4,214 results match your criteria changed decade


: COVID-19 adopted Hybrid and Parallel deep information fusion framework for stock price movement prediction.

Expert Syst Appl 2021 Sep 20:115879. Epub 2021 Sep 20.

Concordia Institute for Information Systems Engineering, Concordia University, Canada.

The novel of coronavirus (COVID-19) has suddenly and abruptly changed the world as we knew at the start of the 3rd decade of the 21st century. Particularly, COVID-19 pandemic has negatively affected financial econometrics and stock markets across the globe. Artificial Intelligence (AI) and Machine Learning (ML)-based prediction models, especially Deep Neural Network (DNN) architectures, have the potential to act as a key enabling factor to reduce the adverse effects of the COVID-19 pandemic and future possible ones on financial markets. Read More

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September 2021

Time Trends in Physical Activity Using Wearable Devices: A Systematic Review and Meta-analysis of Studies from 1995 to 2017.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Department of Kinesiology, Boise State University, Boise, ID Department of Clinical & Applied Movement Sciences, University of North Florida, Jacksonville, FL Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, TN Department of Food, Nutrition, and Sport Science, University of Gothenburg, Sweden Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan.

Introduction: Conflicting evidence exists on whether physical activity (PA) levels of humans have changed over the last quarter-century. The main objective of this study was to determine if there is evidence of time trends in PA, from cross-sectional studies that assessed PA at different time points using wearable devices (e.g. Read More

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September 2021

Treatment Trends of Adult Brachial Plexus Injury: A Bibliometric Analysis.

Plast Reconstr Surg Glob Open 2021 Sep 15;9(9):e3803. Epub 2021 Sep 15.

Department of Hand, Plastic, Reconstructive, and Burn Surgery, BG Trauma Clinic University of Tübingen, Tübingen, Germany.

Brachial plexus injury is often debilitating because it can severely impair upper extremity function and, thus, quality of life. The surgical treatment of injuries to the brachial plexus is very demanding because it requires a profound understanding of the anatomy and expertise in microsurgery. The aim of this study was to get an overview of the landscape in adult brachial plexus injury surgery, and to understand how this has changed over the years. Read More

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September 2021

Food traceability systems, consumers' risk perception, and purchase intention: Evidence from the "4-label-1-Q" approach in Taiwan.

J Food Prot 2021 Sep 21. Epub 2021 Sep 21.

National Cheng Kung University Professor Department of Food Safety/Hygiene and Risk Management 138 Sheng Li Road TAIWAN Tainan 701.

Many food safety issues have occurred in Taiwan during the past decade. Therefore, in 2016, the Taiwan government proposed the "Five rings of food safety" policy to comprehensively protect consumer food supply. Among these policies, the "4-labels-1-Q" approach was adopted to ensure the selection of "retrospective foods" with traceable labels. Read More

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September 2021

Malnutrition Prevalence Rates among Dutch Nursing Home Residents: What Has Changed over One Decade? A Comparison of the Years 2009, 2013 and 2018.

J Nutr Health Aging 2021 ;25(8):999-1005

Irma Everink, Maastricht University, Maastricht, Nederland,

Objectives: To assess changes in prevalence of malnutrition and its associated factors among people living in Dutch nursing homes in 2009, 2013 and 2018.

Design: Secondary data analysis of the International Prevalence Measurement of Care Quality (LPZ) study.

Setting: Dutch nursing homes. Read More

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January 2021

Immunotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck.

Front Oncol 2021 1;11:705614. Epub 2021 Sep 1.

Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.

Head and neck cancer is the 6 most common cancer worldwide with the most common histology being squamous cell carcinoma (HNSCC). While the majority of patients present at a stage where curative intent therapy is possible, when patients recur and/or develop metastatic disease, outcomes are generally poor, especially with systemic therapy alone, and they lag behind other solid tumors. Over the last decade immunotherapy has revolutionized the field of oncology, and anti-PD-1-based therapy has changed the standard of care in recurrent/metastatic (R/M) HNSCC as well. Read More

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September 2021

Interventional Spine and Pain Procedure Credentialing: Guidelines from the American Society of Pain & Neuroscience.

J Pain Res 2021 8;14:2777-2791. Epub 2021 Sep 8.

The Spine & Nerve Centers of the Virginias, Charleston, WV, USA.

Background: The discipline of interventional pain management has changed significantly over the past decade with an expected greater evolution in the next decade. Not only have the number of procedures increased, some of the procedures that were created for spine surgeons are becoming more facile in the hands of the interventional pain physician. Such change has outpaced academic institutions, societies, and boards. Read More

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September 2021

Venous thromboembolism: Recent advancement and future perspective.

