208,806 results match your criteria cell capacity

The food, the bug, and the ugly: A recipe for food-induced gut pain.

Allergy 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University Medical Center, Hamilton Health Sciences, Hamilton, L8S 4K1, ON, Canada.

It is estimated that one-fifth of the general population experiences adverse reactions to food. There is evidence of an increase in the prevalence of well-defined food sensitivities such as celiac disease, food allergy, and food intolerance, suggesting a critical role of yet unknown environmental factors as modifiers of disease expression. The role of microorganisms in inciting sensitivity to foods has garnered significant attention. Read More

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Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates.

Curr Opin Genet Dev 2021 Jul 19;71:39-47. Epub 2021 Jul 19.

Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Bellinzona, Switzerland; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland. Electronic address:

DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Read More

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Leishmania infantum strains from cats are similar in biological properties to canine and human strains.

Vet Parasitol 2021 Jul 15;298:109531. Epub 2021 Jul 15.

Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (NOVA), 1349-008, Lisbon, Portugal; Medical Parasitology Unit, IHMT/NOVA, 1349-008, Lisbon, Portugal. Electronic address:

Zoonotic visceral leishmaniosis is a worldwide severe disease caused by Leishmania infantum, a protozoan that has phlebotomine sand flies as vectors and dogs as primary reservoir hosts. Over the last few decades, cats have been regarded as an indisputable piece within the ecological system in which L. infantum is maintained indefinitely. Read More

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Development of rivaroxaban microemulsion-based hydrogel for transdermal treatment and prevention of venous thromboembolism.

Colloids Surf B Biointerfaces 2021 Jul 16;206:111978. Epub 2021 Jul 16.

Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS, Cidade Universitária, Rio de Janeiro, 21.941-902, Brazil. Electronic address:

We have developed a microemulsion (ME)-based hydrogel, containing propylene glycol, Azone®, Labrasol®, isobutanol and water (20:3:18:3:56), for the transdermal delivery of rivaroxaban (RVX). Formulation ME-1:RVX, which was loaded with 0.3 mg/g of RVX, presented as a clear, homogenous fluid with a droplet size of 82. Read More

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Engineering atorvastatin loaded Mg-Mn/LDH nanoparticles and their composite with PLGA for bone tissue applications.

Int J Pharm 2021 Jul 19:120901. Epub 2021 Jul 19.

Department of Biomaterials, Faculty of Science, Iran Polymer and Petrochemical Institute, Tehran, Iran.

The impact of mixing method in conventional co-precipitation synthesis of layered double hydroxides (LDHs), on particle size, size distribution and drug loading capacity is reported. Synthesis of Mg (II)/Mn (III)-LDH nano-platelets was performed at constant pH using three different mixing systems, magnetic stirrer, mechanical mixer, and homogenizer at ambient temperature and a fixed Mg/Mn ratio of 3/1. The LDH characterization results showed that mechanical mixing and homogenization lead to production of very fine LDH nano-platelets (about 90-140nm), with narrow particle size distribution. Read More

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Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.

Neurochem Int 2021 Jul 19;149:105137. Epub 2021 Jul 19.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE-17121, Sweden. Electronic address:

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma correlated with poor patient survival. There are no curative treatments for GB, and it becomes resistant to chemotherapy, radiation therapy, and immunotherapy. Resistance in GB cells is closely related to their states of redox imbalance, and the role of reactive oxygen species and its impact on cancer cell survival is still far from elucidation. Read More

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MG53 suppresses NFκB activation to mitigate age-related heart failure.

JCI Insight 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, The Ohio State University, Columbus, United States of America.

Aging is associated with chronic oxidative stress and inflammation that impact the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. Here we demonstrate that the expression of MG53 is reduced in failing human heart and aging mouse heart, concomitant with elevated NFκB activation. Read More

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Extraction of Au(III) by Microbially Reduced Metal-Organic Frameworks.

