243,594 results match your criteria cellular behavior

Neurovascular Interactions in Malaria.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil.

Malaria is caused by Plasmodium infection and remains a serious public health problem worldwide, despite control efforts. Malaria can progress to severe forms, affecting multiple organs, including the brain causing cerebral malaria (CM). CM is the most severe neurological complication of malaria, and cognitive and behavior deficits are commonly reported in surviving patients. Read More

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Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Department of Ophthalmology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasizes its protective behavior in retinal cells that help to provide new information about the development of treatment for retinal complications.

Objectives: This study analyzes the effect of in vitro changes associated with the cell survival and rescue mechanism in IGF2 inhibition and activation using chromeceptin and IGF2 peptides in ARPE-19 cells cultured in high glucose conditions. Read More

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Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells.

Neuroimmunomodulation 2021 May 5:1-9. Epub 2021 May 5.

Institute of Education and Research, Santa Casa BH, Belo Horizonte, Brazil.

Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with increased plasma levels of pro-inflammatory mediators targeting all tissues including the brain. Importantly, pro-inflammatory cytokines (ex., tumor-necrosis factor alpha [TNF-α], interleukin [IL]-6) regulate mood behavior and cognition by influencing neurotransmitter levels, activating stress-responsive endocrine axes, among other effects. Read More

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Hypopharyngeal spindle cell lipoma: A case report and review of literature.

Medicine (Baltimore) 2021 May;100(18):e25782

Department of Otorhinolaryngology.

Rationale: Spindle cell lipoma is a rare, uncommon type of benign lipomatous tumor, a distinct group of lipomas composed of mature adipocytes, uniform spindle cells, and multinucleated giant cells associated with ropey collagen. Immunohistochemically, spindle cell lipoma is characterized by the diffuse expression of CD34.

Patient Concerns: We present a rare case of a 56-year-old man who complained of vomiting out of a smooth and giant mass in the oral cavity provoked by an intra-abdominal pressure increase. Read More

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Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility.

Elife 2021 May 5;10. Epub 2021 May 5.

Physiology Department, David Geffen School of Medicine, UCLA, Los Angeles, United States.

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions play key roles in memory, cognition, decision making, social behaviors, and mood. Dysfunction in mPFC is implicated in psychiatric disorders in which these behaviors go awry. The prolonged maturation of mPFC likely enables complex behaviors to emerge, but also increases their vulnerability to disruption. Read More

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Haematotoxic effects of methanolic extract of oleo gum resin (frankinccense) in rats.

Sci Prog 2021 Apr-Jun;104(2):368504211015102

Pharmaceutical Services Administration, Health Oasis Hospital, Riyadh, Saudi Arabia.

In several parts of the world, Fluck. is one of the most commonly used herbs for the treatment of arthritis. Its usage should be validated in light of recent findings of haematotoxicity. Read More

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PEG-PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy.

J Mater Chem B 2021 May;9(17):3666-3676

Department of Chemistry, National Institute of Technology Rourkela, Odisha, 769008, India.

A novel hybrid drug carrier has been designed, taking N-doped mesoporous carbon (NMCS) as the core and PEG-PEI as the outer shell. NMCS was functionalized with a photocleavable nitrobenzyl-based linker following a click reaction. Gemcitabine was loaded into NMCS prior to the functionalization via π-π stacking interactions. Read More

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Chiral self-sorting of active semiflexible filaments with intrinsic curvature.

Soft Matter 2021 May;17(17):4559-4565

Department of Physics, University of Colorado, Boulder, CO 80309, USA. and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Many-body interactions in systems of active matter can cause particles to move collectively and self-organize into dynamic structures with long-range order. In cells, the self-assembly of cytoskeletal filaments is critical for cellular motility, structure, intracellular transport, and division. Semiflexible cytoskeletal filaments driven by polymerization or motor-protein interactions on a two-dimensional substrate, such as the cell cortex, can induce filament bending and curvature leading to interesting collective behavior. Read More

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Sonic hedgehog signaling is associated with resistance to zoledronic acid in CD133high/CD44high prostate cancer stem cells.

Mol Biol Rep 2021 May 4. Epub 2021 May 4.

