319,727 results match your criteria cell migration


3D bioprinting of tissue units with mesenchymal stem cells, retaining their proliferative and differentiating potential, in polyphosphate-containing bio-ink.

Biofabrication 2021 Dec 1. Epub 2021 Dec 1.

Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, GERMANY, Mainz, 55128, GERMANY.

The three-dimensional (3D)-printing processes reach increasing recognition as important fabrication techniques to meet the growing demands in tissue engineering. However, it is imperative to fabricate 3D tissue units, which contain cells that have the property to be regeneratively active. In most bio-inks, a metabolic energy-providing component is missing. Read More

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December 2021

Schwann Cell-Derived EVs Facilitate Dental Pulp Regeneration through Endogenous Stem Cell Recruitment via SDF-1/CXCR4 Axis.

Acta Biomater 2021 Nov 28. Epub 2021 Nov 28.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University. Electronic address:

The dental pulp is critical for physiological vitality of the tooth, and dental pulp regeneration has great potential for rebuilding live pulp tissue after pulp disease. Schwann cells (SCs) play a critical role in the support, maintenance, and regeneration of nerve fibers in dental pulp. Extracellular vesicles (EVs), which possess cell homing and tissue repair potential, derived from SCs (SC-EVs), can regulate dental mesenchymal stem cell (MSC) proliferation, multipotency, and self-renewal. Read More

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November 2021

Actinidia chinensis Planch. root extract inhibits the proliferation, migration and invasion of breast cancer cells via the AKT/GSK-3β signaling pathway.

Folia Histochem Cytobiol 2021 Dec 1. Epub 2021 Dec 1.

School of Pharmacy, Tianjin Medical University, Tianjin, China, Tianjin, China.

Introduction: Actinidia chinensis Planch. root extract (acRoots), known as a traditional Chinese medicine (TCM), has shown antitumor efficacy in various types of human cancers. However, its role and underlying mechanisms in breast cancer (BCa) have not been elucidated. Read More

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December 2021

Lycorine nanoparticles induce apoptosis through mitochondrial intrinsic pathway and inhibit migration and invasion in HepG2 cells.

IEEE Trans Nanobioscience 2021 Dec 1;PP. Epub 2021 Dec 1.

Lycorine-nanoparticles (LYC-NPs) were successfully synthesized using anti-solvent precipitation-freeze drying method, and characterized using transmission electron microscopy (TEM), particle size analysis and Fourier transform infrared spectroscopy (FTIR). Then, the antitumor effects of LYC-NPs against HepG2 cells were investigated, and the underlying molecular mechanisms were explored. Our results showed that LYC-NPs displayed potent antiproliferative against HepG2 cells concentration dependently. Read More

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December 2021

Paxillin Promotes Breast Tumor Collective Cell Invasion through Maintenance of Adherens Junction Integrity.

Mol Biol Cell 2021 Dec 1:mbcE21090432. Epub 2021 Dec 1.

Department of Cell and Developmental Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.

Distant organ metastasis is linked to poor prognosis during cancer progression. The expression level of the focal adhesion adapter protein paxillin varies among different human cancers, but its role in tumor progression is unclear. Herein, we utilize a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion. Read More

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December 2021

Transcriptomic and histological analysis of exposed facial skin areas wrinkled or not and unexposed skin.

Mol Biol Rep 2021 Dec 1. Epub 2021 Dec 1.

Department of Dermatology, Universidade Federal de Sao Paulo, São Paulo, Brazil.

Background: Skin aging involves genetic, environmental and hormonal factors. Facial wrinkles also depend on muscular activity. Gene expression investigation may be useful for new anti-aging products. Read More

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December 2021

Surface-Anchored Acetylcholine Regulates Band-Edge States and Suppresses Ion Migration in a 21%-Efficient Quadruple-Cation Perovskite Solar Cell.

Small 2021 Dec 1:e2105184. Epub 2021 Dec 1.

School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

Although incorporating multiple halogen (bromine) anions and alkali (rubidium) cations can improve the open-circuit voltage (V ) of perovskite solar cells (PSCs), severe voltage loss and poor stability have remained pivotal limitations to their further commercialization. In this study, acetylcholine (ACh ) is anchored to the surface of a quadruple-cation perovskite to provide additional electron states near the valence band maximum of the perovskite surface, thereby enhancing the band alignment and minimizing the V loss significantly. Moreover, the quaternary ammonium and carbonyl units of ACh passivate the antisite and vacancy defects of the organic/inorganic hybrid perovskite. Read More

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December 2021

[Retracted] miR‑494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN.

