94 results match your criteria changed interdepartmental

Paranoia and belief updating during the COVID-19 crisis.

Nat Hum Behav 2021 Jul 27. Epub 2021 Jul 27.

Department of Psychiatry, Connecticut Mental Health Center, Yale University, New Haven, CT, USA.

The COVID-19 pandemic has made the world seem less predictable. Such crises can lead people to feel that others are a threat. Here, we show that the initial phase of the pandemic in 2020 increased individuals' paranoia and made their belief updating more erratic. Read More

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Acute healthcare resource utilization by age: A cohort study.

PLoS One 2021 19;16(5):e0251877. Epub 2021 May 19.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Granular data related to the likelihood of individuals of different ages accessing acute and critical care services over time is lacking.

Methods: We used population-based, administrative data from Ontario to identify residents of specific ages (20, 30, 40, etc. to 100) on January 1st every year from 1995-2019. Read More

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Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report.

A A Pract 2021 May 14;15(5):e01479. Epub 2021 May 14.

Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.

Recent studies have demonstrated that vasopressors can be delivered safely through peripheral intravenous lines. While norepinephrine is usually delivered at a concentration of 16 to 32 μg/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters. We describe a case of severe hyponatremia and seizure resulting from administration of norepinephrine concentrated at 4 μg/mL in dextrose 5% in water. Read More

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Nutrients handling after bariatric surgery, the role of gastrointestinal adaptation.

Eat Weight Disord 2021 Apr 24. Epub 2021 Apr 24.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.

Bariatric surgery determines a rearrangement of the gastrointestinal tract that influences nutrient handling and plays a role in the metabolic changes observed after surgery. Most of the changes depend on the accelerated gastric emptying observed in Roux-en-Y gastric bypass (RYGB) and, to a lesser extent, in sleeve gastrectomy (SG). The rapid delivery of meal into the jejunum, particularly after RYGB, contributes to the prompt appearance of glucose in peripheral circulation. Read More

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Survey of One Health programs in U.S. medical schools and development of a novel one health elective for medical students.

One Health 2021 Jun 1;12:100231. Epub 2021 Mar 1.

Division of Comparative Medicine, Georgetown University, Washington, DC 20057, USA.

Lessons learned from recent pandemics, such as SARS-CoV-2 have illustrated that education and training in a One Health approach, which recognizes the interdependency of the health of people, animals and the environment, are essential in improving preparations for and responses to disease outbreaks. For this reason and others, there is a critical need to provide One Health (OH) training to medical professionals early in their careers. 133 U. Read More

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Suitability Assessment of PLA Bottles for High-Pressure Processing of Apple Juice.

Foods 2021 Feb 2;10(2). Epub 2021 Feb 2.

Department of Life Sciences, University of Modena and Reggio Emilia, 42122 Reggio Emilia, Italy.

The aim of the present study is to assess the use of polylactic acid (PLA) bottles as an alternative to polyethylene terephthalate (PET) ones for high-pressure processing (HPP) of apple juice. The treatment of PLA bottles at 600 MPa for 3 min did not cause alterations in the packaging shape and content, confirming the suitability of PLA bottles to withstand HPP conditions as well as PET bottles. Quantification of total mesophilic bacterial and fungal load suggested HPP treatment can be effectively applied as an alternative to pasteurization for apple juice packed in PLA bottles since it guarantees microbial stability during at least 28 days of refrigerated storage. Read More

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February 2021

Community Hospital Perioperative Services Department Responds to the COVID-19 Pandemic.

AORN J 2021 02;113(2):165-178

Early in 2020, government leaders declared a public health emergency because of the coronavirus disease 2019 (COVID-19) outbreak. After World Health Organization leaders declared that the spread of COVID-19 was a pandemic, it became evident that patients suspected or confirmed to have COVID-19 would present for surgery at our community hospital, the only facility in the county. The Maryland governor charged hospital administrators with expanding bed capacity in anticipation of a surge of critically ill patients. Read More

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February 2021

A brief very-low oxygen tension regimen is sufficient for the early chondrogenic commitment of human adipose-derived mesenchymal stem cells.

Adv Med Sci 2021 Mar 15;66(1):98-104. Epub 2021 Jan 15.

BioEngLab, Health Science and Technology - Interdepartmental Center for Industrial Research (HST-CIRI), University of Bologna, Cesena, Italy; Laboratory of Cellular and Molecular Engineering "Silvio Cavalcanti" - DEI, University of Bologna, Cesena, Italy.

Purpose: The aim of this study was to evaluate the effects exerted over chondrogenic commitment of human adipose-derived mesenchymal stem cells (ADSCs) by a very low oxygen tension (<1% pO).

