4,942 results match your criteria centre zagreb


Psychometric properties of the Croatian version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25).

Int Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, University Hospital Center "Zagreb", Kišpatićeva 12, 10 000, Zagreb, Croatia.

Purpose: The purpose of the study was to translate, adapt and validate the Croatian version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) in participants with visual impairment. This study also aims at evaluating the relationship between visual impairment and health-related quality of life (HRQoL).

Methods: The prospective observational study was conducted at the University Hospital Centre Zagreb, Department of Ophthalmology. Read More

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Risk of Breakthrough SARS-CoV-2 Infections in Adult Transplant Recipients.

Transplantation 2021 Jul 23. Epub 2021 Jul 23.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Surgery, Houston Methodist Hospital, Houston, Texas, USA Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, Florida, USA Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA Transplant Institute, NYU Langone Health, New York, New York, USA Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health, Richmond, Virginia, USA Department of Surgery, Columbia University College of Physicians & Surgeons, New York, New York, USA Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA Avera Medical Group Nephrology, Sioux Falls, South Dakota, USA Department of Transplant, Mayo Clinic, Jacksonville, Florida, USA Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Virginia Transplant Center at Henrico Doctors' Hospital, Henrico, Virginia, USA Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA Department of Medicine, Division of Infectious Diseases & Global Public Health, University of California San Diego, San Diego, California, USA Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé publique (iPLESP), APHP, Hôpital Pitié-Salpêtrière, Paris, France.

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Survey on the Research Misconduct and Questionable Research Practices of Medical Students, PhD Students, and Supervisors at the Zagreb School of Medicine in Croatia.

J Empir Res Hum Res Ethics 2021 Jul 26:15562646211033727. Epub 2021 Jul 26.

Centre for Medical Ethics, University of Oslo, Oslo, Norway.

This cross-sectional study evaluates the knowledge, attitudes, experiences, and behavior of final year medical students, PhD students, and supervisors at the School of Medicine of the University of Zagreb in relation to research misconduct, questionable research practices, and the research environment. The overall response rate was 36.4% (68%-100% for the paper survey and 8%-15% for the online surveys). Read More

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Ultrasound Biomicroscopy Documented Anterior Uveal Melanoma Regression after Ruthenium-106 Plaque Therapy.

Ocul Oncol Pathol 2021 Jun 15;7(3):224-232. Epub 2021 Feb 15.

University Eye Clinic, University Hospital Centre Zagreb, Zagreb, Croatia.

Introduction: Ultrasound biomicroscopy (UBM) is the only widely used method for the evaluation of anterior uveal melanoma (AUM).

Objective: Documentation of regression of AUM treated with ruthenium-106 (Ru-106) plaque types CCB and CCC using UBM.

Methods: This single institution-based retrospective case series involved 10 Caucasian patients with AUM followed after brachytherapy with UBM from January 2014 until February 2019. Read More

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Identification of 22 susceptibility loci associated with testicular germ cell tumors.

Nat Commun 2021 07 23;12(1):4487. Epub 2021 Jul 23.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Read More

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Associations of aspirin, statins and metformin with lung cancer risk and related mortality.

Breathe (Sheff) 2021 Jun;17(2):200325

Dept of Clinical Immunology, Pulmonology and Rheumatology, University Hospital Centre "Sestre Milosrdnice", Zagreb, Croatia.

https://bit.ly/3hlYTtY. Read More

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Evaluating the impact of COVID-19 on the adoption of virtual care in general practice in 20 countries (inSIGHT): rationale and study protocol.

JMIR Res Protoc 2021 Jul 19. Epub 2021 Jul 19.

Institute of Global Health Innovation, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, Institute of Global Health Innovation, Room 1035/7, QEQM Wing, St Mary's Hospital Campus, London, GB.

Background: In recent decades, virtual care has emerged as a promising option to support primary care delivery. However, despite the potential, adoption rates remained low. With the outbreak of COVID-19, it has suddenly been pushed to the forefront of care delivery. Read More

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Laser treatment of pilonidal disease: a systematic review.

Lasers Med Sci 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, University Hospital Centre Zagreb, Kispaticeva 12, 10 000, Zagreb, Croatia.

Pilonidal disease (PD) is a common condition, and there is still an ongoing debate on ideal management that should be minimally invasive, safe, and efficient. The use of radially emitting laser in the treatment of chronic PD is a novel minimally invasive technique, and initial studies with a small number of patients showed promising results. This study aimed to assess the efficacy and safety of chronic PD treatment with a laser using a systematic review of the published literature. Read More

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Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot.

Front Public Health 2021 5;9:691163. Epub 2021 Jul 5.

