204,742 results match your criteria cell included


Outcomes of the First Pregnancy After Fertility-Sparing Surgery for Early-Stage Ovarian Cancer.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Department of Gynecologic Oncology and Reproductive Medicine, the Department of Health Services Research, Division of Cancer Prevention and Population Sciences, and the Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas; the Department of Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Obstetrics and Gynecology, the University of Texas Medical Branch at Galveston, Galveston, Texas; and the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University Vagelos College of Physicians and Surgeons, and the Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York.

Objective: To evaluate the outcomes of the first pregnancy after fertility-sparing surgery in patients treated for early-stage ovarian cancer.

Methods: We performed a retrospective study of women aged 18-45 years with a history of stage IA or IC ovarian cancer reported to the California Cancer Registry for the years 2000-2012. These data were linked to the 2000-2012 California Office of Statewide Health Planning and Development birth and discharge data sets to ascertain oncologic characteristics and obstetric outcomes. Read More

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BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort.

Oncology 2021 May 6:1-9. Epub 2021 May 6.

Department of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.

Purpose: Glioblastoma, the most common malignant brain tumor, was associated with a median survival of <1 year in the pre-temozolomide (TMZ) era. Despite advances in molecular and genetic profiling studies identifying several predictive biomarkers, none has been translated into routine clinical use. Our aim was to investigate the prognostic significance of a panel of diverse cellular molecular markers of tumor formation and growth in an annotated glioblastoma tissue microarray (TMA). Read More

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Estrogenicity of chemical mixtures revealed by a panel of bioassays.

Sci Total Environ 2021 Apr 27;785:147284. Epub 2021 Apr 27.

Department Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstraße 15, 04318 Leipzig, Germany.

Estrogenic compounds are widely released to surface waters and may cause adverse effects to sensitive aquatic species. Three hormones, estrone, 17β-estradiol and 17α-ethinylestradiol, are of particular concern as they are bioactive at very low concentrations. Current analytical methods are not all sensitive enough for monitoring these substances in water and do not cover mixture effects. Read More

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Frequency of high grade squamous cervical lesions among women over age 65 years living with the human immunodeficiency virus.

Am J Obstet Gynecol 2021 May 3. Epub 2021 May 3.

Albert Einstein School of Medicine, Bronx, NY.

Background: Current U.S. cervical cancer screening guidelines recommend a stop to screening at age 65 years provided women have adequate prior screening and no history of precancer. Read More

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Core liver homeostatic co-expression networks are preserved but respond to perturbations in an organism- and disease-specific manner.

Cell Syst 2021 Apr 29. Epub 2021 Apr 29.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia. Electronic address:

Findings about chronic complex diseases are difficult to extrapolate from animal models to humans. We reason that organs may have core network modules that are preserved between species and are predictably altered when homeostasis is disrupted. To test this idea, we perturbed hepatic homeostasis in mice by dietary challenge and compared the liver transcriptome with that in human fatty liver disease and liver cancer. Read More

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Advanced trophectoderm quality increases the risk of a large for gestational age baby in single frozen-thawed blastocyst transfer cycles.

Hum Reprod 2021 May 6. Epub 2021 May 6.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Study Question: Does trophectoderm (TE) quality affect birthweight after single frozen-thawed blastocyst transfer?

Summary Answer: Transfer of single blastocyst with advanced TE quality was associated with higher birthweight and increased risk of a large for gestational age (LGA) baby.

What Is Known Already: Transfer of blastocysts with advanced TE quality results in higher ongoing pregnancy rates and a lower miscarriage risk. However, data on the relationship between TE quality and birthweight are still lacking. Read More

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Identification of a genetic variant underlying familial cases of recurrent benign paroxysmal positional vertigo.

PLoS One 2021 6;16(5):e0251386. Epub 2021 May 6.

Vestibular Genetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska, United States of America.

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo in humans, yet the molecular etiology is currently unknown. Evidence suggests that genetic factors may play an important role in some cases of idiopathic BPPV, particularly in familial cases, but the responsible genetic variants have not been identified. In this study, we performed whole exome sequencing [including untranslated regions (UTRs)] of 12 families and Sanger sequencing of additional 30 families with recurrent BPPV in Caucasians from the United States (US) Midwest region, to identify the genetic variants responsible for heightened susceptibility to BPPV. Read More

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Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis.

PLoS One 2021 6;16(5):e0251184. Epub 2021 May 6.

Department of Biology and Center for Cellular Dynamics, The Pennsylvania State University, University Park, PA, United States of America.

