16,458 results match your criteria cells mda-mb-231


Quercetin inhibiting the PD-1/PD-L1 interaction for immune-enhancing cancer chemopreventive agent.

Phytother Res 2021 Sep 24. Epub 2021 Sep 24.

Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, School of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.

Targeting the PD-1/PD-L1 immune checkpoints has achieved significant positive results in the treatment of multiple cancers. Quercetin is one of the most abundant dietary flavonoids found in various vegetables and fruits, and has a wide range of biological activities including immunomodulation. Here we report that quercetin dihydrate was screened and shown to inhibit the PD-1/PD-L1 interaction. Read More

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September 2021

Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells.

Chem Biol Interact 2021 Sep 21:109673. Epub 2021 Sep 21.

Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address:

2,3-Dimethyl-1,4-benzoquinones named as Plastoquinone (PQ) analogs have antiproliferative activity and are promising new members of molecules that can be used to cope with cancer. In an attempt to develop effective and potentially safe antiproliferative agents, previously reported twelve Plastoquinone analogs (PQ1-12) have been obtained to understand their antiproliferative profile. All PQ analogs have been selected by the National Cancer Institute (NCI) of Bethesda based on the NCI Developmental Therapeutics Program and tested against the panel of 60 cancer cell lines. Read More

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September 2021

Selective Single-Cell Sorting Using a Multisectorial Electroactive Nanowell Platform.

ACS Nano 2021 Sep 24. Epub 2021 Sep 24.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

Current approaches in targeted patient treatments often require the rapid isolation of specific rare target cells. Stream-based dielectrophoresis (DEP) based cell sorters have the limitation that the maximum number of sortable cell types is equivalent to the number of output channels, which makes upscaling to a higher number of different cell types technically challenging. Here, we present a microfluidic platform for selective single-cell sorting that bypasses this limitation. Read More

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September 2021

PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin.

Eur J Nucl Med Mol Imaging 2021 Sep 24. Epub 2021 Sep 24.

Institute of Pathology, Technische Universität München, Munich, Germany.

Purpose: To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas.

Methods: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. The tracer was characterized by ELISA for activities towards integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1, as well as by cell binding assays on H2009 (αvβ6-positive) and MDA-MB-231 (αvβ6-negative) cells. Read More

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September 2021

Neighbor-enhanced diffusivity in dense, cohesive cell populations.

PLoS Comput Biol 2021 Sep 23;17(9):e1009447. Epub 2021 Sep 23.

Department of Physics, Korea University, Seoul, Korea.

The dispersal or mixing of cells within cellular tissue is a crucial property for diverse biological processes, ranging from morphogenesis, immune action, to tumor metastasis. With the phenomenon of 'contact inhibition of locomotion,' it is puzzling how cells achieve such processes within a densely packed cohesive population. Here we demonstrate that a proper degree of cell-cell adhesiveness can, intriguingly, enhance the super-diffusive nature of individual cells. Read More

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September 2021

Identification of Novel Pyroptosis-Related lncRNAs Associated with the Prognosis of Breast Cancer Through Interactive Analysis.

Authors:
Lili Gao Qing Li

Cancer Manag Res 2021 15;13:7175-7186. Epub 2021 Sep 15.

Department of Pathology, Pudong New Area People's Hospital, Shanghai, People's Republic of China.

Background: The role of pyroptosis and lncRNAs in breast cancer remains controversial. This study aimed to explore the pyroptosis-related lncRNAs in breast cancer.

Methods: All the data used for bioinformatics analysis were downloaded from The Cancer Genome Atlas database. Read More

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September 2021

Bio-informatics and Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells.

Bioengineered 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacy, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China.

Schisandrin A (SchA) has been reported to have good anti-cancer effects. However, its anti-cancer mechanism in breast cancer remains unknown. This study aimed to explore the mechanism of SchA in breast cancer treatment using bio-informatics analysis and experiments. Read More

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September 2021

Immunization With RANKL Inhibits Osteolytic Bone Metastasis in Breast Cancer.

J Immunother 2021 Sep 21. Epub 2021 Sep 21.

Laboratory of Orthopaedic Research Department of Orthopaedic Surgery, Chosun University Hospital Department of Premedical Science, College of Medicine, Chosun University, Gwangju Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea.

Breast cancer cells often metastasize to bone. Accumulating evidence suggests that inhibiting the receptor activator of nuclear factor-κB ligand (RANKL) not only leads to reduced bone metastasis of breast cancer but also has antitumoral effects. Here, we used mutant receptor activator of nuclear factor-κB ligand (RANKLM) as a vaccine for active immunization to induce antibodies for immunotherapy of bone metastatic cancer. Read More

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September 2021

Trojan-Like Peptide Drug Conjugate Design and Construction for Application in Treatment of Triple-Negative Breast Cancer.

