63,402 results match your criteria cell neuroendocrine


Aromatase and non-aromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.

Eur J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA.

Estrogens support major brain functions including cognition, reproduction, neuroprotection, and sensory processing. Neuroestrogens are synthesized within some brain areas by the enzyme aromatase and can rapidly modulate local circuit functions, yet the cellular physiology and sensory-response profiles of aromatase neurons are essentially unknown. In songbirds, social and acoustic stimuli drive neuroestrogen elevations in the auditory forebrain caudomedial nidopallium (NCM). Read More

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September 2021

Large Cell Neuroendocrine Carcinoma Transformation as a Mechanism of Acquired Resistance to Osimertinib in Non-small Cell Lung Cancer: Case Report and Literature Review.

Clin Lung Cancer 2021 Aug 10. Epub 2021 Aug 10.

Division of Medical Oncology, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY. Electronic address:

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Molecular Subtypes of Primary Small Cell Lung Cancer Tumors and Their Associations with Neuroendocrine and Therapeutic Markers.

J Thorac Oncol 2021 Sep 14. Epub 2021 Sep 14.

Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health. Electronic address:

Introduction: A new molecular subtype classification was recently proposed for small cell lung cancer (SCLC). It is necessary to validate it in primary SCLC tumors by immunohistochemical (IHC) staining and define its clinical relevance.

Methods: We used IHC to assess four subtype markers (ASCL1, NEUROD1, POU2F3, and YAP1) in 194 cores from 146 primary SCLC tumors. Read More

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September 2021

Trophoblast cell-surface antigen 2 expression in lung cancer patients and the effects of anti-cancer treatments.

J Cancer Res Clin Oncol 2021 Sep 17. Epub 2021 Sep 17.

Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Trophoblast cell-surface antigen 2 (TROP2) is expressed on the surface of trophoblast cells and many malignant tumor cells. However, data on TROP2 expression in advanced lung cancer are insufficient, and its changes have not been fully evaluated.

Methods: We assessed the prevalence and changes in TROP2 expression in patients with lung cancer who received anti-cancer treatments using immunohistochemical (IHC) analysis with an anti-TROP2 antibody (clone: SP295). Read More

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September 2021

Absence of Biomarker-Driven Treatment Options in Small Cell Lung Cancer, and Selected Preclinical Candidates for Next Generation Combination Therapies.

Front Pharmacol 2021 31;12:747180. Epub 2021 Aug 31.

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI, United States.

Lung cancer is the second most common cancer in the United States, and small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. In SCLC, more than other malignancies, the standard of care is based on clinical demonstration of efficacy, and less on a mechanistic understanding of why certain treatments work better than others. This is in large part due to the virulence of the disease, and lack of clinically or biologically relevant biomarkers beyond routine histopathology. Read More

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[Pathological diagnosis and clinical significance of appendiceal epithelial neoplasms].

Zhonghua Zhong Liu Za Zhi 2021 Sep;43(9):906-911

Department of Pathology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.

Appendiceal epithelial neoplasms including benign and malignant, are clinically rare. There were quite a lot of changings in classification systems for them and different pathological diagnostic terminologies were used, resulted in confusions of understanding and communication for both pathologists and clinicians. Basically, appendiceal epithelial neoplasms include adenoma, serrated lesion and polyps, mucinous neoplasms, carcinoma and neuroendocrine neoplasms. Read More

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September 2021

Improving differential diagnosis of pulmonary large cell neuroendocrine carcinoma and small cell lung cancer via a transcriptomic, biological pathway-based machine learning model.

Transl Oncol 2021 Sep 13;14(12):101222. Epub 2021 Sep 13.

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China. Electronic address:

Background: Accurately differentiating between pulmonary large cell neuroendocrine carcinomas (LCNEC) and small cell lung cancer (SCLC) is crucial to make appropriate therapeutic decisions. Here, a classifier was constructed based on transcriptome data to improve the diagnostic accuracy for LCNEC and SCLC.

Methods: 13,959 genes mapped to 186 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were included. Read More

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September 2021

Acinic cell carcinoma of the parotid gland with neuroendocrine differentiation.

