178,889 results match your criteria cellular uptake


Placental Changes in the serotonin transporter (Slc6a4) knockout mouse suggest a role for serotonin in controlling nutrient acquisition.

Placenta 2021 Oct 1;115:158-168. Epub 2021 Oct 1.

Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA; MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO, 65211, USA; Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO, 65211, USA; Genetics Area Program, University of Missouri, Columbia, MO, 65211, USA. Electronic address:

Introduction: The mouse placenta accumulates and possibly produces serotonin (5-hydroxytryptamine; 5-HT) in parietal trophoblast giant cells (pTGC) located at the interface between the placenta and maternal deciduum. However, the roles of 5-HT in placental function are unclear. This lack of information is unfortunate, given that selective serotonin-reuptake inhibitors are commonly used to combat depression in pregnant women. Read More

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October 2021

Biofilm with highly heterogeneous interior structure for pollutant removal: Cell distribution and manipulated mass transport.

Bioresour Technol 2021 Sep 8;343:125913. Epub 2021 Sep 8.

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Mechanical Engineering, City University of Hong Kong, Kowloon Tang, Hong Kong, China; College of Engineering, Tunghai University, Taichung 40704, Taiwan. Electronic address:

Biofilm wastewater treatment had been applied in practice. Conventionally the biofilm was modeled as a uniform structure to simplify the analysis. This study for the first time established a three-dimensional biofilm model with distributions separating living cells, Extracellular polymeric substances (EPS) and pores, based on which the local fluid flow velocity and pollutant diffusion and reaction fluxes inside the biofilm were numerically evaluated. Read More

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September 2021

Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures.

J Biotechnol 2021 Oct 11. Epub 2021 Oct 11.

Naprogenix™, UK-AsTeCC, 145 Graham Avenue, Lexington, KY, 40506-0286, USA; College of Arts and Sciences, Department of Psychology, University of Kentucky, Kastle Hall, Lexington, KY, 40506-0044, USA; College of Medicine, Department of Neurology, University of Kentucky Chandler Medical Center, 740 S. Limestone, Lexington, KY, 40536-0298, USA.

The dopamine transporter (DAT) is targeted in substance use disorders (SUDs), and "non-classical"" DAT inhibitors with low abuse potential are therapeutic candidates. Lobinaline, from Lobelia cardinalis, is an atypical DAT inhibitor lead. Chemical synthesis of lobinaline is challenging; thus, "target-directed evolution" was used for lead optimization. Read More

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October 2021

FV-429 enhances the efficacy of paclitaxel in NSCLC by reprogramming HIF-1α-modulated FattyAcid metabolism.

Chem Biol Interact 2021 Oct 11:109702. Epub 2021 Oct 11.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address:

Solid tumors often exhibit hypoxia in their centers, which has been associated with a marked reduction in the sensitivity of the tumor cells to anti-tumor and chemotherapeutic interventions. Here, we found that the occurrence and progress of hypoxic insensitivity to paclitaxel in non-small cell lung cancer (NSCLC) are closely associated with the HIF-1α pathway. The HIF-1α protein upregulated the expression of adipose differentiation-related protein (ADRP), fatty acid synthase (FASN), and sterol regulatory element binding protein 1(SREBP1), while simultaneously downregulating carnitine palmitoyltransferase 1 (CPT1), thereby leading to a more pronounced uptake of lipids and reduced oxidation of fatty acids. Read More

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October 2021

Loss of Mitochondrial Ca Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy.

Circulation 2021 Oct 14. Epub 2021 Oct 14.

Department of Translational Research, Comprehensive Heart Failure Center, University Clinic Würzburg, Germany; Clinic for Internal Medicine III, Saarland University Clinic, Homburg/Saar, Germany; Department for Internal Medicine 1, University Clinic Würzburg, Germany.