J Biomed Nanotechnol 2021 Aug;17(8):1554-1563

Department of Integrative Medicine & Geratology, Mudanjiang Medical University Affiliated Hongqi Hospital, Mudanjiang, Heilongjiang Province, 157000, P. R. China.

Clinical treatment of triple negative breast cancer (TNBC) is very poor for lack of effective treatment combination selection. Protein C receptor (PROCR) is a novel cancer stem marker in TNBC patients tumor tissues. Developed based on peptide BP10 with affinity to PROCR as a targeting element, constructing a peptide drug conjugate of BP10 covalently coupling doxorubicin with disulfide bonds. Read More

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Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells.

Bioconjug Chem 2021 Sep 20. Epub 2021 Sep 20.

Department of Biomedical Engineering, University of Delaware, 161 Colburn Lab, Newark, Delaware 19716, United States.

The use of nucleic acids to regulate gene expression is a rapidly developing field with immense clinical potential. Nanomaterials are frequently used to deliver nucleic acids into cells as they can overcome the poor cellular uptake and endo/lysosomal degradation of bare nucleic acids. For these nanocarriers to be effective, they must escape endo/lysosomal compartments to deliver their nucleic acid cargo into the cytosol (for ribonucleic acid (RNA)) or nucleus (for deoxyribonucleic acid (DNA)). Read More

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September 2021

Amentoflavone inhibits tumor necrosis factor-α-induced migration and invasion through AKT/mTOR/S6k1/hedgehog signaling in human breast cancer.

Food Funct 2021 Sep 20. Epub 2021 Sep 20.

Institute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China.

Inflammatory cytokine tumor necrosis factor-α (TNFα) has been demonstrated to accelerate the progression and metastasis of various carcinomas. In this study, we investigated the effect of amentoflavone on inhibiting the migration and invasion of TNFα-induced breast cancer cells. Results showed that amentoflavone significantly blocked the cellular migration and invasion of MCF10DCIS. Read More

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September 2021

Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells.

Oncol Lett 2021 Nov 27;22(5):749. Epub 2021 Aug 27.

Beijing Key Laboratory of Therapeutic Gene Engineering Antibody, Beijing 100850, P.R. China.

The receptor tyrosine kinase, anexelekto (Axl) is involved in tumor cell growth, migration and invasion, and has been associated with chemotherapy resistance, which makes it an attractive target for cancer therapy. In total, six Axl-targeted monoclonal antibodies (mAbs) and two antibody-drug conjugates have been reported in the last 10 years, which have been shown to have bioactivity in inhibiting tumor cell proliferation and migration. The Axl external cell domain (Axl), consisting of 426 amino acids, has always been used as an antigen in the screening process for all six of these Axl-targeted mAbs. Read More

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November 2021

α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway.

Front Pharmacol 2021 30;12:739658. Epub 2021 Aug 30.

School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is one of the main active ingredients of the hull of the mangosteen. The main objective of the study was to elucidate its anti-cancer function and possible mechanism. α-Mangostin was separated and structurally confirmed. Read More

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Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer.

J Med Chem 2021 Sep 20. Epub 2021 Sep 20.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Triple-negative breast cancer (TNBC) is highly aggressive with very limited treatment options due to the lack of efficient targeted therapies and thus still remains clinically challenging. Targeting transcription-associated cyclin-dependent kinases to remodel transcriptional regulation shows great promise in cancer therapy. Herein, we report the synthesis, optimization, and evaluation of new series of heterobifunctional molecules as highly selective and efficacious CDK9 degraders, enabling potent inhibition of TNBC cell growth and rapidly targeted degradation of CDK9. Read More

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September 2021

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.

Eur J Med Chem 2021 Sep 9;226:113812. Epub 2021 Sep 9.

Department of Chemistry, Tsinghua University, Beijing, 100084, PR China; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, PR China; National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, PR China. Electronic address:

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid-leucine-arginine sequence-contained chemokines CXCs (ELR CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block CXCLs/CXCR2 axis, and are widely used in regulating immune cell migration, tumor metastasis, apoptosis and angiogenesis. Read More

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September 2021

Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression.

NPJ Breast Cancer 2021 Sep 17;7(1):122. Epub 2021 Sep 17.

Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.

