130,541 results match your criteria cerebellar

1,2-Dichloroethane induces apoptosis in the cerebral cortexes of NIH Swiss mice through microRNA-182-5p targeting phospholipase D1 via a mitochondria-dependent pathway.

Toxicol Appl Pharmacol 2021 Sep 21:115728. Epub 2021 Sep 21.

NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address:

1,2-Dichloroethane (1,2-DCE) is a pervasive environmental pollutant found in ambient and residential air, as well as ground and drinking water. Overexposure to it results in cortex edema, in both animals and humans. 1,2-DCE induces apoptosis in the cerebellum, liver and testes. Read More

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September 2021

Alteration of long non-coding RNAs and mRNAs expression profiles by compound heterozygous ASXL3 mutations in the mouse brain.

Bioengineered 2021 Dec;12(1):6935-6951

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou, China.

Compound mutations in the additional sex combs-like 3 (ASXL3) gene greatly impact the expression of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mouse myocardial tissues. Little is known about ASXL3 mutation effects on lncRNAs and mRNAs expression in the cerebrum and cerebellum. This study aims to clarify this point using quantitative real-time polymerase chain reaction and Western blotting. Read More

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December 2021

Long-term surgical outcome of Chiari type-I malformation-related syringomyelia: an experience of tertiary referral hospital.

Neurol Res 2021 Sep 24:1-12. Epub 2021 Sep 24.

Department of Psychiatry - AMATEM Unit, Bakırköy Research and Training Hospital for Neurology Neurosurgery, and Psychiatry, University of Health Sciences, Istanbul, Turkey.

Objective: Syringomyelia is a common condition seen in patients with Chiari type-I malformation (CM1). The purpose of this retrospective study was to evaluate the long-term clinical and radiological outcomes of posterior fossa decompression with duraplasty (PFDD) with coagulation of tonsillar ectopia in consecutive surgically treated adult patients with CM1-related syringomyelia (CRS).

Methods: Over 9 years' duration (1993-2001), medical charts of diagnosed patient with CM1 at our neurosurgical center were reviewed retrospectively. Read More

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September 2021

Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study.

Neural Regen Res 2022 May;17(5):1051-1058

Department of Neurological Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.

Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively improve impaired swallowing in Parkinson's disease (PD) patients with dysphagia. However, little is known about how rTMS affects the corresponding brain regions in this patient group. In this case-control study, we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy, Capital Medical University. Read More

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Is it possible to develop a cerebellar reserve?

Neural Regen Res 2022 May;17(5):994-996

IRCCS Fondazione Santa Lucia, Rome, Italy.

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Dihydroergotamine affects spatial behavior and neurotransmission in the central nervous system of Wistar rats.

Ann Agric Environ Med 2021 Sep 20;28(3):437-445. Epub 2020 Oct 20.

Centre for Preclinical Research and Technology CePT, Medical University, Warsaw, Poland.

Introduction: Dihydroergotamine (DHE) is a derivative of an ergot alkaloid used as an antimigraine medication. Nowadays, ergot alkaloids may still endanger the safety of humans and animals as food or medicine pollutants, but the outcomes of long-term DHE administration on the behaviour and neurotransmission remain undescribed.

Material And Methods: Adult male Wistar Albino Glaxo rats pre-treated orally with DHE for six weeks were investigated to assess the relationship between concentration of neurotransmitters and behavioural response. Read More

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September 2021

Immunopathogenesis and proposed clinical score for identifying Kelch-like protein-11 encephalitis.

Brain Commun 2021 26;3(3):fcab185. Epub 2021 Aug 26.

French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.

In this study, we report the clinical features of Kelch-like protein 11 antibody-associated paraneoplastic neurological syndrome, design and validate a clinical score to facilitate the identification of patients that should be tested for Kelch-like protein 11 antibodies, and examine in detail the nature of the immune response in both the brain and the tumour samples for a better characterization of the immunopathogenesis of this condition. The presence of Kelch-like protein 11 antibodies was retrospectively assessed in patients referred to the French Reference Center for paraneoplastic neurological syndrome and autoimmune encephalitis with (i) antibody-negative paraneoplastic neurological syndrome [limbic encephalitis ( = 105), cerebellar degeneration ( = 33)] and (ii) antibody-positive paraneoplastic neurological syndrome [Ma2-Ab encephalitis ( = 34), antibodies targeting N-methyl-D-aspartate receptor encephalitis with teratoma ( = 49)]. Additionally, since 1 January 2020, patients were prospectively screened for Kelch-like protein 11 antibodies as new usual clinical practice. Read More

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Homozygous missense variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course.

