2,674 results match your criteria central fovea


Eye movement abnormalities in movement disorders.

Clin Park Relat Disord 2019 30;1:54-63. Epub 2019 Aug 30.

The Truong Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA 92708, USA.

The visual system represents the most well-developed sensory system in humans, who are highly dependent on vision for organized response to their environment. The region of eye that is responsible for sharp central vision is the fovea. Thus, to see the world, images of objects of interest should fall on fovea. Read More

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Efficiency comparison with fovea-sparing internal limiting membrane peeling and complete internal limiting membrane peeling for treating myopic traction maculopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, Military Ophthalmological Center, General Hospital of Xinjiang Military Region, No. 754 Beijing Middle Road, Urumqi, 830054, Xinjiang, China.

Purpose: To explore whether the efficacy of fovea-sparing internal limiting membrane peeling (FS-ILMP) is better than that of complete internal limiting membrane peeling (ILMP).

Methods: This retrospective clinical study included 34 cases (34 eyes) with myopic traction maculopathy collected from June 2017 to February 2019. Twenty-three-gauge (23-G) pars plana vitrectomy (23G PPV) was performed on all patients. Read More

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Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa.

Int Ophthalmol 2021 Jul 25. Epub 2021 Jul 25.

Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, China.

Purpose: Several parameters on optical coherence tomography (OCT) have been suggested as biomarkers for photoreceptor degeneration in retinitis pigmentosa (RP). This study is to compare the spatial distribution of the changes of OCT biomarkers in RP patients.

Methods: OCT line scans of the horizontal meridian were conducted in 22 eyes of 22 RP patients and 30 eyes of 30 healthy controls. Read More

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Spectral domain optical coherence tomography assessment of macular and optic nerve alterations in patients recovered from COVID-19: a comparative study.

Can J Ophthalmol 2021 Jul 5. Epub 2021 Jul 5.

Bursa Uludag University School of Medicine, Department of Chest Diseases, Bursa, Turkey.

Objective: To quantify microstructutal alterations in the macula and peripapillary retinal nerve fibre layer (RNFL) in patients recovered from coronavirus disease 2019 (COVID-19) using spectral domain optic coherence tomography (SD-OCT).

Design: Retrospective, observational.

Participants: This comparative, cross-sectional study included patients who recovered from COVID-19 (Group 1) and age- and sex-matched normal controls (Group 2). Read More

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The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):31

Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

Purpose: The cellular topography of the human foveola, the central 1° diameter of the fovea, is strikingly non-uniform, with a steep increase of cone photoreceptor density and outer segment (OS) length toward its center. Here, we assessed to what extent the specific cellular organization of the foveola of an individual is reflected in visual sensitivity and if sensitivity peaks at the preferred retinal locus of fixation (PRL).

Methods: Increment sensitivity to small-spot, cone-targeted visual stimuli (1 × 1 arcmin, 543-nm light) was recorded psychophysically in four human participants at 17 locations concentric within a 0. Read More

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Short term morphological rescue of the fovea after gene therapy with voretigene neparvovec.

Acta Ophthalmol 2021 Jul 21. Epub 2021 Jul 21.

Center for Ophthalmology, University Eye Hospital, University of Tübingen, Tübingen, Germany.

Purpose: Leber congenital amaurosis type 2 (LCA2) and early-onset severe retinal dystrophy (EOSRD) are linked to visual impairment with nyctalopia and visual acuity reduction in early childhood. In 2017, the first gene therapy voretigene neparvovec (Luxturna™) for patients with LCA and EOSRD cause by bi-allelic mutations in the RPE65 gene has been approved. Here we report on an example of short-term change in the foveal morphology after functionally successful gene therapy with voretigene neparvovec in a 15-year old patient. Read More

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Behavioural Adaptation to Hereditary Macular Dystrophy: A Systematic Review on the Effect of Early Onset Central Field Loss on Peripheral Visual Abilities.

Br Ir Orthopt J 2021 16;17(1):104-118. Epub 2021 Jun 16.

University of Sheffield, GB.

Purpose: Hereditary macular dystrophies (HMD) result in early onset central field loss. Evidence for cortical plasticity has been found in HMD, which may enhance peripheral visual abilities to meet the increased demands and reliance on the peripheral field, as has been found in congenitally deaf adults and habitual action video-game players. This is a qualitative synthesis of the literature on the effect of early onset central field loss on peripheral visual abilities. Read More

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An ERG and OCT study of neuronal ceroid lipofuscinosis CLN2 Battens retinopathy.

Eye (Lond) 2021 Jul 16. Epub 2021 Jul 16.

Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.

