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[Inflammatory Bowel Diseases: Regional Deprivation, Disease Characteristics and Relevant Health Care].

Gesundheitswesen 2021 Sep 24. Epub 2021 Sep 24.

Institut für Sozialmedizin und Epidemiologie, Universität zu Lübeck, Lübeck, Deutschland.

Hintergrund: Regionale Deprivation ist als ökologischer Parameter eine Komponente der sozialen Determinanten von Gesundheit. Zu ihrer Messung stehen in Deutschland der "German Index of Multiple Deprivation" (GIMD) und der "German Index of Socioeconomic Deprivation" (GISD) zur Verfügung. Chronisch entzündliche Darmerkrankungen (CED) sind keine häufigen, aber ernste körperliche Erkrankungen unklarer Ätiologie, mit vergleichsweise frühem Auftreten im Erwachsenenalter, oft chronisch-behandlungsbedürftigem Verlauf und unsicherer Prognose. Read More

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September 2021

Chromosome-scale assembly and whole-genome sequencing of 266 giant panda roundworms provide insights into their evolution, adaptation and potential drug targets.

Mol Ecol Resour 2021 Sep 22. Epub 2021 Sep 22.

College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Helminth diseases have long been a threat to the health of humans and animals. Roundworms are important organisms for studying parasitic mechanisms, disease transmission and prevention. The study of parasites in the giant panda is of importance for understanding how roundworms adapt to the host. Read More

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September 2021

Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome.

Gut 2021 Sep 20. Epub 2021 Sep 20.

Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Department for Internal Medicine (Gastroenterology, Infectious Diseases, Rheumatology, Berlin, Germany.

Objective: A considerable proportion of patients with irritable bowel syndrome (IBS) may be wheat-sensitive and respond to a gluten-free diet (GFD) although they do not have coeliac disease. However, a diagnostic test for wheat sensitivity (WS) is missing. Our study evaluated the diagnostic accuracy (sensitivity and specificity) of confocal laser endomicroscopy (CLE) for the identification of WS as primary outcome. Read More

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September 2021

Engineering threshold-based selection systems.

G3 (Bethesda) 2021 Sep;11(9)

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Using model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of activated CED-10/Rac to disrupt Caenorhabditis elegans embryonic morphogenesis, titrated to 100% lethality. The strategy of engineering thresholds for positive selection using experimental animals was validated with pharmacological and genetic suppression and is generalizable to diverse molecular processes and experimental systems. Read More

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September 2021

Students' Personality Contributes More to Academic Performance than Well-Being and Learning Approach-Implications for Sustainable Development and Education.

Eur J Investig Health Psychol Educ 2020 Dec 6;10(4):1132-1149. Epub 2020 Dec 6.

Instituto de Psicologia e de Ciências da Educação [Institute of Psychology and Education], Universidade Lusíada-Norte, 4369-006 Porto, Portugal.

The present study aimed to describe the predictive role of personality dimensions, learning approaches, and well-being in the academic performance of students. In total, 602 students participated in this cross-sectional study and completed a set of questionnaires assessing personality, learning approach, and well-being. Two indexes were calculated to assess affective and non-affective well-being. Read More

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December 2020

Expected years lived with intimate partner violence: a new approach for public health.

Glob Health Action 2021 Jan;14(1):1976442

Centre d'Estudis Demogràfics (CED-CERCA), UAB, Cerdanyola Del Vallès, Spain.

Background: Intimate Partner Violence against women (IPV) is a major public health problem. However, mainstream indicators used in public health are not designed to fully capture the pervasive and enduring impact of IPV.

Objective: We propose a new indicator that considers the burden of IPV in women during their middle life years, estimating the number of years that women are expected to live under IPV, and provide estimates for 151 countries. Read More

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January 2021

BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9/bcl-2 transcription.

Development 2021 Sep 20. Epub 2021 Sep 20.

Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan.

Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here we report a mechanism controlling tail-spike cell death onset during C. Read More

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September 2021

Can decontamination and reuse of N95 respirators during COVID-19 pandemic provide energy, environmental, and economic benefits?

Appl Energy 2021 Dec 14;304:117848. Epub 2021 Sep 14.

Systems Engineering, Cornell University, Ithaca, NY 14853, USA.

The widespread COVID-19 pandemic led to a shortage in the supply of N95 respirators in the United States until May 2021. In this study, we address the energy, environmental, and economic benefits of the decontamination-and-reuse of the N95 masks. Two popular decontamination methods, including dry heat and vapor hydrogen peroxide (VHP), are investigated in this study for their effective pathogen inactivation and favorable performance in preserving filtration efficiency and structural integrity of respirators. Read More

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December 2021

The cumulative radiation dose paradigm in pediatric imaging.

