162,185 results match your criteria changes structure

Lens Epithelial Cell Proliferation in Response to Ionizing Radiation.

Radiat Res 2021 May 13. Epub 2021 May 13.

Department of Biosciences, University of Durham, Mountjoy Science Site, Durham DH13LE, United Kingdom.

Lens epithelial cell proliferation and differentiation are naturally well regulated and controlled, a characteristic essential for lens structure, symmetry and function. The effect of ionizing radiation on lens epithelial cell proliferation has been demonstrated in previous studies at high acute doses, but the effect of dose and dose rate on proliferation has not yet been considered. In this work, mice received single acute doses of 0. Read More

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Photoluminescence and optical temperature measurement of Mn/Er co-activated double perovskite phosphor through site-advantageous occupation.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 9;259:119797. Epub 2021 Apr 9.

Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, PR China.

Because traditional methods based on thermal coupling energy level temperature measurement have large errors, a new temperature sensing strategy is proposed to attain strong sensitivity and excellent signal resolution ability. The rare-earth and also transition metal ions with poles apart thermal quenching channels are used as dual emission centers to find a suitable host to achieve high-efficiency dual-mode emission. In this work, a string of phosphors with NaLaMgWO (NLMW) as the host, the single-doped and double-doped Mn and Er phosphors were adopted by the traditional high temperature solid-state reaction method. Read More

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Enriching activities during childhood are associated with variations in functional connectivity patterns later in life.

Neurobiol Aging 2021 Apr 20;104:92-101. Epub 2021 Apr 20.

Department of Psychology, Northeastern University, Boston, MA, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Champaign, IL, USA.

Enriching early life experiences (e.g., sport, art, music, volunteering, language learning) during a critical period of brain development may promote structural and functional brain changes that are still present decades later (>60 years). Read More

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Microstructural changes of the wall of uterine horn in the domestic cat (Felis silvestris catus) during postnatal development.

Theriogenology 2021 May 3;170:23-35. Epub 2021 May 3.

Department of Histology and Embryology, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wojska Polskiego 71C, PL-60-625, Poznań, Poland.

The study describes the details of histological changes occurring during the postnatal development of the wall of the uterine horn in the European shorthair domestic cat. Light microscope observations and morphometric analysis were carried out to investigate the rate of development of the wall of the uterine horns in order to estimate the maturing time. Uterine horns of newborn and 1week-old cats are fetal-like and showing smooth, nonfolded endometrium lined with pseudostratified epithelium, deprived of uterine glands, and poorly developed two-layered myometrium. Read More

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A six-factor structure of individual variation in the tendencies to become sleepy and to sleep at different times of the day.

Acta Psychol (Amst) 2021 May 10;217:103327. Epub 2021 May 10.

Laboratory of Nanobiotechnology and Biophysics of the North-Caucasus Federal University, Stavropol, Russia.

A multidimensional approach has been previously applied for modeling and assessment of individual differences in the ability to sleep or to stay awake at certain clock hours. More recently the 19 time-point Visuo-verbal Judgment Task (VJT) has been proposed to predict changes in sleepiness level from the morning hours to the next day afternoon. The dimensionality of the VJT has not been explored so far. Read More

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Effects of concentrations, temperature, pH and co-solutes on the rheological properties of mucilage from Dioscorea opposita Thunb. and its antioxidant activity.

Food Chem 2021 May 6;360:130022. Epub 2021 May 6.

Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan International Joint Laboratory of Medicinal Plants Utilization, School of Pharmacy, School of Life Sciences, Henan University, Kaifeng 475004, China. Electronic address:

The mucilage from Dioscorea opposita (DOM) dispersions presented shear-thinning behaviour that well fitted to the Power Law model. The effects of different concentrations (2%-10% w/v), temperatures (25-80 °C), pH (3.0-9. Read More

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25-hydroxycholesterol interacts differently with lipids of the inner and outer membrane leaflet - The Langmuir monolayer study complemented with theoretical calculations.

J Steroid Biochem Mol Biol 2021 May 10:105909. Epub 2021 May 10.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Kraków, Poland.

