29 results match your criteria cevus

  • Page 1 of 1

Contrast-enhanced voiding urosonography in the assessment of vesical-ureteral reflux: the time has come.

Radiol Med 2021 May 5. Epub 2021 May 5.

Section of Radiological Sciences, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, "G. Martino" Policlinic, Via Consolare Valeria 1, 98100, Messina, Italy.

Vesicoureteral reflux (VUR) is a pathological condition contradistinguished by monolateral or bilateral retrograde flow of urine from the bladder to the ureter and to the kidney. If not properly recognized and treated, VUR can potentially be associated to several complications such as recurrent infections and possible secondary scars with Chronic Kidney Disease (CKD). Furthermore, it represents an important risk factor for nephrovascular hypertension. Read More

View Article and Full-Text PDF

Contrast-enhanced voiding urosonography, part 1: vesicoureteral reflux evaluation.

Pediatr Radiol 2021 Mar 31. Epub 2021 Mar 31.

Pediatric Ultrasound Center, Thessaloniki, Greece.

Contrast-enhanced voiding urosonography (ceVUS) is a well-established, sensitive and safe ultrasound (US) modality for detecting and grading vesicoureteral reflux (VUR) and urethral imaging in children. Nearly three decades of remarkable advances in US technology and US contrast agents have refined ceVUS's diagnostic potential. The recent approval of Lumason/SonoVue in the United States, Europe and China for pediatric intravesical applications marked the beginning of a new era for this type of contrast US imaging. Read More

View Article and Full-Text PDF

Intrarenal Reflux in the Light of Contrast-Enhanced Voiding Urosonography.

Front Pediatr 2021 2;9:642077. Epub 2021 Mar 2.

University Hospital Split, Split, Croatia.

The aim of this study was to analyze the incidence of intrarenal reflux (IRR) among vesicoureteral refluxes (VURs), diagnosed by contrast-enhanced voiding urosonography (ceVUS), to define VURs which are positive to IRR and their locations in the kidney. Seventy patients with VURs, including 103 uretero-renal units (URUs) with VURs of grades II-V (37 URUs were excluded because of renal anomalies or absence of VUR) were examined with ceVUS due to recurrent febrile UTI or first febrile UTI accompanied by abnormalities on renal ultrasonography. Patients were examined on GE Logiq S8 ultrasound machine, using second generation of ultrasound contrast agent. Read More

View Article and Full-Text PDF

Contrast-enhanced voiding urosonography in the diagnosis of intrarenal reflux.

J Ultrasound 2021 Feb 26. Epub 2021 Feb 26.

Children's Hospital Zagreb, Ul. Vjekoslava Klaića 16, 10000, Zagreb, Croatia.

Purpose: Although contrast-enhanced urosonography (ceVUS) has shown capable diagnostic accuracy for the diagnosis of vesicoureteral reflux (VUR) in children, the ability of ceVUS to detect intrarenal reflux (IRR) is considered limited. The purpose of our study is to assess the ability of ceVUS to detect IRR as well as its association with age, gender, and the grade of VUR.

Methods: This study included 5153 children who were referred to our clinic for ceVUS. Read More

View Article and Full-Text PDF
February 2021

Assessment of distal ureteral and ureterovesical junction visualization on contrast-enhanced voiding urosonography.

Pediatr Radiol 2021 Feb 12. Epub 2021 Feb 12.

Department of Medical Imaging, Ann & Robert Lurie Children's Hospital, 225 E. Chicago Ave., Chicago, IL, 60611, USA.

Background: Contrast-enhanced voiding urosonography (CEVUS) uses intravesically administered microbubble contrast to detect vesicoureteral reflux (VUR) and urethral anomalies with ultrasound. Multiple studies have suggested CEVUS can replace voiding cystourethrogram (VCUG) as a radiation-free alternative. Analysis of the ureterovesical junction and ureters on VCUG documenting the ureterovesical junction position, ureteral duplication, periureteral diverticula and ureteroceles is important as anatomical variations may affect management and surgical approach. Read More

View Article and Full-Text PDF
February 2021

Evaluation of the Diagnostic Value of Contrast-Enhanced Voiding Urosonography with Regard to the Further Therapy Regime and Patient Outcome-A Single-Center Experience in an Interdisciplinary Uroradiological Setting.

