Search Our Scientific Publications & Authors

Planta Med 2021 Apr 14. Epub 2021 Apr 14.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Brazil.

is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction of cancer cell death and the compounds involved remain unknown. To ascertain these bioactive compounds, bioassay-guided fractionation was performed, alongside the appropriate tests. Read More

ORL J Otorhinolaryngol Relat Spec 2021 Apr 14:1-7. Epub 2021 Apr 14.

Department of Otorhinolaryngology-Head and Neck Surgery, National Medical Center, Seoul, Republic of Korea.

Introduction: Tissue remodeling refers to structural changes that occur in damaged tissue and is associated with disease severity in asthma. However, the characteristics of tissue remodeling and its prognostic role in chronic rhinosinusitis (CRS) remain unclear. In this report, we evaluated the clinical implications of tissue remodeling in CRS. Read More

Eur J Med Chem 2021 Apr 3;219:113429. Epub 2021 Apr 3.

Institute of Organic Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924, Łódź, Poland. Electronic address:

Herein we report an efficient synthesis of a series of regioisomeric N,O-syn and N,O-anti 3-diethoxyphosphorylfuroquinoline-4,9-diones combining furoquinoline-5,8-dione skeleton, present in several highly cytotoxic compounds, with diethoxyphosphoryl moiety. The cytotoxic activity of the obtained analogs was tested against two human cancer cell lines: promyelocytic leukemia HL-60 and breast cancer adenocarcinoma MCF-7 and for comparison on human umbilical vein endothelial cells HUVEC and mammary gland/breast MCF-10 A cells. Several diethoxyphosphorylfuroquinoline-4,9-diones proved to be highly cytotoxic for cancer cells with IC values even below 0. Read More

Cell Metab 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA. Electronic address:

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N-methyladenosine (mA) RNA modification, is implicated in development, but its role in most diseases is unknown. Here, we show that Mettl3 and mA levels are increased in mouse and human ADPKD samples and that kidney-specific transgenic Mettl3 expression produces tubular cysts. Read More

Cell Rep 2021 Apr;35(2):108965

Molecular, Cellular and Developmental Biology Department (MCD), Centre de Biologie Intégrative (CBI), University of Toulouse, CNRS, UPS, 31062 Toulouse, France. Electronic address:

Conversion of promoter-proximally paused RNA polymerase II (RNAPII) into elongating polymerase by the positive transcription elongation factor b (P-TEFb) is a central regulatory step of mRNA synthesis. The activity of P-TEFb is controlled mainly by the 7SK small nuclear ribonucleoprotein (snRNP), which sequesters active P-TEFb into inactive 7SK/P-TEFb snRNP. Here we demonstrate that under normal culture conditions, the lack of 7SK snRNP has only minor impacts on global RNAPII transcription without detectable consequences on cell proliferation. Read More

Cell Rep 2021 Apr;35(2):108952

Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland; Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy. Electronic address:

The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in ensuring correct synaptogenesis. We show that mitochondrial biogenesis in developing astrocytes is necessary for coordinating post-natal astrocyte maturation and synaptogenesis. The astrocytic mitochondrial biogenesis depends on the transient upregulation of metabolic regulator peroxisome proliferator-activated receptor gamma (PPARγ) co-activator 1α (PGC-1α), which is controlled by metabotropic glutamate receptor 5 (mGluR5). Read More

Cell Rep 2021 Apr;35(2):108991

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Laboratory for Translational Cell Biology, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordinate proliferation and differentiation during early neural development. However, whether loss of FMRP-mediated translational control is related to impaired cell fate specification in the developing human brain remains unknown. Read More

Can J Physiol Pharmacol 2021 Apr 14. Epub 2021 Apr 14.

Eastern District of the Hospital Jining No.1 People's Hospital, Neonatal Ward, No. 6 Health Road, Jining City, Shandong Province 272000,China., Jining, Shandong, China, 272000;

Background: Sepsis often leads to systemic multiple organ dysfunction, with the majority of deaths attributable to acute myocardial injury (AMI). In this study, we aimed to explore the functional role of miR-365a-3p in sepsis induced AMI.

Materials And Methods: The sepsis myocardial injury model was constructed using lipopolysaccharide (LPS) both in vitro and in vivo with selective regulation of miR-365a-3p expression. Read More

Dev Neurobiol 2021 Apr 14. Epub 2021 Apr 14.

School of Graduate Studies, Rutgers -The State University of New Jersey, Piscataway, NJ, USA.

Abnormalities in genes that regulate early brain development are known risk factors for neurodevelopmental disorders. Engrailed-2 (En2) is a homeodomain transcription factor with established roles in cerebellar patterning. En2 is highly expressed in the developing mid-hindbrain region and En2 knockout (KO) mice exhibit major deficits in mid-hindbrain structures. Read More

Endocr Relat Cancer 2021 Apr 1. Epub 2021 Apr 1.