Knocking down delta-5-desaturase (D5D) by siRNA or shRNA is a promising strategy to achieve 8-hydroxyoctanoic acid (8-HOA) production for cancer inhibition. However, the RNAi-based strategy to stimulate 8-HOA is restricted due to endonucleases mediated physiological degradation and off-target effects. Thus, to get persistent 8-HOA in the cancer cell, we recognized a D5D inhibitor Iminodibenzyl. Read More

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September 2021

[Knockdown of lysine-specific demethylase 3A (KDM3A) inhibits the invasion and migration of MDA-MB-231 breast cancer cells and arrests the cell cycle in the G0/G1 phase].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):808-814

Imaging Center of First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China. *Corresponding author, E-mail:

Objective To investigate the effect of lysine-specific demethylase 3A (KDM3A) on the invasion and migration of MDA-MB-231 breast cancer cells. Methods The mRNA and the protein expressions of KDM3A in MDA-MB-231 breast cancer cells and MCF-10A normal breast cells were detected by real-time quantitative PCR and Western blotting, respectively; the KDM3A level of MDA-MB-231 cells was knocked down by lentivirus infection of KDM3A short hairpin RNA (shKDM3A). The change of invasion and migration ability of MDA-MB-231 cells was detected by Transwell assay, and the change in the cell cycle was detected by flow cytometry. Read More

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September 2021

Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells.

Ann Transl Med 2021 Aug;9(16):1300

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: While current basic studies indicate adipose-derived stem cells (ADSCs) can promote cell proliferation, clinical trials have shown no significant difference in breast cancer recurrence rates for patients with or without autologous fat grafting (AFG). In this study we attempted to explore the underlying mechanism for these contradictory results.

Methods: ADSCs and umbilical mesenchymal stem cells (UMSCs) were co-cultured with breast cancer cells (MCF-7 and MDA-MB-231), and the cell viability analyzed by CCK-8 cell proliferation assay, TUNEL assay and immunofluorescence assay. Read More

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Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase.

Breast Cancer Res Treat 2021 Sep 16. Epub 2021 Sep 16.

Department of Biology, University of Nebraska-Kearney, 2401 W. 11th Ave, BHS335, Kearney, NE, 68849, USA.

Purpose: Several cancer subtypes (pancreatic, breast, liver, and colorectal) rapidly advance to higher aggressive stages in diabetes. Though hyperglycemia has been considered as a fuel for growth of cancer cells, pathways leading to this condition are still under investigation. Cellular polyamines can modulate normal and cancer cell growth, and inhibitors of polyamine synthesis have been approved for treating colon cancer, however the role of polyamines in diabetes-mediated cancer advancement is unclear as yet. Read More

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September 2021

The interaction of ATP11C-b with ezrin contributes to its polarized localization.

J Cell Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

ATP11C, a member of the P4-ATPase family, translocates phosphatidylserine and phosphatidylethanolamine at the plasma membrane. We previously revealed that its C-terminal splice variant ATP11C-b exhibits polarized localization in motile cell lines, such as MDA-MB-231 and BaF3. In the present study, we found that the C-terminal cytoplasmic region of ATP11C-b interacts specifically with ezrin. Read More

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September 2021

Comparison of the effects of rutaecarpine on molecular subtypes of breast cancer.

J Cancer Res Ther 2021 Jul-Sep;17(4):988-993

Department of Medical Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey.

Objective: Natural compounds have gained considerable attention in recent years due to disadvantages and properties of current chemotherapy drugs in cancer therapy. In addition, the impact of these compounds is specific for each type and/or subtypes of cancer due to different treatment response. Rutaecarpine, an alkaloid obtained from Evodia Rutaecarpa Chinese herb, has anticancer activity by inhibiting topoisomerase and/or cyclo-oxygenase-2 levels. Read More

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September 2021

Identification of Optimal Expression Parameters and Purification of a Codon-Optimized Human GLIS1 Transcription Factor from Escherichia coli.

Mol Biotechnol 2021 Sep 15. Epub 2021 Sep 15.

Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

GLIS1 has multiple roles in embryonic development and in deriving induced pluripotent stem cells by aiding signaling pathways and chromatin assembly. An inexpensive and simple method to produce human GLIS1 protein from Escherichia coli (E. coli) is demonstrated in this study. Read More

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September 2021

An HDAC8-selective fluorescent probe for imaging in living tumor cell lines and tissue slices.

Org Biomol Chem 2021 Sep 16. Epub 2021 Sep 16.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China.

Histone deacetylase 8 (HDAC8) has been used as a therapeutic target for many cancers as it is highly expressed in neuroblastoma cells and breast cancer cells. HDAC8-selective fluorescent probes need to be urgently developed. Herein, two novel fluorescent probes, namely and , based on the conjugation of 1,8-naphthalimide with a highly selective inhibitor of HDAC8 () were reported. Read More

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September 2021

Decrease in Cell Viability of Breast Cancer Cells by a Di-Hydroxylated Derivative of N-(2-hydroxyphenyl)-2-Propylpentanamide.

