428,220 results match your criteria cell chemical

Fabrication of Chinese Traditional Medicines incorporated collagen biomaterials for human bone marrow mesenchymal stem cells.

Biomed Pharmacother 2021 May 4;139:111659. Epub 2021 May 4.

Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

Chinese Traditional Medicines (CTMs) are very popular for therapeutic applications to cure several chronic diseases. Many researchers are trying to discover the potential application and actual mechanism of CTMs in order to scientifically prove their effects for commercial use. One of the main functions of CTMs is to aid stem cell regeneration. Read More

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A review on energy and cost effective phase separated pretreatment of biosolids.

Water Res 2021 Apr 21;198:117169. Epub 2021 Apr 21.

School of Civil and Environmental Engineering, Yonsei University, Seoul, 03722, Republic of Korea; Institute of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway. Electronic address:

Extracellular Polymeric Substances (EPS) existent in anaerobic sludge proves to be a barrier for sludge liquefaction and biomass lysis efficiency. Hence EPS deaggregation heightens the surface area for the subsequent pretreatment thereby uplifting the sludge disintegration and biomethanation rate. This review documents the role of EPS and its components which inhibits sludge hydrolysis and also the various phase separated pretreatment methods available with its disintegration mechanism to enhance the biomass lysis and methane production rate. Read More

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Early time-point cell morphology classifiers successfully predict human bone marrow stromal cell differentiation modulated by fiber density in nanofiber scaffolds.

Biomaterials 2021 Apr 26;274:120812. Epub 2021 Apr 26.

National Institute of Standards & Technology, Biosystems & Biomaterials Division, 100 Bureau Dr. Stop 8543, Gaithersburg, MD, 20899, USA. Electronic address:

Nanofiber scaffolds can induce osteogenic differentiation and cell morphology alterations of human bone marrow stromal cells (hBMSCs) without introduction of chemical cues. In this study, we investigate the predictive power of day 1 cell morphology, quantified by a machine learning based method, as an indicator of osteogenic differentiation modulated by nanofiber density. Nanofiber scaffolds are fabricated via electrospinning. Read More

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Near-Infrared absorbing J-Aggregates of boron dipyrromethene for high efficient photothermal therapy.

J Colloid Interface Sci 2021 Apr 24;599:476-483. Epub 2021 Apr 24.

School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, 2055 Yanan Street, Changchun, Jilin 130012, PR China. Electronic address:

Constructing bioactive materials remains a big challenge through the aggregates of molecules. Herein, a boron dipyrromethene (BODIPY) derivative containing three nitro groups (BDP-(NO)) was synthesized, which displays the characteristic of J-aggregate with pronounced red-shifted absorption in nonpolar solvent and aqueous media. The bathochromic shift from 635 to 765 nm facilitates photothermal transition upon the irradiation of near-infrared (NIR) light. Read More

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A hafnium oxide-coated dendrite-free zinc anode for rechargeable aqueous zinc-ion batteries.

J Colloid Interface Sci 2021 Apr 24;599:467-475. Epub 2021 Apr 24.

School of Chemical Engineering, North China University of Science and Technology, Tangshan 063009, PR China. Electronic address:

In aqueous zinc-ion batteries, metallic zinc is widely used as an anode because of its non-toxicity, environmental benignity, low cost, high abundance and theoretical capacity. However, growth of zinc dendrites, corrosion of zinc anode, passivation, and occurrence of side reactions during continuous charge-discharge cycling hinder development of zinc-ion batteries. In this study, a simple strategy involving application of a HfO coating was used to guide uniform deposition of Zn to suppress formation of zinc dendrites. Read More

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CuSe nanowires shelled with NiFe layered double hydroxide nanosheets for overall water-splitting.

J Colloid Interface Sci 2021 Apr 21;599:370-380. Epub 2021 Apr 21.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science (Ministry of Education), State Key Laboratory Base of Eco-chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

It is imperative but challenging to develop non-noble metal-based bifunctional electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Our work reports a core-shell nanostructure that is constructed by the electrodeposition of ultrathin NiFe-LDH nanosheets (NiFe-LDHNS) on CuSe nanowires, which are obtained by selenizing Cu(OH) nanowires in situ grown on Cu foam. The obtained CuSe@NiFe-LDHNS electrocatalyst provides more exposed edges and catalytic active sites, thus exhibiting excellent OER and HER electrocatalytic performance in alkaline electrolytes. Read More

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Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects.