25-hydroxycholesterol (25-OH), a molecule with unusual behavior at the air/water interface, being anchored to the water surface alternatively with a hydroxyl group at C(3) or C(25), has been investigated in mixtures with main membrane phospholipids (phosphatidylcholines - PCs, and phosphatidylethanolamines - PEs), characteristic of the outer and inner membrane leaflet, respectively. To achieve this goal, the classical Langmuir monolayer approach based on thermodynamic analysis of interactions was conducted in addition to microscopic imaging of films (in situ with BAM and after transfer onto mica with AFM), surface-sensitive spectroscopy (PM-IRRAS), as well as theoretical calculations. Our results show that the strength of interactions is primarily determined by the kind of polar group (strong, attractive interactions leading to surface complexes formation were found to occur with PCs while weak or repulsive ones with PEs). Read More

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Structure-Redox Response Correlation in a Few Select Heme Systems Using X-ray Absorption Spectroelectrochemistry.

J Phys Chem B 2021 May 13. Epub 2021 May 13.

Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.

Heme based biomolecules control some of the most crucial life processes, such as oxygen and electron transport during respiration and energy metabolism, respectively. The active site of the heme, viz., the metal center, plays a key role and attributes functionality to these biomolecules. Read More

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Comparative Protein Structure Network Analysis on 3CL from SARS-CoV-1 and SARS-CoV-2.

Proteins 2021 May 13. Epub 2021 May 13.

Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, INDIA.

The main protease M , 3CL is an important target from coronaviruses. In spite of having 96% sequence identity among M from SARS-CoV-1 and SARS-CoV-2; the inhibitors used to block the activity of SARS-CoV-1 M so far, were found to have differential inhibitory effect on M of SARS-CoV-2. The possible reason could be due to the difference of few amino acids among the peptidases. Read More

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Manifestation of surfactant films in underwater solar path images: numerical experiment.

Aleksandr Molkov

Appl Opt 2021 Apr;60(11):3257-3265

This paper continues a series of studies on using underwater solar path imagery (USPI) to retrieve characteristics of wind-driven waves and their variations in the field of near-surface hydrophysical processes under the influence of surfactant films. Research is based on previously developed mathematical models of USPI and its statistical moments, the Elfouhaily spectrum of wind-driven waves, the Ermakov model of wave damping by a thin film, and the Cox-Munk result for a thick oil film. A high sensitivity of two statistical moments of USPI to variations of wind-wave conditions and viscoelastic characteristics of oil films was shown. Read More

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Simultaneous measurement of the refractive index and the pressure by mode splitting in concentric triple microring resonators with a single opening.

Appl Opt 2021 Apr;60(11):2958-2966

Concentric triple microring resonators with a single opening on the flexible SU-8 substrate are proposed and theoretically demonstrated for simultaneous detection of refractive index (RI) and pressure changes. Since an opening defect is introduced, the mode splitting occurs, which forms a symmetric and an asymmetric standing wave mode (SWM). The energy distribution of the two SWMs is quite different so that the sensitivities of the RI and pressure in the SWMs can be distinguished. Read More

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Hybrids of Pd Nanoparticles and Metal-Organic Frameworks for Enhanced Magnetism.

J Phys Chem Lett 2021 May 13:4742-4748. Epub 2021 May 13.

Max Planck Institute for Intelligent Systems, Stuttgart D-70569, Germany.

Nonmagnetic Pd exhibits ferromagnetism in the nanosize regime. Various stabilization agents, including surfactants, metal oxide supports, polymers, and porous materials (e.g. Read More

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Implementation of free breathing respiratory amplitude-gated treatments.

J Appl Clin Med Phys 2021 May 13. Epub 2021 May 13.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.

Purpose: The purpose of this study was to provide guidance in developing and implementing a process for the accurate delivery of free breathing respiratory amplitude-gated treatments.

Methods: A phase-based 4DCT scan is acquired at time of simulation and motion is evaluated to determine the exhale phases that minimize respiratory motion to an acceptable level. A phase subset average CT is then generated for treatment planning and a tracking structure is contoured to indicate the location of the target or a suitable surrogate over the planning phases. Read More

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Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways.

Aging (Albany NY) 2021 May 12;13. Epub 2021 May 12.

Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.

