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Conjunctival Chemosis and Annular Ciliochoroidal Detachments Detected by Anterior-Segment Optical Coherence Tomography in a Case of Systemic Lupus Erythematosus.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):154-158. Epub 2021 Apr 12.

Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan.

A 61-year-old Japanese woman presented to our hospital for treatment of systemic serositis associated with systemic lupus erythematosus (SLE). At the initial ophthalmologic examination, her best-corrected visual acuity was 1.2 and 0. Read More

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Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology.

Drug Des Devel Ther 2021 4;15:1883-1902. Epub 2021 May 4.

Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.

Background: Rhubarb, as a traditional Chinese medicine, is the preferred drug for the treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism in vivo is still unclear.

Methods: In this study, the chemical components in rhubarb were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology. Read More

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A New Spiropyran-Based Fluorescent Probe for Dual Sensing of Ferrous Ion and pH.

J Fluoresc 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 200433, Shanghai, China.

A new spiropyran-based fluorescent probe was developed for dual detection of Fe ion and pH. Addition of Fe and Ag to the probe solution enhanced the fluorescence intensity by 6 and 5 fold, respectively. Addition of Fe, Hg and Ni caused slight increase in the fluorescence intensity of the probe. Read More

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Homochiral metal-organic frameworks for enantioseparation.

Chem Soc Rev 2021 May 22;50(9):5706-5745. Epub 2021 Mar 22.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

Obtaining homochiral compounds is of high importance to human health and environmental sustainability. Currently, enantioseparation is one of the most effective approaches to obtain homochiral compounds. Thanks to their controlled synthesis and high efficiency, homochiral metal-organic frameworks (HMOFs) are one of the most widely studied porous materials to enable enantioseparation. Read More

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Responsive manipulation of neural circuit pathology by fully implantable, front-end multiplexed embedded neuroelectronics.

Proc Natl Acad Sci U S A 2021 May;118(20)

Department of Electrical Engineering, Columbia University, New York, NY 10027;

Responsive neurostimulation is increasingly required to probe neural circuit function and treat neuropsychiatric disorders. We introduce a multiplex-then-amplify (MTA) scheme that, in contrast to current approaches (which necessitate an equal number of amplifiers as number of channels), only requires one amplifier per multiplexer, significantly reducing the number of components and the size of electronics in multichannel acquisition systems. It also enables simultaneous stimulation of arbitrary waveforms on multiple independent channels. Read More

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Cochrane Rehabilitation: 2020 annual report.

Eur J Phys Rehabil Med 2021 Apr;57(2):303-308

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

During its fourth year of existence, Cochrane Rehabilitation went on to promote evidence-informed health decision-making in rehabilitation. In 2020, the outbreak of the COVID-19 pandemic has made it necessary to alter priorities. In these challenging times, Cochrane Rehabilitation has firstly changed its internal organisation and established a new relevant project in line with pandemic needs: the REH-COVER (Rehabilitation - COVID-19 evidence-based response) action. Read More

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Inhibition of voltage-dependent K channels in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic agent lorcainide.

Eur J Pharmacol 2021 May 7:174158. Epub 2021 May 7.

Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea. Electronic address:

Voltage-dependent K (Kv) channels play the role of returning the membrane potential to the resting state, thereby maintaining the vascular tone. Here, we used native smooth-muscle cells from rabbit coronary arteries to investigate the inhibitory effect of lorcainide, a class Ic antiarrhythmic agent, on Kv channels. Lorcainide inhibited Kv channels in a concentration-dependent manner with an IC of 4. Read More

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Computational and Synthetic Target-Based Approaches to the Discovery of Novel Anticonvulsant Compounds.

Curr Med Chem 2021 May 6. Epub 2021 May 6.

Laboratory of Bioactive Research and Development (LIDeB), Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina.

Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development of drug-resistant epilepsy and the occurrence of severe toxic effects caused by the medication in responsive patients. The retrospective analysis of the strategies for discovering known anticonvulsant drugs showed that screening campaigns on animal models of epilepsy had been almost the exclusive strategy for identifying the marketed compounds. Read More

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Coating of Wood with FeO-Decorated Carbon Nanotubes by One-Step Combustion for Efficient Solar Steam Generation.

ACS Appl Mater Interfaces 2021 May 10. Epub 2021 May 10.

Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China.