Phytochemistry 2021 May 4;187:112743. Epub 2021 May 4.

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Read More

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Diterpenoids from the seeds of Euphorbia lathyris and their anti-inflammatory activity.

Bioorg Chem 2021 Apr 26;112:104944. Epub 2021 Apr 26.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Twelve previously undescribed diterpenoids, euplarisans A-L (1-12), including one premyrsinane and eleven lathyranes, along with ten known analogues 13-22 were isolated from the seeds of Euphorbia lathyris. Their chemical structures were delineated by spectroscopic analysis and single-crystal X-ray diffraction. Interestingly, both 5 and 6 possessed an unusual trans-gem-dimethylcyclopropane as structural features and compound 8 was elucidated as premyrsinane-type diterpenoid. Read More

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Harnessing the therapeutic potential of extracellular vesicles for cancer treatment.

Semin Cancer Biol 2021 May 4. Epub 2021 May 4.

School of Pharmaceutical Sciences, Tsinghua University, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing, 100082, China; Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China; Beijing Advanced Innovation, Center for Structural Biology, Tsinghua University, Beijing, China. Electronic address:

Cancer therapeutic strategies include surgeries, radiotherapy, chemotherapy, targeted therapy and immunotherapies. However, current cancer treatment still faces challenges such as postoperative residuals, postoperative recurrence, chemoradiotherapy resistance and lack of drugs with high specificity, due to the complexity of the cancer environment. Extracellular vesicles (EVs) are lipid-capsuled membrane vesicles secreted from cells, communicating vital messages between cells and regarding function in tumorigenesis and metastasis. Read More

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Quality by design to define critical process parameters for mesenchymal stem cell expansion.

Biotechnol Adv 2021 May 4:107765. Epub 2021 May 4.

Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, Nancy, France. Electronic address:

Stem cell-based therapeutic products could be the key to treat the deadliest current pathologies, ranging from neuro-degenerative to respiratory diseases. However, in order to bring these innovative therapeutics to a commercialization stage, reproducible manufacturing of high quality cell products is required. Although advances in cell culture techniques have led to more robust production processes and dramatically accelerated the development of early-phase clinical studies, challenges remain before regulatory approval, particularly to define and implement science-based quality standards (essential pre-requisites for national health agencies). Read More

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Effect of wheat gluten on improved thermal cross-linking and osteogenesis of hydroxyapatite-gelatin composite scaffolds.

Int J Biol Macromol 2021 May 4. Epub 2021 May 4.

Amrita Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682024, India. Electronic address:

Promising strategies to stabilize gelatin or collagen include glutaraldehyde-based chemical cross-linking or dehydrothermal treatment at different temperatures (120-180 °C). However, these procedures require 24-48 h for complete cross-linking to occur. The present study aims to evaluate the role of wheat gluten in enhancing thermal cross-linking of silica-nanohydroxyapatite (nanoHA)-gelatin composite scaffolds, within a shorter period (2 h). Read More

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Finite-size transitions in complex membranes.

Biophys J 2021 May 4. Epub 2021 May 4.

Van 't Hoff Institute for Molecular Sciences and Informatics Institute, University of Amsterdam, Amsterdam 1098 XH, The Netherlands; Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.

The lipid-raft hypothesis postulates that cell membranes possess some degree of lateral organization. The hypothesis has attracted much attention while remaining controversial, with an underlying mechanism that remains elusive. One idea that supports rafts relies on the membrane to lie near a critical point. Read More

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Structure and Dynamics of Electric-Field-Driven Convective Flows at the Interface between Liquid Electrolytes and Ion-Selective Membranes.

Langmuir 2021 May 7. Epub 2021 May 7.

School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.

At voltages above a certain critical value, ≈ 20 kT/e, a space charge layer forms near ion-selective interfaces in liquid electrolytes. Interactions between the space charge and an imposed electric field drives a hydrodynamic instability known as electroconvection. Through particle tracking velocimetry we experimentally study the structure and dynamics of the resultant electroconvective flow. Read More

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Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes.

PLoS Biol 2021 May 7;19(5):e3001209. Epub 2021 May 7.

MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine, Tsinghua University, Beijing, China.

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring accelerating development of prophylactic and therapeutic interventions. Molecular understanding of neutralizing antibodies (NAbs) would greatly help advance the development of monoclonal antibody (mAb) therapy, as well as the design of next generation recombinant vaccines. Here, we applied H2L2 transgenic mice encoding the human immunoglobulin variable regions, together with a state-of-the-art antibody discovery platform to immunize and isolate NAbs. Read More

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Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling.

