AIDS 2021 Jun 9. Epub 2021 Jun 9.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria Centre for Drug Discovery, Development and Production (CDDDP), Faculty of Pharmacy, University of Ibadan Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, USA Department of Pharmacology and Therapeutics, University of Liverpool, UK Division of Infectious Diseases and Center for Global Health, Northwestern University, Chicago, USA Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria Department of Neurology, University of North Carolina, Chapel Hill, NC, USA.
Objective: Efavirenz use is associated with neuropsychiatric side effects, which may include poor neurocognitive performance. We evaluated single nucleotide polymorphisms (SNPs) in genes that contribute to efavirenz pharmacokinetics and examined them in association with EFV concentrations in plasma and hair, as well as neurocognitive performance.
Design: Cross-sectional study where adults with HIV (PWH) receiving 600 mg efavirenz for at least two months were recruited and paired hair and dried blood spots (DBS) samples collected. Read More