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Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Ecotoxicol Environ Saf 2021 Jun 8;220:112401. Epub 2021 Jun 8.

Department of Botany, S.P. College, Srinagar, Jammu and Kashmir, India. Electronic address:

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0. Read More

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Nonlinear dynamics for the spread of pathogenesis of COVID-19 pandemic.

J Infect Public Health 2021 Apr 20;14(7):817-831. Epub 2021 Apr 20.

University School of Basic & Applied Sciences (USBAS), Head, Non-Linear Dynamics-Research-Lab, GGS Indraprastha University, New Delhi, India. Electronic address:

Coronaviruses did not invite attention at a global level and responsiveness until the series of 2003-SARS contagion followed by year-2012 MERS plus, most recently, 2019-nCoV eruptions. SARS-CoV &MERS-CoV are painstaking, extremely pathogenic. Also, very evidently, both have been communicated from bats to palm-civets & dromedary camels and further transferred ultimately to humans. Read More

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Recovery trend to co-exposure of iron oxide nanoparticles (γ-FeO) and glyphosate in liver tissue of the fish Poecilia reticulata.

Chemosphere 2021 Jun 1;282:130993. Epub 2021 Jun 1.

Laboratory of Cellular Behavior, Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:

Citrate-coated iron oxide nanoparticles (IONPs) have potential use in environmental remediation, with possibilities in decontaminating aquatic environments exposed to toxic substances. This study analyzed IONPs associated to Roundup Original, a glyphosate-based herbicide (GBH), and pure glyphosate (GLY), through ultrastructural and histopathological biomarkers in liver tissue, from females of Poecilia reticulata exposed to: iron ions (0.3 mg/L) (IFe) and IONPs (0. Read More

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Deepening of sedation with propofol has limited effect on intra-abdominal pressure - An interventional study in mechanically ventilated adult patients with intra-abdominal hypertension.

J Crit Care 2021 May 28;65:98-103. Epub 2021 May 28.

Department of Anaesthesiology and Intensive Care, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia; Department of Intensive Care Medicine, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland.

Purpose: To evaluate the effect of deepening of sedation on intra-abdominal pressure (IAP).

Methods: 37 adult mechanically ventilated ICU patients with intra-abdominal hypertension received a bolus dose and subsequent infusion of propofol (bolus: 1 mg/kg, infusion: 3 mg/kg/h). IAP, mean arterial pressure (MAP), abdominal perfusion pressure (APP), depth of sedation according to Richmond Agitation-Sedation Scale (RASS), respiratory parameters, and vasopressor dose were assessed after bolus and at 15, 30 and 60 min of infusion of propofol. Read More

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Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH.

Mol Metab 2021 Jun 9:101270. Epub 2021 Jun 9.

Department of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

Objective: Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH). Notably, immune cell-driven inflammation is a key mechanism in the transition from fatty liver to the more serious NASH. Although exercise training is effective at ameliorating obesity-related diseases, the underlying mechanisms of the beneficial effects of exercise remain unclear. Read More

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Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. Electronic address:

Background Context: Laminoplasty of the cervical spine is widely used as an effective surgical method to treat compressive myelopathy of the cervical spine; however, there is an adverse effect of kyphosis after surgery. The risk factors or predictors of kyphosis have not been sufficiently evaluated.

Purpose: To assess the risk factors for kyphosis following laminoplasty. Read More

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Unfolding the Apoptotic Mechanism of Antioxidant Enriched-Leaves of Tabebuia pallida (Lindl.) Miers in EAC Cells and Mouse Model.

J Ethnopharmacol 2021 Jun 9:114297. Epub 2021 Jun 9.

Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. Electronic address:

Ethnopharmacological Relevance: Tabebuia pallida (Lindl.) Miers (T. pallida) is a well-known native Caribbean medicinal plant. Read More

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Effects of somatic tissue cryopreservation on puma (Puma concolor Linnaeus, 1771) tissue integrity and cell preservation after in vitro culture.

Cryobiology 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid (UFERSA), Mossoro, RN, Brazil. Electronic address:

Somatic resource banks play a crucial role in the conservation of genetic diversity, allowing for the preservation of biological samples from different populations. Puma somatic cells can be recovered from these banks and used in assisted techniques toward enhancing their multiplication and conservation. In response to the population reduction of this ecologically importance species, we aimed to evaluate the capacity of cryopreservation of somatic tissues on the maintenance of the integrity and quality of the cells recovered after culture, with the aim of establishing a somatic tissue bank that will allow for the safeguarding of a wide genetic sampling of pumas. Read More

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Periodontal condition of mandibular incisors treated with modified Kazanjian vestibuloplasty compared to untreated sites: A prospective study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Periodontology, Medical University of Warsaw, Poland.