PLoS Comput Biol 2021 May 7;17(5):e1008983. Epub 2021 May 7.

Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America.

Marine nitrogen-fixing microorganisms are an important source of fixed nitrogen in oceanic ecosystems. The colonial cyanobacterium Trichodesmium and diatom symbionts were thought to be the primary contributors to oceanic N2 fixation until the discovery of the unusual uncultivated symbiotic cyanobacterium UCYN-A (Candidatus Atelocyanobacterium thalassa). UCYN-A has atypical metabolic characteristics lacking the oxygen-evolving photosystem II, the tricarboxylic acid cycle, the carbon-fixation enzyme RuBisCo and de novo biosynthetic pathways for a number of amino acids and nucleotides. Read More

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Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.

J Med Chem 2021 May 7. Epub 2021 May 7.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C. 20007, United States.

Mutant p53 rescue by small molecules is a promising therapeutic strategy. In this structure-activity relationship study, we examined a series of adamantyl isothiocyanates (Ad-ITCs) to discover novel agents as therapeutics by targeting mutant p53. We demonstrated that the alkyl chain connecting adamantane and ITC is a crucial determinant for Ad-ITC inhibitory potency. Read More

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Site-Specific Conjugation of Metal-Chelating Polymers to Anti-Frizzled-2 Antibodies Microbial Transglutaminase.

Biomacromolecules 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 1H6, Canada.

Metal-chelating polymer-based radioimmunoconjugates (RICs) are effective agents for radioimmunotherapy but are currently limited by nonspecific binding and off-target organ uptake. Nonspecific binding appears after conjugation of the polymer to the antibody and may be related to random lysine conjugation since the polymers themselves do not bind to cells. To investigate the role of conjugation sites on nonspecific binding of polymer RICs, we developed a microbial transglutaminase reaction to prepare site-specific antibody-polymer conjugates. Read More

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Direct Z-Scheme Heterojunction of Ligand-Free FAPbBr/α-FeO for Boosting Photocatalysis of CO Reduction Coupled with Water Oxidation.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

MOE International Joint Laboratory of Materials Microstructure, Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.

Up to now, the majority of the developed photocatalytic CO reduction systems need to use expensive sacrificial reductants as electron source. It is still a huge challenge to drive the photocatalytic CO reduction using water as an electron source. Herein, we report a facile strategy for the construction of direct Z-scheme heterojunction of LF-FAPbBr/α-FeO, which is manufactured by the in situ and two-step controlled growth of ligand-free formamidinium lead bromide (LF-FAPbBr) nanocrystals on the surface of α-FeO nanorods. Read More

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An Experimental Liver Metastasis Mouse Model Suitable for Short and Long-Term Intravital Imaging.

Curr Protoc 2021 May;1(5):e116

Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2333ZC Leiden, the Netherlands.

The liver is a frequent site of cancer metastasis, but current treatment options for cancer patients with liver metastasis are limited, resulting in poor prognosis. Colonization of the liver by cancer cells is a multistep and temporally controlled process. Investigating this process in biological relevant settings in a dynamic manner may lead to new therapeutic avenues. Read More

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Genomic appraisal of Klebsiella PGPB isolated from soil to enhance the growth of barley.

Genes Genomics 2021 May 7. Epub 2021 May 7.

Department of Microbiology and Biotechnology, School of Sciences, Gujarat University, Ahmedabad, 380009, India.

Background: PGPR has substituted chemical fertilizers to enhance the nutrient profile of the soil. Although gene encoding for PGP activity is present in PGPB their activity changes in response to conditions.

Objective: To study comparative genomics for three Klebsiella strains and their PGPR activity in response to in vitro and soil condition. Read More

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Role of calcium phosphate and bioactive glass coating on in vivo bone healing of new Mg-Zn-Ca implant.

J Mater Sci Mater Med 2021 May 7;32(5):55. Epub 2021 May 7.

Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India.

Present investigation focuses on development and detailed characterization of a new Mg alloy sample (BM) with and without coating of hydroxyapatite (BMH) and bioactive glass (BMG) by air plasma spray method. After detailed mechano-physico-chemical characterization of powders and coated samples, electrochemical corrosion and SBF immersion tests were carried out. Detailed in vitro characterizations for cell viability were undertaken using MG-63 cell line followed by in vivo tests in rabbit model for studying bone healing up to 60 days. Read More

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CD1a selectively captures endogenous cellular lipids that broadly block T cell response.