C García-Jiménez, Area Physiology. Dpt Basic Health Sciences., Rey Juan Carlos University, ALCORCÓN, Spain.

Obesity is the strongest known risk factor to develop Type 2 diabetes (T2D) and both share a state of chronic, diffuse and low-grade inflammation, impaired immune responses and alterations in the composition and function of the microbiome. Notably, these hallmarks are shared with colorectal cancer (CRC), which is epidemiologically associated to obesity and T2D. Gut barrier damages in T2D, destabilize the microbiome that metabolizes the diet and modulates the host immune response triggering inflammatory and proliferative pathways. Read More

Endocr Relat Cancer 2021 Apr 1. Epub 2021 Apr 1.

H Heemers, Cancer Biology, Cleveland Clinic, Cleveland, 44195, United States.

The recent genomic characterization of patient specimens has started to reveal the landscape of somatic alterations in clinical prostate cancer (CaP) and its association with disease progression and treatment resistance. The extent to which such alterations impact hallmarks of cancer is still unclear. Here, we interrogate genomic data from thousands of clinical CaP specimens that reflect progression from treatment-naïve, to castration-recurrent, and in some cases, neuroendocrine CaP for alterations in cell cycle-associated and -regulated genes, which are central to cancer initiation and progression. Read More

Adv Biol (Weinh) 2021 Apr 15;5(4):e2000280. Epub 2021 Feb 15.

Biosciences Institute, Newcastle University, International Centre for Life, Newcastle upon Tyne, NE1 3BZ, UK.

Biological tissues comprise complex structural environments known to influence cell behavior via multiple interdependent sensing and transduction mechanisms. Yet, and despite the predominantly nonplanar geometry of these environments, the impact of tissue-size (milliscale) curvature on cell behavior is largely overlooked or underestimated. This study explores how concave, hemicylinder-shaped surfaces 3-50 mm in diameter affect the migration, proliferation, orientation, and differentiation of C2C12 myoblasts. Read More

Cell Tissue Res 2021 Apr 14. Epub 2021 Apr 14.

DoD-VA Extremity Trauma and Amputation Center of Excellence, Bethesda, MD, USA.

Biologic scaffolds (BS) are the most widely studied therapeutics for the treatment of volumetric muscle loss (VML) owing to their purported effects on cell proliferation, chemotaxis, migration, and differentiation. Despite these claims, variability in reports on the nature of the immune response to their implantation suggests that BS-associated inflammation may be limiting their regenerative efficacy. To address this shortcoming, this study sought to evaluate licofelone (ML3000), a dual 5-LOX/COX inhibitor, as an anti-inflammatory adjunct therapy to a BS in the treatment of VML. Read More

J Cell Biol 2021 May;220(5)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Cell adhesion controls cell survival and proliferation via multiple mechanisms. Rabanal-Ruiz et al. (2021. Read More

Cell Biol Int 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.

The nerve conduits have been developed for the nerve defect repair. However, no artificial conduits have obtained the comparable results to autografts to bridge the large gaps. A possible reason for this poor performance may be lack of sustainable neurotrophic support for axonal regrowth. Read More

Biosci Rep 2021 Apr;41(4)

Drugs Today (Barc) 2021 Apr;57(4):277-289

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.

Bruton tyrosine kinase (BTK) plays an important role in the B-cell receptor (BCR) signaling pathway by mediating proliferation, migration and adhesion in B-cell malignancies. Therefore, the components of BCR signaling, especially BTK, are considered to be attractive therapeutic targets. Ibrutinib, a first-in-class BTK inhibitor, has been approved for the treatment of several types of B-cell malignancies worldwide. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):362-368

Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, Ningbo, China.

There were rare clinical reports on clear cell tumor of the lung (CCTL). The clinical characteristics and underlying genetic mutation status of CCTL are poorly understood. From 2012 to 2017, patients pathologically diagnosed with CCTL in our hospital were investigated and analyzed based on clinical manifestations, pathological characteristics, prognosis and full gene mutation status through next generation sequencing (NGS) technology. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):294-301

Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China.

Background: Xanthoceraside is a component obtained in the husks of Xanthoceras sorbifolia Bunge. Series of researches proved that xanthoceraside had functions of anti-inflammation and anti-tumor effects. However, the mechanisms of xanthoceraside against bladder cancer are unclear. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):238-242

Department of Pathology, Health Sciences University, Antalya Education and Research Hospital, Antalya, Turkey.

Context: Pterygium is a degenerative disease that consists of conjunctival epithelia and fibrovascular tissue. Some studies suggest that there is a defect in the regulation of apoptosis in the epithelial cell cycle characterized by the development of the disease. But, still this matter being debated. Read More

Am J Physiol Gastrointest Liver Physiol 2021 Apr 14. Epub 2021 Apr 14.

Cell Biology and Histology, University of the Basque Country, Spain.

