37,112 results match your criteria central diabetes

Chronic Kidney Disease of Undetermined Etiology around the World.

Kidney Blood Press Res 2021 Apr 12:1-10. Epub 2021 Apr 12.

Nephrology and Dialysis, G. Brotzu Hospital, Università degli Studi di Cagliari, Cagliari, Italy.

Background: Epidemics of chronic kidney disease of uncertain etiology (CKDu) are occurring on the Pacific coast of Central America, in Sri Lankan and Indian agricultural communities, and in other hotspots around the world. CKDu primarily affects male agricultural workers, and traditional risk factors such as diabetes and hypertension are not involved in the pathogenesis. Although a causal factor has not yet been identified, culprits include repeated volume depletion-induced kidney injury, as well as exposure to agrichemicals, heavy metals and nephrotoxins contained in drugs, beverages, and traditional medications. Read More

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Effects of SGLT2 inhibitor on ischemic events stemming from atherosclerotic coronary diseases: A systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

J Cardiovasc Pharmacol 2021 Apr 8. Epub 2021 Apr 8.

Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to reduce cardiovascular complications of type 2 diabetes mellitus. However, the beneficial effects of SGLT2 inhibition are mainly associated with decline in hospitalization and death of heart failure. This systematic review will focus on the effect of SGLT2 inhibitors on ischemic events stemming from atherosclerotic coronary diseases, including angina pectoris, angina unstable, and myocardial infarction. Read More

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Contribution of food groups to energy, grams and nutrients-to-limit: The Latin American Study of Nutrition and Health/Estudio Latino Americano de Nutrición y Salud (ELANS).

Public Health Nutr 2021 Apr 12:1-34. Epub 2021 Apr 12.

Nutrition and Feeding Difficulties Center- PENSI, Brazil.

Objective: To quantify the energy, nutrients-to-limit and total gram amount consumed, and identify their top food sources consumed by Latin Americans.

Design: Data from The Latin American Study of Nutrition and Health (ELANS).

Setting: ELANS is a cross-sectional study representative of eight Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela. Read More

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GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery.

J Med Chem 2021 Apr 10. Epub 2021 Apr 10.

Department of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged as new and exciting drug targets, due to their plausible translation from pharmacology to medicines. This perspective aims to report recent research about GPR120/FFAR4 and its involvement in several diseases, including cancer, inflammatory conditions, and central nervous system disorders. The focus is to highlight the importance of GPR120 in Type 2 diabetes mellitus (T2DM). Read More

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LncRNA MEG3 Alleviates Diabetic Cognitive Impairments by Reducing Mitochondrial-Derived Apoptosis through Promotion of FUNDC1-Related Mitophagy via Rac1-ROS Axis.

ACS Chem Neurosci 2021 Apr 12. Epub 2021 Apr 12.

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410078, Hunan, China.

Mitochondrial dysfunction and elevated ROS generation are predominant contributors of neuronal death that is responsible for the diabetes-related cognitive impairments. Emerging evidence has demonstrated that long noncoding RNA-MEG3 can serve as an important regulator in the pathogenesis of diabetes. However, the underlying mechanisms remain to be further clarified. Read More

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A clinical diagnostic model based on an eXtreme Gradient Boosting algorithm to distinguish type 1 diabetes.

Ann Transl Med 2021 Mar;9(5):409

Department of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, Changsha, China.

Background: Accurate classification of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in the early phase is crucial for individual precision treatment. This study aimed to develop a classification model having fewer and easier to access clinical variables to distinguish T1DM in newly diagnosed diabetes in adults.

Methods: Clinical and laboratory data were collected from 15,206 adults with newly diagnosed diabetes in this cross-sectional study. Read More

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Decreased serum fibroblast growth factor 19 level is a risk factor for type 1 diabetes.

Ann Transl Med 2021 Mar;9(5):376

Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.

Background: Increasing evidence suggests that fibroblast growth factor 19 (FGF19) is a regulator of glucose metabolism and may provide a new therapeutic target for type 1 diabetes (T1D). However, the clinical relevance of FGF19 in T1D remains unclear. In this study, we examined the relationship between the serum FGF19 concentration and T1D. Read More

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Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease.

