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Prevalence and Risk Factors of Intestinal Helminthiasis in Remote Mountainous Villages of Northern Lao PDR: A Cross-Sectional Study.

Korean J Parasitol 2021 Apr 22;59(2):131-138. Epub 2021 Apr 22.

Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 03080, Korea.

Helminth infections are prevalent in Lao People's Democratic Republic (Lao PDR). This study aimed at determining the prevalence and risk factors of intestinal helminthiasis in remote mountainous villages of northern Lao PDR. During the dry season in January 2017, a cross-sectional survey was conducted in 3 remote mountainous villages in Oudomxay province, Lao PDR. Read More

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Bee- and Wasp-Venom Sensitization in Schoolchildren of High- and Low-Socioeconomic Status Living in an Urban Area of Indonesia.

Int Arch Allergy Immunol 2021 May 5:1-10. Epub 2021 May 5.

Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.

Background: There is not much known about venom allergy in tropical regions. Here, we studied the prevalence of specific IgE (sIgE) and skin prick test (SPT) reactivity and reported sting-related symptoms, in high- and low-socioeconomic status (SES) schoolchildren living in urban city of Makassar in Indonesia.

Methods: Children from high- (n = 160) and low- (n = 165) SES schools were recruited. Read More

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Multiple sclerosis-like NMOSD patients suffer severe worsening of status after fingolimod initiation.

Mult Scler Relat Disord 2021 Apr 24;52:102975. Epub 2021 Apr 24.

Service de Neurologie, Hôpital Zobda Quitman, 97261 Fort-de-France, French West Indies.

Background: Initial clinical manifestations of NMOSD may rarely overlap with MS. Fingolimod may trigger severe attacks in patients with NMOSD previously misdiagnosed as MS. These cases are rare and their pathophysiology remains elusive. Read More

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Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, PRC. Electronic address:

Purpose: To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life outcomes to medical treatment in China.

Design: LiGHT China trial is an unmasked, single-center, pragmatic, Randomized controlled trial.

Methods: 771 previously undiagnosed patients with primary open angle glaucoma (POAG, 622 patients) or ocular hypertension (OHT, 149 patients) at Zhongshan Ophthalmic Center were recruited from March 2015 to January 2019. Read More

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Confirming the contribution and genetic spectrum of de novo mutation in infantile spasms: Evidence from a Chinese cohort.

Mol Genet Genomic Med 2021 May 5:e1689. Epub 2021 May 5.

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, China.

Objective: We determined the yield, genetic spectrum, and actual origin of de novo mutations (DNMs) for infantile spasms (ISs) in a Chinese cohort. The efficacy of levetiracetam (LEV) for STXBP1-related ISs was explored also.

Methods: Targeted sequencing of 153 epilepsy-related candidate genes was applied to 289 Chinese patients with undiagnosed ISs. Read More

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Prevalence and factors associated with ulcer-related pain in persons with chronic leg ulcers-an explorative study.

J Clin Nurs 2021 May 5. Epub 2021 May 5.

Faculty of Nursing and Health Sciences, University of South-Eastern, Notodden, Norway.

Aims And Objectives: The aims of this study were to explore the prevalence of background pain and identify demographic, clinical and psychosocial factors associated with moderate to severe background pain in persons with leg ulcers.

Background: All chronic leg ulcers are potentially painful. Research indicates that 80% of persons with chronic leg ulcers experience wound-related background pain. Read More

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Degradation of the Endothelial Glycocalyx Contributes to Metabolic Acidosis in Children Following Cardiopulmonary Bypass Surgery.

Pediatr Crit Care Med 2021 May 4. Epub 2021 May 4.

Paediatric Intensive Care, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Department of Women and Children's Health, School of Life Course Sciences, King's College London, St Thomas' Hospital, London, United Kingdom. Thrombosis and Vascular Biology Research Group, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Department of Cardiology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Institute of Women and Children's Health, King's College London, St Thomas' Hospital, London, United Kingdom. Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom. Department of Intensive Care, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Objectives: Cardiopulmonary bypass surgery is complicated by metabolic acidosis, microvascular dysfunction, and capillary leak. The glycocalyx-a layer of proteins and sugars lining the vascular endothelium-is degraded during cardiopulmonary bypass. We aimed to describe the kinetics of glycocalyx degradation during and following cardiopulmonary bypass. Read More

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Cost-Effectiveness Implications of Increasing the Efficiency of the Extended-Release Naltrexone Induction Process for the Treatment of Opioid Use Disorder: A Secondary Analysis.