Colorectal cancer (CRC) colonization of the liver and its further metastatic growth are the result of complex interaction between the tumor cell, the collagenous extracellular matrix (ECM) and the hepatic sinusoidal cells (SCs). Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor activated by collagen and a bad prognosis factor in cancer. DDR1 signaling regulates key cell functions for tumor development, such as proliferation, migration, invasion and metalloproteinases (MMPs) secretion. Read More

Eur J Nucl Med Mol Imaging 2021 Apr 13. Epub 2021 Apr 13.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA, USA.

Purpose: The objective of this review was to explore the potential clinical application of unconventional non-amino acid PET radiopharmaceuticals in patients with gliomas.

Methods: A comprehensive search strategy was used based on SCOPUS and PubMed databases using the following string: ("perfusion" OR "angiogenesis" OR "hypoxia" OR "neuroinflammation" OR proliferation OR invasiveness) AND ("brain tumor" OR "glioma") AND ("Positron Emission Tomography" OR PET). From all studies published in English, the most relevant articles were selected for this review, evaluating the mostly used PET radiopharmaceuticals in research centers, beyond amino acid radiotracers and 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG), for the assessment of different biological features, such as perfusion, angiogenesis, hypoxia, neuroinflammation, cell proliferation, tumor invasiveness, and other biological characteristics in patients with glioma. Read More

Mol Hum Reprod 2021 Apr 14. Epub 2021 Apr 14.

Institut de Génétique Humaine, Centre National de la Recherche Scientifique, Université de Montpellier, 34396 Montpellier, France.

Adenomyosis is characterised by epithelial gland and mesenchymal stroma invasion of the uterine myometrium. Adenomyosis is an oestrogen-dependent gynaecological disease in which a number of factors, such as inflammatory molecules, prostaglandins (PGs), angiogenic factors, cell proliferation and extracellular matrix remodelling proteins also play a role as key disease mediators. In this study, we used mice lacking both L- and H-prostaglandin D synthase (Pgds) genes in which PGD2 is not produced to elucidate PGD2 roles in the uterus. Read More

iScience 2021 Apr 11;24(4):102297. Epub 2021 Mar 11.

Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Individual cell environment stimulating single cell is a suitable strategy for the generation of sophisticated multicellular aggregates with localized biochemical signaling. However, such strategy for induced pluripotent stem cell (iPSC)-derived embryoid bodies (EBs) is limited because the presence of external stimulation can inhibit spontaneous cellular communication, resulting in misdirection in the maturation and differentiation of EBs. In this study, a facile method of engineering the iPSC membrane to stimulate the inner cell of EBs while maintaining cellular activities is reported. Read More

Data Brief 2021 Apr 18;35:106889. Epub 2021 Feb 18.

Laboratory of Developmental Biology Research and Experimental Teratogenicity, Children´s Hospital of Mexico Federico Gomez (HIMFG), CP 06720 Mexico City, Mexico.

The present work benefits the use of sodium tetraborate to prevent and treat hypertrophic cardiac. The data obtained from the work could serve as a reference point to compare with data obtained in vivo studies with cardiac damage. This research will be an advantage for future researches to stimulate the ones focused on developing food supplements to prevent heart diseases such as cardiac hypertrophic. Read More

Ann Transl Med 2021 Mar;9(6):500

Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.

Background: Hepatocellular carcinoma (HCC) often has an insidious onset and rapid progression. Often, when the disease is first diagnosed, the opportune time for surgical intervention has already lapsed. In addition, the effects of systemic treatment is relatively unsatisfactory. Read More

Ann Transl Med 2021 Mar;9(6):498

Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Circular RNA (circRNA) has become a new focus in the field of tumor biology research in recent years. Many circRNAs have been showed to play an important role in the progression of lung adenocarcinoma (LUAD). In this work, we studied the oncological role of hsa-circ-000881 in LUAD and attempted to explore the related mechanism. Read More

Ann Transl Med 2021 Mar;9(6):492

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China.

Background: Extracellular matrix proliferation is an issue which leads to lung tissue damage in diabetes mellitus. Glucagon-like peptide-1 (GLP-1) analogues can improve the proliferation of extracellular matrix in diabetic pulmonary disease. In this study, we investigated the effect of GLP-1 on pulmonary fibrosis through the AMPK/microRNA-27a (miR-27a) pathway. Read More

Ann Transl Med 2021 Mar;9(6):488

Department of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Osteosarcoma (OS) is an aggressive bone cancer that most commonly affects adolescents and children. Emerging studies have shown that long noncoding RNA (lncRNA) performs essential roles in the occurrence and development of many tumors. Prostate androgen-regulated transcript 1 (PART 1) has been reported as a tumor oncogene; despite this, the mechanisms underlying its involvement in OS are unclear. Read More

Ann Transl Med 2021 Mar;9(6):487

Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Background: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with intense cytogenetic aberrations. Importantly, our recent report indicated that thyroid hormone receptor interactor 13 () is a potential new therapeutic target in CLL. In this study, we predicted 20 -related genes and found that KIAA0101 is a novel gene that regulates cell proliferation and the cell cycle of CLL cells. Read More