Langmuir 2021 Jul 22. Epub 2021 Jul 22.

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States.

Gold is a critical resource in the jewelry and electronics industries and is facing increased consumer demand. Accordingly, methods for its extraction from waste effluents and environmental water sources have been sought to supplement existing mining infrastructure. Redox-mediated treatments, such as Fe(II)-based platforms, offer promise for precipitating soluble Au(III). Read More

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Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.

Mol Pharm 2021 Jul 22. Epub 2021 Jul 22.

Division of Internal Medicine, Universitätsspital and University of Zurich, Zurich 8091, Switzerland.

Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve tissue Hb exposure. Haptoglobin (Hp) captures Hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation. Read More

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Transforming C Molecules into Polyhedral Carbon Micro-Nano Shells for Electrochemically Producing HO in Neutral Electrolytes.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

The electrochemical production of hydrogen peroxide (HO) via the two-electron oxygen reduction reaction (ORR) can realize the customer-oriented onsite synthesis of HO in a green and sustainable method. The ongoing challenge that needs to be solved is the fabrication of robust electrocatalysts of excellent performance. In this work, C was selected as a precursor due to its uniform structure and abundant pentagon rings. Read More

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Facile Production of Phosphorene Nanoribbons towards Application in Lithium Metal Battery.

Adv Mater 2021 Jul 22:e2102083. Epub 2021 Jul 22.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.

Like phosphorene, phosphorene nanoribbon (PNR) promises exotic properties but unzipping phosphorene into edge-defined PNR is non-trivial because of uncontrolled cutting of phosphorene along random directions. Here a facile electrochemical strategy to fabricate zigzag-edged PNRs in high yield (>80%) is reported. The presence of chemically active zigzag edges in PNR allows it to spontaneously react with Li to form a Li ion conducting Li P phase, which can be used as a protective layer on Li metal anode in lithium metal batteries (LMBs). Read More

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Forever young: stem cell and plant regeneration one century after Haberlandt 1921.

Protoplasma 2021 Jul 22. Epub 2021 Jul 22.

Department of Biology, Stanford University, Stanford, CA, 94305, USA.

Plants are characterized by a post-embryonic mode of organ development, which results in a need for these photoautotrophic organisms to regenerate lost parts in the course of their life cycle. This capacity depends on the presence of "pluripotent stem cells," which are part of the meristems within the plant body. One hundred years ago, the botanist Gottlieb Haberlandt (1854-1945) published experiments showing wounding-induced callus formation, which led ultimately to plant regeneration in tissue culture and thence to the techniques of "plant biotechnology," with practical applications for mankind. Read More

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Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.

Acta Neuropathol 2021 Jul 22. Epub 2021 Jul 22.

Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epileptogenic brain have not been addressed in detail. Iron-related neuropathology and antioxidant metabolic processes were investigated in resected brain tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS), post-mortem brain tissue from patients who died after status epilepticus (SE) as well as brain tissue from the electrically induced SE rat model of TLE. Read More

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Highly Selective Entrapment of His-Tagged Enzymes on Superparamagnetic Zirconium-Based MOFs with Robust Renewability to Enhance pH and Thermal Stability.

ACS Biomater Sci Eng 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

Metal-organic frameworks (MOFs), as a kind of poriferous nanoparticle, are promising candidates for enzyme immobilization to enhance their stability and reusability. However, most MOFs could not specifically immobilize enzymes and regenerate easily, which inevitably leads to serious high consumption and environmental pollution. In this study, renewable and magnetic MOFs were first constructed to specially immobilize His-tagged enzymes from the cell lysates without purification. Read More

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Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration.

ACS Biomater Sci Eng 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P.R. China.

