Hypertension 2021 Sep 20:HYPERTENSIONAHA12117037. Epub 2021 Sep 20.
Neuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. (Y.S., S.L.B., A.M.D.W., C.G., K.L.J., K.L., G.A.H.).
There is increasing evidence that renal denervation is effective in alleviating hypertension associated with elevation of renal sympathetic nerve activity (RSNA) in chronic kidney disease (CKD), but whether this is due to reduction in renal afferent signaling is unclear. We determined the cardiovascular and sympathetic effects of total renal denervation or afferent renal denervation (topical capsaicin) on CKD induced by glomerular layer lesioning of the left kidney and right nephrectomy in conscious rabbits. CKD increased blood pressure by 18±2 mmHg and plasma creatinine by 40% over 2 to 4 weeks (both <0. Read More