Materials/methods: Cell morphology, mRNA levels of chondrocyte-specific marker genes and the involvement of p38 MAPK signalling were monitored in human ADSCs under a very low oxygen tension.

Results: Cell morphology was significantly changed after two days of hypoxic preconditioning when they featured as elongated spindle-shaped cells. Read More

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Alignment free identification of clones in B cell receptor repertoires.

Nucleic Acids Res 2021 02;49(4):e21

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

Following antigenic challenge, activated B cells rapidly expand and undergo somatic hypermutation, yielding groups of clonally related B cells with diversified immunoglobulin receptors. Inference of clonal relationships based on the receptor sequence is an essential step in many adaptive immune receptor repertoire sequencing studies. These relationships are typically identified by a multi-step process that involves: (i) grouping sequences based on shared V and J gene assignments, and junction lengths and (ii) clustering these sequences using a junction-based distance. Read More

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February 2021

Current and evolving standards of care for patients with ARDS.

Intensive Care Med 2020 12 6;46(12):2157-2167. Epub 2020 Nov 6.

Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Care for patients with acute respiratory distress syndrome (ARDS) has changed considerably over the 50 years since its original description. Indeed, standards of care continue to evolve as does how this clinical entity is defined and how patients are grouped and treated in clinical practice. In this narrative review we discuss current standards - treatments that have a solid evidence base and are well established as targets for usual care - and also evolving standards - treatments that have promise and may become widely adopted in the future. Read More

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December 2020

Effect of soy consumption on liver enzymes, lipid profile, anthropometry indices, and oxidative stress in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials.

Iran J Basic Med Sci 2020 Oct;23(10):1245-1250

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

 The present systematic review and meta-analysis was conducted to investigate the effects of soy intake on liver enzymes, lipid profile, anthropometry indices, and oxidative stress in non-alcoholic fatty liver disease (NAFLD). A systematic search was undertaken in PubMed, Embase, Scopus, Web of Science, and Cochrane Library covering up to 10 January 2020. A fixed-effect or random-effects models were applied to pool mean difference (MD) and its 95 % confidence intervals (CI). Read More

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October 2020

Barriers and Facilitators to Early Rehabilitation in the ICU: A Theory Driven Delphi Study.

Crit Care Med 2020 12;48(12):e1171-e1178

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Objectives: There is conflicting evidence for the effectiveness of early rehabilitation in the intensive care and marked variation in rates of implementation in practice. We aimed to identify barriers and facilitators to early rehabilitation in mechanically ventilated patients and their relevance to practice, as perceived by key ICU clinicians across North America.

Design: A Delphi study using the Theoretical Domains Framework, consisting of an initial qualitative round and subsequent quantitative rounds, was conducted to gather clinician agreement and perceived importance of barriers and facilitators to early rehabilitation. Read More

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December 2020

Emerging challenges and possible strategies in maxillo-facial and oral surgery during the COVID-19 pandemic.

J Oral Sci 2020 Sep 24;62(4):452-454. Epub 2020 Aug 24.

Cranio-Maxillo-Facial Unit and Biomaterials Laboratory, Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia.

The Coronavirus disease 2019 (COVID-19) pandemic suddenly took the world by storm and Italy was one of the hardest hit countries. Maxillo-facial surgery and dentistry procedures had to be significantly reorganized, since they are considered high-risk procedures. Protocols had to be changed and interdepartmental cooperation was put in place to plan surgical interventions and maintain high standards. Read More

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September 2020

A Gas-Powered, Patient-Responsive Automatic Resuscitator for Use in Acute Respiratory Failure: A Bench and Experimental Study.

Respir Care 2021 03 18;66(3):366-377. Epub 2020 Aug 18.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Background: During the COVID-19 pandemic, a need for innovative, inexpensive, and simple ventilator devices for mass use has emerged. The Oxylator (CPR Medical Devices, Markham, Ontario, Canada) is an FDA-approved, fist-size, portable ventilation device developed for out-of-hospital emergency ventilation. It has not been tested in conditions of severe lung injury or with added PEEP. Read More

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COVID-19 in a community hospital.

Semin Perinatol 2020 10 23;44(6):151292. Epub 2020 Jul 23.

Assistant Professor of Obstetrics & Gynecology, Columbia University Medical Center, Division Chief of Obstetrics & Gynecology, New York-Presbyterian Hudson Valley Hospital, Regional Director of Women's Health Services, New York-Presbyterian Medical Group. Electronic address:

The rapid spread of COVID-19 across the globe quickly and drastically changed the way we practice medicine. In order to respond to its effects, careful planning and implementation of new guidelines and protocols was crucial to ensure the safety of both patients and staff. Given the limitations of space, staff, and resources in the community hospitals, a centralized command center, robust lines of communication within the department and between departments, and contingency and surge planning in this setting were critical. Read More

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October 2020

Immediate and Long-Term Health Care Support Needs of Older Adults Undergoing Cancer Surgery: A Population-Based Analysis of Postoperative Homecare Utilization.

