12,687 results match your criteria central lymph


Role of robotic natural orifice specimen extraction surgery in colorectal neoplasms.

Sci Rep 2021 May 10;11(1):9818. Epub 2021 May 10.

Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.

Natural orifice specimen extraction surgery (NOSES) is especially suitable for colorectal surgery. Until now, most of the reports published were about laparoscopic NOSES, the reports about robotic NOSES are extremely rare. This study aims to explore the safety and feasibility of robotic NOSES for colorectal neoplasms. Read More

View Article and Full-Text PDF

Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo.

PLoS One 2021 10;16(5):e0250974. Epub 2021 May 10.

Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America.

The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological activities. Transcriptional control of the Tnfsf11 gene, which encodes RANKL, is complex and involves distant regulatory regions. Read More

View Article and Full-Text PDF

Dysregulation of microRNAs as the risk factor of lymph node metastasis in papillary thyroid carcinoma: systematic review.

Endokrynol Pol 2021 ;72(2):145-152

Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Papillary thyroid carcinoma (PTC) has an excellent prognosis with a relatively low mortality rate, but a small portion of PTC patients suffer from an aggressive form of the disease. In such cases early detection of lymph node metastasis (LNM) is as paramount as it is problematic. The routine use of central neck lymph node dissection is not recommended. Read More

View Article and Full-Text PDF
January 2021

The emerging role of FTY720 as a sphingosine 1-phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms.

Brain Behav 2021 May 10:e02179. Epub 2021 May 10.

Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

Finding novel and effective drugs for the treatment of ischemic stroke is warranted because there is not a definitive treatment for this prevalent disease. Due to the relevance between the sphingosine 1-phosphate (S1P) receptor and several neurological diseases including ischemic stroke, it seems that fingolimod (FTY720), as an agonist of S1P receptor, can be a useful therapeutic strategy in these patients. FTY720 is the first oral drug approved by the US food and drug administration for the treatment of multiple sclerosis. Read More

View Article and Full-Text PDF

Application of Carbon Nanoparticles in Neck Dissection of Clinically Node-Negative Papillary Thyroid Carcinoma.

Biomed Res Int 2021 21;2021:6693585. Epub 2021 Apr 21.

Department of Otolaryngology, China-Japan Friendship Hospital, Beijing 100029, China.

Purpose: The purpose of this retrospective study was to evaluate the advantages of carbon nanoparticles in neck dissection and to conclude its application in the treatment of clinically node-negative papillary thyroid carcinoma (CN0PTC).

Methods: As a retrospective cohort study, we divided the enrolled patients into two groups, the carbon nanoparticle (CN) group and the control group according to the usage of CN. In the CN group, CN was applied to reveal drainage lymph nodes and the picked LNs were sent for fast frozen testing. Read More

View Article and Full-Text PDF

The systemic immune-inflammation index-based model is an effective biomarker on predicting central lymph node metastasis in clinically nodal-negative papillary thyroid carcinoma.

Gland Surg 2021 Apr;10(4):1368-1373

Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: A high proportion of papillary thyroid carcinoma (PTC) patients are involved in central lymph node metastasis (CLNM) with preoperative imaging examinations showing clinically nodal-negative (cN0). Meanwhile, many inflammatory biomarkers are also proven as effective factors to predict the outcomes of cancer patients and tumor progression. Thus, the values of these factors are investigated to help detecting CLNM in cN0 PTC patients. Read More

View Article and Full-Text PDF

Unilateral axilla-bilateral areola approach for thyroidectomy by da Vinci robot open surgery in thyroid cancer: a retrospective observational study.

Gland Surg 2021 Apr;10(4):1291-1299

Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.

Background: To compare the efficacy and safety of unilateral axilla-bilateral areola (UABA) approach for robot-assisted thyroidectomy with conventional open surgery in thyroid cancer patients.

Methods: The clinicopathological features and surgical outcomes of 194 thyroid cancer patients treated by robotic surgery using the UABA approach and 217 patients treated by open surgery in our department from January 2017 to August 2018 were analysed and compared.

Results: The operation time was longer in the robotic group than in the open surgery group. Read More

View Article and Full-Text PDF

Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells.