Barth syndrome (BTHS) is caused by mutations of the gene encoding tafazzin, which catalyzes maturation of mitochondrial cardiolipin and often manifests with systolic dysfunction during early infancy. Beyond the first months of life, BTHS cardiomyopathy typically transitions to a phenotype of diastolic dysfunction with preserved ejection fraction, blunted contractile reserve during exercise and arrhythmic vulnerability. Previous studies traced BTHS cardiomyopathy to mitochondrial formation of reactive oxygen species (ROS). Read More

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October 2021

Precisely Shaped Self-Adjuvanting Peptide Vaccines with Enhanced Immune Responses for HPV-Associated Cancer Therapy.

ACS Appl Mater Interfaces 2021 Oct 14. Epub 2021 Oct 14.

Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Peptide vaccines exhibit great potential in cancer therapy via eliciting antigen-specific host immune response and long-term immune memory to defend cancer cells. However, the low induced immune response of many developing vaccines implies the imperatives for understanding the favorable structural features of efficient cancer vaccines. Herein, we report on the two groups of self-adjuvanting peptide vaccines with distinct morphology and investigate the relationship between the morphology of peptide vaccines and the induced immune response. Read More

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October 2021

METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis.

Cell Biol Toxicol 2021 Oct 14. Epub 2021 Oct 14.

Department of Cardiology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.

Doxorubicin (DOX) has toxic effects on the heart, causing cardiomyopathy and heart injury, but the underlying mechanisms of these effects require further investigation. This study investigated the role of DOX in promoting ferroptosis to induce myocardial injury. AC16 cardiomyocyte and neonatal rat ventricle cardiomyocytes were used as an in vitro model to study the molecules involved in myocardial injury using gene silencing, ectopic expression, and RNA immunoprecipitation. Read More

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October 2021

Intracellular Biotransformation of Cu(II)/Cu(I) Explained High Cu Toxicity to Phytoplankton .

Environ Sci Technol 2021 Oct 14. Epub 2021 Oct 14.

School of Energy and Environment and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China.

The toxicity of Cu is related to its redox species, but the differential toxicity of Cu(II) and Cu(I) remains unknown. In the present study, we developed a novel protocol to simultaneously detect the biologically produced extracellular Cu(I) and internalized Cu(II) in a freshwater phytoplankton . The intracellular Cu(I) was further imaged using a fluorometric probe. Read More

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October 2021

Boosting ionizable lipid nanoparticle-mediated mRNA delivery through optimization of lipid amine-head groups.

Biomater Sci 2021 Oct 14. Epub 2021 Oct 14.

Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, and School of Chemistry and Chemical Engineering, Shandong University, Jinan 25010, China.

transcribed messenger RNA (IVT-mRNA) holds great promise for the development of novel therapeutics, such as immunotherapy and vaccination. However, the main obstacle towards clinical translation is the lack of effective delivery systems. Herein, we have synthesized a series of ionizable lipids by the addition of an alkyl-acrylate to amine-containing molecules (amine-head groups) as a key component of ionizable lipid nanoparticles (iLNPs) and thoroughly investigated the impact of the amine-head group on the transfection efficiency of iLNPs/mRNA lipoplexes both and . Read More

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October 2021

Lactobacillus johnsonii BFE6154 Ameliorates Diet-Induced Hypercholesterolemia.

Probiotics Antimicrob Proteins 2021 Oct 13. Epub 2021 Oct 13.

Department of Advanced Convergence, Handong Global University, Pohang, South Korea.

The functional characteristics of Lactobacillus johnsonii BFE6154, first isolated from Maasai traditional fermented milk, were previously identified in vitro, but its cholesterol-lowering properties have not been verified yet. In this study, we investigated the effect of L. johnsonii BFE6154 on cholesterol regulation and the mode of action. Read More

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October 2021

A Novel Blood-Brain Barrier-Permeable Chemotherapeutic Agent for the Treatment of Glioblastoma.

Cureus 2021 Aug 31;13(8):e17595. Epub 2021 Aug 31.

