1 January 2008 to 31 December 2017 in TB registers and treatment cards. Read More

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Pneumothorax detection in chest radiographs: optimizing artificial intelligence system for accuracy and confounding bias reduction using in-image annotations in algorithm training.

Eur Radiol 2021 Mar 27. Epub 2021 Mar 27.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Objectives: Diagnostic accuracy of artificial intelligence (AI) pneumothorax (PTX) detection in chest radiographs (CXR) is limited by the noisy annotation quality of public training data and confounding thoracic tubes (TT). We hypothesize that in-image annotations of the dehiscent visceral pleura for algorithm training boosts algorithm's performance and suppresses confounders.

Methods: Our single-center evaluation cohort of 3062 supine CXRs includes 760 PTX-positive cases with radiological annotations of PTX size and inserted TTs. Read More

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Cardiophrenic Lymph Node Metastasis of Ovarian High-grade Serous Carcinoma Showing Wild-type p53 Immunostaining Pattern and Aberrant CD56 Expression.

Int J Surg Pathol 2021 Mar 25:10668969211006194. Epub 2021 Mar 25.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea.

Patterns of p53 immunostaining are used as a surrogate marker for tumor protein 53 () mutations in the diagnosis of ovarian high-grade serous carcinoma (HGSC). We present a rare case of ovarian HGSC that metastasized to the diaphragm and cardiophrenic lymph nodes and showed the immunostaining pattern of wild-type p53 and aberrant neural cell adhesion molecule (CD56) expression. A 63-year-old woman developed multifocal metastases in the diaphragmatic pleura and cardiophrenic lymph nodes. Read More

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COVID-19 integrated imaging: our experience and literature review.

Pol J Radiol 2021 1;86:e78-e86. Epub 2021 Feb 1.

Department of Radiology, SG Moscati Hospital, ASL Caserta, Aversa, Italy.

Purpose: To investigate the imaging features of emerging COVID-19 pneumonia on chest ultrasound, radiographs and computed tomography examinations performed at admission. In addition, we provide a review of the literature and compare our results with recent evidence regarding the imaging characteristics of this novel disease.

Material And Methods: From March 17, 2020 to April 25, 2020, 23 patients with real-time polymerase chain reaction (RT-PCR) assay confirmed COVID-19 were identified. Read More

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February 2021

Cellular solitary fibrous tumor in the mental area: a case report and literature review.

J Int Med Res 2021 Mar;49(3):3000605211000536

Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.

Solitary fibrous tumors (SFTs) are rare benign mesenchymal tumors that occur mainly in the pleura. We herein report the first case of a cellular SFT located in the mental region of the head and neck in a 46-year-old woman. Facial computed tomography revealed a mass measuring 0. Read More

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Comparison of Clinical Outcomes Following Lumbar Endoscopic Unilateral Laminotomy Bilateral Decompression and Minimally Invasive Transforaminal Lumbar Interbody Fusion for One-Level Lumbar Spinal Stenosis With Degenerative Spondylolisthesis.

Front Surg 2020 26;7:596327. Epub 2021 Feb 26.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Both lumbar endoscopic unilateral laminotomy bilateral decompression (LE-ULBD) and minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) have been used to treat one-level lumbar spinal stenosis (LSS) with degenerative spondylolisthesis, while the differences of the clinical outcomes are still uncertain. Among 60 consecutive patients included, 24 surgeries were performed by LE-ULBD and 36 surgeries were performed by MI-TLIF. Patient demographics, operation characteristics and complications were recorded. Read More

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February 2021

A Machine Learning Model Based on PET/CT Radiomics and Clinical Characteristics Predicts ALK Rearrangement Status in Lung Adenocarcinoma.

Front Oncol 2021 2;11:603882. Epub 2021 Mar 2.

Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: Anaplastic lymphoma kinase (ALK) rearrangement status examination has been widely used in clinic for non-small cell lung cancer (NSCLC) patients in order to find patients that can be treated with targeted ALK inhibitors. This study intended to non-invasively predict the ALK rearrangement status in lung adenocarcinomas by developing a machine learning model that combines PET/CT radiomic features and clinical characteristics.

Methods: Five hundred twenty-six patients of lung adenocarcinoma with PET/CT scan examination were enrolled, including 109 positive and 417 negative patients for ALK rearrangements from February 2016 to March 2019. Read More

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Relationship between epidermal growth factor receptor mutations and CT features in patients with lung adenocarcinoma.

Clin Radiol 2021 Mar 14. Epub 2021 Mar 14.

Key Laboratory of Medical Imaging, Gansu Province, China; Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China. Electronic address:

Aim: The purpose of this study was to investigate the relationship between epidermal growth factor receptor (EGFR) mutation status and computed tomography (CT) features in patients with lung adenocarcinoma.

Materials And Methods: A total of 483 patients with lung adenocarcinoma diagnosed between January 2015 and April 2020 were included in this study. All patients underwent a preoperative chest CT, and a total of 31 detailed CT features were quantified. Read More

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Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity.

Ann Surg Oncol 2021 Mar 16. Epub 2021 Mar 16.

Department of Surgery, Section of Thoracic Surgery, University of California, San Francisco, USA.