Front Med (Lausanne) 2021 24;8:659013. Epub 2021 Mar 24.

Université de Paris, Paris Cardiovascular Center, Inserm, Paris, France.

Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Read More

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Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials.

Front Public Health 2021 26;9:645035. Epub 2021 Mar 26.

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

This study aimed to review the data from randomized controlled trials (RCTs) and identify evidence for microbiota's role and use of probiotics, pre-biotics, or synbiotics in pre-diabetes. RCTs of pro-, pre-, synbiotics for the treatment of pre-diabetes population will be summarized. We searched for EMBASE, MEDLINE, Web of Science, Cochrane Central, Clinical Trials (ClinicalTrials. Read More

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Association between maternal folate status and gestational diabetes mellitus.

Food Sci Nutr 2021 Apr 17;9(4):2042-2052. Epub 2021 Feb 17.

Department of Metabolism and Endocrinology Metabolic Syndrome Research Center Key Laboratory of Diabetes Immunology Ministry of Education National Clinical Research Center for Metabolic Diseases The Second Xiangya Hospital of Central South University Changsha China.

Studies on the association between maternal folate status and gestational diabetes mellitus (GDM) have yielded inconsistent results. This meta-analysis was performed to determine whether there may exist some association between maternal folate status and GDM. Unrestricted searches of PubMed, Web of Science, Cochrane, and Embase were conducted. Read More

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Risk factors for cognitive impairment in patients with first-time ischemic stroke.

Am J Transl Res 2021 15;13(3):1884-1889. Epub 2021 Mar 15.

Department of The Third Neurology, Cangzhou Central Hospital Cangzhou 061000, Hebei, China.

Objective: To determine the risk factors for cognitive impairment (CI) in patients with first-time ischemic stroke.

Methods: The clinical data of 180 patients with ischemic stroke who were admitted to our hospital from January 2018 to December 2019 was retrospectively analyzed. Patients with MMSE score ≤24 were included into the CI group and the rest of the patients were placed into the normal group. Read More

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Centrality Analysis of Protein-Protein Interaction Networks and Molecular Docking Prioritize Potential Drug-Targets in Type 1 Diabetes.

Iran J Pharm Res 2020 ;19(4):121-134

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Type 1 diabetes (T1D) occurs as a consequence of an autoimmune attack against pancreatic β- cells. Due to a lack of a clear understanding of the T1D pathogenesis, the identification of effective therapies for T1D is the active area in the research. The study purpose was to prioritize potential drugs and targets in T1D via systems biology approach. Read More

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January 2020

Associations of Mitochondrial Variants With Lipidomic Traits in a Chinese Cohort With Coronary Artery Disease.

Front Genet 2021 25;12:630359. Epub 2021 Mar 25.

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.

Plasma lipids have been at the center stage of the prediction and prevention strategies for cardiovascular diseases (CVDs), and novel lipidomic traits have been recognized as reliable biomarkers for CVD risk prediction. The mitochondria serve as energy supply sites for cells and can synthesize a variety of lipids autonomously. Therefore, investigating the relationships between mitochondrial single nucleotide polymorphism (SNPs) and plasma lipidomic traits is meaningful. Read More

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Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice.

Front Immunol 2021 25;12:645817. Epub 2021 Mar 25.

St. Vincent's Institute, Fitzroy, VIC, Australia.

T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differentially expressed, with predominant proinsulin-2 expression in the thymus and proinsulin-1 in islet beta-cells. In contrast to proinsulin-2, proinsulin-1 knockout NOD mice are protected from autoimmune diabetes. Read More

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Efficacy of Various Hypoglycemic Agents in the Treatment of Patients With Nonalcoholic Liver Disease With or Without Diabetes: A Network Meta-Analysis.

Front Endocrinol (Lausanne) 2021 24;12:649018. Epub 2021 Mar 24.

Department of Endocrinology, Xijing Hospital of Air Force Medical University, Xi'an, China.

Objective: To comprehensively evaluate and compare the therapeutic effects of various hypoglycemic agents in NAFLD patients with or without diabetes.