Addiction 2021 May 5. Epub 2021 May 5.

Department of Healthcare Policy & Research, Weill Cornell Medical College, New York, NY, USA.

Background And Aims: In a United States randomized-effectiveness trial comparing extended-release naltrexone (XR-NTX) with buprenorphine-naloxone (BUP-NX) for the prevention of opioid relapse among participants recruited during inpatient detoxification (CTN-0051), the requirement to complete opioid detoxification prior to initiating XR-NTX resulted in lower rates of initiation of XR-NTX (72%-XR-NTX vs. 94%-BUP-NX). This led to higher relapse rates and average healthcare costs among XR-NTX participants. Read More

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Shame in medical clerkship: "You just feel like dirt under someone's shoe".

Perspect Med Educ 2021 May 5. Epub 2021 May 5.

Centre for Medical Education and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Introduction: This study explores how senior medical students' experience and react to shame during clinical placements by asking them to reflect on (1) manifestations of shame experiences, (2) situations and social interactions that give rise to shame, and (3) perceived effects of shame on learning and professional identity development.

Methods: In this interpretive study, the authors recruited 16 senior medical students from two classes at a Norwegian medical school. In three focus group interviews, participants were invited to reflect on their experiences of shame. Read More

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Persistence of inefficient HIV prevention interventions: a mixed-method analysis of the reasons why.

Transl Behav Med 2021 May 5. Epub 2021 May 5.

The Brown School, Washington University in St. Louis, St. Louis, MO, USA.

Growing evidence suggests that public health organizations continue to provide inefficient interventions even when better intervention options may be available. Factors informing an organization's decision to continue providing inefficient interventions are unclear. We present an analysis of HIV service organizations to understand factors influencing organizations to continue or end interventions. Read More

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The contributions of the left hippocampus and bilateral inferior parietal lobule to form-meaning associative learning.

Psychophysiology 2021 May 5:e13834. Epub 2021 May 5.

Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, China.

Existing studies have identified crucial roles for the hippocampus and a distributed set of cortical regions (e.g., the inferior parietal cortex) in learning novel words. Read More

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Description of Participants in the "Atout Age Mobility" Prevention Workshops at the University Hospital Center of La Réunion: A Prospective Study.

J Nutr Health Aging 2021 ;25(5):628-636

Dr Legrand Florian, Chef de clinique des universités - médecine générale, UFR Santé - Département universitaire de médecine générale, Université de La Réunion, Site de l'IES - CHU Réunion, Terre Sainte BP 350, 97448 Saint Pierre Cedex, E-mail: Tel: 0692721402 E-mail address:

Introduction: As the population ages, loss of autonomy is becoming a priority public health issue. "Atout Age Mobility" prevention interventions for seniors aim to limit frailty, which is a predictive and reversible factor in the loss of autonomy and disability.

Objectives: The objective of this study is to describe the impact of these interventions on the physical performance and quality of life of a pilot sample of participants. Read More

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January 2021

Analysis of the Prevalence of Sarcopenia and Its Risk Factors in the Elderly in the Chengdu Community.

J Nutr Health Aging 2021 ;25(5):600-605

Birong Dong, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China, Email:

Objective: To understand the prevalence of sarcopenia in the Chengdu community, analyze the risk factors of sarcopenia, and provide a theoretical basis for further development of strategies for sarcopenia prevention and treatment.

Methods: A total of 938 individuals aged 60 years and above were recruited from the community of Chengdu. Skeletal muscle mass was measured by the bioelectrical impedance analysis (BIA), and sarcopenia was diagnosed according to the Asian Sarcopenia Working Group (AWGS) 2019 diagnostic criteria. Read More

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January 2021

Maternal Mental Health Symptoms and Clusters Predict Toddler Sleep in Low-Income Homes.

J Genet Psychol 2021 May 5:1-17. Epub 2021 May 5.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, Ohio, USA.

The authors examined the association of maternal mental health symptoms and symptom clusters with the sleeping behaviors of toddlers living in low-income homes. The sample is comprised of 174 racially diverse mother and toddler (15-19 months old) dyads who were participating in a longitudinal birth cohort study. Dyads were initially recruited from Women, Infant, and Children clinics in a Midwestern county of the United States. Read More

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Depression in midlife women attending a menopause clinic is associated with a history of childhood maltreatment.