The ESCRT pathway is evolutionarily conserved across eukaryotes and plays key roles in a variety of membrane remodeling processes. A new Drosophila mutant recovered in our forward genetic screens for synaptic transmission mutants mapped to the vps24 gene encoding a subunit of the ESCRT-III complex. Molecular characterization indicated a loss of VPS24 function, however the mutant is viable and thus loss of VPS24 may be studied in a developed multicellular organism. Read More

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The genetic diversity of human papillomavirus types from the species Gammapapillomavirus 15: HPV135, HPV146, and HPV179.

PLoS One 2021 6;16(5):e0249829. Epub 2021 May 6.

Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia.

Objectives: To determine the prevalence, viral load, tissue tropism, and genetic variability of novel human papillomavirus (HPV) type 179, which is etiologically associated with sporadic cases of common warts in immunocompromised patients, and phylogenetically related HPV types 135 and 146.

Methods: The representative collection of 850 HPV-associated clinical samples (oral/nasopharyngeal/anal, archival specimens of oral/oropharyngeal/conjunctival/cervical/skin cancer, benign lesions of the larynx/conjunctiva/skin, and eyebrows), obtained from immunocompetent individuals, was tested for the presence of HPV179, HPV135, and HPV146 using type-specific real-time PCRs. To assess the genetic diversity of the HPVs investigated in the non-coding long control region (LCR), several highly sensitive nested PCR protocols were developed for each HPV type. Read More

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Ophthalmologic findings and complications before and after hematopoietic stem cell transplantation: single-center study.

Int Ophthalmol 2021 May 6. Epub 2021 May 6.

Pediatric Hematology and Oncology, Bone Marrow Transplantation Unit, TC Istanbul Yeni Yuzyil University Faculty of Medicine, Istanbul, Turkey.

Purpose: Different and various system complications and late effects may occur after hematopoietic stem cell transplantation (HSCT). It was aimed to obtain information about the frequency of ophthalmologic complications and their relationship with treatment.

Methods: This retrospective study includes 104 children who underwent HSCT between February 2019 and June 2020 at the Pediatric Bone Marrow Transplant Unit. Read More

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Nivolumab vs Pembrolizumab for Treatment of US Patients With Platinum-Refractory Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Network Meta-analysis and Cost-effectiveness Analysis.

JAMA Netw Open 2021 May 3;4(5):e218065. Epub 2021 May 3.

Medical Decision and Economic Group, Department of Pharmacy, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Importance: Nivolumab and pembrolizumab are approved for treating platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). Physicians and patients are uncertain which drug is preferable, rendering a cost-effectiveness comparison between them necessary.

Objective: To evaluate the cost-effectiveness of nivolumab vs pembrolizumab in treating platinum-refractory R/M HNSCC. Read More

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Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers.

JAMA 2021 May 6. Epub 2021 May 6.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Importance: Randomized clinical trials have provided estimates of the effectiveness of the BNT162b2 vaccine against symptomatic SARS-CoV-2 infection, but its effect on asymptomatic infections remains unclear.

Objective: To estimate the association of vaccination with the Pfizer-BioNTech BNT162b2 vaccine with symptomatic and asymptomatic SARS-CoV-2 infections among health care workers.

Design, Setting, And Participants: This was a single-center, retrospective cohort study conducted at a tertiary medical center in Tel Aviv, Israel. Read More

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Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.

JAMA Oncol 2021 May 6. Epub 2021 May 6.

Division of Blood & Marrow Transplantation, Stanford University, Stanford, California.

Importance: Primary central nervous system lymphoma (PCNSL) requires induction and consolidation to achieve potential cure. High-dose therapy and autologous hematopoietic cell transplant (AHCT) is an accepted and effective consolidation strategy for PCNSL, but no consensus exists on the optimal conditioning regimens.

Objective: To assess the outcomes in patients with PCNSL undergoing AHCT with the 3 most commonly used conditioning regimens: thiotepa/busulfan/cyclophosphamide (TBC), thiotepa/carmustine (TT-BCNU), and carmustine/etoposide/cytarabine/melphalan (BEAM). Read More

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Correlations between apparent diffusion coefficient values and histopathologic factors in breast cancer.

Clin Ter 2021 May;172(3):218-224

Department of Radiology, Ha Noi Medical Uni-versity, Ha Noi, Viet Nam.

Background: Breast cancer is the most common malignancy dia-gnosed in women, and the incidence gradually increases. Magnetic resonance imaging (MRI) is become widely used to identify benign and malignant breast tumors. Objective: The aim of this study was to evaluate the relationships between apparent diffusion coefficient (ADC) values and histopathologic prognostic factors in breast cancer. Read More

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Anterior Chamber Versus Ciliary Sulcus Ahmed Glaucoma Valve Tube Placement: Longitudinal Evaluation of Corneal Endothelial Cell Profiles.