Methods: All literature from the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Clinical Trials was searched, and the language was limited to English. Two reviewers independently assessed study eligibility, continuous data extraction, and independent assessment of bias risk. Read More

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Can case-based discussions in a group setting be used to assess residents' clinical skills?

Int J Med Educ 2021 Apr 9;12:64-73. Epub 2021 Apr 9.

Diagnostic Center, Regional Hospital Silkeborg, Regional Hospital Central, Jutland, Denmark.

Objectives: The purpose of this study was to explore residents' and assessors' perception of a new group assessment concept.

Methods: This qualitative study consists of observations of four group assessment sessions, followed by semi-structured interviews with six residents and four assessors (specialists in internal medicine), who all volunteered to be interviewed. All residents at a medical department (eleven to fifteen each time) and four assessors participated in four group assessments, where the residents' clinical skills were assessed through case-based discussions. Read More

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Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach.

Environ Sci Pollut Res Int 2021 Apr 11. Epub 2021 Apr 11.

Mahavir Cancer Sansthan and Research Centre, Phulwarisharif, Patna, Bihar, 801505, India.

Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar, out of 38 districts, 18 districts are exceptionally influenced with groundwater arsenic defilement. Read More

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Uncontrolled diabetes mellitus and advanced cirrhosis.

Yan Zong

Dig Liver Dis 2021 Apr 8. Epub 2021 Apr 8.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes.

Transl Oncol 2021 Apr 7;14(7):101089. Epub 2021 Apr 7.

Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung City 807, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Taiwan; Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Liquid Biopsy and Cohort Research, Taiwan. Electronic address:

Diabetes mellitus (DM) and hyperglycemia have been shown to have significant effects on the incidence, chemoresistance, and prognosis of colorectal cancer (CRC), as well as the outcomes of localized and metastatic CRC. Inflammation and endocrine effects may act as central mechanisms of DM and cancer and stimulate the insulin-like growth factor 1-phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (IGF-1-PI3K-AKT-mTOR) pathway. Dysregulation of the AMP-activated protein kinase (AMPK) pathway leads to metabolic imbalance and indicates cancer risk. Read More

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Role of dietary modifications in the management of type 2 diabetic complications.

Pharmacol Res 2021 Apr 7:105602. Epub 2021 Apr 7.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Diabetes is a chronic metabolic disorder with a high rate of morbidity and mortality. Insufficient insulin secretion and insulin action are two major causes for the development of diabetes, which is characterized by a persistent increase in blood glucose level. Diet and sedentary life style play pivotal role in development of vascular complications in type 2 diabetes. Read More

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Effect of cataract surgery on wet age-related macular degeneration activity.

Acta Ophthalmol 2021 Apr 10. Epub 2021 Apr 10.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Background: Wet age-related macular degeneration (AMD) and age-related cataract are often coexisting causes of visual impairment. Yet, the timing of cataract surgery in wet AMD patients is controversial.

Methods: One hundred and eleven eyes of 111 patients with wet AMD underwent cataract surgery at Helsinki University Hospital in Finland during 2014-2018. Read More

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Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.

Pediatr Diabetes 2021 Apr 10. Epub 2021 Apr 10.

Life for a Child Program, Diabetes NSW, Glebe, New South Wales, Australia.

To further understand clinical and biochemical features, and HLA-DRB1 genotypes, in new cases of diabetes in Sudanese children and adolescents. Demographic characteristics, clinical information, and biochemical parameters (blood glucose, HbA1c, C-peptide, autoantibodies against glutamic acid decarboxylase 65 [GADA] and insulinoma-associated protein-2 [IA-2A], and HLA-DRB1) were assessed in 99 individuals <18 years (y), recently (<18 months) clinically diagnosed with T1D. HLA-DRB1 genotypes for 56 of these Arab individuals with T1D were compared to a mixed control group of 198 healthy Arab (75%) and African (25%) individuals without T1D. Read More

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The Combination of Disease Duration to Age at Diagnosis and Hemoglobin A1c to Serum C-Peptide Reactivity Ratios Predicts Patient Response to Glucose-lowering Medication in Type 2 Diabetes: A Retrospective Cohort Study Across Japan (JDDM59).

