Chem Biol Drug Des 2021 May 8. Epub 2021 May 8.
Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences Saifai, Etawah, U.P., 206130, India.
Caspases, a group of protease enzymes (cysteine proteases) exist as inactive zymogens in the cells and execute apoptosis (programmed cell death). Caspase-3, an executioner caspase plays an imperative role in apoptosis and becomes a primary target for cancer treatment. A number of analogues of quinazoline, quinazolinone, indoloquinazolines, quinone, naphthoquinones, pyrroloiminoquinones, styrylquinolines, tetheredtetrahydroquinoline, fluoroquinolone, thiosemicarbazones, benzotriazole, pyrimidines, chalcone and carbazoles have been reported till date, representing caspase-3 mediated apoptosis for cancer therapy. Read More