30,374 results match your criteria change leading

Violence towards women and their decisions to take action: A complex systems approach.

Med Hypotheses 2021 Mar 30;151:110589. Epub 2021 Mar 30.

Department of Family & Community Medicine, University of Texas Health Science Center at San Antonio, United States.

Intimate partner violence (IPV) is a blight on society. Our traditional understanding suggests that interventions should be straightforward, leading to predictable positive results. However, these assumptions do not reflect the reality of IPV, which continues to frustrate physicians. Read More

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Combined effect of microplastics and global warming factors on early growth and development of the sea urchin (Paracentrotus lividus).

Sci Total Environ 2021 Apr 1;782:146888. Epub 2021 Apr 1.

Centro Oceanográfico de Vigo, Instituto Español de Oceanografía, IEO, Subida a Radio Faro, 50, 36390 Vigo, Pontevedra, Spain.

The aim of this work was to estimate the potential risk of the combined effect of global change factors (acidification, temperature increase) and microplastic (MP) pollution on the growth and development of the sea urchin P. lividus. Embryo-larval bioassays were conducted to determine growth and morphology after 48 h of incubation with MP (1000 and 3000 particles/mL); with filtered sea water at pH = 7. Read More

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An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern.

Bioorg Med Chem 2021 Apr 2;38:116130. Epub 2021 Apr 2.

State Key Laboratory of Natural Medicines, and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Protein-protein interactions (PPIs) are essentially fundamental to all cellular processes, so that developing small molecule inhibitors of PPIs have great significance despite representing a huge challenge. Studying PPIs with the help of peptide motifs could obtain the structural information and reference significance to reduce the difficulty in the development of small molecules. Computational methods are powerful tools to characterize peptide-protein interactions, especially molecular dynamics simulation and binding free energy calculation. Read More

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Unexpected decline in pediatric asthma morbidity during the coronavirus pandemic.

Pediatr Pulmonol 2021 Apr 13. Epub 2021 Apr 13.

Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.

The Coronavirus disease 2019 (COVID-19) pandemic profoundly impacted health care utilization. We evaluated asthma-related emergency department (ED) and inpatient health care utilization by a county-specific Medicaid population, ages 2-18, during the COVID-19 pandemic and compared it to utilization from a 3-year average including 2017-2019. All-cause ED utilization and asthma medication fill rates were evaluated during the same timeframes. Read More

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What Is on the Outside Matters-Surface Charge and Dissolve Organic Matter Association Affect the Toxicity and Physiological Mode of Action of Polystyrene Nanoplastics to .

Environ Sci Technol 2021 Apr 13. Epub 2021 Apr 13.

UK Centre for Ecology and Hydrology, Wallingford OX10 8BB, United Kingdom.

To better understand nanoplastic effects, the potential for surface functionalization and dissolve organic matter eco-corona formation to modify the mechanisms of action and toxicity of different nanoplastics needs to be established. Here, we assess how different surface charges modifying functionalization (postive (+ve) aminated; neutral unfunctionalized; negative (-ve) carboxylated) altered the toxicity of 50 and 60 nm polystyrene nanoplastics to the nematode . The potency for effects on survival, growth, and reproduction reduced in the order +ve aminated > neutral unfunctionalized ≫ -ve carboxylated with toxicity >60-fold higher for the +ve than -ve charged forms. Read More

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Assessing changes of carbon stock in dipterocarp forest due to hydro-electric dam construction in Malaysia.

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaaan Malaysia, UKM, 43600, Bangi, Selangor, Malaysia.

Deforestation and forest degradation are among the leading global concerns, as they could reduce the carbon sink and sequestration potential of the forest. The impoundment of Kenyir River, Hulu Terengganu, Malaysia, in 1985 due to the development of hydropower station has created a large area of water bodies following clearance of forested land. This study assessed the loss of forest carbon due to these activities within the period of 37 years, between 1972 and 2019. Read More

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Acute colonic pseudo-obstruction and rapid septic progression after transabdominal preperitoneal hernia repair: a case report.

BMC Surg 2021 Apr 12;21(1):191. Epub 2021 Apr 12.

Division of Surgery, Kenpoku Medical Center, Takahagi Kyodo Hospital, 1006-9, Agehocho, Kamitezuna, Takahagi, Ibaraki, Japan.

Background: Acute colonic pseudo-obstruction (ACPO) is a rare condition observed in patients with some underlying medical or surgical conditions. To the best of our knowledge, this is the first case report of a patient with ACPO development and rapid septic progression after laparoscopic inguinal hernia repair.

Case Presentation: A 78-year-old man who underwent transabdominal preperitoneal hernia repair (TAPP) for right inguinal hernia presented with difficulty in defecation and abdominal distension. Read More

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Ubiquitin forms conventional decorated micelle structures with sodium dodecyl sulfate at saturation.

J Colloid Interface Sci 2021 Mar 24;596:233-244. Epub 2021 Mar 24.

