Eur J Pharmacol 2021 May 11:174153. Epub 2021 May 11.
Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200 Porto, Portugal; MedInUp - Center for Drug Discovery and Innovative Medicines, University of Porto, 4200 Porto, Portugal; Division of Research and Development, BIAL-Portela & C(a), S.A, 4745-457 Coronado (S. Mamede & S. Romão), Portugal. Electronic address:
Type 1 salt-inducible kinases (SIK1) has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. Type 2 SIK (SIK2) modulates various biological functions and acts as a signal transmitter in various pathways. To evaluate the role of both SIK isoforms in renal and intestinal Na,K-ATPase (NKA) activity, we made use of constitutive sik1 (SIK1-KO), sik2 (SIK2-KO), double sik1sik2 (double SIK1*2-KO) knockout and wild-type (WT) mice challenged to a standard (0. Read More