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Classification of certain vertebral degenerations using MRI image features.

Biomed Phys Eng Express 2021 May 13. Epub 2021 May 13.

Engineering Design, IIT Madras, IIT Madras, Chennai, 600036, INDIA.

This article describes a fully automatic system for classifying various spinal degenerative phenotypes namely Modic changes, endplate defects and focal changes which are associated with lower back pain. These are obtained from T1/T2 Magnetic Resonance Imaging (MRI) scans. Lower back pain is a predominantly occurring ailment, which is prone to have various roots including the anatomical and pathophysiological aspects. Read More

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Symptom severity moderates the outcome of attention bias modification for depression: An exploratory study.

J Psychiatr Res 2021 May 5;138:528-534. Epub 2021 May 5.

Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway; Division of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway.

A recent meta-analysis has questioned the relevance of attention bias modification (ABM) for depression outcomes. However, there might be patient characteristics not yet accounted for, that are relevant to the outcome. In the context of personalized treatment, the lack of moderator studies have limited the potential for matching ABM-treatment to individual patient characteristics. Read More

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A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial.

Int Immunopharmacol 2021 Apr 30;96:107743. Epub 2021 Apr 30.

Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Navi Mumbai, India.

Objective: Ozone therapy has tremendous therapeutic potential owing to its antiviral, anti-inflammatory and antioxidant properties, and potential to improve oxygenation. A pilot clinical trial was conducted to evaluate the safety and efficacy ofintravenous ozonised saline treatment in patients with moderate COVID-19 pneumonia.

Patients And Methods: 10 patients were administered 200 ml freshly prepared ozonised saline intravenously over 1 h once a day for 8 days along with standard medical treatment. Read More

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Impact of the 12-gene recurrence score assay on deciding adjuvant chemotherapy for stage II and IIIA/B colon cancer: the SUNRISE-DI study.

ESMO Open 2021 May 10;6(3):100146. Epub 2021 May 10.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: Recent advances in adjuvant chemotherapy for early colon cancer have widened physicians' recommendations on the regimen and duration (3 or 6 months) of the treatment. We conducted this prospective study to evaluate whether the 12-gene recurrence score (12-RS) assay affected physicians' recommendations on adjuvant treatment selection.

Patients And Methods: Patients with stage IIIA/IIIB or stage II colon cancer were enrolled. Read More

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Evaluation of different strategic control protocols for Rhipicephalus microplus on cattle according to tick burden.

Ticks Tick Borne Dis 2021 May 1;12(4):101737. Epub 2021 May 1.

Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil; Departamento de Biociências e Tecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

The development of a strategic protocol is fundamental to the control of Rhipicephalus microplus. The efficacy of different strategic tick control protocols (Day 1 to Day 119) using commercial acaricides according to R. microplus burden on bovines was evaluated. Read More

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Climate change impact on EU rivers' dilution capacity and ecological status.

Water Res 2021 Apr 22;199:117166. Epub 2021 Apr 22.

Catalan Institute for Water Research (ICRA). Carrer Emili Grahit 101, 17003 Girona, Spain; University of Girona. Plaça de Sant Domènec 3, 17004 Girona, Spain. Electronic address:

Impacts from urban wastewater treatment plants (WWTP) to receiving riverine surface water bodies (SWBs) depend on the load of contaminants discharged, as well as on their dilution capacity. Yet, climate change impacts on such dilution capacity and ultimately on the SWBs ecological status remain unclear. Here, we assess SWBs dilution capacity across the European continent to identify most vulnerable areas using information from centralized European databases. Read More

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Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients - A randomized, double-blinded trial.

Brain Stimul 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Technical University of Munich, Germany, School of Medicine, Klinikum Rechts der Isar, Germany; TUM Neuroimaging Center, Technical University of Munich, Germany, School of Medicine, Klinikum Rechts der Isar, Germany. Electronic address:

Background: Navigated repetitive transcranial magnetic stimulation (nrTMS) is effective therapy for stroke patients. Neurorehabilitation could be supported by low-frequency stimulation of the non-damaged hemisphere to reduce transcallosal inhibition.