The complexity of the nervous system structure and function, and its slow regeneration rate, makes it more difficult to treat compared to other tissues in the human body when an injury occurs. Moreover, the current therapeutic approaches including the use of autografts, allografts, and pharmacological agents have several drawbacks and can not fully restore nervous system injuries. Recently, nanotechnology and tissue engineering approaches have attracted many researchers to guide tissue regeneration in an effective manner. Read More

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Chemerin deficiency regulates adipogenesis is depot different through TIMP1.

Genes Dis 2021 Sep 9;8(5):698-708. Epub 2020 Apr 9.

Biology Science Institutes, Chongqing Medical University, Chongqing, 400016, PR China.

Adipocytes and immune cells are vital for the development of adipose tissue. Adipokines secreted by adipocytes regulate adipogenesis and body metabolism. Chemerin is one of the adipokines. Read More

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September 2021

p63 and p53: Collaborative Partners or Dueling Rivals?

Front Cell Dev Biol 2021 5;9:701986. Epub 2021 Jul 5.

Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.

The tumor suppressor p53 and its oncogenic sibling p63 (ΔNp63) direct opposing fates in tumor development. These paralog proteins are transcription factors that elicit their tumor suppressive and oncogenic capacity through the regulation of both shared and unique target genes. Both proteins predominantly function as activators of transcription, leading to a paradigm shift away from ΔNp63 as a dominant negative to p53 activity. Read More

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Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.

Front Cell Dev Biol 2021 5;9:681087. Epub 2021 Jul 5.

Sunnybrook Research Institute, Biological Sciences Platform, Toronto, ON, Canada.

Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new neurons in the brain, which previously was not achievable, has created great excitement in the field as it has opened the door for the potential treatment of incurable neurodegenerative diseases and brain injuries such as stroke. These neurological disorders are associated with frank neuronal loss, and as new neurons are not made in most of the adult brain, treatment options are limited. Read More

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Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration.

Biomicrofluidics 2021 Jul 13;15(4):044101. Epub 2021 Jul 13.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, North Carolina 27695, USA.

Microfluidics approaches have gained popularity in the field of directed cell migration, enabling control of the extracellular environment and integration with live-cell microscopy; however, technical hurdles remain. Among the challenges are the stability and predictability of the environment, which are especially critical for the observation of fibroblasts and other slow-moving cells. Such experiments require several hours and are typically plagued by the introduction of bubbles and other disturbances that naturally arise in standard microfluidics protocols. Read More

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection.

Cell Mol Immunol 2021 Jul 21. Epub 2021 Jul 21.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. Read More

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Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration.

Sci Rep 2021 Jul 21;11(1):14924. Epub 2021 Jul 21.

Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.

Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RGCs thus fail to regenerate their axons after injury, leading to vision loss. To uncover mechanisms that promote regeneration of RGC axons, we identified transcription factors (TF) and open chromatin regions that are enriched in rat embryonic RGCs (high axon growth capacity) compared to postnatal RGCs (low axon growth capacity). Read More

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Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.

Cell Death Dis 2021 Jul 21;12(8):725. Epub 2021 Jul 21.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No 639, Zhizaoju Rd, 200011, Shanghai, China.

Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck squamous cell carcinoma (HNSCC). PKM2 expression was detected using immunohistochemical staining. Read More

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An Aerolysin-like Pore-Forming Protein Complex Targets Viral Envelope to Inactivate Herpes Simplex Virus Type 1.

J Immunol 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China;

Because most of animal viruses are enveloped, cytoplasmic entry of these viruses via fusion with cellular membrane initiates their invasion. However, the strategies in which host cells counteract cytoplasmic entry of such viruses are incompletely understood. Pore-forming toxin aerolysin-like proteins (ALPs) exist throughout the animal kingdom, but their functions are mostly unknown. Read More

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Fingerprinting diverse nanoporous materials for optimal hydrogen storage conditions using meta-learning.

Sci Adv 2021 Jul 21;7(30). Epub 2021 Jul 21.

Department of Chemistry and Chemical Theory Center, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455-0431, USA.