Background: Late infantile neuronal ceroid lipofuscinosis (CLN2 Batten disease) is a rare, progressive neurodegenerative disease of childhood. The natural history of motor and language regression is used to monitor the efficacy of CNS treatments. Less is known about CLN2 retinopathy. Read More

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Composition of the Inner Nuclear Layer in Human Retina.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):22

The University of Sydney, Faculty of Medicine and Health, Save Sight Institute and Discipline of Clinical Ophthalmology, Sydney, Australia.

Purpose: The purpose of this study was to measure the composition of the inner nuclear layer (INL) in the central and peripheral human retina as foundation data for interpreting INL function and dysfunction.

Methods: Six postmortem human donor retinas (male and female, aged 31-56 years) were sectioned along the temporal horizontal meridian. Sections were processed with immunofluorescent markers and imaged using high-resolution, multichannel fluorescence microscopy. Read More

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Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography.

Exp Biol Med (Maywood) 2021 Jul 14:15353702211028540. Epub 2021 Jul 14.

Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.

The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Read More

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[The influence of pseudoexfoliation syndrome on central retina in elderly patients.]

Adv Gerontol 2021 ;34(2):258-263

I.I.Pavlov First Saint-Petersburg State Medical University, 6-8 L'vaTolstogo str., St. Petersburg 197022, Russian Federation, e-mail: e-mail:

Purpose: to evaluate the effect of pseudoexfoliation syndrome (PXF) on the stage of age-related macular degeneration (AMD) and central retinal thickness, measured by optical coherence tomography (OCT) in elderly patients living in Saint-Petersburg. 25 elderly patients (30 eyes) with PXF and 25 age-matched patients (29 eyes) without PXF (control group) were included in the study. Retinal thickness in fovea and parafovea as well as AMD stage were compared in the groups. Read More

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A proximal radius of Barberapithecus huerzeleri from Castell de Barberà: Implications for locomotor diversity among pliopithecoids.

J Hum Evol 2021 Aug 4;157:103032. Epub 2021 Jul 4.

Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, Campus de la UAB, Cerdanyola del Vallès, 08193, Barcelona, Spain. Electronic address:

Pliopithecoids are a diverse group of Miocene catarrhine primates from Eurasia. Their positional behavior is still unknown, and many species are known exclusively from dentognathic remains. Here, we describe a proximal radius (IPS66267) from the late Miocene of Castell de Barberà (Vallès-Penedès Basin, NE Iberian Peninsula) that represents the first postcranial specimen of the pliopithecoid Barberapithecus huerzeleri. Read More

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Mean macular intercapillary area in eyes with diabetic macular oedema after anti-VEGF therapy and its association with treatment response.

Clin Exp Ophthalmol 2021 Jun 29. Epub 2021 Jun 29.

New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.

Background: To evaluate the changes in the mean macular intercapillary area (ICA) from sequential enface optical coherence tomography angiography (OCTA) images following intravitreal anti-VEGF therapy in initially treatment-naïve eyes with diabetic macular oedema (DME).

Methods: In this multicenter retrospective study, 6x6 and 3x3 mm customized, total retinal projection enface OCTA images were collected and processed for quantitative assessment of ICA by a customized MATLAB software. Measurements were done in concentric regions centered on the fovea -with the exclusion of foveal avascular zone (FAZ)- in 0. Read More

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Spontaneous Closure of Large Full-Thickness Macular Hole in a Patient with Degenerative Myopia: Case Report

Turk J Ophthalmol 2021 06;51(3):184-187

Gazi University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Macular hole is characterized by a full-thickness defect of the retinal layers in the center of the fovea and is an important cause of central vision loss. Spontaneous closure of a macular hole is rare, most often occurring in traumatic and idiopathic macular holes. In this case report, we present a 51-year-old woman with a myopic macular hole that closed spontaneously. Read More

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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases.

J Vis Exp 2021 Jun 14(172). Epub 2021 Jun 14.

Department of Ophthalmology, National University Hospital, Singapore; Macula Center Saar, Eye Clinic Sulzbach, Knappschaft Hospital Saar; Department of Ophthalmology, University of Bonn;

Retinal pigment epithelial (RPE) transplantation holds great promise for the treatment of inherited and acquired retinal degenerative diseases. These conditions include retinitis pigmentosa (RP) and advanced forms of age-related macular degeneration (AMD), such as geographic atrophy (GA). Together, these disorders represent a significant proportion of currently untreatable blindness globally. Read More

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Choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman: a life-threatening metastasis.

Rom J Ophthalmol 2021 Apr-Jun;65(2):196-200

Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Health Campus, Universiti Sains Malaysia; Hospital Universiti Sains Malaysia, Malaysia.

To report a case of choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman. A case report. A 21-year-old woman presented with insidious painless, progressive, central scotoma of the right eye for 5 weeks. Read More

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Myopic Simple Hemorrhage Presenting as Radial Hemorrhage in Henle's Fiber Layer.