Anticancer Agents Med Chem 2021 Sep 14. Epub 2021 Sep 14.

Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation). Escuela Superior de Medicina, Instituto Politécnico Nacional. Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340. Mexico.

Background: A preliminary study of the biotransformation by cytochrome P450 enzymes (CYP) of N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), an HDAC inhibitor, led to the synthesis of two hydroxylated derivatives: N-(2,4-dihydroxyphenyl)-2-propylpentanamide (5a) and N-(2,5-dihydroxyphenyl)-2-propylpentanamide (5b).

Objective: The study aims to evaluate the anti-proliferative activity of these di-hydroxylated derivatives in breast cancer cell lines.

Methods: MTT assays were conducted in MCF-7 and MDA-MB-231 cell lines. Read More

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September 2021

Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells.

Acta Pharmacol Sin 2021 Sep 14. Epub 2021 Sep 14.

Laboratory of Molecular Target Therapy of Cancer, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, 442000, China.

Dysregulation of the Hippo signaling pathway seen in many types of cancer is usually associated with a poor prognosis. Paris saponin VII (PSVII) is a steroid saponin isolated from traditional Chinese herbs with therapeutic action against various human cancers. In this study we investigated the effects of PSVII on human breast cancer (BC) cells and its anticancer mechanisms. Read More

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September 2021

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.

J Am Chem Soc 2021 Sep 14;143(37):15073-15083. Epub 2021 Sep 14.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Proteolysis targeting chimeras (PROTACs) represent a new class of promising therapeutic modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading to selective degradation of the target proteins. However, only a very limited number of E3 ligases have been leveraged to generate effective PROTACs. Read More

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September 2021

A new fluorescently labeled bisphosphonate for theranostics in tumor bone metastasis.

Talanta 2021 Dec 11;235:122796. Epub 2021 Aug 11.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing, 210023, PR China. Electronic address:

Bone metastasis of malignant solid tumors has become one of the most serious complications, especially in breast cancer, which was particularly challenging for early detection and treatment in clinical practice. In this work, we reported a new fluorescently labeled bisphosphonate for bone metastasis detection of breast cancer. The designed probes were based on Rhodamine B and bisphosphonate as recognition group, which can specifically target hydroxyapatite (HA) existed in bone tissue. Read More

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December 2021

Targeting HER2 protein in individual cells using ICP-MS detection and its potential as prognostic and predictive breast cancer biomarker.

Talanta 2021 Dec 8;235:122773. Epub 2021 Aug 8.

Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), C/ Julián Clavería 8, 33006, Oviedo, Spain. Electronic address:

The human epidermal growth factor receptor 2 (HER2) is a transmembrane protein that has become one of the most specific prognostic and predictive biomarker of breast cancer. Its early detection is key for optimizing the patient clinical outcome. This work is focused on the detection of HER2 in individual cells using an antibody containing lutetium (Lu) as reporter group that is monitored by introducing the individual cells into the inductively coupled plasma mass spectrometer (ICP-MS). Read More

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December 2021

Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.

J Med Chem 2021 Sep 13;64(18):13918-13932. Epub 2021 Sep 13.

Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.

Human dihydroorotate dehydrogenase (DHODH) is an attractive tumor target essential to de novo pyrimidine biosynthesis. Novel potent DHODH inhibitors with low toxicity are urgently needed. Herein, we demonstrate the isolation of 25 ascochlorin (ASC) derivatives, including 13 new ones, from the coral-derived fungus , and several of them showed pronounced inhibitions against DHODH and triple-negative breast cancer (TNBC) cell lines, MDA-MB-231/-468. Read More

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September 2021

Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in Mono-and Combination Therapy Against Breast Cancer Cell Models.

Anticancer Agents Med Chem 2021 Sep 9. Epub 2021 Sep 9.

Metabolomics Section, Department of Clinical Genomics, Center for Genomics Medicine, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh, 11564. Saudi Arabia.

Background: Chronic inflammation plays a crucial role in the initiation, promotion, and invasion of tumors, and thus the antiproliferative effects of numerous anti-inflammatory drugs have been frequently reported in the literature. Upregulation of the pro-inflammatory enzyme cyclooxygenase-2 (COX-2) has been linked to various human cancers, including breast cancer.

Objectives: This research aims to investigate the antiproliferative activity of different Non-steroidal anti-inflammatory drugs (NSAIDs), including COX-2 selective and non-selective agents, against various breast cancer cell lines and to elucidate possible molecular pathways involved in their activity. Read More

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September 2021