J Cancer Res Ther 2021 Jul-Sep;17(4):1115-1118

Department of Otorhinolaryngology And Head And Neck Surgery, Maulana Azad Medical College, New Delhi, India.

Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. Read More

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September 2021

Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis.

Front Oncol 2021 30;11:645623. Epub 2021 Aug 30.

Department of Pathology, University of São Paulo Medical School (USP), São Paulo, Brazil.

Typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological and histogenesis differences, The hierarchical structure reveals high cohesiveness between neoplastic cells by mechanical desmosomes barrier assembly in carcinoid tumors and LCNEC, while SCLC does not present an organoid arrangement in morphology, the neoplastic cells are less cohesive. However, the molecular mechanisms that lead to PNENs metastasis remain largely unknown and require further study. In this work, epithelial to mesenchymal transition (EMT) transcription factors were evaluated using a set of twenty-four patients with surgically resected PNENs, including carcinomas. Read More

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MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer.

Comput Struct Biotechnol J 2021 31;19:4941-4953. Epub 2021 Aug 31.

Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518000, China.

MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regulated transcriptome with non-negative matrix factorization. Using 478 PCa samples from The Cancer Genome Atlas, four molecular subtypes (S-I, S-II, S-III, and S-IV) were identified and validated in two merged microarray and RNAseq datasets with 656 and 252 samples, respectively. Read More

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Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma.

Int J Clin Exp Pathol 2021 15;14(8):875-880. Epub 2021 Aug 15.

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences Beijing 100190, P. R. China.

Primary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5. Read More

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Therapeutic approaches and outcomes in patients with larynx or hypopharynx high-grade neuroendocrine carcinoma: A single-center retrospective analysis.

Head Neck 2021 Sep 15. Epub 2021 Sep 15.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Background: High-grade neuroendocrine carcinoma of the larynx (HG-NECL) is rare and aggressive with limited data regarding response to systemic therapy. We evaluated clinicopathological features, therapeutic approaches, and outcomes in patients with laryngeal or hypopharyngeal HG-NECL.

Methods: Data were retrospectively collected through 1997-2020. Read More

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September 2021

Management and Survival Analysis of Gastrointestinal Neuroendocrine Tumors by Different Tumor Characteristics: Tertiary Center Experience.

J Gastrointest Cancer 2021 Sep 15. Epub 2021 Sep 15.

Department of Pathology, Faculty of Medicine, Inonu University, Malatya, 44280, Turkey.

Background: Gastrointestinal neuroendocrine tumor (GI-NET) is a group of neoplasia consisting of amine and acid producing cells with different hormonal profiles. Although the entire GIS accounts for about 2% of tumors, recent research reveals that the incidence rate has increased. Given the increasing incidence in GI-NETs, more and more extensive research is needed on this subject. Read More

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September 2021

Robotic Surgery in Pediatric Oncology: Lessons Learned from the First 100 Tumors-A Nationwide Experience.

Ann Surg Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: While robotics has become commonplace in adult oncology, it remains rare in pediatric oncology due to the rarity of childhood cancers. We present the results of a large nationwide experience with robotic oncology, with the aim of providing practical and feasible guidelines for child selection.

Methods: This was a prospective analysis performed over a period of 4 years. Read More

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September 2021

The improved clinical course of persistent tachypnea of infancy with inhaled bronchodilators and corticosteroids.

Pediatr Pulmonol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatric Pneumology and Allergy, Medical University of Warsaw, Warsaw, Poland.

Background: Persistent tachypnea of infancy (PTI) is the most common interstitial lung disease in young children. As no standardized therapeutic guidelines exist, different pharmaceutics are used to treat PTI. Inhaled corticosteroids (ICS) and bronchodilators being mostly used. Read More

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September 2021

Small cell neuroendocrine tumour of the cervix in pregnancy: the importance of multidisciplinary management.

BMJ Case Rep 2021 Sep 13;14(9). Epub 2021 Sep 13.

Department of Gynaecological Oncology, Somerset NHS Foundation Trust, Taunton, UK

A woman in her mid-20s presented with bleeding at 18 weeks gestation from a cervical 'polyp'. Histopathology demonstrated a rare small cell neuroendocrine of the cervix. There were only 18 cases of neuroendocrine tumours of the cervix in and around pregnancy in the literature, so the evidence base for treatment was scarce. Read More

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September 2021

A Case of Adult Pancreatoblastoma With Novel Mutation and Genetic Heterogeneity.