Background: A shallow vestibule, insufficient keratinized tissue width and pulling of marginal gingiva may be associated with gingival recession, plaque accumulation and gingivitis. Conventional techniques for treatment of gingival recession use autogenous or allogenic grafts. However, these methods result in soreness at the donor site and pose an economic burden, which may cause patients to withdraw from treatment. Read More

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Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity.

FASEB J 2021 Jul;35(7):e21714

School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.

We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, with different responses in muscles with the prevalence of glycolytic and oxidative fibers. We used cysteine-specific isotopic coded affinity tags (OxICAT) and gel-free mass spectrometry analysis to investigate the cysteine Ox-PTMs profile in the proteome of both plantaris (glycolytic) and soleus (oxidative) muscles in tumor-bearing and control rats. Histological analysis revealed muscle atrophy in type II fibers in plantaris muscle, with no changes in plantaris type I fibers and no differences in both soleus type I and II fibers in tumor-bearing rats when compared to healthy controls. Read More

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Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Biostructure, University School of Physical Education in Wroclaw, Al. I. J. Paderewskiego 35, 51-612, Wroclaw, Poland.

Background And Aim: The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Read More

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Blood-brain barrier leakage and perivascular collagen accumulation precede microvessel rarefaction and memory impairment in a chronic hypertension animal model.

Metab Brain Dis 2021 Jun 12. Epub 2021 Jun 12.

Koç University Research Center for Translational Medicine, Istanbul, Turkey.

Hypertension (HT) is one of the main causes of vascular dementia, lead to cognitive decline. Here, we investigated the relationship between cerebral microvessels, pericytes, extracellular matrix (ECM) accumulation, blood-brain barrier (BBB) breakdown, and memory impairment at mid-life in a chronic hypertension animal model. Spontaneously hypertensive rats (SHRs) (n = 20) are chosen for the model and age matched Wistar rats (n = 16) as controls. Read More

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Quantitative Susceptibility Mapping for Staging Acute Cerebral Hemorrhages: Comparing the Conventional and Multiecho Complex Total Field Inversion magnetic resonance imaging MR Methods.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The perceived acuity of intracerebral hemorrhage (ICH) impacts the management of patients, both within emergent and outpatient/urgent settings. Morphology enabled dipole inversion (MEDI) quantitative susceptibility imaging (QSM) has improved characterization of ICH acuity, despite outstanding limitations in distinguishing blood products.

Purpose/hypothesis: Using improved susceptibility quantification, novel postprocessing QSM method from multiecho complex total field inversion (mcTFI) may better discriminate between acute and subacute ICH, compared to MEDI. Read More

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Objective and quantitative measurement of skin micro-relief by image analysis and application in age-dependent changes.

Skin Res Technol 2021 Jun 12. Epub 2021 Jun 12.

Faculty of Science and Technology, Keio University, Yokohama, Japan.

Background: Skin micro-relief has been researched by a variety of devices and methods, which usually are expensive or complicated. On the other hand, skin micro-relief relates to quite a few parameters, and it is hard to evaluate all of them at the same time. In the study, all parameters related to skin micro-relief are extracted and evaluated by image analysis. Read More

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Parameterizing elastic network models to capture the dynamics of proteins.

J Comput Chem 2021 Jun 11. Epub 2021 Jun 11.

Unité de Dynamique Structurale des Macromolécules, Institut Pasteur, UMR 3528 du CNRS, Paris, France.

Coarse-grained normal mode analyses of protein dynamics rely on the idea that the geometry of a protein structure contains enough information for computing its fluctuations around its equilibrium conformation. This geometry is captured in the form of an elastic network (EN), namely a network of edges between its residues. The normal modes of a protein are then identified with the normal modes of its EN. Read More

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The effects of systemic aromatase inhibitors on meibomian glands and corneal structure.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Private Practice, Ankara, Turkey.

Objectives: To evaluate the ocular surface, meibomian glands and corneal structural changes using in vivo confocal microscopy (IVCM) in patients receiving aromatase inhibitor (AI) therapy due to the breast cancer.

Methods: This prospective observational study included 13 patients undergoing AI therapy. The patients were evaluated before the treatment, at 3- and 6-month timepoints of AI therapy. Read More

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Effects of Medical Masks on Voice Assessment During the COVID-19 Pandemic.

