103,812 results match your criteria cerebral artery

Perfusion image guided mechanical thrombectomy combined with tirofiban successfully revascularize systemic lupus erythematosus related acute large vessel occlusion: A case report.

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

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Uncrossed corticospinal tract in health and genetic disorders: Review, case report and clinical implications.

Eur J Neurol 2021 May 5. Epub 2021 May 5.

University Hospital of the LMU Munich, Department of Neurology, Marchioninistr. 15, 81377, Munich, Germany.

Background: Crossing pathologies of the corticospinal tract (CST) are rare and often associated with genetic disorders. However, they can be present in healthy humans and lead to ipsilateral motor deficits when a lesion to motor areas occurs. Here we review historical and current literature of CST crossing pathologies and present a rare case of asymmetric crossing of the CST. Read More

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Extracranial vertebral artery to middle cerebral artery bypass in therapeutic internal carotid artery occlusion for epipharyngeal carcinoma: A technical case report.

Surg Neurol Int 2021 8;12:149. Epub 2021 Apr 8.

Department of Neurosurgery, Sapporo Teishinkai Hospital, Higashi-ku, Sapporo, Japan.

Background: Vertebral artery (VA) to middle cerebral artery (MCA) bypass is a rarely selected technique because a complex expanded dissection is required, and often, a better donor artery than VA exists. A good indication for VA-MCA bypass is the treatment of head-and-neck malignancies with the sacrifice of the internal carotid artery (ICA) or for carotid artery rupture.

Methods: A 23-year-old man with epipharyngeal carcinoma, treated by ligating the carotid artery with a VAMCA bypass before chemoradiotherapy, was reported. Read More

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Coil embolization of subarachnoid hemorrhage with ruptured persistent primitive olfactory artery aneurysm.

Surg Neurol Int 2021 8;12:147. Epub 2021 Apr 8.

Department of Neurosurgery, Yamagata University, Yamagata, Japan.

Background: Persistent primitive olfactory artery (PPOA) is a rare anomaly of the anterior cerebral artery. We experienced a rare case of subarachnoid hemorrhage caused by a ruptured saccular aneurysm of PPOA.

Case Description: A 72-year-old man was transported to our hospital with sudden headache. Read More

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Aneurysmal subarachnoid hemorrhage, a presentation of metastatic carcinoma: A case report and review of the literature.

Surg Neurol Int 2021 8;12:143. Epub 2021 Apr 8.

Department of Neurosurgery, Ascension St Mary's Hospital, Saginaw, Michigan, United States.

Background: Neoplastic cerebral aneurysms related to metastatic processes are exceptionally rare and carry a dismal prognosis. Only four previous reports exist of neoplastic aneurysms secondary to metastatic adenocarcinoma, all of which were found to be lung cancer in origin. We present the fifth reported metastatic adenocarcinomatous cerebral aneurysm, and the first case is secondary to a non-lung cancer primary. Read More

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Adult Pilocytic Astrocytoma in the insula: Case report and review of the literature.

Ann Med Surg (Lond) 2021 May 15;65:102300. Epub 2021 Apr 15.

Department of Surgery, King Hussein Cancer Center, Amman, Jordan.

Introduction: and Importance: Adult Pilocytic Astrocytomas (APA) are infrequent low grade tumors. While supratentorial APA is considered rare, insular APA is extremely rare.

Case Presentation: We present a case of pure insular APA along with surgical outcomes. Read More

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Effect of first pass reperfusion on outcome in patients with posterior circulation ischemic stroke.

J Neurointerv Surg 2021 May 4. Epub 2021 May 4.

Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Background: First pass reperfusion (FPR), that is, excellent reperfusion (expanded treatment in cerebral ischemia (eTICI) 2C-3) in one pass, after endovascular treatment (EVT) of an occluded artery in the anterior circulation, is associated with favorable clinical outcome, even when compared with multiple pass excellent reperfusion (MPR). In patients with posterior circulation ischemic stroke (PCS), the same association is expected, but currently unknown. We aimed to assess characteristics associated with FPR and the influence of FPR versus MPR on outcomes in patients with PCS. Read More

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Computed Tomography Perfusion Deficit Volumes Predict Functional Outcome in Patients With Basilar Artery Occlusion.

Stroke 2021 May 5:STROKEAHA120032924. Epub 2021 May 5.

Department of Radiology, University Hospital, LMU Munich, Germany. (M.P.F., D.P.-W., S.G., S.M., V.S., J.R., L.S., J.R., W.G.K., P.R.).

Background And Purpose: Basilar artery occlusion is associated with high morbidity and mortality. Optimal imaging and treatment strategy are still controversial and prognosis estimation challenging. We, therefore, aimed to determine the predictive value of computed tomography perfusion (CTP) parameters for functional outcome in patients with basilar artery occlusion in the context of endovascular treatment. Read More

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Therapeutic Effects of hiPSC-Derived Glial and Neuronal Progenitor Cells-Conditioned Medium in Experimental Ischemic Stroke in Rats.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Research Centre for Medical Genetics, 115522 Moscow, Russia.