Pediatric Hematology-Oncology, New York University (NYU), New York, USA.

Introduction The standard treatment for glioblastoma (GBM) patients is surgical tumor resection, followed by radiation and chemotherapy with temozolomide (TMZ). Unfortunately, 60% of newly diagnosed GBM patients express high levels of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) and are TMZ-resistant, and all patients eventually become refractory to treatment. The blood-brain barrier (BBB) is an obstacle to the delivery of chemotherapeutic agents to GBM, and BBB-permeable agents that are efficacious in TMZ-resistant and refractory patients are needed. Read More

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Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.

Prostate Cancer Prostatic Dis 2021 Oct 13. Epub 2021 Oct 13.

Department of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.

Background: Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models to study this disease have been difficult to establish because of limited specimen availability and poor uptake rates in immunodeficient mice. Ancestrally diverse PCPDXs are even more rare, and only six PCPDXs from self-identified African American patients from one institution were recently made available. Read More

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October 2021

ANGPTL4-mediated promotion of glycolysis facilitates the colonization of Fusobacterium nucleatum in colorectal cancer.

Cancer Res 2021 Oct 13. Epub 2021 Oct 13.

Department of Cariology and Endodontics, West China School of Stomatology, Sichuan University

Colorectal cancer (CRC) is a severe health problem worldwide, and accumulating evidence supports the contribution of Fusobacterium nucleatum to CRC development, metastasis, and chemoresistance. However, the mechanisms underlying the colonization of F. nucleatum in CRC tissue is not yet clarified. Read More

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October 2021

EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma.

Cancer Cell Int 2021 Oct 13;21(1):535. Epub 2021 Oct 13.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.

Background: Ephrin receptors (Eph) and their ligands, called ephrins, function in various disease processes. However, the expression level and prognostic value of Eph/ephrins in lung adenocarcinoma (LUAD) are still unclear.

Methods: The Oncomine and GEPIA databases were used to explore the differential expression of Eph/ephrins in LUAD. Read More

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October 2021

Physiological responses and transcriptomic changes reveal the mechanisms underlying adaptation of Stylosanthes guianensis to phosphorus deficiency.

BMC Plant Biol 2021 Oct 13;21(1):466. Epub 2021 Oct 13.

Institute of Tropical Crop Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P.R. China.

Background: Phosphorus (P) is an essential macronutrient for plant growth that participates in a series of biological processes. Thus, P deficiency limits crop growth and yield. Although Stylosanthes guianensis (stylo) is an important tropical legume that displays adaptation to low phosphate (Pi) availability, its adaptive mechanisms remain largely unknown. Read More

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October 2021

Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells.

Toxicol Mech Methods 2021 Oct 13:1-32. Epub 2021 Oct 13.

Morphology and Pathology Department, Federal University of São Carlos, São Carlos, Brazil.

The extensive use of titanium dioxide nanoparticles (TiO NPs) in cosmetics, food, personal care products, and industries brought concerns about their possible harmful effects. Nowadays it has become important to assess TiO NPs toxic effects as a way to understand their primary risks. In the cellular environment, after cell uptake, TiO NPs were described to induce reactive oxygen species (ROS) production, unbalance oxidative state, and activate apoptosis in several cell lines. Read More

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October 2021

Accumulation of radio-iron and plutonium, alone and in combination, in pseudomonas putida grown in liquid cultures.

J Radiol Prot 2021 Oct 13. Epub 2021 Oct 13.

Environmental Engineering and Earth Sciences, Clemson University, 342 Computer Ct, Anderson, South Carolina, 29625, UNITED STATES.