Authors:
Donald Frush

Br J Radiol 2021 Oct 14;94(1126):20210478. Epub 2021 Sep 14.

Duke University Medical Center, Durham, North Carolina 27710, United States.

Medical imaging professionals have an accountability for both quality and safety in the care of patients that have unexpected or anticipated repeated imaging examinations that use ionizing radiation. One measure in the safety realm for repeated imaging is cumulative effective dose (CED). CED has been increasingly scrutinized in patient populations, including adults and children. Read More

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October 2021

Serum anti-Müllerian hormone as a marker of ovarian reserve after cancer treatment and/or hematopoietic stem cell transplantation in childhood: proposal for a systematic approach to gonadal assessment.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

A Cattoni, Department of Pediatrics, Università degli Studi di Milano-Bicocca, Milano, Italy.

Objective Female patients treated with alkylating agents in childhood are at risk for ovarian impairment. We aimed at describing the pattern of residual ovarian function in a cohort of survivors of hematological malignancies and/or hematopoietic stem cell transplantation (HSCT) and assessing the relationship between Cyclophosphamide Equivalent Dose (CED) and Anti-Müllerian Hormone (AMH). Design and methods Gonadal health was clinically and biochemically assessed in 124 post-menarchal survivors who underwent treatment for pediatric hematological malignancies and/or HSCT between 1992 and 2019. Read More

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September 2021

Molecular and Structural Parallels between Gluten Pathogenic Peptides and Bacterial-Derived Proteins by Bioinformatics Analysis.

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Department of Chemistry, Organic Chemistry OCIII, Universität Bielefeld, Universitätsstraße 25, 33615 Bielefeld, Germany.

Gluten-related disorders (GRDs) are a group of diseases that involve the activation of the immune system triggered by the ingestion of gluten, with a worldwide prevalence of 5%. Among them, Celiac disease (CeD) is a T-cell-mediated autoimmune disease causing a plethora of symptoms from diarrhea and malabsorption to lymphoma. Even though GRDs have been intensively studied, the environmental triggers promoting the diverse reactions to gluten proteins in susceptible individuals remain elusive. Read More

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Specification of Environmental Consequences of the Life Cycle of Selected Post-Production Waste of Wind Power Plants Blades.

Materials (Basel) 2021 Aug 31;14(17). Epub 2021 Aug 31.

Faculty of Mechanical Engineering, University of Science and Technology in Bydgoszcz, 85-796 Bydgoszcz, Poland.

Wind power plants during generation of electricity emit almost no detrimental substances into the milieu. Nonetheless, the procedure of extraction of raw materials, production of elements and post-use management carry many negative environmental consequences. Wind power plant blades are mainly made of polymer materials, which cause a number of problems during post-use management. Read More

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Pan-Gastrointestinal Tract Mucosal Pathologies in Patients with Celiac Disease with the Demonstration of IgA Anti-Transglutaminase Mucosal Deposits: A Case-Control Study.

Dig Dis Sci 2021 Sep 9. Epub 2021 Sep 9.

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Background: While celiac disease (CeD) is considered to affect primarily the small intestine, pathological changes in other parts of the gastrointestinal tract (GIT) are also known to occur. IgA anti-tissue transglutaminase-2 antibody (anti-TG2 Ab) deposits at the site of involvement is one of the methods to establish CeD-related tissue pathology.

Aims: To explore the utility of IgA anti-TG2 Ab deposits in pan-gastrointestinal mucosal biopsies as evidence of CeD-related pathologies. Read More

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September 2021

Deciphering the vedolizumab dosing conundrum in IBD: when less is more.

Gut 2021 Sep 8. Epub 2021 Sep 8.

Medical Department I, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Berlin, Germany

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September 2021

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies.

Adv Sci (Weinh) 2021 Sep 8:e2102778. Epub 2021 Sep 8.

KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.

Gluten-specific CD4 T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T-cell-directed therapy can change with time and upon activation in CeD and other autoimmune conditions. In-depth characterization of gluten-specific CD4 T cells and CeD-associated (CD38 and CD103 ) CD8 and γδ T cells in blood of treated CeD patients undergoing a 3 day gluten challenge is reported. Read More

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September 2021

Alteration of Bone Density, Microarchitecture, and Strength in patients with Camurati-Engelmann Disease: assessed by HR-pQCT.

J Bone Miner Res 2021 Sep 7. Epub 2021 Sep 7.

Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Camurati-Engelmann disease is a rare autosomal dominant skeletal dysplasia caused by mutations in the transforming growth factor-β1 (TGFB1) gene. In this study, we performed a retrospective review of patients with CED evaluated in Peking Union Medical College Hospital from November 30, 2000 to November 30, 2020. Data including demographic data, manifestations and examination results were characterized. Read More

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September 2021

Computed tomography findings in a cohort of 169 dogs with elbow dysplasia - a retrospective study.

BMC Vet Res 2021 Sep 6;17(1):296. Epub 2021 Sep 6.

Department of Preclinical Sciences and Infectious Diseases, Poznan University of Life Sciences, ul. Wołyńska 35, 60-637, Poznań, Poland.

Background: Canine elbow dysplasia (CED) is a complex developmental skeletal disorder associated with a number of pathological conditions within the cubital joint. Because CED is a heritable disease, it is important to identify and remove the affected animals from breeding. The first objective of this study was to describe the prevalence of medial coronoid process disease (MCPD) without (MCD) or with (FMCP) fragmented medial coronoid process, osteochondrosis (OC) and/or osteochondritis dissecans (OCD), ununited anconeal process (UAP), radio-ulnar incongruence (INC R-U) and humero-ulnar incongruence (INC H-U) in dogs with the use of CT imaging. Read More

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September 2021

Systematic Review of the Effects of Oat Intake on Gastrointestinal Health.

J Nutr 2021 Sep 6. Epub 2021 Sep 6.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Oats are a food source with multiple health benefits that could support beneficial bacterial groups and provide important bioactive compounds for the gut.

Objectives: This review explores the association between oat intake, gastrointestinal (GI) symptoms, and microbial community changes in individuals with celiac disease (CeD), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) and without GI disease.

Methods: Four databases and Google Scholar were systematically searched from inception until April 29, 2021. Read More

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September 2021

Anxiety Disorders Are Associated With Coronary Endothelial Dysfunction in Women With Chest Pain and Nonobstructive Coronary Artery Disease.

J Am Heart Assoc 2021 Sep 28;10(17):e021722. Epub 2021 Aug 28.

Department of Cardiovascular Medicine Mayo College of Medicine Rochester MN.

Background Anxiety disorders are the most prevalent mental disorders and are an emerging risk factor for coronary artery disease and its complications. We determine the relationship between having a clinical diagnosis of an anxiety disorder and coronary endothelial dysfunction (CED) using invasive coronary reactivity testing across both sexes. Methods and Results Patients presenting with chest pain and nonobstructive coronary artery disease (stenosis <40%) at coronary angiography underwent an invasive assessment of CED. Read More

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September 2021

Sustainable Development of Hot-Pressed All-Lignocellulose Composites-Comparing Wood Fibers and Nanofibers.

Polymers (Basel) 2021 Aug 16;13(16). Epub 2021 Aug 16.

Wallenberg Wood Science Center, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.

Low-porosity materials based on hot-pressed wood fibers or nanocellulose fibrils (no polymer matrix) represent a new concept for eco-friendly materials with interesting mechanical properties. For the replacement of fossil-based materials, physical properties of wood fiber materials need to be improved. In addition, the carbon footprint and cumulative energy required to produce the material also needs to be reduced compared with fossil-based composites, e. Read More

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Histopathology of Celiac Disease. Position Statements of the Italian Group of Gastrointestinal Pathologists (GIPAD-SIAPEC).

Transl Med UniSa 2020 Sep 1;23:28-36. Epub 2020 Oct 1.

Department of Pathological Anatomy, AUSL Romagna, Morgagni-Pierantoni Hospital, Forlì, Italy.

Celiac Disease (CeD) is an immune-mediated inflammatory disorder of the small intestine, affecting genetically susceptible individuals when exposed to gluten. Small intestinal biopsy interpretation has been the "gold standard" for celiac disease (CeD) for over 50 years. Despite today's availability of sensitive and specific serological tests, the histopathological features from mucosal biopsy play a key role in diagnosing when CeD is suspected. Read More

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September 2020

Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in Model of Parkinson's Disease.

Molecules 2021 Aug 10;26(16). Epub 2021 Aug 10.

Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand.

Parkinson's disease (PD) is a currently incurable neurodegenerative disorder characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta and α-synuclein aggregation. Accumulated evidence indicates that the saponins, especially from ginseng, have neuroprotective effects against neurodegenerative disorders. Interestingly, saponin can also be found in marine organisms such as the sea cucumber, but little is known about its effect in neurodegenerative disease, including PD. Read More

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A Real-World Assessment of Outcomes, Health Resource Utilization, and Costs Associated with Cerebral Edema in US Patients with Large Hemispheric Infarction.

Pharmacoecon Open 2021 Aug 22. Epub 2021 Aug 22.

Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Background: Patients with large hemispheric infarction (LHI) are at risk of cerebral edema (CED). This study analyzed health resource use, costs, and outcomes during and after acute hospitalization for LHI in US patients with and without CED.

Methods: Using IBM MarketScan Commercial, Medicaid, and Medicare databases, patients with incident hospitalization for LHI (International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis codes of I63. Read More

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Current pharmacological approaches and potential future therapies for Celiac disease.

Eur J Pharmacol 2021 Oct 18;909:174434. Epub 2021 Aug 18.

Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Tampa Bay Campus, Clearwater, FL, USA. Electronic address:

Celiac Disease (CeD) is estimated to currently affect 2 million Americans in the United States. This autoimmune disorder occurs when the consumption of gluten-based products leads to an inflammatory response in the small intestine. Over time, this inflammatory response permanently damages the villi in the small intestine. Read More

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October 2021

A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.

Sci Immunol 2021 Aug;6(62)

Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway.

Antibodies specific for peptides bound to human leukocyte antigen (HLA) molecules are valuable tools for studies of antigen presentation and may have therapeutic potential. Here, we generated human T cell receptor (TCR)-like antibodies toward the immunodominant signature gluten epitope DQ2.5-glia-α2 in celiac disease (CeD). Read More

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Small intestinal biopsy findings consistent with celiac disease in patients with idiopathic inflammatory myopathy: Review of existing literature.

Semin Arthritis Rheum 2021 Oct 25;51(5):1033-1044. Epub 2021 Jul 25.

Department of Rheumatology, Oslo University Hospital - Rikshospitalet, P.O. box 4950 Nydalen, 0424 Oslo, Norway; Department of Rheumatology and Infectious Diseases, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Case reports have described patients with idiopathic inflammatory myopathies (IIM) and a concurrent diagnosis of celiac disease (CeD) for whom the muscle inflammation (myositis) component of IIM improves after the patients start standard treatment with gluten-free diet (GFD). A connection between IIM and CeD is not commonly recognized.

Aim: In this first systematic review of the topic, we aimed to explore all peer-reviewed publications of IIM cases and concomitant small intestinal biopsy findings consistent with CeD, published after 1975. Read More

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October 2021

Co-factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment.

Gastroenterology 2021 Aug 17. Epub 2021 Aug 17.

Institute of Translational Immunology,Research Center for Immune Therapy and Celiac Center, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Celiac disease (CeD) is a frequent immune-mediated disease that affects not only the small intestine but also many extraintestinal sites. The role of gluten proteins as dietary triggers, HLA-DQ2 or -DQ8 as major necessary genetic predisposition, and tissue transglutaminase (TG2) as mechanistically involved autoantigen, are unique features of CeD. Recent research implicates many cofactors working in synergism with these key triggers, including the intestinal microbiota and their metabolites, nongluten dietary triggers, intestinal barrier defects, novel immune cell phenotypes, and mediators and cytokines. Read More

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[Decrease in life expectancy in 2020 and SARS-CoV-2 seroprevalence].

Gac Sanit 2021 Jul 28. Epub 2021 Jul 28.

Ikerbasque, Fundación Vasca para la Ciencia, Bilbao, España; OPIK, Departamento de Sociología, Universidad del País Vasco EHU/UPV, Leioa, Bizkaia, España.

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The effects of mindfulness on health profession students' simulation training outcomes: An integrative review.

Nurse Educ Today 2021 Nov 8;106:105082. Epub 2021 Aug 8.

Marrakesh Simulation and Innovation in Health Sciences Center, Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Marrakesh, Morocco.

Health profession students (HPSs) continuously experience psychological issues which can exacerbate cognitive errors and harm emotional well-being. The Healthcare simulation environment is stressful and overwhelming in nature and may impair learning outcomes. Therefore, integrating psychological interventions into simulation-based learning (SBL) instructional design may alleviate students' psychological distress and improve their learning outcomes. Read More

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November 2021

Oxidative stress, intestinal damage, and cell apoptosis: Toxicity induced by fluopyram in Caenorhabditis elegans.

Chemosphere 2021 Aug 9;286(Pt 3):131830. Epub 2021 Aug 9.

Key Laboratory of Pesticide Toxicology & Application Technique, College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong, 271018, China. Electronic address:

Fluopyram, a succinate dehydrogenase inhibitor fungicide and nematicide, has been used extensively for agricultural pest control and toxicologically affects non-target organisms. In the present study, Caenorhabditis elegans, a well-established model organism, was used to evaluate the toxic effect of fluopyram and the possible molecular mechanisms. C. Read More

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