Curr Opin Pharmacol 2021 Apr 11;58:35-43. Epub 2021 Apr 11.
Bone Muscle Research Center, College of Nursing & Health Innovation, The University of Texas at Arlington, 701 South Nedderman Drive, Arlington, TX, 76019, USA; Department of Nursing, College of Nursing & Health Innovation, The University of Texas at Arlington, 411 South Nedderman Drive Box 19407, Arlington, TX, 76019, USA. Electronic address:
Musculoskeletal conditions are the highest contributor to global disability, accounting for 16% of all ages lived with disability. Volumetric muscle loss (VML) is classified as significant damage to skeletal muscle compartments and motor units, leading to significant tissue loss, functional deficits, and long-term disability. In this review, the current tissue engineering approaches in terms of fabrication techniques, materials, cell sources, and growth factors for enhanced angiogenesis and neuromuscular junction (NMJ) in VML repair, are discussed. Read More