Medicina (Kaunas) 2021 Jan 9;57(1). Epub 2021 Jan 9.

Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.

: Vesicoureteral reflux (VUR) describes a common pediatric anomaly in pediatric urology with a prevalence of 1-2%. In diagnostics, in addition to the gold standard of voiding cystourethrography (VCUG), contrast-enhanced urosonography (ceVUS) offers a radiation-free procedure, which, despite its advantages, is not yet widely used. In the present single-center study, subsequent therapeutic procedures and outcomes after ceVUS of 49 patients were investigated. Read More

View Article and Full-Text PDF
January 2021

Role of Contrast-Enhanced Voiding Urosonography in the Evaluation of Renal Transplant Reflux - Comparison with Voiding Cystourethrography and a New Classification.

Ultraschall Med 2021 Jan 12. Epub 2021 Jan 12.

Department of Radiology, University La Sapienza, Rome, Italy.

Vesicoureteral reflux (VUR) is a common urological complication in renal transplant patients.

The Aim: of this study is to evaluate the performance of contrast-enhanced voiding urosonography (CEvUS) in the diagnosis and classification of reflux into the renal allograft, to evaluate and classify VUR into the allograft using voiding cystourethrography (VCUG) and CEvUS, to compare the two methods, and to propose a new classification of reflux into the allograft based on CEvUS and VCUG assessment, in line with the international reflux grading system.

Materials And Methods:  From January 2017 to July 2019, 84 kidney transplant patients were enrolled. Read More

View Article and Full-Text PDF
January 2021

Contrast-enhanced voiding urosonography (CEVUS) as a novel technique for evaluation in a case of male urethral diverticulum.

Indian J Radiol Imaging 2020 Jul-Sep;30(3):409-414. Epub 2020 Oct 15.

Department of Urology and Renal Transplant, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Male urethral diverticulum is an uncommon entity, the abnormality being more frequently encountered in females. The pathology may be congenital or acquired and the more frequent acquired type usually occurs following trauma. Afflicted patients usually lack specific symptoms, although in a few instances, symptoms of lower urinary tract obstruction, calculi, or infection may prevail. Read More

View Article and Full-Text PDF
October 2020

Relationship between Vesicoureteral Reflux and Glomerular Filtration Rate in Children.

Curr Med Sci 2020 Oct 29;40(5):845-850. Epub 2020 Oct 29.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children and causes renal damage and studies focusing on the effect of VUR on renal function are rare. We recruited 35 primary VUR patients with recurrent urinary tract infection (UTI) and 10 non-VUR patients with recurrent UTI. Contrast-enhanced voiding urosonography (ceVUS) was performed for VUR grading, and renal dynamic imaging was used for evaluating glomerular filtration rate (GFR, mL/min). Read More

View Article and Full-Text PDF
October 2020

A quantitative grading system of vesicoureteral reflux by contrastenhanced voiding urosonography.

Med Ultrason 2020 Sep 14;22(3):287-292. Epub 2020 Apr 14.

Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aims: Contrast-enhanced voiding urosonography (ceVUS) is a well-established imaging modality for the diagnosis of vesicoureteral reflux (VUR). However, discrepancies of grading diagnosis of VUR exist due to the qualitative grading criteria currently used in clinics. This study aimed to evaluate numerical markers for a quantitative VUR grading system. Read More

View Article and Full-Text PDF
September 2020

[Diagnosis of vesicoureterorenal Reflux: pro ceVUS].

Aktuelle Urol 2020 Apr 8;51(2):145-150. Epub 2019 Oct 8.

Universitätsklinikum Jena, Sektion Kinderradiologie, Institut für Diagnostische und Interventionelle Radiologie, Jena.

There are various imaging modalities available for the diagnosis of vesicoureterorenal reflux. In childhood, it is important to use the gentlest diagnostic technique available. Contrast-enhanced voiding urosonography (ceVUS) allows for dynamic imaging of the urinary tract without exposure to ionising radiation. Read More

View Article and Full-Text PDF

The learning curve of contrast-enhanced 'microbubble' voiding urosonography-validation study.

J Pediatr Urol 2019 Aug 19;15(4):385.e1-385.e6. Epub 2019 Apr 19.