Aging is a universal biological process characterized by a progressive deterioration in functional capacity and an increased risk of morbidity and mortality over time. In the lungs, there are considerable changes in lung structure and function with advancing age; however, research on the transcriptomic profile implicated in this process is scanty. In this study, we addressed the lung transcriptome changes during aging, through a global gene expression analysis of normal lungs of mice aged 4- and 18-months old. Read More

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Impact of non-synonymous mutations on the structure and function of telomeric repeat binding factor 1.

J Biomol Struct Dyn 2021 May 13:1-14. Epub 2021 May 13.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Telomeric repeat binding factor 1 (TRF1) is one of the major components of the shelterin complex. It directly binds to the telomere and controls its function by regulating the telomerase acting on it. Several variations are reported in the gene; some are associated with variety of diseases. Read More

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The Power of Fiber Twist.

Acc Chem Res 2021 May 13. Epub 2021 May 13.

Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, Texas 75080, United States.

ConspectusNature's evolution over billions of years has led to the development of different kinds of twisted structures in a variety of biological species. Twisted fibers from nanoscale- to micrometer-scale diameter have been prepared by mimicking natural twisted structures. Mechanically inserting twist in a yarn is an efficient and important method, which generates internal stress, changes the macromolecular orientation, and increases compactness. Read More

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[Effect of Dendrobii officinalis superfine powder on overeating greasy-induced metabolic hypertension in rats].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1658-1666

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobii officinalis, with a definite effect of nourishing Yin and clearing heat, has been a folk habit for drinking after being mixed with water. Because its superfine powder has the advantages of high dissolution and convenient drinking, we observed the effect of D. officinalis superfine powder on metabolic hypertension model rats and its possible mechanism in this experiment, which can be used as a reference for its clinical application for hypertension. Read More

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Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on Respiratory Depression: A Randomized, Double-Blind, Placebo-Controlled Trial.

Clin Transl Sci 2021 May 13. Epub 2021 May 13.

Cara Therapeutics, Stamford, CT, USA.

Difelikefalin, a selective kappa opioid receptor agonist designed to limit central nervous system (CNS) penetration, is under development for the treatment of pruritus. Its hydrophilic, small-peptidic structure limits CNS entry, minimizing potential CNS-mediated adverse events (AEs). This study assessed the effect of difelikefalin on key relevant measures of respiratory depression in healthy volunteers. Read More

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Freezing stress damage and growth viability in Vaccinium macrocarpon Ait. bud structures.

Physiol Plant 2021 May 13. Epub 2021 May 13.

Department of Horticulture, University of Wisconsin-Madison 1575 Linden Dr., Madison, Wisconsin.

After a freezing event, it can be challenging to extrapolate levels of freezing damage to plant growth viability based on the presence or absence of symptoms in specific bud tissues. This study investigated the relationship between freezing damage in terminal buds during ecodormancy and their viability during the subsequent growing season. We identified the bud structure that best explained this relationship, and developed a model to explain the changes in bud cold hardiness. Read More

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Traumatic brain injury: a comparison of diffusion and volumetric magnetic resonance imaging measures.

Brain Commun 2021 2;3(2):fcab006. Epub 2021 Jan 2.

Division of Brain Sciences, Computational, Cognitive and Clinical Neuroimaging Laboratory, Imperial College London, Hammersmith Hospital, London, UK.

Cognitive impairment after traumatic brain injury remains hard to predict. This is partly because axonal injury, which is of fundamental importance, is difficult to measure clinically. Advances in MRI allow axonal injury to be detected after traumatic brain injury, but the most sensitive approach is unclear. Read More

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January 2021

The conformational structural change of β-lactoglobulin via acrolein treatment reduced the allergenicity.

Food Chem X 2021 Jun 20;10:100120. Epub 2021 Apr 20.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

β-lactoglobulin (BLG) is a major allergen of milk. Since lipid peroxidation such as acrolein commonly exists during milk processing, it is necessary to evaluate its influence on BLG structure and potential allergenicity. The structure of acrolein-treated BLG was detected using SDS-PAGE, fluorescence, ultraviolet spectrum (UV), circular dichroism (CD) and LC-MS-MS, and the potential allergenicity was assessed by and assays. Read More

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Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study.

Eur Thyroid J 2021 Apr 8;10(2):150-160. Epub 2020 Jul 8.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background: Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain.