As the global water shortage becomes increasingly serious, it is highly imperative to develop efficient, renewable, and large-scale water purification devices. Herein, an efficient solar-driven water purification device of wood coated with FeO nanoparticle-decorated carbon nanotubes (FeO/CNT) is fabricated in only a few seconds by one-step combustion of ferric acetylacetonate in an ambient environment. The thin layer of the FeO/CNT hybrid coated on the upper surface of the wood serves as a solar-light absorber for converting solar energy to thermal energy, while the thermally insulating wood layer with vertically aligned channels endows the device with rapid water upward transport and localizes the generated heat inside the FeO/CNT layer for solar-driven water evaporation. Read More

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Correlated conformational dynamics of the human GluN1-GluN2A type N-methyl-D-aspartate (NMDA) receptor.

J Mol Model 2021 May 10;27(6):162. Epub 2021 May 10.

Bioinformatics and Genetics Department, Faculty of Engineering and Natural Sciences, Kadir Has University, 34083 Fatih, Istanbul, Turkey.

N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels found in the nerve cell membranes. As a result of overexcitation of NMDARs, neuronal death occurs and may lead to diseases such as epilepsy, stroke, Alzheimer's disease, and Parkinson's disease. In this study, human GluN1- GluN2A type NMDAR structure is modeled based on the X-ray structure of the Xenopus laevis template and missing loops are added by ab-initio loop modeling. Read More

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Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).

Exp Ther Med 2021 Jun 20;21(6):656. Epub 2021 Apr 20.

College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.

Ventricular arrhythmia (VA) is a highly fatal arrhythmia that involves multiple ion channels. Of all sudden cardiac death events, ~85% result from VAs, including ventricular tachycardia and ventricular fibrillation. Calcium/calmodulin-dependent pro-tein kinase II (CaMKII) is an important ion channel regulator that participates in the excitation-contraction coupling of the heart, and as such is important for regulating its electrophysiological function. Read More

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Relaxant Effect of on Tracheal Smooth Muscle Mediated by the Effect on Beta-2 Adrenergic, Muscarinic Receptors and Calcium and Potassium Channels.

Evid Based Complement Alternat Med 2021 20;2021:6637990. Epub 2021 Apr 20.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

() showed anti-inflammatory, antioxidant, antibacterial, diuretic, vasodilatation, and wound-healing effects on fungal infections, cardiac disorders, digestive disorders, rheumatoid disease, and respiratory disorders such as bronchitis, bronchial nosocomial infections, and severe cough. To examine the bronchodilatory effect of , the relaxant effect of its extract on rat tracheal smooth muscle (TSM) and its possible mechanism was examined in this study. Male Wistar rats' TSM were divided into eight groups ( = 8 in each group). Read More

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Triadin Decrease Impairs the Expression of E-C Coupling Related Proteins in Muscles of MPTP-Induced Parkinson's Disease Mice.

Front Neurosci 2021 22;15:649688. Epub 2021 Apr 22.

Department of Korean Medicine, Sangji University, Wonju, South Korea.

Parkinson's disease (PD), caused by destruction of dopaminergic neurons in the brain, leads to motor symptoms like bradykinesia, tremor, and walking impairments. While most research effort focuses on changes in neuronal pathology we examined how muscle proteins were altered in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. A Ca release channel complex, consisting of ryanodine receptors (RYR), triadin (TRDN), and calsequestrin (CSQ1), is important for excitation-contraction coupling in the sarcoplasmic reticulum membrane in muscles. Read More

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(An overview of) Synergistic reconstruction for multimodality/multichannel imaging methods.

Philos Trans A Math Phys Eng Sci 2021 Jun 10;379(2200):20200205. Epub 2021 May 10.

Institute of Nuclear Medicine, University College London, London, UK.

Imaging is omnipresent in modern society with imaging devices based on a zoo of physical principles, probing a specimen across different wavelengths, energies and time. Recent years have seen a change in the imaging landscape with more and more imaging devices combining that which previously was used separately. Motivated by these hardware developments, an ever increasing set of mathematical ideas is appearing regarding how data from different imaging modalities or channels can be synergistically combined in the image reconstruction process, exploiting structural and/or functional correlations between the multiple images. Read More

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Multichannel Immunosensor Platform for the Rapid Detection of SARS-CoV-2 and Influenza A(H1N1) Virus.

ACS Appl Mater Interfaces 2021 May 9. Epub 2021 May 9.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, P. R. China.