Department of Histology and Embryology, Faculty of Medicine, Ege University, Izmir, 35080, Turkey.

Cancer stem cells (CSCs) are a unique population that has been linked to drug resistance and metastasis and recurrence of prostate cancer. The sonic hedgehog (SHH) signal regulates stem cells in normal prostate epithelium by affecting cell behavior, survival, proliferation, and maintenance. Aberrant SHH pathway activation leads to an unsuitable expansion of stem cell lineages in the prostate epithelium and the transformation of prostate CSCs (PCSCs). Read More

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Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements.

Nat Commun 2021 May 4;12(1):2502. Epub 2021 May 4.

Institute of Applied Physics, TU Wien, Vienna, Austria.

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their magnitude, spread, and temporal behavior are still poorly defined. We here report a FRET-based sensor equipped either with a TCR-reactive single chain antibody fragment or peptide-loaded MHC, the physiological TCR-ligand. The sensor was tethered to planar glass-supported lipid bilayers (SLBs) and informed most directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level. Read More

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Super-resolved visualization of single DNA-based tension sensors in cell adhesion.

Nat Commun 2021 May 4;12(1):2510. Epub 2021 May 4.

Faculty of Physics and Center for Nanoscience, Ludwig Maximilian University, Munich, Germany.

Cell-extracellular matrix sensing plays a crucial role in cellular behavior and leads to the formation of a macromolecular protein complex called the focal adhesion. Despite their importance in cellular decision making, relatively little is known about cell-matrix interactions and the intracellular transduction of an initial ligand-receptor binding event on the single-molecule level. Here, we combine cRGD-ligand-decorated DNA tension sensors with DNA-PAINT super-resolution microscopy to study the mechanical engagement of single integrin receptors and the downstream influence on actin bundling. Read More

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A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats.

Nat Commun 2021 May 4;12(1):2517. Epub 2021 May 4.

Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA.

Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Read More

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MC3T3-E1 cell response to microporous tantalum oxide surfaces enriched with Ca, P and Mg.

Mater Sci Eng C Mater Biol Appl 2021 May 2;124:112008. Epub 2021 Mar 2.

CFUM-UP, Physics Department, University of Minho, Campus of Azurém, 4800-058 Guimarães, Portugal; SEG-CEMMPRE, Mechanical Engineering Department, University of Coimbra, 3030-788 Coimbra, Portugal.

The formation of a porous oxide surface doped with osteoconductive elements, Ca, P and Mg, to enhance osseointegration, was achieved through micro arc oxidation. Micro arc oxidation parameters, such as electrolyte composition, concentration and applied voltage, were studied to understand their effect on the morphology and chemical composition of the samples surface. Considering the optimum atomic concentration reported in literature for each osteoconductive element, microporous Ta anodic oxide samples treated with calcium acetate (CaA) and β-glycerophosphate (β-GP) revealed that an increase of β-GP molarity in the electrolyte boosts Ca incorporation, as well as, increasing the porosity. Read More

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Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis.

Mater Sci Eng C Mater Biol Appl 2021 May 26;124:112077. Epub 2021 Mar 26.

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China. Electronic address:

The heart contains a wide range of cell types, which are not isolated but interact with one another via multifarious paracrine, autocrine and endocrine factors. In terms of cardiac angiogenesis, previous studies have proved that regulating the communication between cardiomyocytes and endothelial cells is efficacious to promote capillary formation. Firstly, this study investigated the effect and underlying mechanism of bioactive glass (BG) acted on vascular endothelial growth factor (VEGF) paracrine signaling in cardiomyocytes. Read More

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The effects of plasma electrolytically oxidized layers containing Sr and Ca on the osteogenic behavior of selective laser melted Ti6Al4V porous implants.

Mater Sci Eng C Mater Biol Appl 2021 May 31;124:112074. Epub 2021 Mar 31.

Additive Manufacturing Laboratory, Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, the Netherlands.

Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without strontium. Various levels of Sr and Ca were incorporated in the oxide layers by using different current densities and oxidation times. Read More

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Effect of sodium alginate molecular structure on electrospun membrane cell adhesion.

Mater Sci Eng C Mater Biol Appl 2021 May 26;124:112067. Epub 2021 Mar 26.