Front Oncol 2021 27;11:725290. Epub 2021 Aug 27.

Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Japan.

Background: Pancreatoblastoma is a rare malignant epithelial neoplasm of the pancreas that mainly occurs in children and involves abnormalities in the WNT/β-catenin pathway, such as mutation. However, the molecular abnormalities in adult pancreatoblastoma are not well known.

Case Presentation: An elderly man, who underwent elective distal pancreatectomy and splenectomy, was referred to our hospital with a mass in the tail of the pancreas. Read More

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Management of Large Cell Neuroendocrine Carcinoma.

Front Oncol 2021 27;11:653162. Epub 2021 Aug 27.

Division of Medical Oncology, Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, United States.

Background: Large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal tract; however, it can occur throughout the body. Recently advances in the understanding of the molecular underpinnings of this disease have paved the way for additional novel promising therapies. Read More

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Adjuvant therapy for lung neuroendocrine neoplasms.

World J Clin Oncol 2021 Aug;12(8):664-674

Division of Medical Oncology, University of Kentucky, Lexington, KY 40536, United States.

Pulmonary neuroendocrine neoplasms (NENs) represent a minority of lung cancers and vary from slower growing pulmonary carcinoid (PC) tumors to aggressive small cell lung cancer (SCLC). While SCLC can account for up to 15% of lung cancer, PCs are uncommon and represent about 2% of lung cancers. Surgical resection is the standard of care for early-stage PCs and should also be considered in early stage large cell neuroendocrine carcinoma (LCNEC) and SCLC. Read More

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Pathology and Molecular Characteristics of Pancreatic Cancer.

Surg Oncol Clin N Am 2021 Oct 22;30(4):609-619. Epub 2021 Jul 22.

Surgery and Pharmacology, University of North Carolina at Chapel Hill, 101 Manning Drive, 1150 Physicians Office Building, 21-245 Lineberger CB# 7213, Chapel Hill, NC 27599-7213, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. However, it should be kept in mind that there are other pancreatic cancers that are classified by their cellular lineage: acinar cell carcinomas (acinar differentiation), neuroendocrine neoplasms (arising from the islets), solid-pseudopapillary neoplasms (showing no discernible cell lineage), and pancreatoblastomas (characterized by multiphenotypic differentiation, including acinar endocrine and ductal). This article focuses on the molecular and pathology alterations in PDAC. Read More

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October 2021

Involvement of papillomavirus type 2 in the tumorigenesis of feline Merkel cell carcinoma.

Vet Pathol 2021 Sep 13:3009858211045440. Epub 2021 Sep 13.

The University of Tokyo, Tokyo, Japan.

Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine tumor. We recently demonstrated that cats with MCC often have other proliferative cutaneous lesions, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Based on this finding, we hypothesize that papillomavirus (FcaPV) is involved in the development of MCC in cats, similar to SCC and BCC. Read More

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September 2021

Outcome for sinonasal malignancies: a population-based survey.

Eur Arch Otorhinolaryngol 2021 Sep 12. Epub 2021 Sep 12.

Department of ORL, Head & Neck Surgery, Skåne University Hospital, 221 85, Lund, Sweden.

Purpose: Sinonasal malignancies (SNM) represent a rare and complex group of cancers that includes a wide range of histopathological subtypes. Data from population-based cohorts are scarce but warranted as a basis for randomized controlled treatment trials (RCTs). Our aim was to assess overall and histology subset-specific outcomes for SNM patients treated at a tertiary referral centre. Read More

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September 2021

Clinicopathologic features and BRAF mutation status of tracheal glomus tumors - Characterization of 4 cases and the distinction from low-grade neuroendocrine tumors.

Ann Diagn Pathol 2021 Jul 31;55:151797. Epub 2021 Jul 31.