Transplantation of various types of stem cells as a possible therapy for stroke has been tested for years, and the results are promising. Recent investigations have shown that the administration of the conditioned media obtained after stem cell cultivation can also be effective in the therapy of the central nervous system pathology (hypothesis of their paracrine action). The aim of this study was to evaluate the therapeutic effects of the conditioned medium of hiPSC-derived glial and neuronal progenitor cells in the rat middle cerebral artery occlusion model of the ischemic stroke. Read More

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Reliability of CT angiography scoring systems used for brain death and the effect of cranial interventions on the results.

Clin Imaging 2021 Apr 29;79:142-147. Epub 2021 Apr 29.

Department of Radiology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective: To assess vascular opacifications, the efficiency, and interobserver agreement (IOA) of five different computed tomography angiography (CTA) brain death (BD) scoring systems in patients with and without cranial interventions, for determining alternative findings correctly supporting BD diagnosis by CTA even in cranial intervention presence.

Methods: 45 patients clinically identified with BD and evaluated with CTA were included. IOA of five different scoring systems used for CTA BD diagnosis, the effect of intracranial interventions on scoring systems, and vascular opacification were evaluated. Read More

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Intracranial dolichoectasia in patients with symptomatic intracranial atherosclerotic disease: Results from the MYRIAD study.

J Neuroimaging 2021 May 4. Epub 2021 May 4.

Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background And Purpose: It is unknown whether intracranial atherosclerotic disease (ICAD), in addition to causing stenosis, also associates with abnormal arterial enlargement, a condition known as intracranial dolichoectasia (IDE). Across symptomatic ICAD patients, we aim to determine IDE prevalence and IDE impact on cerebral hemodynamics and recurrent cerebral ischemia.

Methods: We analyzed 98 participants (mean age 63. Read More

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COVID-19-Associated Ischemic Stroke in a Patient on Therapeutic Anticoagulation.

Neurologist 2021 May 5;26(3):108-111. Epub 2021 May 5.

Medicine, University of Florida College of Medicine, Jacksonville, FL.

Introduction: The coronavirus disease 2019 (COVID-19) has been associated with a hypercoagulable state, increasing the risk for ischemic stroke. In select cases, patients are already on anticoagulation therapy. Such examples highlight the severity of COVID-19's hyperthrombotic state, and raise questions regarding optimal stroke prevention in these patients. Read More

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Neuroprotective effect of helium after neonatal hypoxic ischemia: a narrative review.

Med Gas Res 2021 Jul-Sep;11(3):121-123

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Neonatal hypoxic ischemia is one of the leading causes of permanent morbidity and mortality in newborns, which is caused by difficulty in supplying blood and oxygen to brain tissue and is often associated with epilepsy, cerebral palsy, death, short-term or long-term neurological and cognitive impairment. In recent years, the clinical therapeutic effects of noble gases have been gradually discovered and recognized. Numerous studies have shown that noble gases have unique neuroprotective effects to restore damaged nerve and relieve symptoms in patients. Read More

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Flared non-flow diverting ends of the FRED flow diverter for cerebral aneurysms facilitate device anchoring at the arterial bifurcation.

Neuroradiol J 2021 May 4:19714009211013508. Epub 2021 May 4.

Department of Neurosurgery, Geisinger, USA.

Introduction: The Flow Redirection Intraluminal Device (FRED) flow diverter has a unique bilayer design, with the outer scaffolding stent extending beyond the inner flow diverting component by about 3 mm at each end. Here, we describe a technique to utilize these unrestrained flared ends for precise flow diverter placement in cases where the aneurysm and an adjacent branch are in close proximity and branch jailing is not desired, such as in posterior communicating artery aneurysms. The distal end of the FRED device is pushed out of the microcatheter at the carotid terminus. Read More

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Eprosartan: A closer insight into its neuroprotective activity in rats with focal cerebral ischemia-reperfusion injury.

J Biochem Mol Toxicol 2021 May 3:e22796. Epub 2021 May 3.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt.

Eprosartan (EPRO), an angiotensin receptor type-1 (AT-1) blocker, exhibited neuroprotective activities in ischemic stroke resulting from focal cerebral ischemia in rats. The current study aimed to clarify the neuroprotective role of EPRO in middle carotid artery occlusion (MCAO)-induced ischemic stroke in rats. Fifty-six male Wistar rats were divided into four groups (n = 14 per group): sham-operated group, sham receiving EPRO (60 mg/kg/day, po) group, ischemia-reperfusion (IR) group, and IR receiving EPRO (60 mg/kg/day, po) group. Read More

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Microglia-mediated phagocytosis of apoptotic nuclei is impaired in the adult murine hippocampus after stroke.