Department of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, 16146 Genoa, Italy. Electronic address:

Alginate-based electrospun nanofibers prepared via electrospinning technique represent a class of materials with promising applications in the biomedical and pharmaceutical industries. However, to date, the effect of alginate molecular mass and block composition on the biological response of such systems remains to some extent unclear. As such, in the present work, three alginates (i. Read More

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A novel and injectable strontium-containing hydroxyapatite bone cement for bone substitution: A systematic evaluation.

Mater Sci Eng C Mater Biol Appl 2021 May 25;124:112052. Epub 2021 Mar 25.

Biomaterials Research and Test Center, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

Reconstruction of bone defects is still a challenge. In this study, we developed and systematically evaluated a novel injectable strontium-containing hydroxyapatite (Sr-HA) bone cement in which Sr-HA powder included 5% Sr and was mixed with a setting liquid that included 5% potassium citrate. This Sr-HA cement was mainly composed of HA and α-tricalcium phosphate (TCP) and exhibited favorable injectability (100%), setting times (the initial setting time was 240 s and the final setting time was 420 s), compressive strength (73. Read More

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The impact of multimodal pore size considered independently from porosity on mechanical performance and osteogenic behaviour of titanium scaffolds.

Mater Sci Eng C Mater Biol Appl 2021 May 10;124:112026. Epub 2021 Mar 10.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leics LE11 3TU, UK.

Titanium porous scaffolds comprising multimodal pore ranges (i.e., uni-, bi-, tri-modal and random) were studied to evaluate the effect of pore size on osteoblastogenesis. Read More

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lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma.

Biomolecules 2021 Apr 29;11(5). Epub 2021 Apr 29.

Central European Institute of Technology, Masaryk University, 625 00 Brno, Czech Republic.

LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. Read More

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Synaptic Zinc: An Emerging Player in Parkinson's Disease.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

CNRS, Laboratoire de Neurosciences Cognitives, (UMR 729), Aix Marseille Université, 13331 Marseille, France.

Alterations of zinc homeostasis have long been implicated in Parkinson's disease (PD). Zinc plays a complex role as both deficiency and excess of intracellular zinc levels have been incriminated in the pathophysiology of the disease. Besides its role in multiple cellular functions, Zn also acts as a synaptic transmitter in the brain. Read More

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Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer () Dermal Papilla Cells to Three-Dimensional Pattern.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

School of Life Sciences, Jilin University, Changchun 130012, China.

The hair follicle dermal papilla is critical for hair generation and de novo regeneration. When cultured in vitro, dermal papilla cells from different species demonstrate two distinguishable growth patterns under the conventional culture condition: a self-aggregative three dimensional spheroidal (3D) cell pattern and a two dimensional (2D) monolayer cell pattern, correlating with different hair inducing properties. Whether the loss of self-aggregative behavior relates to species-specific differences or the improper culture condition remains unclear. Read More

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Prion Protein of Extracellular Vesicle Regulates the Progression of Colorectal Cancer.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Colorectal cancer (CRC) is one of the leading causes of cancer-related death due to its aggressive metastasis in later stages. Although there is a growing interest in the tumorigenic role of cellular prion protein (PrP) in the process of metastasis, the precise mechanism behind the cellular communication involving prion proteins remains poorly understood. This study found that hypoxic tumor microenvironment increased the PrP-expressing exosomes from CRC, and these exosomes regulate the CRC cell behavior and tumor progression depending on the expression of PrP. Read More

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Wound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell Function.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Obstetrics and Gynecology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Intraoperative radiotherapy (IORT) displays an increasingly used treatment option for early breast cancer. It exhibits non-inferiority concerning the risk of recurrence compared to conventional external irradiation (EBRT) in suitable patients with early breast cancer. Since most relapses occur in direct proximity of the former tumor site, the reduction of the risk of local recurrence effected by radiotherapy might partially be due to an alteration of the irradiated tumor bed's micromilieu. Read More

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Metabolic Profiling of VOCs Emitted by Bacteria Isolated from Pressure Ulcers and Treated with Different Concentrations of Bio-AgNPs.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Interdisciplinary Centre of Modern Technologies, Nicolaus Copernicus University in Toruń, 4 Wileńska St., 87-100 Toruń, Poland.