Brain Commun 2021 3;3(3):fcab183. Epub 2021 Sep 3.

Human Genetics and Genome Research Division, Clinical Genetics Department, National Research Centre, 12311 Cairo, Egypt.

is a member of the human WIPI protein family (seven-bladed b-propeller proteins binding phosphatidylinositols, PROPPINs), which play a pivotal role in autophagy and has been implicated in the pathogenesis of several neurological conditions. The homozygous variant c.745G>A; p. Read More

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September 2021

Fahr's Syndrome Presenting With Hypocalcemia and Psychotic Features.

Cureus 2021 Sep 19;13(9):e18091. Epub 2021 Sep 19.

Geriatric Medicine, Ain Shams University, Cairo, EGY.

Fahr's disease is a rare genetic neurodegenerative disorder described as "bilateral striopallidodentate calcinosis" (BSPDC). It is characterized by calcium deposition crossing the blood-brain barrier and calcifying different brain areas. Here, we report a case of a 26-year-old Saudi young lady, known as a case of epilepsy since childhood, a major depressive disorder with psychotic features, and hypocalcemia related to hypoparathyroidism. Read More

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September 2021

Case Report: Anterior Spinal Cord Ischemia Following Embolization of Cerebellar Arteriovenous Malformation: An Illustrative Case and Review of Spinal Cord Vascular Anatomy.

Front Neurol 2021 7;12:725065. Epub 2021 Sep 7.

Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Spinal cord ischemia (SCI) is a rare entity with high mortality and morbidity which can arise from causes such as atherosclerosis, aortic dissection or aneurysm, thromboembolic events or systemic hypotension, and is a potential complication of spinal surgery. Published literature contains very few reports of SCI as a complication of intracranial interventions, highlighting the uncommon nature of SCI in these circumstances. We report the occurrence of anterior SCI in a 69-year-old patient following successful embolization of a cerebellar arteriovenous malformation (AVM), marked by upper extremity weakness, lower extremity paraplegia, loss of bladder and bowel control, and hypercapnic respiratory failure requiring mechanical ventilation. Read More

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September 2021

The Spectrum of Congenital Central Nervous System Anomalies Among Stillborn: An Autopsy Based Study.

Ann Neurosci 2020 Jul 1;27(3-4):224-231. Epub 2021 Mar 1.

Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Background: Congenital central nervous system (CNS) anomalies are the structural or functional abnormalities of the brain and spinal cord that occur during the intrauterine developmental process.

Purpose: The present study aims to detect the prevalence of congenital CNS anomalies among stillborn fetuses, the association between congenital anomalies and maternal factors, and also the association between autopsy and ultrasound findings.

Methods: This study was conducted on 50 stillborn fetuses, obtained from the Department of Obstetrics and Gynecology at JSS Medical College and Hospital, Mysuru. Read More

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Fetal Familial Cerebral Cavernous Malformation With a Novel Heterozygous Pathogenic Variant.

Neurology 2021 Sep 23. Epub 2021 Sep 23.

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Objectives: To identify fetal familial cerebral cavernous malformation (CCMs) and a novel mutation.

Methods: A 37-year-old pregnant woman (G4P0) presented right-handed numbness since two weeks at 31 weeks of gestation. Evaluation with brain magnetic resonance imaging (MRI) revealed multiple CCMs. Read More

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September 2021

Neurodevelopmental malformations of the cerebellum and neocortex in the Shank3 and Cntnap2 mouse models of autism.

Neurosci Lett 2021 Sep 20:136257. Epub 2021 Sep 20.

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic medicine, Old Westbury, NY 11568. Electronic address:

There are many mouse models of autism with broad use in neuroscience research. Genetic background can be a major contributor to the phenotype observed in any mouse model of disease, including genetic models of autism. C57BL/6 mice display spontaneous glio-neuronal heterotopia in the cerebellar vermis and neocortex which may also exist in mouse models of autism created on this background. Read More

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September 2021

5-HT receptors in Alzheimer's disease.

Neurochem Int 2021 Sep 21:105185. Epub 2021 Sep 21.

