1,256,722 results match your criteria cells induced


LncRNA DLGAP1-AS1 accelerates glioblastoma cell proliferation through targeting miR-515-5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway.

Brain Behav 2021 Sep 18:e2321. Epub 2021 Sep 18.

Department of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Introduction: Glioblastoma (GBM), the primary malignant tumor in the central nervous system, features high aggressiveness and mortality. Long noncoding RNAs (lncRNAs) can exert the crucial function in regulating various human diseases, including GBM. However, the function and mechanism of lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) in GBM remain still unknown. Read More

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September 2021

Liposome interaction with macrophages and foam cells for atherosclerosis treatment: effects of size, surface charge and lipid composition.

Nanotechnology 2021 Sep 18. Epub 2021 Sep 18.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798 Singapore, SG 639798, Singapore, 639798, SINGAPORE.

Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease of surface modifications that allow them to have prolonged circulation half-life and specifically target atherosclerotic sites to increase uptake efficiency. However, the effects of their size, charge, and lipid compositions on macrophage and foam cell behaviour are not fully understood. In this study, liposomes of different sizes (60 nm, 100 nm and 180 nm), charges (-40 mV, -20 mV, neutral, +15 mV and +30 mV) and lipid compositions (1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, L-a-phosphatidylcholine, and egg sphingomyelin) were synthesized, characterized and exposed to macrophages and foam cells. Read More

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September 2021

ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen.

Aging (Albany NY) 2021 Sep 18;13(undefined). Epub 2021 Sep 18.

Department of Urology, Fourth Affiliated Hospital of China Medical University, Shenyang 100032, Liaoning Province, P.R. China.

Adrenocortical carcinoma (ACC) is a rare but aggressive disease that lacks definitive treatment. We aim to evaluate role of ASXL1 in ACC and exploit its therapeutic merits therein. We performed reproduction of datasets of the Cancer Genome Atlas (TCGA), GDSC (Genomics of Drug Sensitivity in Cancer) and Human Protein Atlas using platforms of cBioPortal, UALCAN, NET-GE, GSEA and GEPIA. Read More

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September 2021

Study on degranulation of mast cells under C48/80 treatment by electroporation-assisted and ultrasound-assisted surface-enhanced Raman spectrascopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 27;265:120331. Epub 2021 Aug 27.

MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, Fujian, China; School of opto-electronic and Communication Engineering, Xiamen University of Technology, Xiamen, Fujian, China. Electronic address:

Both electroporation-assisted and ultrasound-assisted delivery methods can rapidly deliver nanoparticles into living cells for surface-enhanced Raman scattering (SERS) detection, but these two methods have never been compared. In this study, electroporation-assisted SERS and ultrasound-assisted SERS were employed to detect the biochemical changes of degranulated mast cells induced by mast cell stimulator (C48/80). The results showed that the cell damage of electroporation based on controllable electric pulse was smaller than that of ultrasound based on cavitation. Read More

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Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α.

Tissue Cell 2021 Sep 8;73:101646. Epub 2021 Sep 8.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yong an Road, Xicheng District, Beijing, 100050, China. Electronic address:

Osteoarthritis (OA) is a prevailing chronic disease in Orthopedics that characterized with severely damaged cartilage and subchondral bone, thus leading to profound disorders of synovial joints. Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from interleukin-1β (IL-1β)-induced apoptosis in vitro. Read More

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September 2021

Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids.

Biomed Pharmacother 2021 Sep 15;143:112142. Epub 2021 Sep 15.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar; Department of Dermatology and Venereology, Rumailah Hospital, Hamad Medical Corporation, Doha 3050, Qatar; Laboratory Animal Research Center, Qatar University, Doha 2713, Qatar. Electronic address:

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer cells maintain a delicate balance between ROS and antioxidants to promote pathogenesis and clinical challenges via targeting a battery of signaling pathways converging to cancer hallmarks. Read More

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September 2021

Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay.

Biomed Pharmacother 2021 Sep 15;143:112173. Epub 2021 Sep 15.

Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE, USA.

We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membrane potential in KOR expressing CHO (CHO-KOR) cells. Treatment of CHO-KOR cells with kappa agonists U50,488 or dynorphin [Dyn (1-13)NH] produced rapid and concentration-dependent decreases in FMP Blue fluorescence reflecting membrane hyperpolarization. Read More

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September 2021

Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.