The impact of low doses of ionizing radiation on biological and environmental systems have been historically difficult to study. Modern biological tools have provided new methods for studying these mechanisms but applying these tools to a dose-response relationship may require refinement of dosimetric techniques that incorporate a detailed understand of radionuclide accumulation in biological cells, particularly when assessing the impact of low doses of ionizing radiation. In this work Pseudomonas putida (KT2440)grown in liquid culture was exposed to low dose rates (10-20 mGy d-1) of 239Pu and 55Fe, both alone and in combination, for a period of 20 days, and the accumulation of 239Pu and 55Fe in cell pellets was analyzed via liquid scintillation counting. Read More

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October 2021

Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.

PLoS One 2021 13;16(10):e0258433. Epub 2021 Oct 13.

Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok, Thailand.

Abnormal calcium absorption and iron overload from iron hyperabsorption can contribute to osteoporosis as found in several diseases, including hemochromatosis and thalassemia. Previous studies in thalassemic mice showed the positive effects of the iron uptake suppressor, hepcidin, on calcium transport. However, whether this effect could be replicated in other conditions is not known. Read More

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October 2021

Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitro.

Graefes Arch Clin Exp Ophthalmol 2021 Oct 13. Epub 2021 Oct 13.

Department of Ophthalmology, University Medical Center, University of Kiel, Quincke Research Center, Rosalind-Franklin-Str. 9, 24105, Kiel, Germany.

Purpose: Bevacizumab is taken up and transported through the retinal pigment epithelium. Inflammatory signaling may influence this interaction. In the present study, we have investigated the effect of pro-inflammatory stimuli on the uptake, intracellular localization, and transepithelial transport of bevacizumab. Read More

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October 2021

LINC01915 Facilitates the Conversion of Normal Fibroblasts into Cancer-Associated Fibroblasts Induced by Colorectal Cancer-Derived Extracellular Vesicles through the miR-92a-3p/KLF4/CH25H Axis.

ACS Biomater Sci Eng 2021 Oct 13. Epub 2021 Oct 13.

Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, P. R. China.

Increasing long non-coding RNAs are reported to regulate the cell growth, apoptosis, and metastasis of cancer-associated fibroblasts (CAFs).This study aimed to explore how LINC01915 influences the conversion of normal fibroblasts (NFs) into CAFs in colorectal cancer (CRC). LINC01915 expression was initially measured in clinical tissue samples and in NFs and CAFs. Read More

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October 2021

Silencing long noncoding RNA LINC01138 inhibits aerobic glycolysis to reduce glioma cell proliferation by regulating the microRNA‑375/SP1 axis.

Mol Med Rep 2021 Dec 13;24(6). Epub 2021 Oct 13.

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Glioma is a primary cerebral neoplasm that originates from glial tissue and spreads to the central nervous system. Long noncoding RNAs are known to play a role in glioma cells by regulating cell proliferation, migration and invasion. The aim of the present study was to investigate the mechanism by which long intergenic non‑protein coding RNA (LINC) 01138 affects glycolysis and proliferation in glioma cells via the microRNA (miR)‑375/specificity protein 1 (SP1) axis. Read More

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December 2021

Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway.

Oncol Rep 2021 Dec 13;46(6). Epub 2021 Oct 13.

Department of Plant Sciences, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.

Glucose transporter 1 (GLUT1) plays a primary role in the glucose metabolism of cancer cells. However, to the best of our knowledge, there are currently no anticancer drugs that inhibit GLUT1 function. The present study aimed to investigate the antineoplastic activity of berberine (BBR), the main active ingredient in numerous Traditional Chinese medicinal herbs, on HepG2 and MCF7 cells. Read More

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December 2021

glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract.

Virulence 2021 Oct 13. Epub 2021 Oct 13.

School of Pharmacy and Medical Science, Griffith University, Gold Coast, QLD, Australia 4222.

glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by , is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses to , bacterial phagocytosis and colonization of the female reproductive tract, a central host niche, is unknown. We expressed and studied purified recombinant GAPDH (rGAPDH) of in cytokine elicitation assays with human monocyte-derived macrophage, epithelial cell, and polymorphonuclear leukocyte (PMN) co-culture infection models. Read More

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October 2021

Solid phase diversity-oriented lysine modification of cyclic peptides.