Front Immunol 2021 21;12:666935. Epub 2021 Apr 21.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. While initially restricted to the skin, malignant cells can appear in blood, bone marrow and secondary lymphoid organs in later disease stages. However, only little is known about phenotypic and functional properties of malignant T cells in relationship to tissue environments over the course of disease progression. Read More

View Article and Full-Text PDF

CD2 Is a Novel Immune-Related Prognostic Biomarker of Invasive Breast Carcinoma That Modulates the Tumor Microenvironment.

Front Immunol 2021 23;12:664845. Epub 2021 Apr 23.

Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Female breast cancer (BCa) is the most commonly occurring cancer worldwide. The tumor microenvironment (TME) plays an essential role in tumor invasion, angiogenesis, unlimited proliferation, and even immune escape, but we know little about the TME of BCa. In this study, we aimed to find a TME-related biomarker for BCa, especially for invasive breast carcinoma (BRCA), that could predict prognosis and immunotherapy efficacy. Read More

View Article and Full-Text PDF

Extrapulmonary tuberculosis.

Expert Rev Respir Med 2021 May 8. Epub 2021 May 8.

Department of Epidemiology and Biostatistics and Occupational Health, McGill International TB Centre, McGill University, Canada.

: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Extrapulmonary TB (EPTB) constitutes about 15%-20% of all TB patients but accounts for 50% among HIV-coinfected. Confirmation of microbial diagnosis of EPTB is usually challenging. Read More

View Article and Full-Text PDF

Ocular tuberculosis in a calf.

BMC Vet Res 2021 May 8;17(1):187. Epub 2021 May 8.

Laboratorio de Investigación en Tuberculosis Bovina, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico city, Mexico.

Background: Bovine tuberculosis is a chronic inflammatory disease that causes granuloma formation mainly in retropharyngeal, tracheobronchial, mediastinal lymph nodes and lungs of bovines. The presence of these lesions in other tissues such as the eyeball is very rare and difficult to diagnose. This study describes macroscopic and microscopic pathological findings in a calf with ocular and meningeal tuberculosis. Read More

View Article and Full-Text PDF

Isolated Extramedullary Relapse After Human Leukocyte Antigen-Matched Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Case Reports and Literature Review.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Research Unit in Translational Hematology, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Isolated extramedullary relapse (iEMR) of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare and has a dismal prognosis. Among 67 patients with AML after allo-HSCT, iEMR and bone marrow relapse occurred in 6% and 20.9%, respectively, with a median time to relapse of 11. Read More

View Article and Full-Text PDF

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks.

J Orthop Surg Res 2021 May 7;16(1):300. Epub 2021 May 7.

Department of Joint Surgery, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, No. 158 Wuyang Avenue, Enshi City, 445000, Hubei Province, China.

Background: CircRNA CNST (circ-CNST) is a newly identified biomarker for prognosis of osteosarcoma (OS). However, its role in OS progression remains to be well documented.

Methods: Expression of circ-CNST, microRNA (miR)-578, lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1) was detected by quantitative real-time polymerase chain reaction and Western blotting. Read More

View Article and Full-Text PDF

Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression.

Clin Sci (Lond) 2021 May;135(9):1065-1082

Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), São Paulo, SP, Brazil.

Cellular therapy with mesenchymal stem cells (MSCs) is a huge challenge for scientists, as little translational relevance has been achieved. However, many studies using MSCs have proved their suppressive and regenerative capacity. Thus, there is still a need for a better understanding of MSCs biology and the establishment of newer protocols, or to test unexplored tissue sources. Read More

View Article and Full-Text PDF

FOXO3A Expression in Upper Tract Urothelial Carcinoma.

Front Oncol 2021 20;11:603681. Epub 2021 Apr 20.

Department of Oncology, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China.

Background: Epidemiological studies have reported various results regarding whether FOXO3A is related to various carcinomas. However, the prognostic significance of FOXO3A in upper tract urothelial carcinoma (UTUC) remains unclear. The purpose of this study was to validate the correlation between FOXO3A expression and oncological outcomes in UTUC. Read More

View Article and Full-Text PDF

Silicone Adenopathy and Intractable Axilary Pain after Breast Implant Augmentation - Case Report.