Ann Surg Oncol 2021 Mar 12;28(3):1298-1310. Epub 2020 Aug 12.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

Background: Functional outcomes are central to decision-making by older adults (OA), but long-term risks after cancer surgery have not been described beyond 1 year for this population. This study aimed to evaluate long-term health care support needs by examining homecare use after cancer surgery for OA.

Methods: This population-based study investigated adults 70 years of age or older with a new cancer diagnosis between 2007 and 2017 who underwent resection. Read More

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48-year trends in systemic sclerosis mortality, 1968-2015: A United States population-based study.

Arthritis Care Res (Hoboken) 2020 Aug 8. Epub 2020 Aug 8.

Department of Medicine, The University of California at Los Angeles (UCLA, David Geffen School of Medicine, Los Angeles, CA, United States.

Objective: To identify secular trends associated with systemic sclerosis (SSc) mortality over 48 years.

Methods: Using national mortality data compiled by the Center for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research, and population data from the United States Census Bureau, we calculated age-standardized mortality rate (ASMR) for SSc and non-SSc (all other causes), and the ratio of SSc-ASMR to non-SSc-ASMR for each year from 1968 through 2015. We then used a joinpoint regression model to evaluate mortality trends, overall, and by sex and race. Read More

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Deaths following withdrawal of life-sustaining therapy: Opportunities for quality improvement?

J Trauma Acute Care Surg 2020 10;89(4):743-751

From the Institute of Health Policy, Management, and Evaluation (M.P.G., B.W.T., B.H., A.B.N.), Department of Surgery (M.P.G., B.H., A.B.N.), Interdepartmental Division of Critical Care Medicine, Department of Medicine (B.W.T., B.H.), University of Toronto, Toronto, Ontario, Canada; and Sunnybrook Research Institute (B.H., A.B.N.), Toronto, Ontario, Canada.

Background: Mortality is an important trauma center outcome. With many patients initially surviving catastrophic injuries and a growing proportion of geriatric patients, many deaths might occur following withdrawal of life-sustaining therapy (WLST). We utilized the American College of Surgeons Trauma Quality Improvement Program database to explore whether deaths following WLST might be preventable and to evaluate the impact of excluding patients who died following WLST on hospital performance. Read More

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October 2020

The current status of disaster preparedness in Canadian trauma centers.

J Trauma Acute Care Surg 2020 09;89(3):e78-e83

From the Interdepartmental Division of Critical Care Medicine (J.N.), University of Toronto, Toronto, Canada; Department of Epidemiology and Preventive Medicine (B.J.G.), Monash University, Melbourne, Australia; Department of Surgery (A.N.), Sunnybrook Health Sciences Center, and Division of General Surgery (D.G.), St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.

Mass casualty incidents (MCIs) put substantial stress on loco-regional resources, and trauma centers are critical to responding to these events. Our previous evaluation of Canadian centers helped to identify several weaknesses in disaster responsiveness. In this analysis, we determined the current state of MCI readiness across Canada and how this has changed over time. Read More

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September 2020

Human pharmaceutical and pesticide residues in Israeli dairy milk in association with dietary risk assessment.

Food Addit Contam Part B Surveill 2020 Dec 14;13(4):233-243. Epub 2020 May 14.

Department of Food Quality & Safety, Institute for Postharvest and Food Sciences, Agricultural Research Organization, Volcani Center , Rishon LeZiyyon, Israel.

Throughout the world, more than six billion people consume milk and milk products yearly. The safety and quality of dairy milk are regularly monitored in most countries worldwide. The Israeli monitoring program of chemical residues in milk has not changed in the last decades, focusing only on major veterinary drugs and few selected environmental contaminants such as heavy metals and persistent organic pollutants. Read More

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December 2020

Improving Education and Training of Dutch Major Hazard Control Inspectors: A 15 Years Longitudinal Case Study.

Int J Environ Res Public Health 2020 03 17;17(6). Epub 2020 Mar 17.

Delft University of Technology, TPM Safety & Security Science Group, 2628 BX Delft, The Netherlands.

The education and training program for inspectors of Major Accident Hazard Establishments, specifically the EC Seveso III directive implicated Dutch chemical companies, changed considerably over a fifteen year period. This longitudinal, time-series cross sectional case study describes the development of the education and training program for Major Hazard Control inspectors, acting as regulators from the Labour inspectorate, belonging to the Dutch Ministry of Social Affairs and Employment. A blueprint had to be constructed in order to assess the development and quality of this program in four cross sections over time. Read More

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Area 2 of primary somatosensory cortex encodes kinematics of the whole arm.