J Cardiol 2021 Sep 10. Epub 2021 Sep 10.

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Clinicians have been more and more often encountering patients with venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis, leading to the increased importance of VTE in daily clinical practice. VTE is becoming a common issue in Asian countries including Japan. The management strategies of VTE have changed dramatically in the past decade including the introduction of direct oral anticoagulants (DOACs). Read More

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September 2021

Ten-Year Trends in Coronary Bifurcation Percutaneous Coronary Intervention: Prognostic Effects of Patient and Lesion Characteristics, Devices, and Techniques.

J Am Heart Assoc 2021 Sep 13;10(18):e021632. Epub 2021 Sep 13.

Division of Cardiology Department of Internal Medicine Ajou University Hospital Suwon Republic of Korea.

Background Despite advances in devices and techniques, coronary bifurcation lesion remains a challenging lesion subset in the field of percutaneous coronary intervention (PCI). We evaluate 10-year trends in bifurcation PCI and their effects on patient outcomes. Methods and Results We analyzed 10-year trends in patient/lesion characteristics, devices, PCI strategy, stent optimization techniques, and clinical outcomes using data from 5498 patients who underwent bifurcation PCI from 2004 to 2015. Read More

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September 2021

Continuous warming shift greening towards browning in the Southeast and Northwest High Mountain Asia.

Sci Rep 2021 Sep 9;11(1):17920. Epub 2021 Sep 9.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, China.

Remote sensing and ground vegetation observation data show that climate warming promotes global vegetation greening, and the increase in air temperature in High Mountain Asia (HMA) is more than twice the global average. Under such a drastic warming in climate, how have the vegetation dynamics in HMA changed? In this study, we use the Normalized Difference Vegetation Index (NDVI) from 1982 to 2015 to evaluate the latest changes in vegetation dynamics in HMA and their climate-driving mechanisms. The results show that over the past 30 years, HMA has generally followed a "warm-wet" trend, with temperatures charting a continuous rise. Read More

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September 2021

Catalytic Amyloids as Novel Synthetic Hydrolases.

Int J Mol Sci 2021 Aug 25;22(17). Epub 2021 Aug 25.

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile.

Amyloids are supramolecular assemblies composed of polypeptides stabilized by an intermolecular beta-sheet core. These misfolded conformations have been traditionally associated with pathological conditions such as Alzheimer's and Parkinson´s diseases. However, this classical paradigm has changed in the last decade since the discovery that the amyloid state represents a universal alternative fold accessible to virtually any polypeptide chain. Read More

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Exploring the global vaginal microbiome and its impact on human health.

Microb Pathog 2021 Sep 6;160:105172. Epub 2021 Sep 6.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France. Electronic address:

Around the world, more than 175,000,000 women are diagnosed every year with gynaecological disease, in many cases contributing to high morbidity and mortality. For this reason, knowledge of the composition of the vaginal microbiome and its variations represents a real health challenge, as this is key to improving therapeutic management. This review traces the history of the poorly known vaginal microbiome and focuses on the latest findings concerning this ecosystem. Read More

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September 2021

Postnatal gene therapy for neuromuscular diseases - opportunities and limitations.

J Perinat Med 2021 Sep 9. Epub 2021 Sep 9.

Department of Neuropediatrics, Medical Faculty, University Hospital Bonn, Bonn, Germany.

During the last decade a number of innovative treatments including gene therapies have been approved for the treatment of monogenic inherited diseases. For some neuromuscular diseases these approaches have dramatically changed the course of the disease. For others relevant challenges still remain and require disease specific approaches to overcome difficulties related to the immune response and the efficient transduction of target cells. Read More

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September 2021

Impacts of climate change on suitability zonation for potato cultivation in Jilin Province, Northeast China.

Sci Rep 2021 Sep 6;11(1):13103. Epub 2021 Sep 6.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Global climate change is causing notable shifts in the environmental suitability of the main regions involved in potato cultivation and has, thus, changed the production potential of potatoes. These shifts can be mapped at fine scales to better understand climate change within areas of potato cultivation and to find infrastructural- and breeding-based solutions. As a case study, we have identified and mapped the structural and spatial shifts that occurred in areas suitable for potato cultivation in Jilin Province, China. Read More

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September 2021

An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?

Eur Urol 2021 Sep 3. Epub 2021 Sep 3.