J Voice 2021 May 9. Epub 2021 May 9.

Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: Voice assessment is of great significance to the evaluation of voice quality. Our study aims to explore the effects of medical masks on healthy people in acoustic, aerodynamic and formant parameters during the COVID-19 pandemic. In addition, we also attempted to verify the differences between different sexes and ages. Read More

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Fusion of wildlife tracking and satellite geomagnetic data for the study of animal migration.

Mov Ecol 2021 Jun 11;9(1):31. Epub 2021 Jun 11.

School of Geography and Sustainable Development, Irvine Building, University of St Andrews, North Street, St Andrews, KY16 9AL, Scotland, UK.

Background: Migratory animals use information from the Earth's magnetic field on their journeys. Geomagnetic navigation has been observed across many taxa, but how animals use geomagnetic information to find their way is still relatively unknown. Most migration studies use a static representation of geomagnetic field and do not consider its temporal variation. Read More

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The effect of minimally invasive lumbar decompression surgery on sagittal spinopelvic alignment in patients with lumbar spinal stenosis: a 5-year follow-up study.

J Neurosurg Spine 2021 Jun 11:1-8. Epub 2021 Jun 11.

1Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka; and.

Objective: Several studies have examined the relationship between sagittal spinopelvic alignment and clinical outcomes after spinal surgery. However, the long-term reciprocal changes in sagittal spinopelvic alignment in patients with lumbar spinal stenosis after decompression surgery remain unclear. The aim of this study was to investigate radiographic changes in sagittal spinopelvic alignment and clinical outcomes at the 2-year and 5-year follow-ups after minimally invasive lumbar decompression surgery. Read More

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Stability of thylakoid protein complexes and preserving photosynthetic efficiency are crucial for the successful recovery of the halophyte Cakile maritima from high salinity.

Plant Physiol Biochem 2021 May 28;166:177-190. Epub 2021 May 28.

Laboratory of Extremophile Plants, Center of Biotechnology of Borj Cedria, (CBBC), P. O. Box 901, 2050, Hammam-Lif, Tunisia; Department of Plant Proteomics, Institute of Plant Genetics, Leibniz University of Hannover, Herrenhäuser Str. 2, 30419, Hannover, Germany.

Plants native to extreme habitats often face changes in environmental conditions such as salinity level and water availability. In response, plants have evolved efficient mechanisms allowing them to survive or recover. In the present work, effects of high salinity and salt-stress release were studied on the halophyte Cakile maritima. Read More

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Potential threat of SARS-CoV-2 in coastal waters.

Ecotoxicol Environ Saf 2021 Jun 8;220:112409. Epub 2021 Jun 8.

The State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address:

A novel coronavirus (SARS-CoV-2) has caused more than 150 million confirmed infections worldwide, while it is not clear whether it affects the coastal waters. This paper proposed a biophysical model based on 16 scenarios with different virus half-life parameters to assess potential viral contamination from 25 municipal sewage outfalls into the Bohai Sea. Viral concentration maps showing spatial and temporal changes are provided based on a biophysical model under multiple scenarios. Read More

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The role of NADPH oxidase in chronic intermittent hypoxia-induced respiratory plasticity in adult male mice.

Respir Physiol Neurobiol 2021 Jun 8;292:103713. Epub 2021 Jun 8.

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address:

Reactive oxygen species (ROS) are proposed as mediators of chronic intermittent hypoxia (CIH)-induced respiratory plasticity. We sought to determine if NADPH oxidase 2 (NOX2)-derived ROS underpin CIH-induced maladaptive changes in respiratory control. Adult male mice (C57BL/6 J) were assigned to one of three groups: normoxic controls (sham); chronic intermittent hypoxia-exposed (CIH, 12 cycles/hour, 8 h/day for 14 days); and CIH + apocynin (NOX2 inhibitor, 2 mM) given in the drinking water throughout exposure to CIH. Read More

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Changes in kinematics, kinetics, and muscle activity in patients with lumbar spinal stenosis during gait: systematic review.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, University of Arkansas for Medical Science, Little Rock, AR; Mechanical and Biomedical Engineering Department, College of Engineering, Boise State University, Boise, ID.

Background Context: Lumbar spinal stenosis (LSS) is one of the most common orthopaedic conditions and affects more than half a million people over the age of 65 in the US. Patients with LSS have gait dysfunction and movement deficits due to pain and symptoms caused by compression of the nerve roots within a narrowed spinal canal.