Glia 2021 May 4. Epub 2021 May 4.

Hans-Berger Department of Neurology, Jena University Hospital, Jena, Germany.

Following stroke, neuronal death takes place both in the infarct region and in brain areas distal to the lesion site including the hippocampus. The hippocampus is critically involved in learning and memory processes and continuously generates new neurons. Dysregulation of adult neurogenesis may be associated with cognitive decline after a stroke lesion. Read More

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Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.

Basic Res Cardiol 2021 May 3;116(1):32. Epub 2021 May 3.

Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments: remote ischaemic conditioning (RIC), involving cycles of ischaemia/reperfusion applied to a peripheral organ or tissue, or by systemic administration of glucagon-like-peptide-1 (GLP-1) receptor (GLP-1R) agonists. The mechanisms underlying RIC- and GLP-1-induced neuroprotection are not completely understood. Read More

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Thrombectomy of symptomatic isolated occlusions of posterior cerebral arteries in segment P1 and P2 in acute stroke treatment.

Acta Radiol 2021 May 3:2841851211014191. Epub 2021 May 3.

Department of Radiology and Neuroradiology, Knappschaftskrankenhaus Bochum, Germany.

Background: Interventional stroke treatments for occlusions of the posterior circulation are established procedures. However, there are limited data on the treatment of isolated symptomatic P1 and P2 occlusions, which we have examined in this study.

Purpose: To investigate the mechanical thrombectomy of distal posterior occlusions. Read More

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Long Noncoding RNA Fos Downstream Transcript Is Developmentally Dispensable but Vital for Shaping the Poststroke Functional Outcome.

Stroke 2021 May 4:STROKEAHA120033547. Epub 2021 May 4.

Department of Neurological Surgery (S.L.M., A.K.C., T.K., S.B., B.C., K.C.M.-B., R.V.).

Background And Purpose: Stroke induces the expression of several long noncoding RNAs in the brain. However, their functional significance in poststroke outcome is poorly understood. We recently observed that a brain-specific long noncoding RNA called Fos downstream transcript (FosDT) is induced rapidly in the rodent brain following focal ischemia. Read More

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Use of Head and Neck Magnetic Resonance Angiography to Explore Neurological Function Recovery and Impact of Rehabilitation Nursing on Patients with Acute Stroke.

World Neurosurg 2021 May;149:470-480

Department of Neurorehabilitation, Cadre Sanatorium of Hainan & Geriatric Hospital of Hainan, Haikou, Hainan, China. Electronic address:

Objective: To analyze neurological function recovery and the impact of rehabilitation nursing in patients with cerebral stroke after treatment to aid clinical diagnosis and treatment of cerebral stroke.

Methods: The study comprised 140 patients who were hospitalized in the neurology department for magnetic resonance angiography examination. Patients were divided into a treatment group (70 patients) and a control group (70 patients) based on treatment plan. Read More

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Unusual Presentation of Atrial Myxoma: A Case Report and Review of the Literature.

Am J Case Rep 2021 May 3;22:e931437. Epub 2021 May 3.

Division of Anatomical Pathology, Stellenbosch University, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

BACKGROUND Although rare, atrial myxoma is the most common benign cardiac tumor. The recognized triad of presenting symptoms relates to constitutional, embolic, and obstructive effects produced by the tumor. However, the presentation may be non-specific and mimic other diseases, confounding diagnosis. Read More

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Inhibition of autophagy-dependent pyroptosis attenuates cerebral ischaemia/reperfusion injury.

J Cell Mol Med 2021 May 2. Epub 2021 May 2.

Department of Neurology and Institute of Neurology, The Affiliated Changshu Hospital of Xuzhou Medical School, Suzhou, Jiangsu, China.

Autophagy is closely associated with cerebral ischaemia/reperfusion injury, but the underlying mechanisms are unknown. We investigated whether Spautin-1 ameliorates cerebral ischaemia/reperfusion injury by inhibiting autophagy and whether its derived pyroptosis is involved in this process. We explored the mechanism of Spautin-1 in cerebral ischaemia/reperfusion. Read More

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Seizures after decompressive hemicraniectomy for large middle cerebral artery territory infarcts: incidence, associated factors and impact on long-term outcomes.

Eur J Neurol 2021 May 3. Epub 2021 May 3.

Univ. Lille, Inserm U1172, CHU Lille, Department of Neurology, Stroke unit, France.

Background: decompressive hemicraniectomy (DH) reduces mortality of large middle cerebral artery (MCA) territory infarcts. Survivors are at high risk of post-stroke seizures (PSS). This study aims to describe the incidence of PSS, to identify associated factors and their impact on long-term outcomes. Read More

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Impact of acute changes in blood pressure and arterial stiffness on cerebral pulsatile hemodynamics in young and middle-aged adults.