Departments of Pathology, China-Japan Friendship Hospital, Beijing, China. Electronic address:

Background: Glomus tumors are uncommon and mostly benign mesenchymal neoplasms of the perivascular family. To date, only a few cases of glomus tumors occurring in the trachea have been reported. Tracheal glomus tumors simulated low-grade neuroendocrine tumors on clinical and histomorphological examination, so the differential diagnosis between these two entities is very necessary. Read More

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Prenatal androgen treatment does not alter the firing activity of hypothalamic arcuate kisspeptin neurons in female mice.

eNeuro 2021 Sep 9. Epub 2021 Sep 9.

Departments of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA

Neuroendocrine control of reproduction is disrupted in many individuals with polycystic ovary syndrome, who present with increased luteinizing hormone (LH), and presumably gonadotropin-releasing hormone (GnRH), release frequency, and high androgen levels. Prenatal androgenization (PNA) recapitulates these phenotypes in primates and rodents. Female offspring of mice injected with dihydrotestosterone (DHT) on gestational D16-18 exhibit disrupted estrous cyclicity, increased LH and testosterone, and increased GnRH neuron firing rate as adults. Read More

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September 2021

Modeling early radiation DNA damage occurring during [Lu]Lu-DOTA-[Tyr]octreotate radionuclide therapy.

J Nucl Med 2021 Sep 9. Epub 2021 Sep 9.

IRSN, Institut de Radioprotection et de Sûreté Nucléaire, France.

: The aim of this study is to build a simulation framework to evaluate the number of DNA double strand breaks (DSBs) induced by targeted radionuclide therapy (TRT). This work represents the first step towards exploring underlying biological mechanisms and influence of physical/chemical parameters to enable a better response prediction in patients. We used this tool to characterize early DSB induction by [Lu]Lu-DOTA-[Tyr]octreotate (Lu-DOTATATE), a commonly used TRT for neuroendocrine tumors. Read More

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September 2021

Elevated Flt3L Predicts Long-Term Survival in Patients with High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms.

Cancers (Basel) 2021 Sep 4;13(17). Epub 2021 Sep 4.

Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

Background: The clinical management of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is challenging due to disease heterogeneity, illustrating the need for reliable biomarkers facilitating patient stratification and guiding treatment decisions. FMS-like tyrosine kinase 3 ligand (Flt3L) is emerging as a prognostic or predictive surrogate marker of host tumoral immune response and might enable the stratification of patients with otherwise comparable tumor features.

Methods: We evaluated Flt3L gene expression in tumor tissue as well as circulating Flt3L levels as potential biomarkers in a cohort of 54 patients with GEP-NEN. Read More

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September 2021

The Microenvironment of Small Intestinal Neuroendocrine Tumours Contains Lymphocytes Capable of Recognition and Activation after Expansion.

Cancers (Basel) 2021 Aug 26;13(17). Epub 2021 Aug 26.

Sahlgrenska Translational Melanoma Group, Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, 40530 Gothenburg, Sweden.

Traditionally, immune evasion and immunotherapy have been studied in cancers with a high mutational load such as melanoma or lung cancer. In contrast, small intestinal neuroendocrine tumours (SINETs) present a low frequency of somatic mutations and are described as genetically stable tumours, rendering immunotherapies largely unchartered waters for SINET patients. SINETs frequently metastasise to the regional lymph nodes and liver at the time of diagnosis, and no curative treatments are currently available for patients with disseminated disease. Read More

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The Differential Roles for Neurodevelopmental and Neuroendocrine Genes in Shaping GnRH Neuron Physiology and Deficiency.

Int J Mol Sci 2021 Aug 30;22(17). Epub 2021 Aug 30.

Department of Health Sciences, University of Milan, 20142 Milano, Italy.

Gonadotropin releasing hormone (GnRH) neurons are hypothalamic neuroendocrine cells that control sexual reproduction. During embryonic development, GnRH neurons migrate from the nose to the hypothalamus, where they receive inputs from several afferent neurons, following the axonal scaffold patterned by nasal nerves. Each step of GnRH neuron development depends on the orchestrated action of several molecules exerting specific biological functions. Read More

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A roadmap for the Human Developmental Cell Atlas.

Nature 2021 09 8;597(7875):196-205. Epub 2021 Sep 8.

Wellcome Sanger Institute, Hinxton, UK.

The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Read More

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September 2021