Elife 2020 01 23;9. Epub 2020 Jan 23.

Department of Biomedical Engineering, Northwestern University, Evanston, United States.

Proprioception, the sense of body position, movement, and associated forces, remains poorly understood, despite its critical role in movement. Most studies of area 2, a proprioceptive area of somatosensory cortex, have simply compared neurons' activities to the movement of the hand through space. Using motion tracking, we sought to elaborate this relationship by characterizing how area 2 activity relates to whole arm movements. Read More

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January 2020

Facilitating supportive care in cardiac intensive care units.

Massimo Romanò

Curr Opin Support Palliat Care 2020 03;14(1):19-24

Interdepartmental University Research Center for Palliative Care, University of Milan, Milan, Italy.

Purpose Of Review: The number of patients who die in the hospital in the Western world is high, and 20-30% of them are admitted to an ICU in the last month of life, including those in cardiac ICUs (CICUs) where invasive procedures are performed and mortality is high. Palliative consultation is provided in only a few cases. The ethical and decisional aspects associated with the advanced stages of illness are very rarely discussed. Read More

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Levothyroxine Formulations: Pharmacological and Clinical Implications of Generic Substitution.

Adv Ther 2019 09 4;36(Suppl 2):59-71. Epub 2019 Sep 4.

Department of Endocrinology and Internal Medicine, Aalborg University Hospital, Aalborg, Denmark.

Oral levothyroxine (LT4) is the standard therapy for patients with hypothyroidism. Oral LT4 is available in several formulations, including tablets, soft gel capsules and oral solution. Multiple brand-name and generic LT4 tablets are available. Read More

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September 2019

Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study.

Ann Intensive Care 2019 Aug 14;9(1):89. Epub 2019 Aug 14.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

Background: The electrical activity of the crural diaphragm (Eadi), a surrogate of respiratory drive, can now be measured at the bedside in mechanically ventilated patients with a specific catheter. The expected range of Eadi values under stressed or assisted spontaneous breathing is unknown. This study explored Eadi values in healthy subjects during unstressed (baseline), stressed (with a resistance) and assisted spontaneous breathing. Read More

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An Examination of Advocacy Education in Residency Training.

Arch Pathol Lab Med 2020 04 17;144(4):497-499. Epub 2019 Jul 17.

From the Department of Pathology and Laboratory Medicine (Dr Black) and Graduate Medical Education, Department of Pathology (Ms Motta), Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

Context.—: Pathology-related advocacy is best when performed directly by pathologists. Practicing advocacy is included in the Milestones 2. Read More

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Complex patterns of sex-biased demography in canines.

Proc Biol Sci 2019 05;286(1903):20181976

1 Interdepartmental Program in Bioinformatics, University of California , Los Angeles, CA 90095 , USA.

The demographic history of dogs is complex, involving multiple bottlenecks, admixture events and artificial selection. However, existing genetic studies have not explored variance in the number of reproducing males and females, and whether it has changed across evolutionary time. While male-biased mating practices, such as male-biased migration and multiple paternity, have been observed in wolves, recent breeding practices could have led to female-biased mating patterns in breed dogs. Read More

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Accumulation of Circulating CCR7 Natural Killer Cells Marks Melanoma Evolution and Reveals a CCL19-Dependent Metastatic Pathway.

Cancer Immunol Res 2019 05 2;7(5):841-852. Epub 2019 Apr 2.

Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.

Immune checkpoint blockade therapy has changed prognoses for many melanoma patients. However, immune responses that correlate with clinical progression of the disease are still poorly understood. To identify immune responses correlating with melanoma clinical evolution, we analyzed serum cytokines as well as circulating NK and T-cell subpopulations from melanoma patients. Read More

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Effects of Harvest Time on the Aroma of White Wines Made from Cold-Hardy Brianna and Frontenac Gris Grapes Using Headspace Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry-Olfactometry.

Foods 2019 Jan 16;8(1). Epub 2019 Jan 16.

Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA 50011, USA.

The Midwest wine industry has shown a marked increase in growers, hectares planted, wineries, and wine production. This growth coincides with the release of cold-hardy cultivars such as Brianna and Frontenac gris, in 2001 and 2003, respectively. These white grape varieties account for one-third of the total area grown in the state of Iowa. Read More

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January 2019

Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting.

FASEB J 2019 04 8;33(4):5168-5180. Epub 2019 Jan 8.

Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; and.

The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present work aimed at evaluating the pro/anti-inflammatory status in the same 2 crewmembers (A, B). Blood circulating (c-)microRNAs (miRs), c-proteasome, c-mitochondrial DNA, and cytokines were assessed by real-time quantitative PCR or ELISA tests. Read More

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