Objective: The present study examines the effect of postoperative nrTMS therapy of the unaffected hemisphere in glioma patients suffering from acute surgery-related paresis of the upper extremity (UE) due to subcortical ischemia. Read More

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Does atorvastatin therapy change the anti-Xa activity in xabans-treated patients with atrial fibrillation?

Pharmacol Res Perspect 2021 May;9(3):e00730

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.

Atorvastatin and direct oral factor Xa inhibitors (xabans) are frequently co-administrated in patients with atrial fibrillation (AF). However, no studies investigating the possibility of the pharmacologic interaction between these agents have been conducted. The aim of this prospective observational study was to determine the impact of atorvastatin therapy on anti-Xa activity in xabans-treated patients with AF. Read More

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Knowledge gaps in Alzheimer's disease immune biomarker research.

Alzheimers Dement 2021 May 13. Epub 2021 May 13.

Division of Epidemiology, Department of Health Sciences Research, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Considerable evidence has accumulated implicating a role for immune mechanisms in moderating the pathology in Alzheimer's disease dementia. However, the appropriate therapeutic target, the appropriate direction of manipulation, and the stage of disease at which to begin treatment remain unanswered questions. Part of the challenge derives from the absence of any selective pressure to develop a coordinated beneficial immune response to severe neural injury in adults. Read More

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Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation.

Invest Ophthalmol Vis Sci 2021 May;62(6):14

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To investigate the characteristics of treatment-naïve nonexudative macular neovascularization (MNV) in age-related macular degeneration before the onset of exudation using swept-source optical coherence tomography angiography.

Methods: MNV area, choriocapillaris (CC) flow deficits (FDs), vessel area density (VAD), vessel skeleton density (VSD), retinal pigment epithelial detachment (PED) volume, mean choroidal thickness (MCT), and choroid vascularity index (CVI) measurements were assessed at two visits prior to exudation. We compared measurements made at the second visit and the rate of change between visits in eyes with and without exudation. Read More

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Mental-physical multimorbidity treatment adherence challenges in Brazilian primary care: A qualitative study with patients and their healthcare providers.

PLoS One 2021 13;16(5):e0251320. Epub 2021 May 13.

Public Health Postgraduate Program, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Improved understanding of multimorbidity (MM) treatment adherence in primary health care (PHC) in Brazil is needed to achieve better healthcare and service outcomes. This study explored experiences of healthcare providers (HCP) and primary care patients (PCP) with mental-physical MM treatment adherence. Adults PCP with mental-physical MM and their primary care and community mental health care providers were recruited through maximum variation sampling from nine cities in São Paulo State, Southeast of Brazil. Read More

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Socially Accountable Canadian Occupational Therapy Fieldwork with Indigenous Peoples: Where Are We At?

Occup Ther Health Care 2021 May 13:1-25. Epub 2021 May 13.

School of Physical and Occupational Therapy, McGill University, Montreal, Canada.

In an increasingly globalized world, there have been mounting calls for social accountability with respect to recognizing Indigenous and nonwhite human rights within nation states. Thus, this perspective paper reflects on the Canadian occupational therapy journey for social change with a specific focus on Indigenous fieldwork experiences. First, we describe the importance of cultural safety in occupational therapy practice and partnership development. Read More

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The Effect of Neprilysin Inhibition on Left Ventricular Remodeling in Patients with Asymptomatic Left Ventricular Systolic Dysfunction Late After Myocardial Infarction.