Clinical Microbiology Department, Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia.

Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g. Read More

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SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells.

Sci Rep 2021 Jul 21;11(1):14880. Epub 2021 Jul 21.

Laboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000, Zagreb, Croatia.

Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs. Read More

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Genistein as a regulator of signaling pathways and microRNAs in different types of cancers.

Cancer Cell Int 2021 Jul 21;21(1):388. Epub 2021 Jul 21.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Read More

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The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.

Curr Issues Mol Biol 2021 Jul 8;43(2):618-636. Epub 2021 Jul 8.

Ruder Boskovic Institute, 10 000 Zagreb, Croatia.

Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. Read More

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THE ENIGMA OF LEWY BODY DEMENTIA: A CASE REPORT.

Acta Clin Croat 2020 Dec;59(4):771-776

1Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3Catholic University of Croatia, Zagreb, Croatia; 4School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Lewy body dementia is a progressive neurodegenerative disease and is considered to be the second most common cause of dementia in the elderly. Because of the complexity of clinical presentation, it is often misdiagnosed and mistaken for other dementias, which may result in administering inappropriate therapy, and thus worsening of the patient condition. We reviewed a case of a 71-year-old patient whose clinical presentation gradually occurred with complex visual hallucinations, atypical extrapyramidal motor symptoms, fluctuating cognitive impairments with delirious episodes, and oscillating syncope. Read More

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December 2020

OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT.

Acta Clin Croat 2020 Dec;59(4):761-764

Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia.

Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Read More

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December 2020

CURRENT ENDOVASCULAR MANAGEMENT OF INFECTED DISTAL BRANCH INTRACRANIAL ANEURYSMS: A CASE REPORT AND INSIGHT INTO THE LITERATURE.

Acta Clin Croat 2020 Dec;59(4):754-760

1Department of Radiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3University of Applied Health Sciences, Zagreb, Croatia; 4Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 5Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek, Croatia; 6Department of Neurosurgery, Dubrava University Hospital, Zagreb, Croatia.

Infected intracranial aneurysms are a rare type of inflammatory vascular lesions that occur due to infection of intracranial arterial wall. Brain aneurysms of distal arterial branches are equally rare and frequently multiple, including those situated at the peripheral middle cerebral artery segments. Although both types represent a small percentage of all intracranial aneurysms, they may bring about high mortality in case of rupture. Read More

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December 2020

TREATMENT OF IN TRADITIONAL MEDICINE.

Acta Clin Croat 2020 Dec;59(4):745-750

1Department of Dermatology and Venereology, Osijek University Hospital Centre, Osijek, Croatia; 2Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 4DermaPlus Clinic of Dermatology and Venereology, Zagreb, Croatia; 5Department of Gastroenterology, Zagreb Children's Hospital, Zagreb, Croatia.

Common warts () are the most common complaint in routine dermatological practice. Warts can be painful on pressure and are often an aesthetic problem, but they are not a major threat to the person's general health. Treatment options are symptomatic and do not eradicate the causative agent. Read More

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December 2020

THE USE OF ELECTRORETINOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH SCHIZOPHRENIA.

Acta Clin Croat 2020 Dec;59(4):729-739

1Sestre milosrdnice University Hospital Centre, Department of Psychiatry, Zagreb, Croatia; 2Sestre milosrdnice University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia; 3Catholic University of Croatia, Zagreb, Croatia.

The use of electroretinography (ERG) and optical coherence tomography (OCT) has currently expanded beyond ophthalmology alone. The aim of this review is to present the results and knowledge acquired by these two methods in patients suffering from schizophrenia. Reviewing the studies applying ERG and OCT methods in the field of psychiatry, one can conclude that results of the research imply morphological and functional changes of retina in patients with schizophrenia that are not consistent. Read More

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December 2020

ENDOVASCULAR MANAGEMENT OF INTRACRANIAL ANEURYSMS ON DISTAL ARTERIAL BRANCHES: ILLUSTRATIVE CASE SERIES AND LITERATURE RETROSPECTION.

Acta Clin Croat 2020 Dec;59(4):712-720

1Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2University of Applied Health Sciences, Zagreb, Croatia; 3Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 4Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek, Croatia; 5Department of Radiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

Intracranial aneurysms located on distal arterial branches are sporadic and scarce. They account for 2%-7% of the middle cerebral artery and 0.7%-2. Read More

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December 2020

THE ASSOCIATION OF SUBCLINICAL INSULIN RESISTANCE WITH THYROID AUTOIMMUNITY IN EUTHYROID INDIVIDUALS.