J Glaucoma 2021 Feb;30(2):170-174

Department of Ophthalmology, Centro Hospitalar e Universitário São João.

Prcis: An Ahmed glaucoma valve (AGV) tube in the ciliary sulcus (CS) is safer for the endothelium. At 4 years of follow-up, there was a significant decrease in endothelial cell count only with anterior chamber (AC) placement.

Purpose: Corneal endothelium (CE) damage is one of the most feared long-term complications that can result from glaucoma drainage devices. Read More

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February 2021

Evaluation of dried papaya pomace meal in laying hen diets.

Vet Med Sci 2021 May 6. Epub 2021 May 6.

Faculty of Veterinary Medicine, Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium.

In the search for alternative feed resources for laying hens, papaya pomace is available as industrial by-product but information on its nutritive value is lacking. Dried papaya pomace was included in a common laying hen diet at 0%, 2.5%, 5% and 7. Read More

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Prognostic factor analysis of patients with small cell lung cancer: Real-world data from 988 patients.

Thorac Cancer 2021 May 6. Epub 2021 May 6.

Department of Thoracic Oncology II, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, China.

Background: Small cell lung cancer (SCLC) is characterized by aggressive spread and poor prognosis, but has limited treatment options. Results of prognostic factors from randomized trials on treatment arrangement are conflicting and large-scale real-world analysis is lacking.

Methods: Patients diagnosed SCLC between 2008 and 2018 in Peking University Cancer Hospital were included in this study. Read More

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Gestational high-fat diet impaired demethylation of Pparα and induced obesity of offspring.

J Cell Mol Med 2021 May 6. Epub 2021 May 6.

The Key Laboratory of Reproductive Genetics (Zhejiang University School of Medicine), Ministry of Education, Hangzhou, China.

Gestational and postpartum high-fat diets (HFDs) have been implicated as causes of obesity in offspring in later life. The present study aimed to investigate the effects of gestational and/or postpartum HFD on obesity in offspring. We established a mouse model of HFD exposure that included gestation, lactation and post-weaning periods. Read More

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BRASSINOSTEROID-SIGNALLING KINASES 7 and 8 associate with the FLS2 immune receptor and are required for flg22-induced PTI responses.

Mol Plant Pathol 2021 May 6. Epub 2021 May 6.

School of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv, Israel.

Pattern-triggered immunity (PTI) is typically initiated in plants by recognition of pathogen- or damage-associated molecular patterns (PAMP/DAMPs) by cell surface-localized pattern recognition receptors (PRRs). Here, we investigated the role in PTI of Arabidopsis thaliana brassinosteroid-signalling kinases 7 and 8 (BSK7 and BSK8), which are members of the receptor-like cytoplasmic kinase subfamily XII. BSK7 and BSK8 localized to the plant cell periphery and interacted in yeast and in planta with FLS2, but not with other PRRs. Read More

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Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy.

Clin Cardiol 2021 May 6. Epub 2021 May 6.

The Heart Institute, Kaplan Medical Center, Rehovot, Hebrew University and Hadassah Medical School, Jerusalem, Israel.

Introduction: Takotsubo cardiomyopathy (TCM) is characterized by transient left ventricle dysfunction.

Hypothesis: A residual cardiac and endothelial dysfunction is present in patients who recovered from TCM.

Methods: In this single-center prospective study, patients with prior TCM were included and followed for 6. Read More

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[Corrigendum] Role of adenosine deaminase 2 gene variants in pediatric deficiency of adenosine deaminase 2: A structural biological approach.

Mol Med Rep 2021 Jul 6;24(1). Epub 2021 May 6.

Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, 11855 Athens, Greece.

Following the publication of the above article on modeling variants of adenosine deaminase 2 (ADA2), previously identified by Gibson [Kristen M. Gibson, Kimberly A. Morishita, Paul Dancey, Paul Moorehead, Britt Drögemöller, Xiaohua Han, Jinko Graham, Robert E. Read More

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Continuous Low-Dose Apatinib Combined With WBRT Significantly Reduces Peritumoral Edema and Enhances the Efficacy of Symptomatic Multiple Brain Metastases in NSCLC.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211011968

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, China.

Background: Symptomatic multiple brain metastases with peritumoral brain edema (PTBE) occur in non-small cell lung cancer patients (NSCLC) who are without driver mutations or are resistant to epidermal growth factor tyrosine kinase (EGFR-TKI) are often associated with an unfavorable prognosis. Whole brain radiation therapy (WBRT) which comes with many complications and unsatisfactory effects, is the only option for the treatment. Previous studies have shown that bevacizumab can reduce the volume of PTBE and improve efficiency of radiotherapy. Read More

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Incidence, risk factors, and long-term outcomes associated with antibody-mediated rejection - the Long-Term Deterioration of Kidney Allograft Function (DeKAF) prospective cohort study.