Background: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors most commonly arising from the pleura in the thoracic cavity. The impact of tumor size on risk of recurrence in thoracic SFTs is not well understood.

Methods: A single institution review was performed on all resected thoracic SFTs (1992-2019) with giant SFT defined as ≥ 15 cm. Read More

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The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience.

J Thorac Dis 2021 Feb;13(2):600-612

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Synovial sarcoma (SS) is a rare malignant soft tissue tumor. Primary intrathoracic SS is extremely rare, with limited diagnosis and treatment experiences. The aim of our study was to retrospectively study the clinicopathological characteristics, treatment and prognosis of primary intrathoracic SS and the impact of multidisciplinary team (MDT) management in diagnosis and treatment on patient prognosis. Read More

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February 2021

Trans-hiatal herniation following esophagectomy or gastrectomy: retrospective single-center experiences with a potential surgical emergency.

Hernia 2021 Mar 13. Epub 2021 Mar 13.

Department of General, Visceral, Thoracic, Transplant and Pediatric Surgery, University Hospital of Giessen, Rudolf-Buchheim-Strasse 7, 35392, Giessen, Germany.

Purpose: Trans-hiatal herniation after esophago-gastric surgery is a potentially severe complication due to the risk of bowel incarceration and cardiac or respiratory complaints. However, measures for prevention and treatment options are based on a single surgeon´s experiences and small case series in the literature.

Methods: Retrospective single-center analysis on patients who underwent surgical repair of trans-hiatal hernia following gastrectomy or esophagectomy from 01/2003 to 07/2020 regarding clinical symptoms, hernia characteristics, pre-operative imaging, hernia repair technique and perioperative outcome. Read More

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Value of CT features for predicting EGFR mutations and ALK positivity in patients with lung adenocarcinoma.

Sci Rep 2021 Mar 11;11(1):5679. Epub 2021 Mar 11.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province, 430022, The People's Republic of China.

The aim of this study was to identify the relationships of epidermal growth factor receptor (EGFR) mutations and anaplastic large-cell lymphoma kinase (ALK) status with CT characteristics in adenocarcinoma using the largest patient cohort to date. In this study, preoperative chest CT findings prior to treatment were retrospectively evaluated in 827 surgically resected lung adenocarcinomas. All patients were tested for EGFR mutations and ALK status. Read More

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Central versus peripheral lesion on chest X-Ray: A case series of 31 endobronchial tuberculosis patients with negative sputum smears.

Int J Mycobacteriol 2021 Jan-Mar;10(1):89-92

Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.

Background: Clinical characteristics of endobronchial tuberculosis (EBTB) patients whose sputum smears were negative have not been elucidated yet.

Method: EBTB patients with negative sputum smears were documented retrospectively at the outpatient pulmonary clinic from late 2015 to early 2019.

Results: We described the characteristics of 31 EBTB patients with negative sputum smears. Read More

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[Expression and clinical significance of SETD2 in maligant pleural mesothelioma].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Feb;39(2):91-98

Hangzhou Medical School (Zhejiang Academy of Medical Sciences) , School of Public Health, Hangzhou 310013, China.

To analyze the gene mutation profile in malignant pleural mesothelioma (MPM) and investigate the expression of high-frequency mutant genes and its relationship with clinicopathological parameters. To screen out key genes and clinicopathologic factors related to the prognosis of MPM patients. The second generation sequencing data, somatic mutation data and clinical pathological data of 86 MPM cases and gene chip expression data of 89 MPM cases were downloaded from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) in March 2020. Read More

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February 2021

Demographic, signs and symptoms, imaging characteristics of 2126 patients with COVID-19 pneumonia in the whole quarantine of Wuhan, China.

Clin Imaging 2021 Feb 23;77:169-174. Epub 2021 Feb 23.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Jie-Fang-Da-Dao 1095, Wuhan 430030, China. Electronic address:

Objective: The accurate knowledge of demographic, signs and symptoms, imaging characteristics of coronavirus disease 2019 (COVID-19) is essential for the accurate management of these patients. However, the claims between the previous papers are not always consistent and may even contradict each other, for example, some claims the virus infects more men than women in Wuhan. In this large-scale cohort study, we aimed to update the demographic, signs and symptoms, imaging characteristics of patients with COVID-19 in the whole quarantine of Wuhan, China. Read More

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February 2021

Imaging Assessment of Visceral Pleural Surface Invasion by Lung Cancer: Comparison of CT and Contrast-Enhanced Radial T1-Weighted Gradient Echo 3-Tesla MRI.

Korean J Radiol 2021 Feb 24. Epub 2021 Feb 24.

Harvard Medical School, Massachusetts General Hospital, Founders House, Boston, MA, USA.

Objective: To compare the diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3-tesla (3T) magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of visceral pleural surface invasion (VPSI). Visceral pleural invasion by non-small-cell lung cancer (NSCLC) can be classified into two types: PL1 (without VPSI), invasion of the elastic layer of the visceral pleura without reaching the visceral pleural surface, and PL2 (with VPSI), full invasion of the visceral pleura.

Materials And Methods: Thirty-three patients with pathologically confirmed VPSI by NSCLC were retrospectively reviewed. Read More

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February 2021