J Pept Sci 2021 Oct 12:e3373. Epub 2021 Oct 12.

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.

Herein, we report a novel strategy for diversity-oriented lysine modification of cyclic peptides based on the orthogonal alkylation of the lysine residues. All steps can be achieved in the solid phase with satisfying conversions. Notably, we demonstrated that the tether modification could help to improve the cellular uptake of peptides. Read More

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October 2021

A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy.

Adv Mater 2021 Oct 13:e2102562. Epub 2021 Oct 13.

Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University, Key Laboratory of Optoelectronic Devices, Systems of Ministry of Education, Guangdong Province Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, P. R. China.

Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano-heterostructures can facilitate photoinduced electron-hole separation and enhance generation of reactive oxygen species (ROS), 2D nano-heterostructure-based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Read More

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October 2021

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.

Nat Commun 2021 Oct 12;12(1):5948. Epub 2021 Oct 12.

Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Read More

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October 2021

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452.

Vaccine 2021 Oct 5. Epub 2021 Oct 5.

Akston Biosciences Corporation., 100 Cummings Center, Suite 454C, Beverly, MA 01915, United States. Electronic address:

AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. The Fc moiety is designed to enhance immunogenicity by increasing uptake via Fc-receptors (FcγR) on Ag-presenting cells (APCs) and prolonging exposure due to neonatal Fc receptor (FcRn) recycling. AKS-452 induced approximately 20-fold greater neutralizing IgG titers in mice relative to those induced by SP/RBD without the Fc moiety and induced comparable long-term neutralizing titers with a single dose vs. Read More

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October 2021

Recent progress and perspectives on the mechanisms underlying Asbestos toxicity.

Authors:
Akio Kuroda

Genes Environ 2021 Oct 12;43(1):46. Epub 2021 Oct 12.

Unit of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi Hiroshima, Hiroshima, 739-8530, Japan.

Most cases of mesothelioma are known to result from exposure to asbestos fibers in the environment or occupational ambient air. The following questions regarding asbestos toxicity remain partially unanswered: (i) why asbestos entering the alveoli during respiration exerts toxicity in the pleura; and (ii) how asbestos causes mesothelioma, even though human mesothelial cells are easily killed upon exposure to asbestos. As for the latter question, it is now thought that the frustrated phagocytosis of asbestos fibers by macrophages prolongs inflammatory responses and gives rise to a "mutagenic microenvironment" around mesothelial cells, resulting in their malignant transformation. Read More

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October 2021

Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy.

J Nanobiotechnology 2021 Oct 12;19(1):314. Epub 2021 Oct 12.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Background: Improving anti-cancer drug delivery performance can be achieved through designing smart and targeted drug delivery systems (DDSs). For this aim, it is important to evaluate overexpressed biomarkers in the tumor microenvironment (TME) for optimizing DDSs.

Materials And Methods: Herein, we designed a novel DDS based on magnetic mesoporous silica core-shell nanoparticles ([email protected]) in which release of doxorubicin (DOX) at the physiologic pH was blocked with gold gatekeepers. Read More

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October 2021

Effect of targeting ligand designation of self-assembly chitosan-poloxamer nanogels loaded Paclitacel on inhibiting MCF-7 cancer cell growth.

J Biomater Sci Polym Ed 2021 Oct 12:1-13. Epub 2021 Oct 12.

Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ho Chi Minh City, Vietnam.

In this study, we investigated two formulations of chitosan-Pluronic P123 with different folate ligand designation for targeted delivery of Paclitaxel (PTX), in which folic acid (FA) was directly conjugated to chitosan (FA-Cs-P123) or substituted onto P123 (Cs-P123-FA). The results showed that the FA content of Cs-P123-FA was determined at 0.71 wt/wt% which was significantly higher than that of FA-Cs-P123 (0. Read More

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October 2021