Purpose: The purpose of the current systematic review was to summarize existing literature reporting biomechanical changes in gait function that occur with LSS, and identify knowledge gaps that merit future investigation in this important patient population. Read More

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Adiabatic dynamic causal modelling.

Neuroimage 2021 Jun 8:118243. Epub 2021 Jun 8.

The Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, United Kingdom.

This technical note introduces adiabatic dynamic causal modelling, a method for inferring slow changes in biophysical parameters that control fluctuations of fast neuronal states. The application domain we have in mind is inferring slow changes in variables (e.g. Read More

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Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study.

Brain Res 2021 Jun 8:147558. Epub 2021 Jun 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previous studies were mainly focused on somatosensory cortices. However, the changes of white matter diffusion properties in nonsensorimotor cortices remain uninvestigated. Read More

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Erbium, Chromium:Yttrium-Scandium-Gallium-Garnet Laser for Root Conditioning and Reduction of Postoperative Morbidity in the Treatment of Gingival Recession Defects: A Randomized Controlled Clinical Trial.

Photobiomodul Photomed Laser Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, New York, USA.

This clinical trial evaluates the effect of erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) root surface biomodification and laser harvesting of de-epithelialized gingival graft (DGG) on root coverage clinical outcomes and postoperative morbidity, and compares this to the conventional blade-harvested DGG method without Er,Cr:YSGG root surface biomodification in treatment of Miller's class I, II gingival recessions (GR). The application of laser technology to enhance tooth root coverage clinical outcomes as well as the impact of laser on postoperative morbidity after harvesting autogenous soft tissue grafts requires further research. This study is a randomized, single-blinded controlled trial, including 24 volunteers with isolated GR defects. Read More

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Cultivation of Chlorella sorokiniana in a bubble-column bioreactor coupled with cooking cocoon wastewater treatment: effects of initial cell density and aeration rate.

Water Sci Technol 2021 Jun;83(11):2615-2628

Jiangsu Key Laboratory of Sericulture Biology and Biotechnology, College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China E-mail:

Previous studies have documented that Chlorella sorokiniana could grow well on cooking cocoon wastewater (CCW) with a maximum biomass of 0.49 g/L. In order to further enhance the biomass production and nutrient removals, a bubble-column bioreactor was designed and performed to cultivate C. Read More

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Functional Ankle Range of Motion but Not Peak Achilles Tendon Force Diminished With Heel-Rise and Jumping Tasks After Achilles Tendon Repair.

Am J Sports Med 2021 Jun 11:3635465211019436. Epub 2021 Jun 11.

Department of Physical Therapy, University of Delaware, Newark, Delaware, USA.

Background: Deficits in sporting performance after Achilles tendon repair may be due to changes in musculotendinous unit structure, including tendon elongation and muscle fascicle shortening.

Purpose/hypothesis: The purpose was to discern whether Achilles tendon rupture reduces triceps surae muscle force generation, alters functional ankle range of motion, or both during sports-related tasks. We hypothesized that individuals who have undergone Achilles tendon repair lack the functional ankle range of motion needed to complete sports-related tasks. Read More

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Prostatic alterations associated to early weaning and its relation with cocoa powder supplementation. Experimental study in adult wistar rats.

Int Braz J Urol 2021 May 20;47. Epub 2021 May 20.

Departamento de Anatomia, Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro, UERJ, Rio de Janeiro, RJ, Brasil.

Early weaning can predispose the offspring to greater risk of developing chronic diseases in adulthood. It is believed that the consumption of functional foods is able to prevent these effects. The aim of this study is to evaluate the effects of maternal and postnatal cocoa powder supplementation on body mass, metabolism, and morphology of the prostate of early weaned Wistar rats. Read More

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Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model.

Andrologia 2021 Jun 11:e14143. Epub 2021 Jun 11.

Department of Anatomy, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

This study was designed to investigate the effects of separate and combined administration of hypothermia and pentoxifylline to preserve the effects on the testicles in an experimental model of testicular torsion/ detorsion injuries in rats. Forty male adult Wistar rats were randomly divided into five groups, control, torsion/detorsion (TD), torsion/detorsion/hypothermia (TD+ICE), torsion/detorsion received of pentoxifylline (40mg/kg, ip) (TD+PTX) and torsion/detorsion/hypothermia/PTX (TD+ICE+PTX). Left testicular torsion (TT) was performed for 4 and half hours, and ice fragments have been used at the beginning of torsion. Read More

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