Interdisciplinary Nanoscience Center (iNANO), Gustav Wieds Vej 14, Aarhus University, DK-8000 Aarhus, Denmark; Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus, Denmark. Electronic address:

The anionic surfactant sodium dodecyl sulfate (SDS) interacts strongly with most globular proteins and denatures and unfolds them. While scattering studies using X-rays and neutrons have shown that this denaturation generally leads to protein-decorated SDS micelles, a different SDS-decorated polypeptide model has recently been suggested for complexes between SDS and Ubiquitin (UBI), in which individual SDS molecules are distributed on a partially stretched protein. To resolve this apparent discrepancy, we have investigated the SDS-UBI system by a number of complementary techniques. Read More

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Inpatient Insulin Pen Implementation, Waste, and Potential Cost Savings: A Community Hospital Experience.

J Diabetes Sci Technol 2021 Apr 12:19322968211002514. Epub 2021 Apr 12.

Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Insulin pen injectors ("pens") are intended to facilitate a patient's self-administration of insulin and can be used in hospitalized patients as a learning opportunity. Unnecessary or duplicate dispensation of insulin pens is associated with increased healthcare costs.

Methods: Inpatient dispensation of insulin pens in a 240-bed community hospital between July 2018 and July 2019 was analyzed. Read More

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Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 Pandemic.

Front Pediatr 2021 25;9:642508. Epub 2021 Mar 25.

Department of Public Health, Robbins College of Health and Human Services, Baylor University, Waco, TX, United States.

The coronavirus disease (COVID-19) has spread worldwide with an increasing number of patients, including pregnant women and neonates. This study aims to evaluate morbidity and mortality in the COVID-19 era compared to the preceding year in the Neonatal Intensive Care Unit (NICU) at Tamale Teaching Hospital, Ghana. This is a cross-sectional study carried out on neonates admitted to NICU between March 1st to August 31st, 2019 (pre-COVID-19 era) and March 1st to August 31st, 2020 (COVID-19 era). Read More

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National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990.

Front Oncol 2021 25;11:561376. Epub 2021 Mar 25.

Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. Read More

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Rethinking the Plant Economics Spectrum for Annuals: A Multi-Species Study.

Front Plant Sci 2021 26;12:640862. Epub 2021 Mar 26.

Functional and Tropical Plant Ecology, Bayreuth Centre of Ecology and Environmental Research (BayCEER), University of Bayreuth, Bayreuth, Germany.

The plant economics spectrum hypothesizes a correlation among resource-use related traits along one single axis, which determines species' growth rates and their ecological filtering along resource gradients. This concept has been mostly investigated and shown in perennial species, but has rarely been tested in annual species. Annuals evade unfavorable seasons as seeds and thus may underlie different constraints, with consequences for interspecific trait-trait, trait-growth, and trait-environment relations. Read More

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Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy-A Systematic Review of Literature.

Front Psychiatry 2021 25;12:608857. Epub 2021 Mar 25.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Electroconvulsive therapy (ECT) is considered to be the most effective acute treatment for otherwise treatment resistant major depressive episodes, and has been used for over 80 years. Still, the underlying mechanism of action is largely unknow. Several studies suggest that ECT affects the cerebral neurotransmitters, such as gamma-aminobutyric acid (GABA) and glutamate. Read More

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Transcranial Doppler Plateau Wave in a Patient with Pseudo-Chiari Malformation.

Acta Neurochir Suppl 2021 ;131:319-322

Intensive Care Unit, Clinicas Hospital School of Medicine, University of the Republic, Montevideo, Uruguay.

Case Report: A 26-year-old woman presented a superior sagittal and transverse sinus thrombosis with venous infarction. Anticoagulation was started. Six months later headache and visual impairment developed, and intracranial hypertension was diagnosed-secondary pseudotumor cerebri. Read More

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January 2021

Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes.

J Biol Chem 2020 Dec 24;296:100219. Epub 2020 Dec 24.

Laboratorio de Bioquímica y Biología Molecular, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile. Electronic address:

ADP-dependent kinases were first described in archaea, although their presence has also been reported in bacteria and eukaryotes (human and mouse). This enzyme family comprises three substrate specificities; specific phosphofructokinases (ADP-PFKs), specific glucokinases (ADP-GKs), and bifunctional enzymes (ADP-PFK/GK). Although many structures are available for members of this family, none exhibits fructose-6-phosphate (F6P) at the active site. Read More

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December 2020

Distribution of hydrogen and oxygen stable isotopes and pollution indicators in water during a monsoon transitional period in Min River Basin.

Sci Total Environ 2021 Mar 27;782:146780. Epub 2021 Mar 27.

Sichuan Water Resources and Hydroelectric Investigation & Design Institute, Chengdu 610072, China.

Based on 197 monthly river water and groundwater samples and 30 event-scale precipitation samples, our study reports the distribution of hydrogen and oxygen isotopes and pollution indicators in Min River Basin. The variation of δO and d-excess indicate that the water source in the upper main course water is more variable and that in the middle-lower part is relatively stable. Comparison between plots of δH versus δO in the river water and precipitation reflect the dominant water source is different between river water in the upper and middle-lower parts. Read More

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Suspended sediment load prediction using long short-term memory neural network.