The coronavirus disease 2019 (COVID-19) can present a similar syndrome to an influenza infection, which may complicate diagnosis and clinical management of these two important respiratory infectious diseases, especially during the peak season of influenza. A rapid and convenient point-of-care test (POCT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus is of great importance for prompt and efficient control of these respiratory epidemics. Herein, a multichannel electrochemical immunoassay (MEIA) platform was developed based on a disposable screen-printed carbon electrode (SPCE) array for the on-site detection of SARS-CoV-2 and A(H1N1). Read More

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FBSED based automatic diagnosis of COVID-19 using X-ray and CT images.

Comput Biol Med 2021 May 2;134:104454. Epub 2021 May 2.

Department of Electrical Engineering, Indian Institute of Technology Indore, Indore, 453552, India. Electronic address:

This work introduces the Fourier-Bessel series expansion-based decomposition (FBSED) method, which is an implementation of the wavelet packet decomposition approach in the Fourier-Bessel series expansion domain. The proposed method has been used for the diagnosis of pneumonia caused by the 2019 novel coronavirus disease (COVID-19) using chest X-ray image (CXI) and chest computer tomography image (CCTI). The FBSED method is used to decompose CXI and CCTI into sub-band images (SBIs). Read More

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A 1,8-naphthalimide-based lysosome-targeting dual-analyte fluorescent probe for the detection of pH and palladium in biological samples.

Talanta 2021 Aug 29;231:122365. Epub 2021 Mar 29.

Institute of Natural Medicine and Health Products, School of Life Science, Taizhou University, Taizhou, 318000, PR China; Department of Pharmaceutics, School of Pharmacy & Key Laboratory of Smart Drug Delivery, Fudan University, Shanghai, 200433, PR China. Electronic address:

Fluorescent probes containing 1,8-naphthalimide dyes have been used to detect biomolecules in the environmental and biological fields. However, most of the probes only exhibit single fluorescent output to one analyte, making them insufficient for detection of more analytes. Herein, we developed a novel 1,8-naphthalimide-based lysosome-targeting dual-analyte sensitive fluorescent probe (DPPP) for the detection of pH and palladium (Pd) using two different emissive channels. Read More

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Synthesis and BK channel-opening activity of 2-Amino-1,3-thiazole derivatives.

Bioorg Med Chem Lett 2021 May 5:128083. Epub 2021 May 5.

Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China. Electronic address:

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring. Read More

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A Prototype Spatial-Spectral CT System for Material Decomposition with Energy-Integrating Detector.

Med Phys 2021 May 8. Epub 2021 May 8.

Johns Hopkins University, 720 Rutland Ave., Traylor Building 605, Baltimore, MD, 21205, USA.

Purpose: Spectral CT has great potential for a variety of clinical applications due to improved tissue and material discrimination over conventional single-energy CT. Many clinical and preclinical spectral CT systems have two spectral channels enabling dual-energy CT. Strategies include split-filtration, dual-layer detectors, photon counting detectors, and kVp-switching. Read More

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Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.

Mol Brain 2021 May 7;14(1):78. Epub 2021 May 7.

Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.

Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened. Manipulating acid-sensing ion channels (ASICs) in the amygdala via carbon dioxide (CO) inhalation enhances memory retrieval and its lability within the reconsolidation window. Read More

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CuSe nanowires shelled with NiFe layered double hydroxide nanosheets for overall water-splitting.

J Colloid Interface Sci 2021 Apr 21;599:370-380. Epub 2021 Apr 21.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science (Ministry of Education), State Key Laboratory Base of Eco-chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

It is imperative but challenging to develop non-noble metal-based bifunctional electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Our work reports a core-shell nanostructure that is constructed by the electrodeposition of ultrathin NiFe-LDH nanosheets (NiFe-LDHNS) on CuSe nanowires, which are obtained by selenizing Cu(OH) nanowires in situ grown on Cu foam. The obtained CuSe@NiFe-LDHNS electrocatalyst provides more exposed edges and catalytic active sites, thus exhibiting excellent OER and HER electrocatalytic performance in alkaline electrolytes. Read More

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Response of vegetation to submergence along Jingjiang Reach of the Yangtze River.

PLoS One 2021 7;16(5):e0251015. Epub 2021 May 7.

Department of Civil and Environmental Engineering, Tokyo Institute of Technology, Tokyo, Japan.

This work explores the changes in vegetation coverage and submergence time of floodplains along the middle and lower reaches of the Yangtze River (i.e., the Jingjiang River) and the relations between them. Read More

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Estimation of Apnea-Hypopnea Index using Deep Learning on 3D Craniofacial Scans.