Stanford Children's Health (Lucile Packard Children's Hospital), Department of Radiology, Stanford University School of Medicine, 725 Welch Road - Room 1890, Stanford, CA 94304-5913, USA. Electronic address:

Introduction: Vesicoureteral reflux (VUR) is a common pediatric urologic condition associated with urinary tract infection and pyelonephritis. It can be diagnosed via fluoroscopic voiding cystourethrogram (VCUG) and, more recently, contrast-enhanced voiding ultrasonography (ceVUS), which does not expose the patient to ionizing radiation. Voiding urosonography contrast agents used for the diagnosis of VUR have been widely available in Europe but were approved by the Food and Drug Administration for use in the United States only in 2016. Read More

View Article and Full-Text PDF

Diagnostic accuracy of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) study for assessment of vesicoureteral reflux in children: a meta-analysis.

World J Urol 2019 Oct 12;37(10):2245-2255. Epub 2018 Dec 12.

Section of Pediatric Imaging, Institute of Radiology, St. Luke's Medical Center, Quezon City, NCR, Philippines.

Purpose: To assess the diagnostic accuracy and safety of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) in detecting vesicoureteral reflux (VUR) among children.

Methods: A systematic literature search was performed in March 2018. Relevant comparative studies from Medline, EMBASE, World of Science, Scopus, CENTRAL, WHO trial registry and Clinicaltrials. Read More

View Article and Full-Text PDF
October 2019

Contrast-enhanced voiding urosonography with intravesical administration of ultrasound contrast agent for the diagnosis of pediatric vesicoureteral reflux.

Exp Ther Med 2018 Dec 25;16(6):4546-4552. Epub 2018 Sep 25.

Department of Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children. It has been reported that VUR may be associated with reflux nephropathy. Ultrasound contrast-enhanced voiding urosonography (CeVUS) has become a routine diagnostic method for VUR in a number of European countries; however, it is not widely used in China. Read More

View Article and Full-Text PDF
December 2018

Potential causes of insufficient bladder contrast opacification and premature microbubble destruction during contrast-enhanced voiding urosonography in children.

J Clin Ultrasound 2019 Jan 4;47(1):36-41. Epub 2018 Nov 4.

Department of Radiology, University Children's Hospital Ljubljana, Slovenia.

Contrast-enhanced voiding urosonography (ceVUS) has been recognized as a child-friendly examination with high diagnostic accuracy for vesicoureteric reflux detection. A single bolus and the infusion techniques of ceVUS are described. Insufficient bladder contrast opacification during the filling phase and premature destruction of SonoVue microbubbles might occur. Read More

View Article and Full-Text PDF
January 2019

3D/4D contrast-enhanced urosonography (ceVUS) in children - is it superior to the 2D technique?

J Ultrason 2018 ;18(73):120-125

Department of Pediatric Radiology, Medical University of Lublin, Lublin, Poland.

Background: By now, two-dimensional contrast-enhanced voiding urosonography (ceVUS) has become a well-established method for the diagnosis and treatment monitoring of vesicoureteral reflux in children, particularly after the recent approval for this application in children in the USA and in Europe. The introduction of three-dimensional static (3D) and real-time (4D) techniques with ultrasound contrast agents opens up new diagnostic opportunities for this imaging modality.

Objective: To analyze whether 3D and 4D ceVUS is a superior technique compared to standard 2D ceVUS in diagnosing vesicoureteral reflux in children. Read More

View Article and Full-Text PDF
January 2018

A Low-Cost, Durable and Re-Usable Bladder Phantom: Teaching Intravesical Ultrasound Contrast Administration.

Ultrasound Med Biol 2018 08 22;44(8):1918-1926. Epub 2018 May 22.

Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Contrast-enhanced voiding urosonography (ceVUS) is a radiation-free and highly sensitive examination for detecting vesicoureteral reflux and imaging the urethra in children. This examination is performed with ultrasound and intravesical administration of a gas-filled microbubble US contrast agent. The U. Read More

View Article and Full-Text PDF

Case of urethral duplication seen by voiding urosonography.

