12,109 results match your criteria central melbourne


Redundancy within hospital-related harm prediction tools.

Intern Med J 2021 Sep;51(9):1535-1538

Department of Aged Care and Rehabilitation, Caulfield Hospital, Alfred Health, Melbourne, Victoria, Australia.

The predictive ability and efficiency of inpatient harm screening tools is unclear. We performed a retrospective analysis of approximately 25 000 people admitted to our hospital in 2019. We found that the discriminatory ability of the harm screening tools was at best moderate and could be attributed to one or two questions that overlapped with each other in the harm they predicted. Read More

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September 2021

Challenges to implementation and strengthening of initial COVID-19 surveillance in Vanuatu: January-April 2020.

Western Pac Surveill Response J 2021 Apr-Jun;12(2):57-64. Epub 2021 Apr 5.

Country Liaison Office, World Health Organization, Port Vila, Vanuatu.

The Pacific island nation of Vanuatu is vulnerable to emerging infectious diseases, including epidemics and pandemics; chronic food and water insecurity; and natural hazards, including cyclones, earthquakes, tsunamis, landslides and flooding. In March 2020, the World Health Organization characterized the outbreak of novel coronavirus disease 2019 (COVID-19) as a global pandemic. By the end of April 2020, Vanuatu had reported no confirmed cases of COVID-19. Read More

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Influenza epidemiology and burden of disease in Mongolia, 2013-2014 to 2017-2018.

Western Pac Surveill Response J 2021 Apr-Jun;12(2):28-37. Epub 2021 Jun 7.

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Background: Mongolia is a vast, sparsely populated country in central Asia. Its harsh climate and nomadic lifestyle make the population vulnerable to acute respiratory infections, particularly influenza. Evidence on the morbidity, mortality and socioeconomic impact of influenza in Mongolia is scarce; however, routine surveillance for influenza-like illness (ILI), severe acute respiratory infection (SARI) and laboratory-detected influenza is conducted. Read More

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spp.: A Review on Phytochemical Composition, Biological Activity, and Health-Promoting Effects.

Oxid Med Cell Longev 2021 7;2021:4014867. Epub 2021 Sep 7.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Cyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, is one of the most promising health supplementing genera of the Cyperaceae family, housing ≈950 species, with L. being the most reported species in pharmacological studies. Read More

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September 2021

Renal Deafferentation Prevents Progression of Hypertension and Changes to Sympathetic Reflexes in a Rabbit Model of Chronic Kidney Disease.

Hypertension 2021 Sep 20:HYPERTENSIONAHA12117037. Epub 2021 Sep 20.

Neuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. (Y.S., S.L.B., A.M.D.W., C.G., K.L.J., K.L., G.A.H.).

There is increasing evidence that renal denervation is effective in alleviating hypertension associated with elevation of renal sympathetic nerve activity (RSNA) in chronic kidney disease (CKD), but whether this is due to reduction in renal afferent signaling is unclear. We determined the cardiovascular and sympathetic effects of total renal denervation or afferent renal denervation (topical capsaicin) on CKD induced by glomerular layer lesioning of the left kidney and right nephrectomy in conscious rabbits. CKD increased blood pressure by 18±2 mmHg and plasma creatinine by 40% over 2 to 4 weeks (both <0. Read More

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September 2021

Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.

Hypertension 2021 Sep 20:HYPERTENSIONAHA12117384. Epub 2021 Sep 20.

Department of Pharmacology, Monash University, Melbourne, Australia. (G.A.H.).

MicroRNA miR-181a is downregulated in the kidneys of hypertensive patients and hypertensive mice. In vitro, miR-181a is a posttranslational inhibitor of renin expression, but pleiotropic mechanisms by which miR-181a may influence blood pressure (BP) are unknown. Here, we determined whether deletion of miR-181a/b-1 in vivo changes BP and the molecular mechanisms involved at the single-cell level. Read More

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September 2021

Vaccination after prior COVID-19 infection: Implications for dose sparing and booster shots.

EBioMedicine 2021 Sep 15;72:103586. Epub 2021 Sep 15.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

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September 2021

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.

CNS Drugs 2021 Sep 18. Epub 2021 Sep 18.

Neurology Unit, Garibaldi Hospital, Catania, Italy.

Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.

Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Read More

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September 2021

Preferences for chlamydia testing and management in Hong Kong: a discrete choice experiment.

Sex Transm Infect 2021 Sep 17. Epub 2021 Sep 17.

Department of Family Medicine & Primary Care, University of Hong Kong, Hong Kong, Hong Kong.

Objectives: As most chlamydia cases are asymptomatic, regular testing and timely management may be necessary for control. We aimed to determine the preferences of people living in Hong Kong for chlamydia testing and management services.

Methods: An online panel of sexually active individuals living in Hong Kong completed the survey with two discrete choice experiments (DCEs). Read More

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September 2021

Predicting regression of cervical intraepithelial neoplasia grade 2 in women under 25 years.

Am J Obstet Gynecol 2021 Sep 14. Epub 2021 Sep 14.