Dpt Pharmacology and Toxicology, University of Navarra, 31008, Pamplona, Spain; IdISNA, Navarra Institute for Health Research, 31008, Pamplona, Spain. Electronic address:

Even though the involvement of serotonin (5-hydroxytryptamine; 5-HT) and its receptors in Alzheimer's disease (AD) is widely accepted, data on the expression and the role of 5-HT receptors in AD is relatively limited. Therefore, the objective of the present work was to study the expression of serotonergic 5-HT receptors in postmortem samples of AD brains and correlate it with neurotransmitter levels, cognition and behavior. The study population consisted of clinically well-characterized and neuropathologically confirmed AD patients (n = 42) and age-matched control subjects (n = 18). Read More

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September 2021

Addiction and the cerebellum with a focus on actions of opioid receptors.

Neurosci Biobehav Rev 2021 Sep 20. Epub 2021 Sep 20.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Increasing evidence suggests that the cerebellum could play a role in the higher cognitive processes involved in addiction as the cerebellum contains anatomical and functional pathways to circuitry controlling motivation and saliency. In addition, the cerebellum exhibits a widespread presence of receptors, including opioid receptors which are known to play a prominent role in synaptic and circuit mechanisms of plasticity associated with drug use and development of addiction to opioids and other drugs of abuse. Further, the presence of perineural nets (PNNs) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. Read More

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September 2021

Does visuospatial motion perception correlate with coexisting movement disorders in Parkinson's disease?

J Neurol 2021 Sep 23. Epub 2021 Sep 23.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Postural instability and balance impairment are common in Parkinson's disease (PD). Multiple factors, such as increased tone, bradykinesia, freezing of gait, posture, axial stiffness, and involuntary appendicular movements, can affect balance. The recent studies found that PD patients have abnormal perception of self-motion in vestibular domain. Read More

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September 2021

Exploring the metabolomic profile of cerebellum after exposure to acute stress.

Stress 2021 Sep 23:1-13. Epub 2021 Sep 23.

Department of Biological Applications and Technology, Laboratory of Biochemistry, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Psychological stress and stress-related disorders constitute a major health problem in modern societies. Although the brain circuits involved in emotional processing are intensively studied, little is known about the implication of cerebellum in stress responses whereas the molecular changes induced by stress exposure in cerebellum remain largely unexplored. Here, we investigated the effects of acute stress exposure on mouse cerebellum. Read More

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September 2021

[Physiological aging spine].

Rev Prat 2021 May;71(5):497-508

Service de Neurochirurgie A, hôpital Pellegrin Tripode, CHU de Bordeaux, Bordeaux, France.

Physiological aging spine. The process of physiological aging or senescence of the spine begins in the first decade of life and then accelerates from the third. It is essentially fundamentally linked to a phenomenon of entropy that inexorably alters the machinery of all the cells of the body, to which are added random pathologies. Read More

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Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus Secondary to Delayed Intracerebellar Hematoma.

Cureus 2021 Aug 19;13(8):e17302. Epub 2021 Aug 19.

Department of Neurological Surgery, Hospital Juarez De Mexico, Mexico City, MEX.

Nowadays, endoscopic third ventriculostomy (ETV) in neurosurgery has yielded good clinical results in various conditions. Intraventricular endoscopic procedures can be performed in different pathologies and not only in non-communicating hydrocephalus. This is presented accordingly in this clinical case. Read More

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Early rebleeding of a foramen magnum dural arteriovenous fistula: A case report and review of the literature.

Radiol Case Rep 2021 Nov 9;16(11):3499-3503. Epub 2021 Sep 9.

Department of Neurosurgery, Kyoto Prefectural University Graduate School of Medicine, 465, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Foramen magnum dural arteriovenous fistula (FM-DAVF) is a subset of craniocervical junction arteriovenous fistulas. We report a rare case of FM-DAVF with early rebleeding and review the literature. A 50-year-old man experienced 3 episodes of intracranial bleeding from a vessel malformation in the acute stage. Read More

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November 2021

Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions.

J Neuroinflammation 2021 Sep 22;18(1):219. Epub 2021 Sep 22.

Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC, 29209, USA.

Background: Despite widespread acceptance that neuroinflammation contributes to age-related cognitive decline, studies comparing protein expression of cytokines in the young versus old brains are surprisingly limited in terms of the number of cytokines and brain regions studied. Complicating matters, discrepancies abound-particularly for interleukin 6 (IL-6)-possibly due to differences in sex, species/strain, and/or the brain regions studied.