Exp Physiol 2021 May 2. Epub 2021 May 2.

Department of Kinesiology & Nutrition, University of Illinois at Chicago.

New Findings: What is the central question of this study? Examine whether cerebrovascular pulsatility responds differently to acute increases in arterial stiffness in middle-aged compared to young adults. What is the main finding and its importance? Compared to young adults, middle-aged adults exhibited similar changes in cerebral pulsatile damping despite attenuated changes in carotid diameter and cerebrovascular pulsatility during blood pressure-dependent, but not blood pressure-independent, increases in large artery stiffness.

Abstract: Acutely manipulating arterial stiffness through interventions that increase sympathetic activity may provoke cerebral pulsatility and damping, and reveal whether cerebrovascular hemodynamics respond differently in middle-age adults to transient elevations in arterial stiffness. Read More

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Acute Hemispheric Stroke: Full Remission Following Surgical Thrombectomy.

EJVES Vasc Forum 2020 8;47:31-34. Epub 2020 Apr 8.

Department for Vascular Medicine, Vascular Surgery, Angiology and Endovascular Therapy, University Heart and Vascular Centre, Hamburg-Eppendorf, Hamburg, Germany.

Introduction: Carotid occlusion because of embolisation or as a distal extension of thrombus formation in an ulcerated plaque can be the cause of a devastating stroke, caused by sudden occlusion of the internal carotid artery (ICA). Often, invasive treatments are not an option because of the limited time frame. In rare situations of acute stroke onset and admission to therapy within six hours however, aggressive recanalisation may be considered. Read More

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Cerebral Artery and Vein Segmentation in Four-dimensional CT Angiography Using Convolutional Neural Networks.

Radiol Artif Intell 2020 Jul 29;2(4):e190178. Epub 2020 Jul 29.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein-Zuid 10, Nijmegen 6500 HB, the Netherlands.

Purpose: To implement and test a deep learning approach for the segmentation of the arterial and venous cerebral vasculature with four-dimensional (4D) CT angiography.

Materials And Methods: Patients who had undergone 4D CT angiography for the suspicion of acute ischemic stroke were retrospectively identified. A total of 390 patients evaluated in 2014 ( = 113) or 2018 ( = 277) were included in this study, with each patient having undergone one 4D CT angiographic scan. Read More

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Stroke in a child with SARS-CoV-2 infection: A case report.

eNeurologicalSci 2021 Apr 28:100345. Epub 2021 Apr 28.

Department of Pediatrics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some patients with COVID-19 show widely neurological manifestations including stroke. We report a child who was hospitalized due to seizures and was later diagnosed with COVID-19. Read More

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Algorithms for segmenting cerebral time-of-flight magnetic resonance angiograms from volunteers and anemic patients.

J Med Imaging (Bellingham) 2021 Mar 28;8(2):024005. Epub 2021 Apr 28.

Rudi Schulte Research Institute, Santa Barbara, California, United States.

To evaluate six cerebral arterial segmentation algorithms in a set of patients with a wide range of hemodynamic characteristics to determine real-world performance. Time-of-flight magnetic resonance angiograms were acquired from 33 subjects: normal controls ( ), sickle cell disease ( ), and non-sickle anemia ( ) using a 3 Tesla Philips Achieva scanner. Six segmentation algorithms were tested: (1) Otsu's method, (2) K-means, (3) region growing, (4) active contours, (5) minimum cost path, and (6) U-net machine learning. Read More

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Genetic Variants of Contribute to Susceptibility of Ischemic Stroke among Southern Chinese Population.

Biomed Res Int 2021 10;2021:6634253. Epub 2021 Apr 10.

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.

Emerging evidence suggests that the long noncoding RNA (lncRNA) growth arrest special 5 (GAS5) plays crucial roles in the pathogenesis of ischemic stroke (IS). The current research is aimed at assessing the correlation between two functional variants (rs145204276 and rs55829688) and susceptibility to IS in a Han Chinese population. This study genotyped the two variants in 1086 IS patients as well as 1045 age-matched healthy controls by using an improved multitemperature ligase detection reaction (iMLDR-TM) genotyping technology. Read More

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Evaluation of hemodynamic changes in nonarteritic anterior ischemic optic neuropathy using multimodality imaging.

Quant Imaging Med Surg 2021 May;11(5):1932-1945

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) patients experience hypo-perfusion in the short posterior ciliary arteries (SPCAs), however, the cause of hypo-perfusion is unclear. Real-time dynamic hemodynamic observations may provide clues into specific NAION pathogenic mechanisms. We aim to analyze hemodynamic changes occurring in NAION using multimodality imaging. Read More

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