Oncol Rep 2022 Feb 1;47(2). Epub 2021 Dec 1.

Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, Jilin, P.R. China.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data in Figs. 3 and 6 were strikingly similar to data appearing in different form in other articles by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere prior to its submission to , the Editor has decided that this paper should be retracted from the Journal. Read More

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February 2022

Stress relaxation amplitude of hydrogels determines migration, proliferation, and morphology of cells in 3-D culture.

Biomater Sci 2021 Dec 1. Epub 2021 Dec 1.

Department of Physics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

The viscoelastic behavior of hydrogel matrices sensitively influences the cell behavior in 3-D culture and biofabricated tissue model systems. Previous reports have demonstrated that cells tend to adhere, spread, migrate and proliferate better in hydrogels with pronounced stress relaxation. However, it is currently unknown if cells respond more sensitively to the amplitude of stress relaxation, or to the relaxation time constant. Read More

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December 2021

Human epidermal growth factor receptor 2 inhibits activating transcription factor 7 to promote breast cancer cell migration by activating histone lysine demethylase 1.

J Cancer Res Ther 2021 Nov;17(5):1192-1201

Department of General Surgery, The First Affiliated Hospital of Xiamen University, Xinglin Branch, Xiamen, China.

Background: Receptor tyrosine-protein kinase erbB-2 (human epidermal growth factor receptor 2 [HER2])-based therapies can improve the prognosis of HER2-positive breast cancer (BRCA) patients; however, HER2-positive patients with distal metastasis do not gain significant clinical benefit from molecular targeted therapy.

Materials And Methods: A database analysis, immunohistochemistry, and quantitative real-time polymerase chain reaction were used to evaluate the expression of activating transcription factor 7 (ATF7) and its clinical value. A transwell chamber assay was used to assess migration and cell signaling was assessed by immunoblotting. Read More

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November 2021

ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis.

Cell Cycle 2021 Dec 1:1-12. Epub 2021 Dec 1.

Department of Respiratory Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Lung adenocarcinoma (LUAD) is originated from the mucus-producing glands of the lungs. The involvement of long noncoding RNAs (lncRNAs) has been discovered in multiple diseases. In the present research, we aimed to unmask the role of C2CD4D and THEM5 antisense RNA 1 (C2CD4D-AS1) in LUAD. Read More

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December 2021

CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.

Thorac Cancer 2021 Dec 1. Epub 2021 Dec 1.

Department of Respiratory, Dongying People's Hospital, Dongying, China.

Background: Circular RNAs (circRNAs) participate in the genesis and progression of tumors, including non-small cell lung cancer (NSCLC). At present, the role and regulatory mechanisms of circRNAs in NSCLC have not been fully elucidated. The aim of this study was to explore the role and regulatory mechanism of circRNA hsa_circ_0008037 (circ_0008037) in NSCLC. Read More

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December 2021

Recognition of potential therapeutic role of 2-hydroxy-3-methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis.

Authors:
Hao Jin Min Cui

Fundam Clin Pharmacol 2021 Dec 1. Epub 2021 Dec 1.

Deputy secretary of Party Committee, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University).

Background: Gallbladder carcinoma (GBC), with early metastasis and high recurrence rates, is a enormous threat to health. As an anthraquinones monomer of traditional Chinese medicine Hedyotis diffusa, 2-hydroxy-3-methylanthraquinones (HMA) has been reported to inhibit the growth of several cancers. But in our preliminary study, HMA could only weakly induce GBC cell apoptosis. Read More

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December 2021

A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription.

EMBO J 2021 Dec 1:e108544. Epub 2021 Dec 1.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA-binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA-modifying enzyme, hTrmt13. Read More

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December 2021

Phosphatidylinositol 3-phosphate regulates SCAB1-mediated F-actin reorganization during stomatal closure in Arabidopsis.

Plant Cell 2021 Nov 22. Epub 2021 Nov 22.

College of Biological Sciences, State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100193, China.

Stomatal movement is critical for plant responses to environmental changes and is regulated by the important signaling molecule phosphatidylinositol 3-phosphate (PI3P). However, the molecular mechanism underlying this process is not well understood. In this study, we show that PI3P binds to stomatal closure-related actin-binding protein1 (SCAB1), a plant-specific F-actin-binding and -bundling protein, and inhibits the oligomerization of SCAB1 to regulate its activity on F-actin in guard cells during stomatal closure in Arabidopsis thaliana. Read More

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November 2021

MicroRNA-106b Overexpression Suppresses Synovial Inflammation and Alleviates Synovial Damage in Patients with Rheumatoid Arthritis.