Case Rep Ophthalmol 2021 May-Aug;12(2):446-450. Epub 2021 May 12.

Ophthalmology Clinic, Department of Medicine and Surgery, University of Insubria, Varese-Como, Italy.

This case report describes a simple hemorrhage (SH) presenting as radial hemorrhage in Henle's fiber layer (HFL) in a patient with high myopia. A 26-year-old girl with high myopia was referred to our center for sudden onset of decreased vision and a central scotoma in the right eye (OD). Best corrected visual acuity (BCVA) was 20/100 OD. Read More

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Correlation between electroretinography, foveal anatomy and visual acuity in aniridia due to PAX6 mutations.

Doc Ophthalmol 2021 Jun 26. Epub 2021 Jun 26.

Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA.

Background: Aniridia patients have poor visual acuity and iris malformation. The fovea in these patients is underdeveloped, but the relationship between structure and electrophysiologic function remains incompletely understood. This study correlates electrophysiology, visual acuity and optical coherence tomography (OCT) in patients with aniridia secondary to mutations in the PAX6 gene and compares with age-similar controls. Read More

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Fixation stability after surgical treatment of strabismus and biofeedback fixation training in amblyopic eyes.

BMC Ophthalmol 2021 Jun 24;21(1):264. Epub 2021 Jun 24.

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Background: Visual fixation may be affected in amblyopic patients and, moreover, its stability may be associated with the effects of amblyopic treatments on visual performance in patients with strabismus. Therefore, fixation stability is a relevant biomarker that might predict the recurrence of amblyopia after a therapeutic intervention. Microperimetric biofeedback fixation training (BFT) can stabilize visual fixation in adult patients with central vision loss. Read More

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Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment: presumed role of glial cells for foveal structure stabilization.

Int J Ophthalmol 2021 18;14(6):818-833. Epub 2021 Jun 18.

Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig 04103, Germany.

Aim: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema (CME) without and with internal limiting membrane (ILM) detachment and to discuss the presumed role of the glial scaffold for foveal structure stabilization.

Methods: A retrospective case series of 38 eyes of 35 patients is described. Of these, 17 eyes of 16 patients displayed foveal regeneration after resolution of CME, and 6 eyes of 6 patients displayed CME with ILM detachment. Read More

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Quantitative evaluation of photoreceptor density in chronic central serous chorioretinopathy using the Spectralis High Magnification Module.

Photodiagnosis Photodyn Ther 2021 Jun 17;35:102410. Epub 2021 Jun 17.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou, China. Electronic address:

Purpose: To quantitatively evaluate the photoreceptor density in patients with chronic central serous chorioretinopathy (cCSC) using the Spectralis High Magnification Module (HMM).

Methods: Twenty-four eyes of 24 patients with resolved cCSC, 24 fellow eyes from 24 other patients with unilateral cCSC, and 24 normal eyes of 24 healthy clients were enrolled in this observational case study. Photoreceptor densities of the retina in the nasal, temporal, superior, and inferior areas 500 μm from the central fovea were counted manually through the High Magnification Module (HMM) images using ImageJ software, and the average values were taken for further analysis. Read More

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Quantifying frequency content in cross-sectional retinal scans of diabetics vs. controls.

PLoS One 2021 18;16(6):e0253091. Epub 2021 Jun 18.

School of Optometry, Indiana University, Bloomington, Indiana, United States of America.

Purpose: To examine subtle differences in the structure of diabetic vs. control retinas.

Methods: Spectral-domain optical coherence tomography (SD-OCT) images were compared for the retinas of 33 diabetic subjects who did not have clinical evidence of diabetic macular edema and age-matched controls, with central macular thicknesses of 275 and 276 microns, respectively. Read More

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Clinical and Morphologic Characteristics of ERK Inhibitor-Associated Retinopathy.

Ophthalmol Retina 2021 Jun 5. Epub 2021 Jun 5.

Ophthalmic Oncology Service; Department of Medicine.

Purpose: Investigate clinical and morphologic characteristics of serous retinal disturbances in patients taking extracellular signal-regulated kinase (ERK) inhibitors.

Participants: Of 61 patients receiving ERK inhibitors for treatment of metastatic cancer, this study included 40 eyes of 20 patients with evidence of retinopathy confirmed by optical coherence tomography (OCT).

Design: Single center, retrospective study of prospectively collected data METHODS: Clinical exam, fundus photography and OCT were used to evaluate ERK inhibitor retinopathy. Read More

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Müller cells and astrocytes in tractional macular disorders.

Prog Retin Eye Res 2021 Jun 5:100977. Epub 2021 Jun 5.

Department of Ophthalmology and Eye Hospital, University of Leipzig, 04103, Leipzig, Germany.