Considering the advent of antibiotic resistance, the study of bacterial metabolic behavior stimulated by novel antimicrobial agents becomes a relevant tool to elucidate involved adaptive pathways. Profiling of volatile metabolites was performed to monitor alterations of bacterial metabolism induced by biosynthesized silver nanoparticles (bio-AgNPs). , , and were isolated from pressure ulcers, and their cultures were prepared in the presence/absence of bio-AgNPs at 12. Read More

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Ameliorative Effects of Boswellic Acid on Fipronil-Induced Toxicity: Antioxidant State, Apoptotic Markers, and Testicular Steroidogenic Expression in Male Rats.

Animals (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516 Egypt.

The study investigated the ability of boswellic acid (BA) to alleviate the testicular and oxidative injury FPN insecticide intoxication in the male rat model. Rats were randomly assigned to six equivalent groups (six rats each) as the following: control rats orally administered with 2 mL physiological saline/kg of body weight (bwt); boswellic acid (BA1) rats orally administered 250 mg BA/kg bwt; boswellic acid (BA2) rats orally administered 500 mg BA/kg bwt; fipronil (FPN) rats orally administered 20 mg FPN/kg bwt; (FPN + BA1) rats orally administered 20 mg FPN/kg bwt plus 250 mg BA/kg bwt, and (FPN + BA2) rats orally administered 20 mg FPN/kg bwt plus 500 mg BA/kg bwt. After 60 days, semen viability percentage and live spermatozoa percentage were decreased, and a considerably increased abnormality of the sperm cells in FPN-administered rats improved substantially with the co-administration of BA. Read More

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Microbiota Associated with Different Developmental Stages of the Dry Rot Fungus .

J Fungi (Basel) 2021 Apr 30;7(5). Epub 2021 Apr 30.

Department of Microbiology, University of Innsbruck, Technikerstrasse 25, 6020 Innsbruck, Austria.

The dry rot fungus causes significant structural damage by decaying construction timber, resulting in costly restoration procedures. Dry rot fungi decompose cellulose and hemicellulose and are often accompanied by a succession of bacteria and other fungi. Bacterial-fungal interactions (BFI) have a considerable impact on all the partners, ranging from antagonistic to beneficial relationships. Read More

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Influence of Culture Substrates on Morphology and Function of Pulmonary Alveolar Cells In Vitro.

Biomolecules 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Management, Information and Production Engineering, University of Bergamo, 24044 Dalmine (BG), Italy.

Cell's microenvironment has been shown to exert influence on cell behavior. In particular, matrix-cell interactions strongly impact cell morphology and function. The purpose of this study was to analyze the influence of different culture substrate materials on phenotype and functional properties of lung epithelial adenocarcinoma (A549) cells. Read More

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Green Propolis Compounds (Baccarin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10.

Medicines (Basel) 2021 Apr 30;8(5). Epub 2021 Apr 30.

Centro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, Brazil.

Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Read More

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Long chain fatty acids can form aggregates and affect the membrane integrity.

Colloids Surf B Biointerfaces 2021 Apr 28;204:111795. Epub 2021 Apr 28.

Department of Biochemistry, School of Medicine, Aydin Adnan Menderes University, Aydin, 09010, Turkey. Electronic address:

Stearic acid (SA) and oleic acid (OA) which are inherently existing fatty acids (FAs) in the body can alter cell membrane function and interact with each other. However, discrepancies arise as to whether these effects are beneficial or harmful on the body. To resolve this ambiguity, there is a dire need to study how FAs can affect the etiology of diseases and their treatment. Read More

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Bioscaffold-based study of glioblastoma cell behavior and drug delivery for tumor therapy.

Neurochem Int 2021 May 1:105049. Epub 2021 May 1.

Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, KS, 67260, USA. Electronic address:

Glioblastoma multiforme (GBM) is a severe form of brain cancer with an average five-year survival rate of 6.7%. Current treatment strategies include surgical resection of the tumor area and lining the lesion site with therapeutics, which offer only a moderate impact on increasing survival rates. Read More

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