Sci Rep 2021 Apr 9;11(1):7826. Epub 2021 Apr 9.

Department of Civil Engineering, Faculty of Engineering, University of Malaya (U.M.), 50603, Kuala Lumpur, Malaysia.

Rivers carry suspended sediments along with their flow. These sediments deposit at different places depending on the discharge and course of the river. However, the deposition of these sediments impacts environmental health, agricultural activities, and portable water sources. Read More

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How will artificial intelligence and bioinformatics change our understanding of IgA in the next decade?

Semin Immunopathol 2021 Apr 9. Epub 2021 Apr 9.

Faculty of Medicine, Heidelberg University, Heidelberg, Germany.

IgA nephropathy (IgAN) is the most common glomerulonephritis. It is characterized by the deposition of immune complexes containing immunoglobulin A (IgA) in the kidney's glomeruli, triggering an inflammatory process. In many patients, the disease has a progressive course, eventually leading to end-stage kidney disease. Read More

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Voltage-Modulated Structure Stress for Enhanced Electrochemcial Performances: The Case of μ-Sn in Sodium-Ion Batteries.

Nano Lett 2021 Apr 9. Epub 2021 Apr 9.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

Alloy-type anodes in alkaline ion batteries have to face the challenges of huge volume change and giant structure strain/stress upon cycling. Here, reducing the structure stress for advanced performances by voltage regulation is demonstrated by using microsized Sn (μ-Sn) for sodium ion batteries as a model. Density functional theory and finite element analysis indicate that Sn/NaSn is the crucial phase transition highly responsible for inducing surface cracks, particle aggregations, and cell failures. Read More

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Clinical Characteristics of Presenile Cataract: Change over 10 Years in Southern Taiwan.

Biomed Res Int 2021 20;2021:9385293. Epub 2021 Mar 20.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Purpose: The purpose of this study is to investigate the clinical characteristics of presenile cataract and compare that to ten years ago in southern Taiwan.

Methods: The subjects who received cataract surgeries aged 30 to 54 years were recruited in Kaohsiung Chang Gung Memorial Hospital during September 2015 and August 2016. Patients with uveitis or those who received combined cataract surgeries were excluded. Read More

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Free neighborhood choice boosts socially optimal outcomes in stag-hunt coordination problem.

Sci Rep 2021 Apr 8;11(1):7745. Epub 2021 Apr 8.

Department of Microeconomics and Public Economics, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Situations where independent agents need to align their activities to achieve individually and socially beneficial outcomes are abundant, reaching from everyday situations like fixing a time for a meeting to global problems like climate change agreements. Often such situations can be described as stag-hunt games, where coordinating on the socially efficient outcome is individually optimal but also entails a risk of losing out. Previous work has shown that in fixed interaction neighborhoods agents' behavior mostly converges to the collectively inefficient outcome. Read More

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Different anterolateral procedures have variable impact on knee kinematics and stability when performed in combination with anterior cruciate ligament reconstruction.

J ISAKOS 2021 Mar 24;6(2):74-81. Epub 2020 Nov 24.

Sydney Orthopaedic Research Institute Ltd, Chatswood, New South Wales, Australia.

Objective: The optimal anterolateral procedure to control anterolateral rotational laxity of the knee is still unknown. The objective was to compare the ability of five anterolateral procedures performed in combination with anterior cruciate ligament reconstruction (ACLR) to restore native knee kinematics in the setting of a deficient anterior cruciate ligament (ACL) and anterolateral structures.

Methods: A controlled laboratory study was performed using 10 fresh-frozen cadaveric whole lower limbs with intact iliotibial band. Read More

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Lateral tenodesis procedures increase lateral compartment pressures more than anterolateral ligament reconstruction, when performed in combination with ACL reconstruction: a pilot biomechanical study.

J ISAKOS 2021 Mar 24;6(2):66-73. Epub 2020 Nov 24.

Sydney Orthopaedic Research Institute Ltd, Chatswood, New South Wales, Australia.

Objectives: Given the common occurrence of residual laxity and re-injury post anterior cruciate ligament reconstruction (ACLR), additional anterolateral procedures are increasingly used in combination with an ACLR. Despite the perception that there is a risk of over-constraining the lateral tibiofemoral (LTF) compartment, potentially leading to osteoarthritis, assessment on their effect on intra-articular compartment pressures is still lacking. Our objective was therefore, through a pilot biomechanical study, to compare LTF contact pressures after the most commonly used anterolateral procedures. Read More

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Leading health reform: a critical review of 'leadership' within allied health competency standards.

Aust Health Rev 2021 Apr 9. Epub 2021 Apr 9.

ObjectiveThe study examined if, when and how select allied health professional standards currently articulate the Health LEADS Australia themes.MethodsEighteen allied health professional standards were searched to locate references to leadership. Data were extracted and analysed inductively, deductively and thematically as a meta-synthesis. Read More

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