Circulation 2021 May 13. Epub 2021 May 13.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Patients with left ventricular systolic dysfunction (LVSD) following myocardial infarction (MI) are at high risk of developing heart failure. The addition of neprilysin inhibition to renin angiotensin system (RAS) inhibition may result in greater attenuation of adverse LV remodeling due to increased levels of substrates for neprilysin with vasodilatory, anti-hypertrophic, anti-fibrotic and sympatholytic effects. We performed a prospective, multi-center, randomized, double-blind, active-comparator trial comparing sacubitril/valsartan 97/103mg twice daily with valsartan 160mg twice daily in patients ≥3 months following MI with a LV ejection fraction (LVEF) ≤40% who were taking a RAS inhibitor (equivalent dose of ramipril ≥2. Read More

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Novel Therapies for Metastatic Triple-Negative Breast Cancer: Spotlight on Immunotherapy and Antibody-Drug Conjugates.

Oncology (Williston Park) 2021 May 13;35(5):249-254. Epub 2021 May 13.

Massachusetts General Hospital Cancer Center, Boston, MA.

Background: Triple-negative breast cancer (TNBC) is a biologically heterogeneous disease that is often associated with worse outcomes compared with other subtypes such as hormone receptor-positive tumors and HER2-positive tumors. While chemotherapy remains the mainstay of standard therapy for metastatic TNBC (mTNBC), several novel treatments have been developed over the past few years. In this review article, we review the major developments in the management of patients with mTNBC. Read More

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High-Risk Population Based on BC Risk Factors.

Adv Exp Med Biol 2021 ;1187:405-417

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Breast cancer (BC) is the second leading cause of female cancers worldwide in 2018, followed by lung cancer, and the fifth fatal cancer, followed by lung, colorectal, gastric, and liver cancers. The incidence and mortality rates of breast cancer in Western women have been shown to decrease for a long period of time, while the incidence and mortality rates of Asian women are rapidly increasing. The incidence and mortality rates of BC in Western women have been changing to a recent decrease from a fluctuation in rates for a long time, while in Asian women, the incidence and mortality rates have increased rapidly. Read More

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January 2021

Circulating endotoxin and inflammation: associations with fitness, physical activity and the effect of a six-month programme of cycling exercise during haemodialysis.

Nephrol Dial Transplant 2021 May 13. Epub 2021 May 13.

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.

Background: Intradialytic cycling (IDC) may provide cardiovascular benefit to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was to investigate the effect of a six-month programme of IDC on circulating endotoxin (secondary analysis from the CYCLE-HD trial). Secondary aims were to investigate changes in circulating cytokines (IL-6, IL-10, TNF-α, CRP and IL6/IL-10), and their associations with physical activity, fitness and cardiovascular outcomes. Read More

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Behavior Change Techniques in Popular Mobile Apps for Smoking Cessation in France: Content Analysis.

JMIR Mhealth Uhealth 2021 May 13;9(5):e26082. Epub 2021 May 13.

Laboratoire EA 4430-Clinique Psychanalyse Developpement, Department of Psychology, University of Paris Nanterre, Nanterre, Ile-de-France, France.

Background: The mobile app market differs from country to country, and to date, no previous review of the content quality of smoking cessation apps has been conducted in France.

Objective: This study aimed to examine the general quality of the most popular smoking cessation apps in France and also determine the degree to which apps adhere to established behavioral and cognitive techniques (BCTs) proven effective in clinical practice.

Methods: A systematic research of smoking cessation apps was conducted in both the Google Play Store and Apple Store in the French market. Read More

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Using Biometric Sensor Data to Monitor Cancer Patients During Radiotherapy: Protocol for the OncoWatch Feasibility Study.

JMIR Res Protoc 2021 May 13;10(5):e26096. Epub 2021 May 13.

Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Patients with head and neck cancer (HNC) experience severe side effects during radiotherapy (RT). Ongoing technological advances in wearable biometric sensors allow for the collection of objective data (eg, physical activity and heart rate), which might, in the future, help detect and counter side effects before they become severe. A smartwatch such as the Apple Watch allows for objective data monitoring outside the hospital with minimal effort from the patient. Read More

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Is the Preoperative Use of Antidepressants and Benzodiazepines Associated with Opioid and Other Analgesic Use after Hip and Knee Arthroplasty?