Methods: Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analyzed. Read More

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Recovering Spatially-Varying Cell-Specific Gene Co-expression Networks for Single-Cell Spatial Expression Data.

Front Genet 2021 26;12:656637. Epub 2021 Apr 26.

Institute of Statistics and Big Data, Renmin University of China, Beijing, China.

Recent advances in single-cell technologies enable spatial expression profiling at the cell level, making it possible to elucidate spatial changes of cell-specific genomic features. The gene co-expression network is an important feature that encodes the gene-gene marginal dependence structure and allows for the functional annotation of highly connected genes. In this paper, we design a simple and computationally efficient two-step algorithm to recover spatially-varying cell-specific gene co-expression networks for single-cell spatial expression data. Read More

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Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.

Front Pharmacol 2021 26;12:658677. Epub 2021 Apr 26.

Department of Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.

Liver injury is one of the serious complications of sepsis. Previous studies suggested that dexmedetomidine (DEX) could alleviate cecal ligation and puncture (CLP)-induced liver injury. However, it is unclear whether the protective effect of DEX on sepsis-induced liver injury is related to autophagy. Read More

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Structural basis for broad coronavirus neutralization.

Nat Struct Mol Biol 2021 May 12. Epub 2021 May 12.

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the possibility of identifying antibodies with broad neutralizing activity, we isolated a monoclonal antibody, termed B6, that cross-reacts with eight β-coronavirus spike glycoproteins, including all five human-infecting β-coronaviruses. B6 broadly neutralizes entry of pseudotyped viruses from lineages A and C, but not from lineage B, and the latter includes SARS-CoV and SARS-CoV-2. Read More

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Water-oriented magnetic anisotropy transition.

Nat Commun 2021 May 12;12(1):2738. Epub 2021 May 12.

Institute for Materials Chemistry and Engineering & Integrated Research Consortium on Chemical Sciences (IRCCS), Kyushu University, Fukuoka, 819-0395, Japan.

Water reorientation is essential in a wide range of chemical and biological processes. However, the effects of such reorientation through rotation around the metal-oxygen bond on the chemical and physical properties of the resulting complex are usually ignored. Most studies focus on the donor property of water as a recognized σ donor-type ligand rather than a participant in the π interaction. Read More

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Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.

Transl Psychiatry 2021 May 12;11(1):282. Epub 2021 May 12.

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Zhejiang, China.

Convergent evidence has suggested a significant effect of antipsychotic exposure on brain structure and function in patients with schizophrenia, yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to examine how large-scale brain networks are modulated by antipsychotic treatment, and whether the longitudinal changes could track the improvements of psychopathologic scores. Thirty-four patients with first-episode drug-naïve schizophrenia and 28 matched healthy controls were recruited at baseline from Shanghai Mental Health Center. Read More

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Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol.

BMJ Open 2021 May 11;11(5):e044062. Epub 2021 May 11.

Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, The Netherlands

Introduction: Postoperative cognitive dysfunction occurs frequently after coronary artery bypass grafting (CABG). The underlying mechanisms remain poorly understood, but neuroinflammation might play a pivotal role. We hypothesise that systemic inflammation induced by the surgical trauma could activate the innate immune (glial) cells of the brain. Read More

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Work Function Modulation of Few-Layer Graphene by Swift Heavy Ion Irradiation.

J Nanosci Nanotechnol 2021 Nov;21(11):5603-5610

School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Here, we report the structural and electronic modification induced in chemical vapor deposited graphene by using swift heavy ions (70 MeV Ni).Raman spectroscopy was used to quantify the irradiation-induced modification in vibrational properties. The increase in defect density with fluence causes an increase in the intensity ratio of its characteristic Raman D and G band. Read More

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November 2021

Coronavirus disease 2019, allergic diseases, and allergen immunotherapy: Possible favorable mechanisms of interaction.

Allergy Asthma Proc 2021 May;42(3):187-197

Hospital General de Zona N. 1, Instituto Mexicano del Seguro Social, Oaxaca, Mexico.

Both, allergen immunotherapy (AIT) and SARS-COV-2 infection cause a set of immunologic changes that respectively vary during the course of the treatment or the disease. To review immune changes brought along by each of these entities and how they might interrelate. We start presenting a brief review of the structure of the new coronavirus and how it alters the functioning of the human immune system. Read More

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