J Biotechnol 2021 Oct 11. Epub 2021 Oct 11.
Naprogenix™, UK-AsTeCC, 145 Graham Avenue, Lexington, KY, 40506-0286, USA; College of Arts and Sciences, Department of Psychology, University of Kentucky, Kastle Hall, Lexington, KY, 40506-0044, USA; College of Medicine, Department of Neurology, University of Kentucky Chandler Medical Center, 740 S. Limestone, Lexington, KY, 40536-0298, USA.
The dopamine transporter (DAT) is targeted in substance use disorders (SUDs), and "non-classical"" DAT inhibitors with low abuse potential are therapeutic candidates. Lobinaline, from Lobelia cardinalis, is an atypical DAT inhibitor lead. Chemical synthesis of lobinaline is challenging; thus, "target-directed evolution" was used for lead optimization. Read More