National Women's Health, Auckland District Health Board, Auckland, New Zealand; Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.

Background: A number of retrospective and prospective studies have documented significant rates of regression in cervical intraepithelial neoplasia grade 2 (CIN2) lesions in young women. The initial observational management of CIN2 is increasingly accepted as appropriate for women under 25 years of age with screen detected abnormalities, and is included in a number of clinical guidelines. However, there has been a paucity of large prospective studies of observational management with strict inclusion criteria. Read More

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September 2021

Constraints on the Initial State of Pb-Pb Collisions via Measurements of Z-Boson Yields and Azimuthal Anisotropy at sqrt[s_{NN}]=5.02  TeV.

Phys Rev Lett 2021 Sep;127(10):102002

Universiteit Antwerpen, Antwerpen, Belgium.

The CMS experiment at the LHC has measured the differential cross sections of Z bosons decaying to pairs of leptons, as functions of transverse momentum and rapidity, in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02  TeV. The measured Z boson elliptic azimuthal anisotropy coefficient is compatible with zero, showing that Z bosons do not experience significant final-state interactions in the medium produced in the collision. Read More

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September 2021

Why Australia was not wet during spring 2020 despite La Niña.

Sci Rep 2021 Sep 16;11(1):18423. Epub 2021 Sep 16.

Bureau of Meteorology, Melbourne, VIC, Australia.

The austral spring climate of 2020 was characterised by the occurrence of La Niña, which is the most predictable climate driver of Australian springtime rainfall. Consistent with this La Niña, the Bureau of Meteorology's dynamical sub-seasonal to seasonal forecast system, ACCESS-S1, made highly confident predictions of wetter-than-normal conditions over central and eastern Australia for spring when initialised in July 2020 and thereafter. However, many areas of Australia received near average to severely below average rainfall, particularly during November. Read More

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September 2021

The impact of COVID-19 on the provision of respectful maternity care: Findings from a global survey of health workers.

Women Birth 2021 Sep 10. Epub 2021 Sep 10.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Significant adjustments to maternity care in response to the COVID-19 pandemic and the direct impacts of COVID-19 can compromise the quality of maternal and newborn care.

Aim: To explore how the COVID-19 pandemic negatively affected frontline health workers' ability to provide respectful maternity care globally.

Methods: We conducted a global online survey of health workers to assess the provision of maternal and newborn healthcare during the COVID-19 pandemic. Read More

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September 2021

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

Br J Pharmacol 2021 Oct;178 Suppl 1:S27-S156

University of Córdoba, Córdoba, Spain.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology. Read More

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October 2021

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors.

Br J Pharmacol 2021 Oct;178 Suppl 1:S246-S263

Monash University, Melbourne, Australia.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology. Read More

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October 2021

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters.

Br J Pharmacol 2021 Oct;178 Suppl 1:S412-S513

University of Salento, Lecce, Italy.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology. Read More

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October 2021

Improving Practices of Mental Health Professionals in Recommending More Physical Activity and Less Sedentary Behaviour to Their Clients: An Intervention Trial.

Issues Ment Health Nurs 2021 Sep 16:1-7. Epub 2021 Sep 16.

Institute for Health and Sport, Victoria University, Melbourne, Australia.

We investigated the effects of increasing physical activity (PA) and reducing sedentary behaviour (SB) of mental health professionals on their attitudes towards and practices in recommending more PA and less SB to their clients. A 4-week pre-post intervention trial was conducted involving 17 mental health professionals. The participants who increased their own physical activity during the intervention increased the frequency of recommending more PA ( = 0. Read More

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September 2021

Meeting community ambulation criteria and confidence with walking on discharge from inpatient rehabilitation were positively associated with performance of outdoor community activities 8 weeks after discharge.

Disabil Rehabil 2021 Sep 16:1-8. Epub 2021 Sep 16.

Peninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.

Purpose: To assess whether meeting criteria for community ambulation and ambulatory self-confidence on discharge from inpatient rehabilitation are associated with participation in community activities.

Methods: Prospective longitudinal observational study design. Participants were assessed within 48-hours of discharge on ability to complete tasks reflective of community ambulation (walking 315 m, ascending/descending three stairs, a ramp, and a street curb and walking at 0. Read More

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September 2021

Uptake of advance care planning and its circumstances: An nationwide survey in Australian general practice.

Health Soc Care Community 2021 Sep 16. Epub 2021 Sep 16.

Monash Nursing and Midwifery, Monash University, Melbourne, Australia.

There are potential benefits associated with advance care planning (ACP), and general practitioners (GPs) are well placed to coordinate ACP initiatives with their patients. Few studies have reported on the uptake of different forms of advance care plan conducted by GPs and how this affects patients' place of death. The primary aims of the study were to examine uptake of verbal (conversations regarding care preferences) and written (documented care preferences) advance care plans and their associated factors from the perspective of Australian GPs. Read More

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September 2021

It doesn't stop at validation: patient reported outcome measures require ongoing and iterative development.

Support Care Cancer 2021 Sep 16. Epub 2021 Sep 16.