Clin Transplant 2021 May 5:e14337. Epub 2021 May 5.

Department of Medicine, Hennepin County Medical Center, Hennepin Healthcare, Minneapolis Minnesota, USA.

Major gaps remain in our understanding of antibody-mediated rejection (AMR) after kidney transplant. We examined incidence, risk factors, response to treatment, and effects on outcomes of AMR at 7 transplant programs in the Long-Term Deterioration of Kidney Allograft Function prospective study cohort. Among 3131 kidney recipients, there were 194 observed AMR cases (6. Read More

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Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries.

Geroscience 2021 May 5. Epub 2021 May 5.

Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Evidence points to an important role of the growth hormone (GH) in the aging process and longevity. GH-deficient mice are smaller, live longer than normal littermates, and females have an increased ovarian reserve. The aim of the study was to evaluate the role of GH in the ovarian reserve by evaluating DNA damage, macrophage infiltration, and granulosa cell number in primordial and primary follicles. Read More

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Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche.

Hum Reprod 2021 May 5. Epub 2021 May 5.

CReATe Fertility Centre, Toronto, ON, Canada.

Study Question: Do phytocannabinoids (PCs) affect follicular endocannabinoid signalling and the epigenome in the surrounding granulosa cells (GCs)?

Summary Answer: Exposure to PCs increases the expression of endocannabinoid receptors and reduces DNA methylation enzyme expression and global DNA methylation in naïve GCs.

What Is Known Already: Cannabis plant derivatives, known as PCs, are used for medicinal and recreational purposes. The main PC, tetrahydrocannabinol (THC), is the third most commonly used substance by women of childbearing age, hence knowledge of the effect it has on reproduction is of utmost importance. Read More

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A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination.

Genetics 2019 Oct;213(2):529-553

Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403.

Anti-Mullerian hormone (Amh) inhibits female reproductive duct development, signals oocyte reserve, and marks polycystic ovarian syndrome. Zebrafish lacks Mullerian ducts and the typical Amh receptor, questioning evolving roles of Amh. Yan et al. Read More

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October 2019

A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination.

Genetics 2019 Oct;213(2):529-553

Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403.

Anti-Mullerian hormone (Amh) inhibits female reproductive duct development, signals oocyte reserve, and marks polycystic ovarian syndrome. Zebrafish lacks Mullerian ducts and the typical Amh receptor, questioning evolving roles of Amh. Yan et al. Read More

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October 2019

Does steroid-free immunosuppression improve the outcome in kidney transplant recipients compared to conventional protocols?

World J Transplant 2021 Apr;11(4):99-113

Department of Transplantation, Sheffield Teaching Hospitals, Sheffield S5 7AU, United Kingdom.

Steroids continue to be the cornerstone of immune suppression since the early days of organ transplantation. Steroids are key component of induction protocols, maintenance therapy and in the treatment of various forms of rejection. Prolonged steroid use resulted in significant side effects on almost all the body organs owing to the presence of steroid receptors in most of the mammalian cells. Read More

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Molecular evidence of the avocado defense response to infection: a deep transcriptome analysis using RNA-Seq.

PeerJ 2021 14;9:e11215. Epub 2021 Apr 14.

Catedrático CONACyT en la Red de Estudios Moleculares Avanzados, Instituto de Ecología A.C., Xalapa, Veracruz, México.

is a novel member of the Ambrosia Clade (AFC) that has been recognized as one of the symbionts of the invasive Kuroshio shot hole borer, an Asian ambrosia beetle. This complex is considered the causal agent of dieback, a disease that has severely threatened natural forests, landscape trees, and avocado orchards in the last 8 years. Despite the interest in this species, the molecular responses of both the host and during the infection process and disease establishment remain unknown. Read More

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Fabrication of chitosan-based electrospun nanofiber scaffold: Amplification of biomechanical properties, structural stability, and seeded cell viability.

Vet Res Forum 2021 15;12(1):25-32. Epub 2021 Mar 15.

Nanotechnology Research Center, Urmia University, Urmia, Iran.

The cell scaffolds should structurally be manufactured similar to the target tissue's extracellular matrix. This property should be maintained until cell differentiation. For this purpose, in the current study, electrospun nanofiber (EN) of chitosan (Ch)/polyvinyl alcohol (PVA), as a tissue-friend scaffold, was fabricated by electrospinning in different formulations and borax was utilized as an innovative cross-linking agent to up-regulate the structural and biomechanical properties. Read More

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