Int Immunopharmacol 2021 Sep 15;100:108131. Epub 2021 Sep 15.

The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an 710004, Shaanxi, China. Electronic address:

Background: Vitamin D receptor (VDR) and NLRP3 inflammasome play critical roles in lupus nephritis (LN) pathogenesis.

Aim Of The Study: This study explored the therapeutic effect of VDR agonist on LN and its molecular mechanism to inhibit NLRP3 signalling.

Methods: C57BL/6 mice, lupus-prone MRL/lpr mice, and VDR agonist paricacitol-treated MRL/lpr mice (300 ng/kg/mouse per dose, 5 times/week for 8 weeks from 8 weeks old) were used to assess kidney histopathology and measure proteinuria, serum anti-ds-DNA antibody and expression of NF-κB/NLRP3/caspase-1/IL-1β/IL-18 axis. Read More

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September 2021

Polydopamine-based nanoplatform for photothermal ablation with long-term immune activation against melanoma and its recurrence.

Acta Biomater 2021 Sep 15. Epub 2021 Sep 15.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The high risk of tumor recurrence presents a big challenge in melanoma therapy. Photothermal therapy (PTT) has merged as a powerful weapon against tumor in recent years, which produces tumor-associated antigens (TAA) and recruits dendritic cells (DCs) to tumor sites through immunogenic cell death (ICD) for immune activation. However, due to the lack of activation signals of DCs, the immune effect induced by PTT is not sufficient to inhibit the recurrence and proliferation of tumor. Read More

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September 2021

Inhibitory G protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart.

Heart Rhythm 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmacology, Hebei Medical University; The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province. Electronic address:

Background: Slow delayed rectifier potassium current (I) is an important component of repolarization reserve during sympathetic nerve excitement. However, little is known about age-related functional changes of I and its involvement in age-dependent arrhythmogenesis.

Objective: To investigate age-related alteration of the I response to β-adrenergic receptor (βAR) activation. Read More

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September 2021

Exosome-mediated circ_0001846 participates in IL-1β-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B.

Clin Immunol 2021 Sep 15:108856. Epub 2021 Sep 15.

Trauma Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China. Electronic address:

Aims: Osteoarthritis (OA) is the leading cause of physical disability in middle-aged and elderly people globally. Previous studies have revealed that circular RNA (circRNA) is involved in the pathogenesis of OA. In this study, we studied the role of circ_0001846 in interleukin-1β (IL-1β)-induced OA progression. Read More

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September 2021

Hinokitiol-induced decreases of tyrosinase and microphthalmia-associated transcription factor are mediated by the endoplasmic reticulum-associated degradation pathway in human melanoma cells.

Biochimie 2021 Sep 15. Epub 2021 Sep 15.

Laboratory of Genomic Medicinal Science, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki Noda, Chiba, 278-8510, Japan. Electronic address:

Tyrosinase (TYR) is a key enzyme for melanin production. We previously showed that hinokitiol, a naturally occurring seven-membered ring terpenoid, potently inhibits human TYR activity. Interestingly, hinokitiol was recently reported to decrease expression of TYR and microphthalmia-associated transcription factor (MITF), which is a main transcription factor of the TYR gene, in murine melanoma cells. Read More

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September 2021

Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.

Cancer Lett 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery, Faculty of Medicine and HKU-SZH, The University of Hong Kong, Hong Kong, China. Electronic address:

Plasmacytoid dendritic cells (pDCs) play immunosuppressive roles in the tumor microenvironment. However, the molecular mechanisms underlying the recruitment and dysfunction of pDCs in the tumor microenvironment remain largely elusive, especially in hepatocellular carcinoma (HCC). In this study, we observed that pDCs accumulated in the blood, tumor tissue, and ascitic fluid of HCC patients. Read More

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September 2021

BMSCs-exosomes containing GDF-15 alleviated SH-SY5Y cell injury model of Alzheimer's disease via AKT/GSK-3β/β-catenin.

Brain Res Bull 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, P.R. China. Electronic address:

Background: Mesenchymal stem cells (MSCs) therapy has great potential for Alzheimer's disease (AD) treatment. Here, we investigated the roles of BMSCs-exosomes containing growth differentiation factor-15 (GDF-15) in regulating SH-SY5Y cell injury in AD.

