Curr Opin Allergy Clin Immunol 2021 Jul 20. Epub 2021 Jul 20.
University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence AZ Jan Palfijn Gent, Department of Immunology and Allergology, Ghent, Belgium Laboratoire d'Immunologie, CHU de Nîmes, Nîmes Aix-Marseille Univ, IRD, APHM, MEPHI IHU Méditerranée Infection, Marseille Université de Paris, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Faculté de Médecine site Bichat, Paris, France; Laboratoire d'Excellence Inflamex, Paris, France IDESP, INSERM UMR UA 11, Montpellier, France.
Purpose Of Review: Mast cell activation syndrome (MCAS) and anaphylaxis are the result of a spontaneous or triggered pathological degranulation of mast cells (MCs) and might have as substrate normal or pathological MCs (increased burden, aberrant MCs or both).
Recent Findings: This review summarizes the most recent evidence on immunoglobulin E (IgE)-mediated and non IgE-mediated mechanisms underlying MC activation and degranulation and highlights the importance of standardized diagnostic criteria for MCAS. Application of these criteria implies that in most cases the clinical presentation of MCAS meets the diagnostic criteria for anaphylaxis. Read More