Methods: As such, we clarified how cytokine expression changes with age by using a Bioplex and Western blot to measure multiple cytokines across several brain regions of both sexes, using 2 mouse strains bred in-house as well as rats obtained from NIA. Read More

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September 2021

Palmitoylated prolactin-releasing peptide reduced Aβ plaques and microgliosis in the cerebellum: APP/PS1 mice study.

Curr Alzheimer Res 2021 Sep 22. Epub 2021 Sep 22.

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 166 10 Prague 6. Czech Republic.

Background: Prolactin-releasing peptide (PrRP) is a potential drug for the treatment of obesity and associated type 2 diabetes mellitus (T2DM) due to its strong anorexigenic and antidiabetic properties. In our recent study, the lipidized PrRP analog palm11-PrRP31 was proven to exert beneficial effects in APP/PS1 mice, a model of Alzheimer´s disease (AD)-like amyloid-β (Aβ) pathology, reducing the Aβ plaque load, microgliosis and astrocytosis in the hippocampus and cortex.

Objective: In this study, we focused on the neuroprotective and anti-inflammatory effects of palm11-PrRP31 and its possible impact on synaptogenesis in the cerebellum of APP/PS1 mice, because others have suggested that cerebellar Aβ plaques contribute to cognitive deficits in AD. Read More

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September 2021

Methylation pattern in the diagnosis and prognosis of brain cancer.

Cesk Patol 2021 ;57(3):154-160

Examination of changes in the methylation profile of DNA in cancer is currently used to determine the diagnosis or prognostic and predictive biomarkers. It complements histological or molecular biological examinations. At the same time, it helps to identify new diagnostic groups and subgroups. Read More

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September 2021

Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain.

Cell Rep 2021 Sep;36(12):109721

Neuroscience Institute, Washington Road, Princeton University, Princeton, NJ 08544, USA. Electronic address:

Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipeline. With retrograde tracing, we find that most descending paths originate from the somatomotor cortex. Read More

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September 2021

Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse.

Cell Rep 2021 Sep;36(12):109719

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facilitation and prominent calcium-dependent recovery from depression at this synapse do not rely on Syt7 and that Syt7 is not normally present in CFs. Read More

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September 2021

Cerebellar spreading depolarization mediates paroxysmal movement disorder.

Cell Rep 2021 Sep;36(12):109743

Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China. Electronic address:

Paroxysmal kinesigenic dyskinesia (PKD) is the most common paroxysmal dyskinesia, characterized by recurrent episodes of involuntary movements provoked by sudden changes in movement. Proline-rich transmembrane protein 2 (PRRT2) has been identified as the major causative gene for PKD. Here, we report that PRRT2 deficiency facilitates the induction of cerebellar spreading depolarization (SD) and inhibition of cerebellar SD prevents the occurrence of dyskinetic movements. Read More

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September 2021

Changes in synaptic density in the subacute phase after ischemic stroke: A C-UCB-J PET/MR study.

J Cereb Blood Flow Metab 2021 Sep 22:271678X211047759. Epub 2021 Sep 22.

Department of Neurosciences, KU Leuven, Leuven, Belgium.

Functional alterations after ischemic stroke have been described with Magnetic Resonance Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on synaptic changes exist. Recently, imaging of synaptic density became available by targeting synaptic vesicle protein 2 A, a protein ubiquitously expressed in all presynaptic nerve terminals. We hypothesized that in subacute ischemic stroke loss of synaptic density can be evaluated with C-UCB-J PET in the ischemic tissue and that alterations in synaptic density can be present in brain regions beyond the ischemic core. Read More

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September 2021

Association of COVID-19 Infection and Juvenile Stroke: a Case Series.

Acta Neurol Taiwan 2021 Mar;30(1):27-34

Neurology resident, Department of Neurology, Bou Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Ischemic stroke has been increasingly reported as a consequence of COVID-19 infection. However, the underlying etiology is not well determined. The objective of this study is to discuss association of juvenile stroke with COVID-19 infection. Read More

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Anti-SOX1 Antibody-Positive Paraneoplastic Syndrome Presenting with Subacute Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome: A Case Report.

Acta Neurol Taiwan 2021 Jun;30(2):74-77

Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Purpose: Paraneoplastic neurological disorders associated with autoantibodies are rare diseases, causing abnormal manifestations in the central or peripheral nervous system separately or simultaneously. Early recognizing the occurrence of paraneoplastic syndrome can lead to prompt and effective management.

Case Report: We presented a patient of subacute cerebellar degeneration with cachectic and bed-ridden status, who was proven to have positive SOX1 antibody. Read More

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