Adsorptive hydrogen storage is a desirable technology for fuel cell vehicles, and efficiently identifying the optimal storage temperature requires modeling hydrogen loading as a continuous function of pressure and temperature. Using data obtained from high-throughput Monte Carlo simulations for zeolites, metal-organic frameworks, and hyper-cross-linked polymers, we develop a meta-learning model that jointly predicts the adsorption loading for multiple materials over wide ranges of pressure and temperature. Meta-learning gives higher accuracy and improved generalization compared to fitting a model separately to each material and allows us to identify the optimal hydrogen storage temperature with the highest working capacity for a given pressure difference. Read More

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Development and pregnancy rates of Camelus dromedarius-cloned embryos derived from in vivo- and in vitro-matured oocytes.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

UAE Biotech Research Center, 30310 Al Wathba, Abu Dhabi, United Arab Emirates.

Objective: The present study evaluated the efficiency of embryo development and pregnancy of somatic cell nuclear transfer (SCNT) embryos using different source-matured oocytes in Camelus dromedarius.

Methods: Camelus dromedarius embryos were produced by SCNT using in vivo- and in vitro- matured oocytes. In vitro embryo developmental capacity of reconstructed embryos was evaluated. Read More

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Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model.

Aging (Albany NY) 2021 Jul 21;13(undefined). Epub 2021 Jul 21.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian Province, People's Republic of China.

Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea (OSA), is associated with various cardiovascular diseases. In the present study, we assessed the effect of the lipid reducing agent atorvastatin on CIH-induced myocardial oxidative stress and apoptosis in a mouse OSA model. Forty-eight C57BL/6J mice were evenly divided among normoxia + vehicle, normoxia + atorvastatin, CIH + vehicle, and CIH + atorvastatin groups. Read More

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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.

Cell Rep 2021 Jul;36(3):109410

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities are not completely understood. Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRAS mutants with bivalent histone H3 lysine 27 trimethylation (H3K27me3) and Polycomb repressive complex 2. Reprogramming of bivalent domains during metastasis occurs on master transcription factors of a mesenchymal phenotype, including ZEB1, TWIST1, and CDH1. Read More

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Simple and sustainable preparation of cathodes for Li-S batteries: Regeneration of granular activated carbon from the odour control system of a WWTP.

ChemSusChem 2021 Jul 21. Epub 2021 Jul 21.

Universidad de Cordoba, Quimica Inorganica, Campus de Rabanales, Edificio Marie Curie, 14071, Cordoba, SPAIN.

In order to obtain a wide variety of green materials, numerous investigations have been undertaken on industrial waste that can act as sustainable resources. The use of hazardous wastes derived from wastewater treatment plants (WWTPs), especially the activated carbon used in odour control systems, is a highly abundant, scalable, and cost-effective strategy. The reuse of waste materials is a key aspect, especially for the sustainable development of emerging energy storage systems, such as lithium-sulfur (Li-S) batteries. Read More

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Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).

Bioengineered 2021 Dec;12(1):3968-3977

Department of Cardiology, The Fourth People's Hospital of Shaanxi, Xi'an, Shaanxi, China.

Vascular smooth muscle cell senescence plays a pivotal role in the pathogenesis of atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of hyperglycemia. Recent progress indicates that DPP-4 inhibitors show a wide range of cardiovascular benefits. Read More

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December 2021

Headless henipaviral receptor binding glycoproteins reveal key post-receptor binding contributions of the globular head and head/stalk interface in fusion promotion.

J Virol 2021 Jul 21:JVI0066621. Epub 2021 Jul 21.

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

Cedar virus (CedV) is a nonpathogenic member of the (HNV) genus of emerging viruses, which includes the deadly Nipah (NiV) and Hendra (HeV) viruses. CedV forms syncytia, a hallmark of henipaviral and paramyxoviral infections and pathogenicity. However, the intrinsic fusogenic capacity of CedV relative to NiV or HeV remains unquantified. Read More

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