Climacteric 2021 May 5:1-5. Epub 2021 May 5.

Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

A growing body of literature has suggested that the perimenopause and the early postmenopausal years are associated with an increased risk of experiencing symptoms of depression and the development of first-onset and recurrent episodes of major depressive disorder. Multiple risk factors have been identified, including stressful life events and lower socioeconomic status, as well as early life adversity. The objective of the current study was to characterize the influence of early life childhood maltreatment and incident depression among women experiencing bothersome menopausal symptoms. Read More

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Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection-A Multicenter Feasibility Randomized Controlled Trial.

J Intensive Care Med 2021 May 5:8850666211014480. Epub 2021 May 5.

Department of Critical Care Medicine, Apollo Main Hospital, Chennai, Tamilnadu, India.

Rationale: The feasibility and safety of awake prone positioning and its impact on outcomes in non-intubated patients with acute respiratory distress syndrome secondary to COVID-19 is unknown. Results of the observational studies published during this pandemic have been conflicting. In this context, we conducted a multi-center, parallel group, randomized controlled feasibility study on awake prone positioning in non-intubated patients with COVID-19 pneumonia requiring supplemental oxygen. Read More

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The oral microbiome in early rheumatoid arthritis patients and individuals at risk differs from healthy controls.

Arthritis Rheumatol 2021 May 4. Epub 2021 May 4.

Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry of Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objective: It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. Our aim was to assess the oral microbiome and the periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA.

Methods: Three groups were recruited (50 participants each): (1) ERA patients (2010 ACR/EULAR criteria), (2) at-risk individuals (arthralgia and autoantibodies), and (3) healthy controls. Read More

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Semiparametric regression analysis of bivariate censored events in a family study of Alzheimer's disease.

Biostatistics 2021 May 5. Epub 2021 May 5.

Department of Biostatistics, Columbia University, New York, NY 10032, USA.

Assessing disease comorbidity patterns in families represents the first step in gene mapping for diseases and is central to the practice of precision medicine. One way to evaluate the relative contributions of genetic risk factor and environmental determinants of a complex trait (e.g. Read More

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Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.

Cell Rep Med 2021 Apr 8;2(4):100239. Epub 2021 Apr 8.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. Here, we show that neutrophils recruited to CF airways and in an transmigration model display rapid and broad transcriptional firing, leading to an upregulation of anabolic genes and a downregulation of antimicrobial genes. Read More

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Serum Levels of ITGBL1 as an Early Diagnostic Biomarker for Hepatocellular Carcinoma with Hepatitis B Virus Infection.

J Hepatocell Carcinoma 2021 27;8:285-300. Epub 2021 Apr 27.

Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200025, People's Republic of China.

Purpose: Early diagnostic biomarkers of hepatocellular carcinoma (HCC) are needed to distinguish hepatitis B virus (HBV) associated HCC (HBV-HCC) patients from at-risk patients. We assessed the diagnostic values of serum Integrin beta-like 1 (ITGBL1) for early-stage HBV-HCC.

Patients And Methods: We recruited 716 participators including 299 in the training and 417 in the validation stage, (HBV-HCC, chronic hepatitis B (CHB), HBV-related liver cirrhosis (HBV-LC), and healthy controls) between 2017 and 2020 from three centers. Read More

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Contemporary external beam radiotherapy boost or high dose-rate brachytherapy boost for cervical cancer: a propensity-score-matched, nationwide, population-based cohort study.

Am J Cancer Res 2021 15;11(4):1719-1732. Epub 2021 Apr 15.

Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University Taichung, Taiwan.

To estimate the survival effects of contemporary external beam radiotherapy (EBRT) boost modalities (intensity-modulated radiation therapy or volumetric modulated arc therapy) and high dose-rate brachytherapy (HDR-BT) boost in patients with cervical cancer (CC). Patients who had been diagnosed as having CC were recruited from the Taiwan Cancer Registry Database. Propensity score matching was performed, and Cox proportional-hazards model curves were used to analyze the all-cause mortality of patients who received standard whole-pelvis irradiation with different boost modalities. Read More

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Understanding shared decision-making experience among vulnerable population: Focus group with food bank clients.

J Clin Transl Sci 2020 Aug 25;5(1):e37. Epub 2020 Aug 25.

School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: Shared decision-making (SDM) is a critical component of delivering patient-centered care. Members of vulnerable populations may play a passive role in clinical decision-making; therefore, understanding their prior decision-making experiences is a key step to engaging them in SDM.