Mod Rheumatol 2021 Nov 27. Epub 2021 Nov 27.

Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China.

Objectives: To explore the effect of miR-106b on synovial inflammation and damage in rheumatoid arthritis (RA) patients, and further to investigate its possible mechanism.

Methods: : Quantitative real-time polymerase chain reaction (qRT-PCR), immunofluorescence, in situ hybridization and immunohistochemistry assay were separately used to verify the levels of miR-106b and cytokines in the synovial tissues of patients with RA or osteoarthritis (OA). Pearson correlation analysis was conducted to examine the bivariate relationship between miR-106b and cytokines or RANKL. Read More

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November 2021

3D Mesoscopic Architecture of a Heterogeneous Cellular Network in the Cementum-Periodontal Ligament-Alveolar Bone Complex.

Microscopy (Oxf) 2021 Nov 29. Epub 2021 Nov 29.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, 830-0011, Japan.

Cell-to-cell communication orchestrates various cell and tissue functions. This communication enables cells to form cellular networks with each other through direct contact via intercellular junctions. Because these cellular networks are closely related to tissue and organ functions, elucidating the morphological characteristics of cellular networks could lead to the development of novel therapeutic approaches. Read More

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November 2021

CircRPPH1 promotes cell proliferation, migration and invasion of non-small cell lung cancer (NSCLC) via the PI3K/AKT and JAK2/STAT3 signaling axes.

J Biochem 2021 Nov 25. Epub 2021 Nov 25.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.

Non-small cell lung cancer (NSCLC) has markedly increased morbidity and mortality rate worldwide. Circular RNAs (circRNAs) were shown to regulate NSCLC progression. But, the underlying pathways of the circRPPH1-mediated regulation of NSCLC still need further exploration. Read More

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November 2021

Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development.

Genetics 2021 Nov 22. Epub 2021 Nov 22.

Physical, Life, Movement & Sport Sciences, Lewis-Clark State College, Lewiston, ID 83501, USA.

The absence of functional BLM DNA helicase, a member of the RecQ family of helicases, is responsible for the rare human disorder Bloom Syndrome, which results in developmental abnormalities, DNA repair defects, genomic instability, and a predisposition to cancer. In Drosophila melanogaster, the orthologous Blm protein is essential during early development when the embryo is under the control of maternal gene products. We show that lack of functional maternal Blm during the syncytial cell cycles of Drosophila embryonic development results in severe nuclear defects and lethality. Read More

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November 2021

Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.

G3 (Bethesda) 2021 Oct;11(11)

Department of Biology, William & Mary, Williamsburg, VA 23187, USA.

To acquire and maintain directed cell motility, Caenorhabditis elegans sperm must undergo extensive, regulated cellular remodeling, in the absence of new transcription or translation. To regulate sperm function, nematode sperm employ large numbers of protein kinases and phosphatases, including SPE-6, a member of C. elegans' highly expanded casein kinase 1 superfamily. Read More

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October 2021

A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration.

G3 (Bethesda) 2021 Oct 11. Epub 2021 Oct 11.

Division of Biology, Kansas State University, Manhattan, KS 66506, USA.

Migrating cell collectives are key to embryonic development but also contribute to invasion and metastasis of a variety of cancers. Cell collectives can invade deep into tissues, leading to tumor progression and resistance to therapies. Collective cell invasion is also observed in the lethal brain tumor glioblastoma, which infiltrates the surrounding brain parenchyma leading to tumor growth and poor patient outcomes. Read More

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October 2021

Transcriptome dataset of HEK293T cells depleted of one of the subunits of the DNA-PK complex: Ku70, Ku80 or DNA-PKcs.

Data Brief 2021 Dec 19;39:107596. Epub 2021 Nov 19.

Chemistry Department, Lomonosov Moscow State University, Moscow 199991, Russia.

DNA-PK is a heterotrimeric complex that consists of Ku70 (XRCC6), Ku80 (XRCC5) and DNA-PKcs (PRKDC) subunits. The complex is a major player in the repair of DNA double strand break (DSB) via the non-homologous end joining (NHEJ) pathway. This process requires all DNA-PK subunits, since Ku70/Ku80 heterodimer firstly binds to DNA ends at DSB and then recruits DNA-PKcs. Read More

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December 2021

Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations.

Comput Struct Biotechnol J 2021 5;19:6050-6063. Epub 2021 Nov 5.

School of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin, Dublin D07 ADY7, Ireland.