Acta Clin Croat 2020 Dec;59(4):696-702

1Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4University of Applied Health Sciences, Zagreb, Croatia; 5Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6School of Medicine, University of Zagreb, Zagreb, Croatia; 7Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia.

Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. Read More

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December 2020

TREATMENT OF PEDIATRIC FEMORAL FRACTURES IN THE CITY OF ZAGREB.

Acta Clin Croat 2020 Dec;59(4):686-695

1Zagreb University Hospital Centre, Department of Surgery, Division of Pediatric Surgery, Zagreb, Croatia; 2University of Zagreb, School of Medicine, Zagreb, Croatia; 3Zagreb Children's Hospital, Department of Surgery, Division of Traumatology, Zagreb, Croatia.

Femur fractures in children can be treated with a number of operative and conservative methods. Numerous factors determine which method is optimal for a specific fracture. The aim of this research was to analyze distribution of femur fractures in children living in the urban communities of Zagreb and Zagreb County by localization, type and frequency of treatment methods used according to age and fracture mechanism. Read More

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December 2020

THE CROATIAN HEALTH INSURANCE FUND DOES NOT RECOGNIZE DIFFERENCES IN THE COST OF DIFFERENT TREATMENTS FOR REVISION TOTAL HIP ARTHROPLASTY.

Acta Clin Croat 2020 Dec;59(4):667-671

1Department of Traumatology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Medicine, University of Split, Split, Croatia; 3School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4University of Applied Health Sciences, Zagreb, Croatia; 5School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 6Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

In recent years, there has been increased interest in the cost of treatment for revision interventions for hip and knee prostheses. In all publications so far, the authors note the high cost of treatment for revision interventions, especially if infection is present. The aim of this study was to compare the cost of treatment and health insurance reimbursements between revision total hip arthroplasty (THA) for infection and revision for aseptic indications (aseptic instability and periprosthetic fracture). Read More

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December 2020

Management of Hyperlipidemia in Very High and Extreme Risk Patients in Croatia: an observational study of treatment patterns and lipid control.

Acta Clin Croat 2020 Dec;59(4):641-649

1University of Zagreb, School of Dental Medicine, Zagreb, Croatia; 2Sestre milosrdnice University Hospital Centre, Department of Internal Medicine, Zagreb, Croatia; 3Amgen Ltd., Cambridge, United Kingdom; 4Osijek University Hospital Centre, Department of Cardiology, Osijek, Croatia; 5Rijeka University Hospital Centre, Rijeka, Croatia; 6University of Zagreb, School of Medicine, Department of Cardiovascular Diseases, Zagreb University Hospital Centre, Zagreb, Croatia.

Our observational study evaluated current management of elevated low-density lipoprotein cholesterol (LDL-C) in adult secondary prevention patients (all very high risk (VHR) by European guidelines) attending specialist clinics across Croatia. Data were collected retrospectively from patient records for the preceding 12 months. The subset judged to be at extreme risk (ER; American Association of Clinical Endocrinologists (AACE) criteria; n=48) were compared with the remaining patients (VHR group; n=41). Read More

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December 2020

FACTORS ASSOCIATED WITH DEPRESSION IN PATIENTS WITH SCHIZOPHRENIA.

Acta Clin Croat 2020 Dec;59(4):605-614

1University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; 2Department of Psychiatry, Clinical Centre of Vojvodina, Novi Sad, Serbia; 3Department of Neurosurgery, Clinical Centre of Vojvodina, Novi Sad, Serbia; 4Clinical Centre of Vojvodina, Novi Sad, Serbia; 5Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6University of Health Applied Sciencies, Zagreb, Croatia; 7University of Belgrade, Faculty of Medicine, Belgrade, Serbia; 8Division of Peripheral Nerve Surgery, Functional Neurosurgery and Pain Management Surgery, Department of Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia.

The aim of this study was to analyze risk factors present in schizophrenic patients with depressive symptomatology. The sample comprised of 76 respondents diagnosed with schizophrenia. In the study, we used the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia. Read More

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December 2020

THE IMPACT OF ANTIEPILEPTIC TREATMENT IN PREGNANCY ON PERINATAL OUTCOME IN CROATIA - A SINGLE-CENTER STUDY.

Acta Clin Croat 2020 Dec;59(4):590-596

1Department of Obstetrics and Gynecology, Zagreb University Hospital Centre, Zagreb, Croatia; 2School of Medicine, University of Zagreb, Zagreb, Croatia; 3Department of Obstetrics and Gynecology, Zadar General Hospital, Zadar, Croatia.