Clin Orthop Relat Res 2021 May 10. Epub 2021 May 10.

T. J. Rajamäki, A. Hietaharju, E. Jämsen, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland T. J. Rajamäki, T. Moilanen, E. Jämsen, Coxa Hospital for Joint Replacement, Tampere, Finland P. A. Puolakka, Department of Anaesthesia, Tampere University Hospital, Tampere, Finland A. Hietaharju, Department of Neurology, Tampere University Hospital, Tampere, Finland.

Background: Mental health disorders can occur in patients with pain conditions, and there have been reports of an increased risk of persistent pain after THA and TKA among patients who have psychological distress. Persistent pain may result in the prolonged consumption of opioids and other analgesics, which may expose patients to adverse drug events and narcotic habituation or addiction. However, the degree to which preoperative use of antidepressants or benzodiazepines is associated with prolonged analgesic use after surgery is not well quantified. Read More

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The human WNT5A isoforms display similar patterns of expression but distinct and overlapping activities in normal human osteoblasts.

J Cell Biochem 2021 May 13. Epub 2021 May 13.

Department of Biology, University of North Carolina Greensboro, Greensboro, North Carolina, USA.

WNT5A activates noncanonical Wnt signaling pathways and has critical functions in early development, differentiation, and tissue homeostasis. Two major WNT5A protein isoforms, which in this study we term WNT5A-L(A) and WNT5A-S(B), have been identified that differ by 18 AA at their amino terminus. Functional differences between the isoforms have been indicated in studies utilizing cancer cell lines but the activities of the isoforms in normal cells and during differentiation have not been explored. Read More

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Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps.

Int J Mol Med 2021 Jul 13;48(1). Epub 2021 May 13.

Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Matrix metalloproteinase (MMP)‑9 is a key enzyme responsible for extracellular matrix degradation and contributes to the progressive histological changes observed in lower respiratory tract infections. Integrin β1 and α‑tubulin are potential MMP‑9‑interacting proteins, and microRNA (miR)‑29b‑3p can regulate MMP‑9 expression. MMP‑9 is highly expressed in chronic rhinosinusitis with nasal polyps (CRSwNPs), regardless of its effects on miR‑29b‑3p, integrin β1 and α‑tubulin expression. Read More

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Intracellular detection of singlet oxygen using fluorescent nanosensors.

Analyst 2021 May 13. Epub 2021 May 13.

Department of Physics and Astronomy, University of Toledo, Toledo, Ohio, USA.

Detection of singlet oxygen is of great importance for a range of therapeutic applications, particularly photodynamic therapy, plasma therapy and also during photo-endosomolytic activity. Here we present a novel method of intracellular detection of singlet oxygen using biocompatible polymeric nanosensors, encapsulating the organic fluorescent dye, Singlet Oxygen Sensor Green (SOSG) within its hydrophobic core. The singlet oxygen detection efficiency of the nanosensors was quantified experimentally by treating them with a plasma source and these results were further validated by using Monte Carlo simulations. Read More

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Corroboration of Height Velocity Prediction Markers for rhGH With an Oral GH Secretagogue Treatment in Children With GHD.

J Endocr Soc 2021 Jun 25;5(6):bvab029. Epub 2021 Feb 25.

Lumos Pharma, Inc., Austin, TX, USA.

Context: Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatment in patients with moderate GHD. Distinguishing children with severe moderate GHD could identify children who would be better treated with rhGH or GHS. Read More

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Efficacy of erenumab in chronic migraine patients with and without ictal allodynia.