Clin Imaging 2018 May - Jun;49:106-110. Epub 2017 Dec 1.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA. Electronic address:

A 3-month-old premature male infant with imperforate anus and hypospadias underwent contrast-enhanced voiding urosonography (ceVUS) followed by voiding cystourethrography (VCUG). Images from the ceVUS demonstrated a distinct linearity arising dorsally from the posterior urethra that partially opacified with contrast. VCUG confirmed a urethral duplication. Read More

View Article and Full-Text PDF
September 2018

Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial.

Pediatr Radiol 2018 02 27;48(2):216-226. Epub 2017 Nov 27.

Department of Radiology, The Children's Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Background: Contrast-enhanced voiding urosonography (ceVUS) is widely used outside the United States to diagnose vesicoureteral reflux (VUR) in children and is highly sensitive while avoiding exposure to ionizing radiation. At the onset of this study, two ultrasound (US) contrast agents were available in the United States. Pediatric safety data for intravenous administration was published for one, Optison™. Read More

View Article and Full-Text PDF
February 2018

Contrast-enhanced Voiding Urosonography for Vesicoureteral Reflux Diagnosis in Children.

Radiographics 2017 Oct;37(6):1854-1869

From the Department of Radiology, UDIAT Centre Diagnòstic, Parc Taulí Hospital Universitari, Institut d'Investigació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Parc Taulí 1, Sabadell 08208, Spain.

Contrast-enhanced voiding urosonography (ceVUS) is a dynamic imaging technique that makes it possible to study the structure of the urinary tract after the administration of intravesical contrast material. Initially, ceVUS was indicated mainly to study vesicoureteral reflux (VUR); however, since the ability of ceVUS to depict the structure of the urethra was demonstrated in both sexes, ceVUS is now indicated for examination of the entire urinary tract. The main benefit of ceVUS is that it does not use ionizing radiation. Read More

View Article and Full-Text PDF
October 2017

Applications of contrast-enhanced ultrasound in the pediatric abdomen.

Abdom Radiol (NY) 2018 04;43(4):948-959

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Contrast-enhanced ultrasound (CEUS) is a radiation-free, safe, and in specific clinical settings, highly sensitive imaging modality. Over the recent decades, there is cumulating experience and a large volume of published safety and efficacy data on pediatric CEUS applications. Many of these applications have been directly translated from adults, while others are unique to the pediatric population. Read More

View Article and Full-Text PDF

Voiding Urosonography with Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric Reflux: First Local Pilot Study.

Open Access Maced J Med Sci 2017 Apr 11;5(2):215-221. Epub 2017 Apr 11.

University Pediatric Surgery Clinic, Medical Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17, Skopje, Republic of Macedonia.

Background: Vesicoureteric reflux (VUR) is an important association of paediatric urinary tract infection (UTI) found in 30-50% of all children presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS) has become an important radiation-free method for VUR detection in children. Its sensitivity in detecting VUR has greatly improved due to the development of the contrast-specific ultrasound techniques and the introduction of the second-generation ultrasound contrast agent, superseding the diagnostic accuracy of standard radiological procedures. Read More

View Article and Full-Text PDF

Residual intravesical iodinated contrast: a potential cause of false-negative reflux study at contrast-enhanced voiding urosonography.

Pediatr Radiol 2016 Oct 27;46(11):1614-7. Epub 2016 Jun 27.

Department of Radiology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

A 9-month-old girl underwent conventional cyclic voiding cystourethrography (VCUG) followed immediately by cyclic contrast-enhanced voiding urosonography (ceVUS). Although the VCUG showed unilateral grade II reflux, the ceVUS showed no reflux. Images from the ceVUS showed posterior dependent layering of the denser iodinated contrast in the bladder. Read More

View Article and Full-Text PDF
October 2016

[CONTRAST ENHANCED VOIDING UROSONOGRAPHY (CEVUS) IN THE DIAGNOSIS OF VESICOURETERAL REFLUX].

Lijec Vjesn 2016 Jan-Feb;138(1-2):39-46

Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children and can be associated with reflux nephropathy (RN). Some patients with RN develop chronic kidney disease, hypertension and a small number of patients progress to end-stage renal disease. Early detection of children with these clinical characteristics should be the goal of clinical, biochemical, and radiological evaluation of patients presenting with prenatal hydronephrosis or febrile urinary tract infection. Read More

View Article and Full-Text PDF

Two-dimensional (2D), three-dimensional static (3D) and real-time (4D) contrast enhanced voiding urosonography (ceVUS) versus voiding cystourethrography (VCUG) in children with vesicoureteral reflux.