J Diabetes Investig 2021 Apr 10. Epub 2021 Apr 10.

Department of Medicine, Division of Diabetology, Endocrinology, and Nephrology, Shiga University of Medical Science, Otsu, Japan.

Aims/introduction: Knowing the collective clinical factors that determine patient response to glucose-lowering medication would be beneficial in the treatment of type 2 diabetes. We conducted a retrospective cohort study to explore the combination of clinical factors involved in its therapeutic efficacy.

Materials And Methods: Results of cohort studies retrieved using the CoDiC database across Japan from January 2005 to July 2018 were analyzed based on criterion that using insulin therapy indicates severe type 2 diabetes. Read More

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Ethnic variation, socioeconomic status, and factors associated with cardio-metabolic multi-morbidity among uncontrolled hypertension in multiethnic Singapore.

J Hum Hypertens 2021 Apr 9. Epub 2021 Apr 9.

Program in Health Services and Systems Research, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

Identifying patients with hypertension at high risk of cardio-metabolic multi-morbidity (CMM) is key for intervention. We examined the independent association of CMM with ethnicity and socioeconomic status (SES) among patients with uncontrolled hypertension. Demographic, socioeconomic, lifestyle, and clinical factors were obtained from 921 patients aged ≥40 years with hypertension in the multiethnic Singapore. Read More

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Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography.

BMC Ophthalmol 2021 Apr 9;21(1):170. Epub 2021 Apr 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital affiliated with Tongji University, 301 Middle Yan Chang Road, Shanghai, 200072, People's Republic of China.

Background: Retinal capillary is vulnerable to diabetes, whether gestational diabetes mellitus (GDM) eyes without clinical retinopathy have capillary abnormalities has not been well studied. To observe the microvasculature changes in eyes of GDM women compared with normoglycemic pregnant women and non-pregnant women by optical coherence tomography-angiography (OCT-A).

Methods: GDM women, age-matched normoglycemic pregnant women and non-pregnant women were included in this study. Read More

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A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism.

PLoS Comput Biol 2021 Apr 9;17(4):e1008891. Epub 2021 Apr 9.

Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden.

The interplay between nutrient-induced signaling and metabolism plays an important role in maintaining homeostasis and its malfunction has been implicated in many different human diseases such as obesity, type 2 diabetes, cancer, and neurological disorders. Therefore, unraveling the role of nutrients as signaling molecules and metabolites together with their interconnectivity may provide a deeper understanding of how these conditions occur. Both signaling and metabolism have been extensively studied using various systems biology approaches. Read More

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From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment.

FASEB J 2021 May;35(5):e21374

Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics School, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Inhibition of insulin-degrading enzyme (IDE) is a possible target for treating diabetes. However, it has not yet evolved into a medical intervention, mainly because most developed inhibitors target the zinc in IDE's catalytic site, potentially causing toxicity to other essential metalloproteases. Since IDE is a cellular receptor for the varicella-zoster virus (VZV), we constructed a VZV-based inhibitor. Read More

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Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight.

Aging (Albany NY) 2021 Apr 4;13. Epub 2021 Apr 4.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Genome-wide association studies (GWASs) have identified hundreds of genetic loci for type 2 diabetes (T2D) and birth weight (BW); however, a large proportion of the total trait heritability remains unexplained. The previous studies were generally focused on individual traits and largely failed to identify the majority of the variants that play key functional roles in the etiology of the disease. Here, we aim to identify novel functional loci for T2D, BW and the pleiotropic variants shared between them by performing a targeted conditional false discovery rate (cFDR) analysis that integrates two independent GWASs with summary statistics for T2D ( = 26,676 cases and 132,532 controls) and BW ( = 153,781) which entails greater statistical power than individual trait analyses. Read More

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A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

Acta Dermatovenerol Croat 2020 Dec;28(4):249-250

Hisayoshi Imanishi, MD, PhD, Division of Dermatology, Daito Central Hospital, 2-1-11 Ono, Daito, Osaka 574-0042, Japan;

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. Read More

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December 2020