Cephalalgia 2021 May 13:3331024211010305. Epub 2021 May 13.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Ictal cutaneous allodynia, common in chronic migraine, is associated with reduced responses to acute treatment with triptans. Allodynia's impact on the efficacy of newer preventive treatments such as erenumab is unknown.

Methods: subgroup analysis of a double-blind, randomized, placebo-controlled 12-week study of erenumab in chronic migraine, contrasting those with no allodynia with those with moderate-severe allodynia assessed with the Allodynia Symptom Checklist-12, was undertaken. Read More

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Neuromodulation in the treatment of postoperative epidural fibrosis: Comparison of the extent of epidural fibrosis and the effect of stimulation.

Physiol Res 2021 May 12. Epub 2021 May 12.

Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

The goal was to prove that when a cohort of patients is chosen precisely, dorsal column stimulation provides significant improvement to quality of life. We studied a cohort of 50 patients with the history of failed back surgery syndrome coupled with epidural fibrosis (EF). A percutaneous implantation technique was used in each of the 50 patients. Read More

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Pharmacokinetics of Ruxolitinib in Patients with Atopic Dermatitis Treated With Ruxolitinib Cream: Data from Phase II and III Studies.

Am J Clin Dermatol 2021 May 12. Epub 2021 May 12.

Incyte Corporation, Wilmington, DE, USA.

Background: Pathogenesis of atopic dermatitis (AD) involves the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. A cream formulation of ruxolitinib, a potent selective JAK1/JAK2 inhibitor, was developed for topical delivery.

Method: Pharmacokinetic data were obtained from three double-blind, vehicle-controlled studies in patients with AD: a phase II study with ruxolitinib cream 0. Read More

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Impact of closed loop stimulation on prognostic cardiopulmonary variables in patients with chronic heart failure and severe chronotropic incompetence: a pilot, randomized, crossover study.

Europace 2021 May 13. Epub 2021 May 13.

Medizinische Klinik für Kardiologie, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

Aims: Clinical effects of rate-adaptive pacing in heart failure patients with chronotropic incompetence (CI) undergoing cardiac resynchronization therapy (CRT) remain unclear. Closed loop stimulation (CLS) is a new rate-adaptive sensor in CRT devices. We evaluated the effectiveness of CLS in CRT patients with severe CI, focusing primarily on key prognostic variables assessed by cardiopulmonary exercise (CPX) testing. Read More

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The conformational structural change of β-lactoglobulin via acrolein treatment reduced the allergenicity.

Food Chem X 2021 Jun 20;10:100120. Epub 2021 Apr 20.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

β-lactoglobulin (BLG) is a major allergen of milk. Since lipid peroxidation such as acrolein commonly exists during milk processing, it is necessary to evaluate its influence on BLG structure and potential allergenicity. The structure of acrolein-treated BLG was detected using SDS-PAGE, fluorescence, ultraviolet spectrum (UV), circular dichroism (CD) and LC-MS-MS, and the potential allergenicity was assessed by and assays. Read More

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Use of a slow-release intravitreal clindamycin implant for the management of ocular toxoplasmosis.

Am J Ophthalmol Case Rep 2021 Jun 16;22:101093. Epub 2021 Apr 16.

Department of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Purpose: To report the first patient with ocular toxoplasmosis treated with a slow-release biodegradable intravitreal clindamycin implant.

Observations: A 39-year-old human immunodeficiency virus (HIV)-positive woman with recurrent toxoplasmic retinochoroiditis and vitritis for whom oral medication was medically contraindicated was treated with an intravitreal slow-release clindamycin implant and three monthly intravitreal injections of clindamycin and dexamethasone. Serial ophthalmologic examinations demonstrated gradual, complete resolution of posterior uveitis and healing of the retinochoroidal lesion with cicatricial changes, as well as gradual improvement of cells in the anterior chamber. Read More

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The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

Clin Transl Radiat Oncol 2021 May 19;28:124-128. Epub 2021 Apr 19.

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.

Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes. Read More

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