Health and Social Care Unit, Monash University, Melbourne, Australia.

Patient reported outcomes (PROs) are a pillar of modern-day patient-centered care and clinical trials. PROs complement clinical information with the patient's own report about their experiences of health, without influence or interpretation by other people. However, choosing an appropriate PRO measure from the many available remains challenging for clinicians and researchers. Read More

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September 2021

Establishing determinants and quality indicators for getting home alive following moderate to severe traumatic brain injury: the Australian Traumatic Brain Injury National Data Project.

Emerg Med Australas 2021 Sep 15. Epub 2021 Sep 15.

National Trauma Research Institute, Alfred Health, Melbourne, Victoria, Australia.

Moderate to severe traumatic brain injury (TBI) contributes to a significant burden across Australia. However, the data required to inform targeted equitable system-level improvements in emergency TBI care do not exist. The incidence and determinants of outcomes following moderate to severe TBI in Australia remain unknown. Read More

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September 2021

Neoproterozoic syn-glacial carbonate precipitation and implications for a snowball Earth.

Geobiology 2021 Sep 16. Epub 2021 Sep 16.

Department of Geology and Geophysics, Yale University, New Haven, CT, USA.

The Neoproterozoic 'snowball Earth' hypothesis suggests that a runaway ice-albedo feedback led to two intense glaciations around 717-635 million years ago, and this global ice cover would have drastically impacted biogeochemical cycles. Testing the predictions of this hypothesis against the rock record is key to understanding Earth's surface evolution in the Neoproterozoic. A central tenet of the snowball Earth hypothesis is that extremely high atmospheric CO  levels-supplied by volcanic degassing over millions of years-would be required to overcome a strong ice-albedo feedback and trigger deglaciation. Read More

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September 2021

Severe maternal morbidity in the Asia Pacific: a systematic review and meta-analysis.

Lancet Reg Health West Pac 2021 Sep 20;14:100217. Epub 2021 Jul 20.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, Victoria, Australia, 3084.

Background: Monitoring rates of severe maternal morbidity (such as eclampsia and uterine rupture) is useful to assess the quality of obstetric care, particularly in low and lower-middle-income countries (LMICs).

Methods: We undertook a systematic review characterising the proportion and causes of severe maternal morbidity in the Asia Pacific region. We searched Medline, Embase, Cochrane CENTRAL library and the World Health Organization Western Pacific Index database for studies in the Asia-Pacific reporting maternal morbidity/near miss using a predefined search strategy. Read More

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September 2021

An Experimental Model of Bronchopulmonary Dysplasia Features Long-Term Retinal and Pulmonary Defects but Not Sustained Lung Inflammation.

Front Pediatr 2021 30;9:689699. Epub 2021 Aug 30.

Leukocyte Signalling Laboratory, Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Bronchopulmonary dysplasia (BPD) is a severe lung disease that affects preterm infants receiving oxygen therapy. No standardized, clinically-relevant BPD model exists, hampering efforts to understand and treat this disease. This study aimed to evaluate and confirm a candidate model of acute and chronic BPD, based on exposure of neonatal mice to a high oxygen environment during key lung developmental stages affected in preterm infants with BPD. Read More

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Oral care practices in stroke: findings from the UK and Australia.

BMC Nurs 2021 Sep 15;20(1):169. Epub 2021 Sep 15.

Faculty of Health and Care, University of Central Lancashire, Preston, PR1 2HE, UK.

Aims: To examine current practice, perceptions of healthcare professionals and factors affecting provision for oral care post-stroke in the UK and Australia.

Background: Poor oral care has negative health consequences for people post-stroke. Little is known about oral care practice in hospital for people post-stroke and factors affecting provision in different countries. Read More

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September 2021

Prediction accuracy of commonly used pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia - a retrospective study.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, Alice Springs Hospital, Central Australian Health Service, Alice Springs, Northern Territory,, Australia.

Aims: Assess the prediction accuracy of pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia (SCAP) and identify risk factors for poor prognosis.

Methods: Retrospective cohort study examining Aboriginal patients admitted to intensive care unit (ICU) with confirmed SCAP between January 2011 and December 2014. Severity scores were calculated for SMARTCOP, SMARTACOP, CURB65, PSI, IDSA/ATS SCAP (IASCAP) and APACHE II/III scores using medical records. Read More

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September 2021

The proteomes of endometrial stromal cell-derived extracellular vesicles following a decidualising stimulus define the cells' potential for decidualisation success.

Mol Hum Reprod 2021 Sep 15. Epub 2021 Sep 15.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia.

Adequate endometrial stromal cell (ESC) decidualisation is vital for endometrial health. Given the importance of extracellular vesicles (EVs) in intercellular communication, we investigated how their protein landscape is reprogrammed and dysregulated during decidual response. Small EVs (sEVs) from human ESC-conditioned media at day-2 and -14 following decidual stimuli, were grouped as well- (WD) or poorly-decidualised (PD) based on their prolactin secretion and subjected to mass spectrometry-based quantitative proteomics. Read More

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September 2021