The G-protein coupled receptor, GPR120, has ubiquitous expression and multifaceted roles in modulating metabolic and anti-inflammatory processes. Recent implications of its role in cancer progression have presented GPR120 as an attractive oncogenic drug target. GPR120 gene knockdown in breast cancer studies revealed a role of GPR120-induced chemoresistance in epirubicin and cisplatin-induced DNA damage in tumour cells. Read More

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November 2021

Prognostic Value of LHFPL Tetraspan Subfamily Member 6 in Gastric Cancer: A Study Based on Bioinformatics Analysis and Experimental Validation.

Pharmgenomics Pers Med 2021 20;14:1483-1504. Epub 2021 Nov 20.

Department of Oncology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, 215600, People's Republic of China.

Purpose: The identification of biomarkers and effective therapeutic targets for gastric cancer (GC), the most common cause of cancer-related deaths around the world, is currently a major focus in research. Here, we examined the utility of LHFPL6 as a prognostic biomarker and therapeutic target for GC.

Methods: We explored the clinical relevance, function, and molecular role of LHFPL6 in GC using the MethSurv, cBioPortal, TIMER, Gene Expression Profiling Interactive Analysis, ONCOMINE, MEXPRESS, and EWAS Atlas databases. Read More

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November 2021

Circular RNA SMARCA5 Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer by miR-19b-3p/HOXA9 Axis [Retraction].

Authors:

Onco Targets Ther 2021 15;14:5261-5262. Epub 2021 Nov 15.

[This retracts the article DOI: 10.2147/OTT.S216320. Read More

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November 2021

Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation.

Nat Commun 2021 Nov 30;12(1):6974. Epub 2021 Nov 30.

Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, 10029, USA.

The phenomenon of tissue fluidity-cells' ability to rearrange relative to each other in confluent tissues-has been linked to several morphogenetic processes and diseases, yet few molecular regulators of tissue fluidity are known. Ommatidial rotation (OR), directed by planar cell polarity signaling, occurs during Drosophila eye morphogenesis and shares many features with polarized cellular migration in vertebrates. We utilize in vivo live imaging analysis tools to quantify dynamic cellular morphologies during OR, revealing that OR is driven autonomously by ommatidial cell clusters rotating in successive pulses within a permissive substrate. Read More

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November 2021

Pongamol Inhibits Epithelial to Mesenchymal Transition Through Suppression of FAK/Akt-mTOR Signaling.

Anticancer Res 2021 Dec;41(12):6147-6154

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

Background/aim: Cancer metastasis is the main cause of mortality in cancer patients. As lung cancer patients are mostly detected at metastatic stages, strategies that inhibit cancer metastasis may offer effective therapies. Activation of FAK and Akt/mTOR pathways promotes the highly metastatic phenotypes of epithelial to mesenchymal transition (EMT). Read More

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December 2021

Cetyltrimethylammonium Bromide Disrupts Mesenchymal Characteristics of Human Tongue Squamous Cell Carcinoma SCC4 Cells Through Modulating Canonical TGF-β/Smad/miR-181b/TIMP3 Signaling Pathway.

Anticancer Res 2021 Dec;41(12):6095-6104

Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan, R.O.C.;

Background/aim: This study investigated the anti-metastatic effects of cetyltrimethylammonium bromide (CTAB) on tongue squamous cell carcinoma (TSCC) SCC4 cells.

Materials And Methods: Cell morphology, viability, cell cycle distribution, adhesion, migration, invasion and the expression levels of associated proteins were examined using microscopy, WST-1, wound-healing, Boyden chamber assays, and western blotting, respectively.

Results: CTAB significantly affected SCC4 cell morphology from spindle-shaped to cobblestone-shaped and resulted in loss of adherence. Read More

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December 2021

Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells.

Anticancer Res 2021 Dec;41(12):6039-6049

Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Background: TAS-102 is effective against unresectable advanced or recurrent colorectal and gastric cancer. However, its effect on oral squamous cell carcinoma (OSCC) is still unknown. Here, we tried to clarify the possible effect of TAS-102 against angiogenesis and proliferation of human OSCC cells. Read More

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December 2021

The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression.

Anticancer Res 2021 Dec;41(12):6013-6021

Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.

Background/aim: The thioredoxin-1 (Trx-1) inhibitor, PX-12, is active against several cancer types. This study aimed to evaluate its effects on local osteosarcoma (OS) progression and to describe PX-12-related signal transduction pathways.

Materials And Methods: Publicly available expression cohort data were analyzed to determine the relationship between the expression levels of TXN, which codes for the Trx protein, and survival in patients with OS. Read More

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December 2021