Chirurgia (Bucur) 2021 Mar-Apr;116(2):248-253

Silicone lymphadenophaty (siliconoma) is a rare complication secondary to breast implant augmentation or breast reconstruction surgery. Although it is usually linked to the age of the implant, the predominant etiology is multifactorial. Herein, we report a case of extensive siliconoma in the axilla in the hope that our experience will contribute to clinical decision making. Read More

View Article and Full-Text PDF

Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence.

bioRxiv 2021 Apr 29. Epub 2021 Apr 29.

CD8+ T cells are important antiviral effectors that can potentiate long-lived immunity against COVID-19, but a detailed characterization of these cells has been hampered by technical challenges. We screened 21 well-characterized, longitudinally-sampled convalescent donors that recovered from mild COVID-19 against a collection of SARS-CoV-2 tetramers, and identified one participant with an immunodominant response against Nuc , a peptide that is conserved in all the SARS-CoV-2 variants-of-concern reported to date. We conducted 38- parameter CyTOF phenotyping on tetramer-identified Nuc -specific CD8+ T cells, and on CD4+ and CD8+ T cells recognizing the entire nucleocapsid and spike proteins from SARS- CoV-2, and took 32 serological measurements on longitudinal specimens from this participant. Read More

View Article and Full-Text PDF

Using Genomics Feature Selection Method in Radiomics Pipeline Improves Prognostication Performance in Locally Advanced Esophageal Squamous Cell Carcinoma-A Pilot Study.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.

Purpose: To evaluate the prognostic value of baseline and restaging CT-based radiomics with features associated with gene expression in esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiation (nCRT) plus surgery.

Methods: We enrolled 106 ESCC patients receiving nCRT from two institutions. Gene expression profiles of 28 patients in the training set were used to detect differentially expressed (DE) genes between patients with and without relapse. Read More

View Article and Full-Text PDF

Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL.

MAbs 2021 Jan-Dec;13(1):1917484

Immunology Department, Hospital Universitario De La Princesa, IIS-IP, Madrid, Spain.

Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially for chronic lymphocytic leukemia (CLL). Within the multiple de-regulated pathways affecting CLL homeostasis, the CC-chemokine receptor 7 (CCR7) grants homing of CLL cells into the LN where protective environments foster tumor progression. To cover the lack of specific therapies targeting the CCR7-dependence of CLL to enter into the LN, and aiming to displace the disease from LN, we generated CAP-100, an antibody that specifically binds to hCCR7 and neutralizes its ligand-binding site and signaling. Read More

View Article and Full-Text PDF

The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation.

Proc Natl Acad Sci U S A 2021 May;118(19)

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118;

Immune checkpoint inhibitors represent some of the most important cancer treatments developed in the last 20 y. However, existing immunotherapy approaches benefit only a minority of patients. Here, we provide evidence that the aryl hydrocarbon receptor (AhR) is a central player in the regulation of multiple immune checkpoints in oral squamous cell carcinoma (OSCC). Read More

View Article and Full-Text PDF

Risk factors for central lymph node metastasis in the cervical region in papillary thyroid carcinoma: a retrospective study.

World J Surg Oncol 2021 Apr 30;19(1):138. Epub 2021 Apr 30.

Department of Thyroid Surgery, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming, 650032, Yunnan, China.

Background: To investigate the influence of different risk factors on central lymph node metastasis (CLNM) in the cervical region in patients with papillary thyroid carcinoma (PTC).

Methods: This retrospective study included 2586 PTC patients. Potential risk factors were identified by univariate analysis, and the relationships between these factors and CLNM were ascertained by multivariable analysis. Read More

View Article and Full-Text PDF

A Pedigree Analysis and Clonal Correlations of the Coexistence of B-Cell Lymphoma and Histiocytic/Dendritic Cell Tumor.

Int J Surg Pathol 2021 May 3:10668969211013402. Epub 2021 May 3.

71069The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Histiocytic/dendritic cell tumors are rare in clinical practice. It is postulated that they originate from bone marrow stem cells. Accumulating evidence has established the existence of immunoglobulin gene and T-cell receptor gene rearrangements in these tumors. Read More

View Article and Full-Text PDF

Expression and clinical significance of B cell translocation gene 2 in esophageal squamous cell carcinoma.

Int J Clin Exp Pathol 2021 15;14(4):475-483. Epub 2021 Apr 15.