Objective: To understand the previous healthcare experiences and current expectations of vulnerable populations on clinical decision-making regarding therapeutic options. Read More

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Ageism and older people's health and well-being during the Covid-19-pandemic: the moderating role of subjective aging.

Eur J Ageing 2021 Apr 30:1-12. Epub 2021 Apr 30.

Department of Behavioural and Cognitive Sciences, University of Luxembourg, 11, Porte des Sciences, 4366 Esch-sur-Alzette, Luxembourg.

In the Covid-19 pandemic, being older means being in a special focus: Probabilities for severe infections and mortality rise with increasing age and protective measures for this population group have been increased. This was accompanied by public discourse that portrayed older adults stereotypically as vulnerable and frail but also highlighted the hardships younger people have to endure to protect them. Given the possibly detrimental effects of ageism on individuals and societies, we were interested in older adults' perception of ageism in the Corona-crisis and its relation to their health and well-being. Read More

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Factors Associated With Lower Limb Injuries in Recreational Runners: A Cross-Sectional Survey Including Mental Aspects and Sleep Quality.

J Sports Sci Med 2021 Jun 5;20(2):204-215. Epub 2021 Mar 5.

University of Groningen, University Medical Center Groningen, Center for Human Movement Science, The Netherlands.

Knowledge about prevalence and etiology of running-related injuries (RRIs) is important to design effective RRI prevention programs. Mental aspects and sleep quality seem to be important potential risk factors, yet their association with RRIs needs to be elucidated. The aims of this study are to investigate the epidemiology of RRIs in recreational runners and the association of mental aspects, sleep, and other potential factors with RRIs. Read More

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Differential Co-Occurring Patterns Between Depressive Symptomatology and Sleep-Wake-Related Disturbances in Mood Disorders.

Nat Sci Sleep 2021 27;13:503-514. Epub 2021 Apr 27.

Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: This study aimed to elucidate the various co-occurring patterns of depressive symptomatology and sleep-wake-related disturbances (SWRDs) in patients with mood disorders.

Patients And Methods: Individuals in non-acute states of major depressive disorder or bipolar disorder were recruited. The Beck Depression Inventory II (BDI-II) was utilized to evaluate depressive symptoms. Read More

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The impact of COVID-19 pandemic on gastrointestinal diseases: a single-center cross-sectional study in central Greece.

Ann Gastroenterol 2021 26;34(3):323-330. Epub 2021 Feb 26.

Department of Gastroenterology, University Hospital of Larissa, Thessaly, Greece (Apostolis Papaefthymiou, Apostolos Koffas, Agoritsa Kaltsa, Fotis Tsiopoulos, Andreas Kapsoritakis, Spyros Potamianos).

Background: The current COVID-19 pandemic induced a suppressive environment for healthcare professionals and patients, especially during the lockdown period. Except for the direct burden of the COVID-19, collateral damage has been identified concerning other diseases. The aim of this study was to evaluate the potential impact of the lockdown on the non-COVID-19 patients' outcome in a tertiary gastroenterology department. Read More

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February 2021

A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats.

Nat Commun 2021 May 4;12(1):2517. Epub 2021 May 4.

Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA.

Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Read More

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SIK2 orchestrates actin-dependent host response upon infection.

Proc Natl Acad Sci U S A 2021 May;118(19)

Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt am Main, Germany;

is an intracellular pathogen of a substantial global health concern. In order to identify key players involved in infection, we performed a global host phosphoproteome analysis subsequent to bacterial infection. Thereby, we identified the kinase SIK2 as a central component of the host defense machinery upon infection. Read More

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The Landscape of Cell-free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Berry Oncology Corporation, Beijing, China.

Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful non-invasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear. Read More

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The D*Phase-study: study protocol for a pragmatic two-phased, randomised controlled (non-inferiority) trial that addresses treatment non-response and compares cognitive behavioural therapy and short-term psychodynamic supportive psychotherapy for major depression.

BMC Psychiatry 2021 05 4;21(1):233. Epub 2021 May 4.

Dimence, Deventer, The Netherlands.

Background: Several evidence-based psychotherapeutic treatment options are available for depression, but the treatment results could be improved. The D*Phase study directly compares short-term psychodynamic supportive psychotherapy (SPSP) and cognitive behavioural therapy (CBT) for Major Depressive Disorder (MDD). The objectives are 1. Read More

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