Pregnancy can alter the natural course of epilepsy and affect pharmacokinetic profile of antiepileptic drugs (AEDs) making therapeutic management more demanding. Since there is no relevant population-based study in Croatia to date, we conducted this research with the aim to observe antiepileptic treatment policy in pregnancy and to determine if the number of AEDs affects pregnancy outcomes. The study included all women with epilepsy with singleton pregnancy exposed to one or more AEDs divided into two groups (group 1: one AED and group 2: more than one AED used). Read More

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December 2020

COMBINED TREATMENT WITH BEVACIZUMAB AND TRIAMCINOLONE ACETONIDE FOR MACULAR EDEMA DUE TO RETINAL VEIN OCCLUSION.

Acta Clin Croat 2020 Dec;59(4):569-575

1Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 2Department of Ophthalmology, Osijek University Hospital Centre, Osijek, Croatia; 3Department of Ophthalmology, Sveti Duh University Hospital, Zagreb; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 4Department of Ophthalmology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 5Department of Ophthalmology, Southampton University Hospital, Southampton, United Kingdom.

The purpose of this study was to determine the efficacy of combined intravitreal bevacizumab and triamcinolone in the treatment of macular edema due to retinal vein occlusion. A prospective randomized trial was conducted in the Department of Ophthalmology, Osijek University Hospital Centre in Osijek including 51 patients divided into three groups depending on the drug received. The first group received 1. Read More

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December 2020

N-glycosylation of immunoglobulin G predicts incident hypertension.

J Hypertens 2021 Jul 19. Epub 2021 Jul 19.

Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia Department of Twin Research, Kings College London, London, UK Genos Glycoscience Research Laboratory, Zagreb, Croatia Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health German Center for Diabetes Research (DZD) Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health LMU Munich, IBE-Chair of Epidemiology, Neuherberg, Germany Department of Public Health, University of Split, School of Medicine, Split, Croatia NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London Academic Rheumatology Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, Nottingham University of Glasgow, Glasgow, Scotland, UK.

Objectives: Glycosylation of immunoglobulin G (IgG) is an important regulator of the immune system and has been implicated in prevalent hypertension.The aim of this study is to investigate whether the IgG glycome begins to change prior to hypertension diagnosis by analysing the IgG glycome composition in a large population-based female cohort with two independent replication samples.

Methods: We included 989 unrelated cases with incident hypertension and 1628 controls from the TwinsUK cohort (mean follow-up time of 6. Read More

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Sex differences in human mate preferences vary across sex ratios.

Proc Biol Sci 2021 Jul 21;288(1955):20211115. Epub 2021 Jul 21.

Department of Psychology, Izmir University of Economics, Izmir 35300, Turkey.

A wide range of literature connects sex ratio and mating behaviours in non-human animals. However, research examining sex ratio and human mating is limited in scope. Prior work has examined the relationship between sex ratio and desire for short-term, uncommitted mating as well as outcomes such as marriage and divorce rates. Read More

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Neuroplastin in human cognition: review of literature and future perspectives.

Transl Psychiatry 2021 Jul 16;11(1):394. Epub 2021 Jul 16.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Šalata12, 10000, Zagreb, Croatia.

Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it was found that some of the effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Read More

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Role of Doppler ultrasonography in the evaluation of hemodialysis arteriovenous access maturation and influencing factors.

J Vasc Access 2021 Jul 20:1129729820965064. Epub 2021 Jul 20.

Department of Radiology, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.

The goal of vascular access creation is to achieve a functioning arteriovenous fistula (AVF) or arteriovenous graft (AVG). An autologous fistula has been shown to be superior to AVG or to central venous catheters (CVCs) with lowest rate of re-intervention, but vessel obstruction or immaturity accounts for 20 % to 54% of cases with primary failure of AVF. This review is focused on the factors influencing maturation; indication and timing of preoperative mapping/creation of vascular access; ultrasound parameters for creation AVF/AVG; early postoperative complications following creation of a vascular access; ultrasound determinants of fistula maturation and endovascular intervention in vascular access with maturation failure. Read More

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Deciphering the Epigenetic Alphabet Involved in Transgenerational Stress Memory in Crops.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy.

Although epigenetic modifications have been intensely investigated over the last decade due to their role in crop adaptation to rapid climate change, it is unclear which epigenetic changes are heritable and therefore transmitted to their progeny. The identification of epigenetic marks that are transmitted to the next generations is of primary importance for their use in breeding and for the development of new cultivars with a broad-spectrum of tolerance/resistance to abiotic and biotic stresses. In this review, we discuss general aspects of plant responses to environmental stresses and provide an overview of recent findings on the role of transgenerational epigenetic modifications in crops. Read More

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