Department of Radiation Oncology, Lianshui County People's Hospital, Kangda College of Nanjing Medical University Huai'an 223400, Jiangsu, P. R. China.

Esophageal squamous cell carcinoma (ESCC) is widely known as a highly fatal cancer, and thus it is important to identify tumor-specific and radiosensitivity-specific markers in ESCC. B cell translocation gene 2 (BTG2) has been considered a novel tumor suppressor gene or radiotherapy sensitivity-associated gene. However, the relationship between BTG2 and ESCC development and radiotherapy sensitivity is uncertain. Read More

View Article and Full-Text PDF

Diagnostic approaches to carcinoma of unknown primary of the head and neck.

Eur J Cancer Care (Engl) 2021 May 1:e13459. Epub 2021 May 1.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Squamous cell carcinoma in cervical lymph nodes arising from an undetected primary tumour, termed carcinoma of unknown primary (SCCUP), is a well-recognized clinical presentation within head and neck oncology. SCCUP is a common presentation for patients with human papillomavirus-mediated oropharyngeal cancer (HPV + OPSCC), as patients with HPV + OPSCC often present with smaller primary tumours and early nodal metastasis. Meticulous work-up of the SCCUP patient is central to the management of these patients as identification of the primary site improves overall survival and allows for definitive oncologic resection or more focused radiation when indicated. Read More

View Article and Full-Text PDF

Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis.

J Immunother Cancer 2021 Apr;9(4)

Department of Internal Medicine 5 for Hematology and Oncology, Universitätsklinikum Erlangen, Erlangen, Bayern, Germany.

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Emerging data suggest that CLL-cells efficiently evade immunosurveillance. T-cell deficiencies in CLL include immuno(metabolic) exhaustion that is achieved by inhibitory molecules, with programmed cell death 1/programmed cell death ligand 1 (PD-L1) signaling emerging as a major underlying mechanism. Read More

View Article and Full-Text PDF

The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma.

Biosci Rep 2021 Apr 30. Epub 2021 Apr 30.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University; The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Tumor microenvironment (TME) plays a particularly important role in the progression, invasion and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the tumor microenvironment in CC. However, the results of studies on the correlation between TAMs and progression in CC are still controversial. Read More

View Article and Full-Text PDF

Corpus Callosum Involvement as Extrahepatic Manifestation of Hepatitis E Virus: An Uncommon Entity.

J Neurosci Rural Pract 2021 Apr 1;12(2):427-430. Epub 2021 Apr 1.

Department of Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. HEV infection is not limited only to liver but has various extrahepatic manifestations. Virus can affect various organs like pancreas, lymph nodes, hematological system, kidneys, spleen, central, and peripheral nervous system. Read More

View Article and Full-Text PDF

Progress in application of near-infrared fluorescence imaging in the diagnosis and treatment of oral cancer.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):316-321

Breast Oncoplastic Surgery Department/ Head and Neck Surgery Department 3, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410006.

The preliminary screening of oral cancer mostly depends on the experience of clinicians, The surgical margin of tumor is mostly based on physical examination and preoperative imaging examination. It lacks real-time and objective intraoperative evaluation methods. Indocyanine green (ICG), as a safe and pollution-free organic fluorescent pigments, combined with near-infrared fluorescence imaging can be applied in the screening of early oral cancer, the determination of tumor resection margins, sentinel lymph node biopsy, cervical lymph node dissection, targeted chemotherapy, and other aspects. Read More

View Article and Full-Text PDF

Long-term tracing and staining of carbon nanoparticles for axillary lymph node in patients with local advanced breast cancer treated with neoadjuvant chemotherapy.

Asian J Surg 2021 Apr 26. Epub 2021 Apr 26.

The First Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. Electronic address:

Background: The regression of positive nodes in breast cancer after neoadjuvant chemotherapy (NAC) remains unknown. This study aimed to investigate this regression by injecting and tracing carbon nanoparticles (CNs) into the fusion node prior to NAC in patients with breast cancer.

Methods: Guided by ultrasound, 0. Read More

View Article and Full-Text PDF

Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma-A Retrospective Multicenter Study.

Medicina (Kaunas) 2021 Apr 12;57(4). Epub 2021 Apr 12.

Department of Otolaryngology-Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. In total, 945 patients with OSCC were retrospectively analyzed. Read More

View Article and Full-Text PDF