J Exp Med 2021 Jul 7;218(7). Epub 2021 May 7.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM). The natural 42:2 SM but not the more common 34:1 SM blocked CD1a tetramer binding to T cells in all human subjects tested. Read More

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AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance.

Food Funct 2021 May 7. Epub 2021 May 7.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China. and Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, P. R. China and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China.

Atrazine (ATR), a ubiquitous environmental contaminant in water and soil, causes environmental nephrosis. To reveal the toxic effect of ATR on the kidney and the potential chemical nephroprotective effect of lycopene (LYC), Kun-Ming mice of specific pathogen-free (SPF) grade were treated with LYC (5 mg kg-1) and/or ATR (50 mg kg-1 or 200 mg kg-1) for 21 days. The degree of renal injury was evaluated by measuring the ion concentration, ATPase activities and the mRNA expressions/levels of associated ATPase subunits. Read More

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Scalable electrochemical synthesis of diaryliodonium salts.

Org Biomol Chem 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Cyclic and acyclic diaryliodonium are synthesised by anodic oxidation of iodobiaryls and iodoarene/arene mixtures, respectively, in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chemical oxidants and generates no chemical waste. More than 30 cyclic and acyclic diaryliodonium salts with different substitution patterns were prepared in very good to excellent yields. Read More

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produces a melanin-like pigment that protects against stress conditions encountered during parasitism.

Future Microbiol 2021 May 7. Epub 2021 May 7.

Departments of Medicine (Division of Infectious Diseases) & Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.

Melanin has been linked to pathogenesis in several fungi. They often produce melanin-like pigments in the presence of L-dihydroxyphenylalanine (L-DOPA), but this is poorly studied in . was grown in minimal medium with or without L-DOPA supplementation and submitted to a chemical treatment with denaturant and hot acid. Read More

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Identification of a New DNA Aptamer by Tissue-SELEX for Cancer Recognition and Imaging.

Anal Chem 2021 May 7. Epub 2021 May 7.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Hunan University, Changsha 410082, China.

Cancer has become one of the most common diseases with high mortality in humans. Early and accurate diagnosis of cancer is of great significance to enhance the survival rate of patients. Therefore, effective molecular ligands capable of selectively recognizing cancer are urgently needed. Read More

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Raleigh Instability-Driven Coaxial Spinning of Knotted Cell-Laden Alginate Fibers as Artificial Lymph Vessels.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark.

Constructing artificial lymph vessels, which play a key role in the immune response, can provide new insights into immunology and disease pathologies. An immune tissue is a highly complex network that consists of lymph vessels, with a "beads-on-a-string" knotted structure. Herein, we present the facile and rapid fabrication of beads-on-a-string knotted cell-laden fibers using coaxial spinning of alginate by exploiting the Plateau-Rayleigh instability. Read More

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SHAPE Directed Discovery of New Functions in Large RNAs.

Kevin M Weeks

Acc Chem Res 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, United States.

ConspectusRNA lies upstream of nearly all biology and functions as the central conduit of information exchange in all cells. RNA molecules encode information both in their primary sequences and in complex structures that form when an RNA folds back on itself. From the time of discovery of mRNA in the late 1950s until quite recently, we had only a rudimentary understanding of RNA structure across vast regions of most messenger and noncoding RNAs. Read More

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Modulation of Mammalian Cell Behavior by Nanoporous Glass.

Adv Biol (Weinh) 2021 May 7:e2000570. Epub 2021 May 7.

Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082, Würzburg, Germany.

The introduction of novel bioactive materials to manipulate living cell behavior is a crucial topic for biomedical research and tissue engineering. Biomaterials or surface patterns that boost specific cell functions can enable innovative new products in cell culture and diagnostics. This study investigates the influence of the intrinsically nano-patterned surface of nanoporous glass membranes on the behavior of mammalian cells. Read More

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Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.

Basal cell nevus syndrome (also known as Gorlin Syndrome; MIM109400) is an autosomal dominant disorder characterized by recurrent pathological features such as basal cell carcinomas and odontogenic keratocysts as well as skeletal abnormalities. Most affected individuals have point mutations or small insertions or deletions within the PTCH1 gene on human chromosome 9, but there are some cases with more extensive deletion of the region, usually including the neighboring FANCC and/or ERCC6L2 genes. We report a 16-year-old patient with a deletion of approximately 400,000 bases which removes only PTCH1 and some non-coding RNA genes but leaves FANCC and ERCC6L2 intact. Read More

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