Methods: The SH-SY5Y cell injury model was constructed by treating SH-SY5Y cells with 10μM Aβ. Read More

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September 2021

Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia.

Brain Res Bull 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

Perioperative neurocognitive disorder (PND) frequently occurs in elderly patients following anesthesia, and is associated with pro-inflammatory activation of microglia in hippocampus. In this study, sevoflurane, a commonly used inhaled anesthetic in clinic, was used to induce PND-like symptoms in aged SD rats (18-20 months). Data from novel object recognition and Y-maze tests first confirmed that aged SD rats exposed to 2% sevoflurane for 5h developed cognitive impairment. Read More

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September 2021

In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.

Life Sci 2021 Sep 15:119961. Epub 2021 Sep 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Faculty of Pharmacy, BUC, Cairo, Egypt.

Aim: Hepatocellular carcinoma (HCC) is a potentially life-threatening cancer. In the current study, anti-HCC efficacy of amygdalin, or metformin alone or in combination in comparison to doxorubicin was studied.

Main Methods: Both in-vitro and in-vivo based models. Read More

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September 2021

A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2.

J Neurosci Methods 2021 Sep 15:109357. Epub 2021 Sep 15.

Centres of Gene and Cell Therapy and Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK. Electronic address:

Background: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2, changing the coded amino acid from a glutamine to arginine at the so-called Q/R site, which is critical for regulating calcium permeability. ADAR2 exists as multiple alternatively-spliced variants within mammalian cells with differing editing efficiency.

New Method: In this study, phosphorodiamidate morpholino oligomers (PMOs) were used to increase Q/R site editing, by affecting the alternative splicing of ADAR2. Read More

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September 2021

Positive Allosteric Modulation of Adenosine A Receptor Alters Immune Cell Responses and Ameliorates Psoriasis-Like Dermatitis in Mice.

J Invest Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Molecular Medicine Research Institute, 428 Oakmead Parkway, Sunnyvale, CA 94085 USA.

Psoriasis is an immune cell-mediated inflammatory disease of the skin with a mixed Th1/Th17 cytokine environment combined with an innate immune response engaging toll-like receptors (TLRs). Inflammatory diseases are characterized by dysregulated immune cell responses and elevated levels of adenosine at disease sites. Adenosine, acting through the AR, regulates inflammation, immune response, T cell homeostasis and tissue repair. Read More

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September 2021

Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration.

Int J Biol Macromol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

The usefulness of sirolimus (SIR) in the treatment of diseases that involve retinal degeneration like age-related macular degeneration (AMD) has been well documented. However, the problem still remains probably owing to the peculiar environment of the eye and/or unfavourable physiochemical profile of SIR. In the present work, we aimed to fabricate sirolimus loaded PLGA nanoparticles (SIR-PLGA-NP) and chitosan decorated PLGA nanoparticles (SIR-CH-PLGA-NP) to be administered via non-invasive subconjunctival route. Read More

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September 2021

GPR120 inhibits colitis through regulation of CD4T cell IL-10 production.

Gastroenterology 2021 Sep 15. Epub 2021 Sep 15.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address:

Background & Aims: G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120 regulates CD4T cell function to inhibit colitis development. Read More

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September 2021

Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives.

Mech Ageing Dev 2021 Sep 16;199:111572. Epub 2021 Sep 16.

Dept. of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which proliferating cells undergo irreversible cell cycle arrest. Read More

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September 2021

Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway.

Chem Biol Interact 2021 Sep 15:109659. Epub 2021 Sep 15.

Department of Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China. Electronic address:

Fluorine is an essential trace element for human health. However, excessive fluoride intake causes skeletal fluorosis which affects cartilage development. Fluoride inhibited chondrocyte proliferation which is the initial and critical step of endochondral ossification, but the underlying mechanism has not been clearly illustrated. Read More

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September 2021

Neuritin attenuates oxygen-glucose deprivation/reperfusion (OGD/R)-induced neuronal injury by promoting autophagic flux.

Exp Cell Res 2021 Sep 15:112832. Epub 2021 Sep 15.

Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, 832000, China. Electronic address:

The autophagy/apoptosis interaction has always been a focus of study in pathogenicity models. Neuritin is a neurotrophic factor that is highly expressed primarily in the central nervous system. Our previous study revealed that it protects against apoptosis in cortical neurons subjected to oxygen-glucose deprivation (OGD)/reoxygenation (OGD/R), and later animal experiments revealed that it can increase the expression of the autophagy-related protein LC3. Read More

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September 2021

LncRNA MEG3 reverses CCl-induced liver fibrosis by targeting NLRC5.

Eur J Pharmacol 2021 Sep 15:174462. Epub 2021 Sep 15.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. Electronic address:

Liver fibrosis is a persistent pathological repair of chronic liver injury, which is characterized by excessive deposition of collagen-dominated extracellular matrix (ECM). It is well known that hepatic fibrosis can be reversed in the absence of etiology. Studies have shown that long non-coding RNA (Lnc RNA) maternally expressed gene3 (MEG3) has strong effects on the activation of hepatic stellata cells (HSCs). Read More

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September 2021

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.

Biochem Pharmacol 2021 Sep 15:114765. Epub 2021 Sep 15.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in men. Although androgen deprivation therapies (ADT) and antiandrogens confer increased survival rates, most patients eventually develop castration resistant disease (CRPC). Previous studies have shown that these treatments have limited cytotoxicity, and instead, promote tumor cell growth arrest. Read More

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September 2021

Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.

Cell Stem Cell 2021 Sep 16. Epub 2021 Sep 16.

Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address:

Microglia are resident macrophages in the brain that emerge in early development and respond to the local environment by altering their molecular and phenotypic states. Fundamental questions about microglia diversity and function during development remain unanswered because we lack experimental strategies to interrogate their interactions with other cell types and responses to perturbations ex vivo. We compared human microglia states across culture models, including cultured primary and pluripotent stem cell-derived microglia. Read More

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September 2021

Serine/threonine kinase 17b (STK17B) signaling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.

Eur J Neurosci 2021 Sep 18. Epub 2021 Sep 18.

Institute of Anatomy, Department of Biomedicine, University of Basel, Basel, Switzerland.

Serine/threonine kinase 17b (STK17B, also known as DRAK2) is known to be a downstream effector of Protein Kinase C (PKC) in the immune system, in particular T-lymphocytes. PKC activity also plays a critical role for dendritic development and synaptic maturation and plasticity in cerebellar Purkinje cells. We present evidence that STK17B is strongly expressed in mouse cerebellar Purkinje cells starting in the early postnatal period and remaining highly expressed throughout adult stages and that STK17B is a target of PKC phosphorylation in the cerebellum. Read More

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September 2021

Selenomethionine Alleviates Intestinal Ischemia-Reperfusion Injury in Mice Through the Bax-Caspase Pathway.

Biol Trace Elem Res 2021 Sep 18. Epub 2021 Sep 18.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Tech Industrial Development Zone, Daqing, Heilongjiang, 163319, People's Republic of China.

Selenomethionine (SeMet) is known to alleviate ischemia-reperfusion (I/R) injury. However, its details of action have not been thoroughly elucidated in mice with intestinal I/R injury. In this study, intestinal I/R injury mice models were established, and ELISAs were performed to determine the levels of redox factors, including glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA), in mice intestinal tissues. Read More

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September 2021

Generation and characterization of a tractable C. elegans model of tauopathy.

Geroscience 2021 Sep 18. Epub 2021 Sep 18.

Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.

Alzheimer's disease(AD) is an age-associated neurodegenerative disease that results in deterioration of memory and cognitive function. As a currently untreatable disorder, AD has emerged as one of the defining biomedical challenges of our time. Thus, new approaches that can examine the cellular and molecular mechanisms underlying age-related AD pathology are sorely needed. Read More

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September 2021

Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior.

Mol Neurobiol 2021 Sep 18. Epub 2021 Sep 18.

Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, 52 Ewhayeodaegil, Seodaemoon-Gu, Seoul, 03760, Republic of Korea.

Aging induces cellular and molecular changes including gene expression alteration in the brain, which might be associated with aging-induced decrease in stress coping ability. In the present study, we investigate how aging changes the ability to cope with stress and increases sensitivity to stress. Aged mice show decreased expression of SUV39H1 histone methyltransferase and increased expression of Mkp-1 in the hippocampus. Read More

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September 2021