IEEE J Biomed Health Inform 2021 May 7;PP. Epub 2021 May 7.

Obstructive sleep apnea (OSA) is characterized by decreased breathing events that occur through the night, with severity reported as the apnea-hypopnea index (AHI), which is associated with certain craniofacial features. In this study, we used data from 1366 patients collected as part of Stanford Technology Analytics and Genomics in Sleep (STAGES) across 11 US and Canadian sleep clinics and analyzed 3D craniofacial scans with the goal of predicting AHI, as measured using gold standard nocturnal polysomnography (PSG). First, the algorithm detects pre-specified landmarks on mesh objects and aligns scans in 3D space. Read More

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Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug.

Drug Deliv 2021 Dec;28(1):894-905

School of Pharmacy, China Medical University, Shenyang, China.

The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. Read More

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December 2021

Objective interictal electrophysiology biomarkers optimize prediction of epilepsy surgery outcome.

Brain Commun 2021 14;3(2):fcab042. Epub 2021 Mar 14.

Department of Paediatrics, Children's Hospital of Michigan, Detroit Medical Centre, Wayne State University, Detroit, MI 48201, USA.

Researchers have looked for rapidly- and objectively-measurable electrophysiology biomarkers that accurately localize the epileptogenic zone. Promising candidates include interictal high-frequency oscillation and phase-amplitude coupling. Investigators have independently created the toolboxes that compute the high-frequency oscillation rate and the severity of phase-amplitude coupling. Read More

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Enhancement of signal-to-noise ratio for fluorescence endoscope image based on fast digital lock-in algorithm.

R Soc Open Sci 2021 Mar 10;8(3):200779. Epub 2021 Mar 10.

School of Life Sciences, Tiangong University, Tianjin 300387, People's Republic of China.

In this paper, the signal-to-noise ratios (SNR) of two image channels were enhanced with the fast digital lock-in algorithm. In order to simultaneously improve the quality of white and fluorescence images obtained by fluorescence endoscope, and improve the SNR to achieve a better image processing effect, two sources of white light and near-infrared light of a fluorescence endoscope were modulated, then the acquired images were demodulated into white and fluorescence images. A fluorescent endoscope experimental platform was setup to acquire endoscopic images of a target dyed by indocyanine green. Read More

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Calcium channels and their role in regenerative medicine.

World J Stem Cells 2021 Apr;13(4):260-280

School of Dentistry, UT Health Science Center San Antonio, San Antonio, TX 78257, United States.

Stem cells hold indefinite self-renewable capability that can be differentiated into all desired cell types. Based on their plasticity potential, they are divided into totipotent (morula stage cells), pluripotent (embryonic stem cells), multipotent (hematopoietic stem cells, multipotent adult progenitor stem cells, and mesenchymal stem cells [MSCs]), and unipotent (progenitor cells that differentiate into a single lineage) cells. Though bone marrow is the primary source of multipotent stem cells in adults, other tissues such as adipose tissues, placenta, amniotic fluid, umbilical cord blood, periodontal ligament, and dental pulp also harbor stem cells that can be used for regenerative therapy. Read More

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Does the Brain Function as a Quantum Phase Computer Using Phase Ternary Computation?

Front Physiol 2021 20;12:572041. Epub 2021 Apr 20.

Dipartimento di Biologia, Università degli Studi di Napoli, Federico II, Napoli, Italy.

Here we provide evidence that the fundamental basis of nervous communication is derived from a pressure pulse/soliton capable of computation with sufficient temporal precision to overcome any processing errors. Signalling and computing within the nervous system are complex and different phenomena. Action potentials are plastic and this makes the action potential peak an inappropriate fixed point for neural computation, but the action potential threshold is suitable for this purpose. Read More

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Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.

Nat Chem Biol 2021 May 6. Epub 2021 May 6.

Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.

Plant-based photosensors, such as the light-oxygen-voltage sensing domain 2 (LOV2) from oat phototropin 1, can be modularly wired into cell signaling networks to remotely control protein activity and physiological processes. However, the applicability of LOV2 is hampered by the limited choice of available caging surfaces and its preference to accommodate the effector domains downstream of the C-terminal Jα helix. Here, we engineered a set of LOV2 circular permutants (cpLOV2) with additional caging capabilities, thereby expanding the repertoire of genetically encoded photoswitches to accelerate the design of optogenetic devices. Read More

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