Department of Operating Rooms, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.

Context: Focal therapy is a promising, minimally invasive strategy to selectively treat localized prostate cancer. A previous systematic review indicated that there is growing evidence for favorable functional outcomes, but that oncological effectiveness was yet to be defined.

Objective: To assess the effectiveness of focal therapy in patients with localized prostate cancer in terms of functional and oncological outcomes. Read More

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September 2021

Marked response to perampanel: A decade-long course of giant somatosensory evoked potentials in Unverricht-Lundborg disease.

Clin Neurophysiol 2021 Oct 22;132(10):2329-2331. Epub 2021 Jul 22.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:

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October 2021

The gut microbiome and efficacy of cancer immunotherapy.

Pharmacol Ther 2021 Aug 25:107973. Epub 2021 Aug 25.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy.

Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented improvement in overall and progression-free survival in several advanced and metastatic cancers. Currently, immune checkpoint inhibitor (ICI) antibodies against cytotoxic T-lymphocyte antigen (CTLA-4) and programmed death/ligand 1 (PD-1/PD-L1) are being tested and approved for different tumors, ranging from melanoma to lung carcinoma. However, only a subgroup of patients can reach treatment benefits and long-term responses, and reliable biomarkers that can accurately predict clinical responses to immunotherapy are still unidentified. Read More

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Branded Price Variation in the United States Drug Market, 2010 to 2019.

Value Health 2021 Sep 5;24(9):1237-1240. Epub 2021 Aug 5.

American Enterprise Institute, Washington, DC, USA.

The transaction price for branded drugs in the United States often varies widely by the eventual payer, a fact that can complicate research and policy discussions surrounding drug pricing. We combine publicly-available data on branded drug prices from a host of sources-prices paid by Medicare (Parts B and D), the Veterans Affairs Administration (VA), those included in the Federal Supply Schedule (FSS), invoice prices paid by pharmacies described in National Average Drug Acquisition Costs (NADAC), list prices, and payments ultimately received by drug makers-to illustrate how prices vary across the U.S. Read More

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September 2021

Prognostic value of blood cell count-derived ratios in BRAF-mutated metastatic melanoma.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Aug 24. Epub 2021 Aug 24.

Department of Oncology and Radiotherapy, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Background: The treatment and prognosis of metastatic melanoma have changed during the last decade to include immunotherapy or targeted therapy as standard therapeutic options for BRAF-mutated melanoma. However, predictive and/or prognostic markers are lacking, especially in clinical situations where several options are available. The aim of this study was to determine the association of pre-therapeutic blood cell count-derived ratios (BCDR) with survival in patients with BRAF-mutated metastatic melanoma. Read More

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The Value of Population Screening in Advancing Personalized Medicine in the Field of Lung Cancer.

Pharmgenomics Pers Med 2021 14;14:987-996. Epub 2021 Aug 14.

Aix Marseille University, CNRS, INSERM, CRCM, APHM, Multidisciplinary Oncology & Therapeutic Innovations Department, Marseille, France.

During the past decade, progress has been made in the field of lung cancer molecular biology and onco-immunology, leading to prolonged survival of patients. The combination of increased fundamental knowledge and the pharmaceutical pipeline has allowed the development of various tyrosine kinase inhibitors, targeting numerous molecular alterations. These drugs are now available in daily practice and have transformed survival outcomes for patients harboring or alterations. Read More

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The forest restoration frontier.

Ambio 2021 Aug 24. Epub 2021 Aug 24.

Minzu University, 27 Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.

Forest restoration has resulted in approximately 300 million ha of restored forests until today. During the second decade of the twenty-first century several international initiatives have sprung up which aim to add 350 million ha of restored forest by 2030. The paper reviews the development of the forest restoration frontier. Read More

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Long-term variability in base cation, sulfur and nitrogen deposition and critical load exceedance of terrestrial ecosystems in China.

Environ Pollut 2021 Aug 14;289:117974. Epub 2021 Aug 14.

School of Environment, Tsinghua University, Beijing, 100084, China.

The rapid development of China's industrial economy and implementation of air pollution controls have led to great changes in sulfur (S), nitrogen (N) and base cation (BC) deposition in the past three decades. We estimated China's anthropogenic BC emissions and simulated BC deposition from 1985 to 2015 with a five-year interval using a multilayer Eulerian model. Deposition of S and N from 2000 to 2015 with a five-year interval was simulated with the EMEP MSC-W model and the Multi-resolution Emission Inventory of China (MEIC). Read More

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Clubfoot treatment in China before and after the advent of the Ponseti technique: a historical narrative review.