Tractional deformations of the fovea mainly arise from an anomalous posterior vitreous detachment and contraction of epiretinal membranes, and also occur in eyes with cystoid macular edema or high myopia. Traction to the fovea may cause partial- and full-thickness macular defects. Partial-thickness defects are foveal pseudocysts, macular pseudoholes, and tractional, degenerative, and outer lamellar holes. Read More

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A bias in saccadic suppression of shape change.

Vision Res 2021 Sep 2;186:112-123. Epub 2021 Jun 2.

Allgemeine und Biologische Psychologie, Philipps-Universität Marburg, Marburg, Germany; Center for Mind, Brain and Behaviour, Philipps-Universität Marburg, Marburg, Germany.

Processing of visual information in the central (foveal) and peripheral visual field is vastly different. To achieve a homogeneous representation of the visual world across eye movements, the visual system needs to compensate for these differences. By introducing subtle changes between peripheral and foveal inputs across saccades, one can test this compensation. Read More

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September 2021

Baseline Optical Coherence Tomography Parameters That May Influence 6 Months Treatment Outcome of Polypoidal Choroidal Vasculopathy Eyes with Combination Therapy: A Short-Term Pilot Study.

Int J Environ Res Public Health 2021 05 18;18(10). Epub 2021 May 18.

Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Malaysia.

Although optical coherence tomography (OCT) parameters have assisted in the diagnosis of polypoidal choroidal vasculopathy (PCV), its potential to evaluate treatment outcomes has not been established. The purpose of this pilot study was to evaluate baseline OCT parameters that may influence treatment outcome in PCV eyes with combination therapy. In this single-centered, prospective study, patients were recruited with at least one treatment-naïve PCV eye and treated with combination therapy of intravitreal anti-vascular endothelial growth factor and photodynamic therapy. Read More

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Choriocapillaris flow loss in center-involving retinitis pigmentosa: a quantitative optical coherence tomography angiography study using a novel classification system.

Graefes Arch Clin Exp Ophthalmol 2021 May 31. Epub 2021 May 31.

Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose: Choriocapillaris insufficiency may play a role in centripetal retinitis pigmentosa (RP) progression involving the fovea. However, the relationship between choriocapillaris integrity and foveal damage in RP is unclear. We examined the relationship between choriocapillaris flow and the presence of foveal photoreceptor involvement in RP. Read More

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In vivo cellular imaging of the retina: present and future

Orv Hetil 2021 05 30;162(22):851-860. Epub 2021 May 30.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Anatómiai, Szövet- és Fejlődéstani Intézet, Budapest, Tűzoltó u. 58., 1094.

Összefoglaló. A látószerv különböző betegségei, valamint egyes szisztémás megbetegedések részben vagy kifejezetten az ideghártya károsodásával járnak. A patológia segítségével ma már tudjuk, hogy ezek a betegségek a retina mely rétegének vagy rétegeinek elváltozásait okozzák: míg az időskori maculadegeneratio a külső retinában található fotoreceptorokat érinti kifejezetten a fovea centralis területén, addig a glaucoma a belső retina ganglionsejtjeinek pusztulásával, valamint e sejtek opticusrostjainak károsodásával jár a stratum ganglionaréban és a stratum neurofibrarumban. Read More

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A window into the future? MRI for evaluation of neuromyelitis optica spectrum disorder throughout the disease course.

Ther Adv Neurol Disord 2021 9;14:17562864211014389. Epub 2021 May 9.

St. Michael's Hospital, 30 Bond Street, Shuter 3-018, Toronto, ON, M5B 1W8, Canada.

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, inflammatory disease of the central nervous system marked by relapses often associated with poor recovery and long-term disability. Magnetic resonance imaging (MRI) is recognized as an important tool for timely diagnosis of NMOSD as, in combination with serologic testing, it aids in distinguishing NMOSD from possible mimics. Although the role of MRI for disease monitoring after diagnosis is not as well established, MRI may provide important prognostic information and help differentiate between relapses and pseudorelapses. Read More

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Microstructural changes after half-dose photodynamic therapy in patients with chronic central serous chorioretinopathy.

Photodiagnosis Photodyn Ther 2021 May 24;35:102347. Epub 2021 May 24.

Department of Ophthalmology, School of Medicine, Cukurova University, Adana, Turkey. Electronic address:

Background: To evaluate the retinal and choroidal microstructural changes at fovea after half-dose photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (CSC), using optical coherence tomography (OCT).

Methods: The study included 35 eyes with unilateral chronic CSC treated with half-dose PDT. The foveal outer nuclear layer (ONL) and subfoveal choroidal thickness (SFCT) in the affected eyes were compared with baseline measurements at month 1, 3, and 6 after half-dose PDT, and those of the healthy contralateral eyes. Read More

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