Eur J Radiol 2016 Jun 5;85(6):1238-45. Epub 2015 Nov 5.

Department of Pediatric Surgery and Traumatology, Medical University of Lublin, Al. Racławickie 1, Lublin 20-059, Poland.

Background: Two-dimensional (2DUS) contrast enhanced voiding urosonography has been used in the diagnosis and treatment monitoring of the vesicoureteral reflux in children for over 15 years. The opportunity of performing this examination with the use of three-dimensional static (3DUS) and real-time (4DUS) techniques opens up new diagnostic horizons.

Objective: To analyze if 3DUS/4DUS bring additional information leading to an increased detection rate or change in the grading of reflux compared to 2DUS and voiding cystouretrography. Read More

View Article and Full-Text PDF

Contrast-enhanced voiding urosonography: in vitro evaluation of a second-generation ultrasound contrast agent for in vivo optimization.

Pediatr Radiol 2015 Sep 1;45(10):1496-505. Epub 2015 May 1.

Department of Radiology, The Children's Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA, 19104, USA,

Background: Pediatric contrast-enhanced ultrasound (CEUS) is primarily performed outside the United States where a track record for safety in intravenous and intravesical applications has been established. Contrast-enhanced voiding urosonography (ceVUS) has also been shown to have a much higher rate of vesicoureteral reflux detection compared to voiding cystourethrography. US contrast agents available in the United States differ from those abroad. Read More

View Article and Full-Text PDF
September 2015

Voiding urosonography with second-generation ultrasound contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux.

Eur J Pediatr 2014 Aug;173(8):1095-101

Department of Radiology and Imaging, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Vesicoureteric reflux has been associated with paediatric urinary tract infection. Fluoroscopic micturating cystourethrography (MCU) has been the gold standard of diagnostic test for decades; however, it has been criticized owing to its lower detection rate and radiation dose to children. Therefore, new radiation-free reflux imaging modalities have been developed, in which ultrasound-based contrast-enhanced voiding urosonography (ceVUS) is a good example. Read More

View Article and Full-Text PDF

Possible use of heterospecific food-associated calls of macaques by sika deer for foraging efficiency.

Authors:
Hiroki Koda

Behav Processes 2012 Sep 26;91(1):30-4. Epub 2012 May 26.

Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan.

Heterospecific communication signals sometimes convey relevant information for animal survival. For example, animals use or eavesdrop on heterospecific alarm calls concerning common predators. Indeed, most observations have been reported regarding anti-predator strategies. Read More

View Article and Full-Text PDF
September 2012

Brief report: a new profile of terminal N-acetyllactosamines glycans on pig red blood cells and different expression of alpha-galactose on Sika deer red blood cells and nucleated cells.

Glycoconj J 2010 May 27;27(4):427-33. Epub 2010 Apr 27.

Department of Blood Biochemistry and Molecular Biology, Beijing Institute of Transfusion Medicine, 27# Taiping Road, Beijing, 100850, China.

It has been reported that: (1) large variations were found in the number of sialic acid (SA) capped with N-acetyllactosamines (SA-Galbeta1-4GlcNAc-R) and alpha-Gal epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) or uncapped N-acetyllactosamines (Galbeta1-4GlcNAc-R) on different mammalian red blood cells, and on nucleated cells originating from a given tissue in various species; (2) goat, sheep, horse and mouse red blood cells lack alpha-Gal epitopes, despite the expression of this epitope on a variety of nucleated cells in these species, including lymphocytes differentiated from the same hematopoietic origin. In this study, flow cytometry and Western blot analyses of pig red blood cells showed that alpha-Gal epitopes on pig red cells developed concomitantly after treatment with neuraminidase, suggesting that the terminal N-acetyllactosaminide glycans were capped with SA-alpha-Gal epitopes. Whereas, the expression of the alpha-Gal epitopes on red blood cells from Sika deer (Cevus nippon hortulorum) were found to be absent even though the epitopes were present on their white blood cells. Read More

View Article and Full-Text PDF
  • Page 1 of 1