Ann Transl Med 2021 Jul;9(13):1107

Lille University Center, Jeanne de Flandre Hospital, Department of Pediatric Orthopedic Surgery, Lille, France.

Congenital clubfoot (CF) was first described by Hippocrates in approximately 400 B.C. In ancient China, manipulations were widely used to correct CF, but the outcomes were frequently unsatisfactory with residual deformity even if corrective devices were used. Read More

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The role of bronchoscopy in the diagnosis and management of pediatric pulmonary tuberculosis.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211037168. Epub 2021 Aug 18.

Department of Surgical Sciences, Division of Cardiothoracic Surgery, Stellenbosch University, and Tygerberg Hospital, Tygerberg, South Africa.

Bronchoscopy is useful as a diagnostic and therapeutic procedure in children with Tuberculosis (TB) disease complicated by airway obstruction. It is needed in children when surgical intervention may be required for airway compression, when drug resistance is suspected, and to rule out an alternative diagnosis for airway obstruction. Bronchoscopy with bronchoalveolar lavage (BAL) should be performed when other, less invasive samples cannot be collected, or when they fail to provide useful diagnostic information. Read More

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Drivers of Food Choice among Children and Caregivers in Post-earthquake Nepal.

Ecol Food Nutr 2021 Aug 22:1-21. Epub 2021 Aug 22.

Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

Food systems in many countries are experiencing a shift from traditional foods toward processed foods high in sugar, fat and salt, but low in dietary fiber and micronutrients. There is an urgent need to better understand drivers of changing food behavior, particularly for lower-income countries. This study analyzes drivers of food choice among children and parents in rural Nepal. Read More

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[Clinical analysis of pregnancy with cardiovascular diseases for a decade of Beijing Anzhen Hospital].

Zhonghua Fu Chan Ke Za Zhi 2021 Aug;56(8):528-536

Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Obstetrics and Gynecology Center for Severe Cardiovascular Diseases, Beijing 100029, China.

To analyze the clinical data of pregnant women complicated with cardiovascular disease in our center in the past 10 years, and to explore the trend of incidence, clinical diagnosis, and treatment of the disease. Clinical data of pregnant women with cardiovascular disease who delivered in Beijing Anzhen Hospital, Capital Medical University from 2010 to 2019 were collected and analyzed retrospectively. According to the time of the establishment of multidisciplinary team (MDT) in the center, the pregnant women were divided into the first 5-year group (2010-2014) and the second 5-year group (2015-2019). Read More

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Fluctuating selection driven by global and local climatic conditions leads to stasis in breeding time in a migratory bird.

J Evol Biol 2021 Aug 20. Epub 2021 Aug 20.

Department of Biological Conservation and Ecosystem Restoration, Pyrenean Institute of Ecology (CSIC), Jaca, Spain.

The origin of natural selection is linked to environmental heterogeneity, which influences variation in relative fitness among phenotypes. However, individuals in wild populations are exposed to a plethora of biotic and abiotic environmental factors. Surprisingly, the relative influence of multiple environmental conditions on the relative fitness of phenotypes has rarely been tested in wild populations. Read More

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A 2020 Environmental Scan of Heart Failure Clinics in Ontario.

CJC Open 2021 Jul 26;3(7):929-935. Epub 2021 Mar 26.

Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.

Background: Multidisciplinary heart failure (HF) clinics decrease hospital admission rates and healthcare use, while improving patient outcomes. To understand the contemporary availability of HF clinics in Ontario, Canada, and the services provided, we performed an environmental scan of physician-led and nurse practitioner (NP)-led HF clinics.

Methods: Between November, 2019 and February 2020, we identified Ontario HF clinics led by physicians or NPs. Read More

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Unintentional injury deaths in children and youth, 2010-2019.

J Safety Res 2021 09 17;78:322-330. Epub 2021 Jul 17.

Division of Injury Prevention, National Center for Injury Prevention and Control, CDC, Atlanta, GA, United States.

Background: Unintentional injuries are the leading cause of death for children and youth aged 1-19 in the United States. The purpose of this report is to describe how unintentional injury death rates among children and youth aged 0-19 years have changed during 2010-2019.

Method: CDC analyzed 2010-2019 data from the National Vital Statistics System (NVSS) to determine two-year average annual number and rate of unintentional injury deaths for children and youth aged 0-19 years by sex, age group, race/ethnicity, mechanism, county urbanization level, and state. Read More

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September 2021