144 results match your criteria ccs involves

Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative interview study of parents.

Cancer Med 2021 Sep 6;10(18):6239-6248. Epub 2021 Aug 6.

Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Survivor-focused care for adolescent and young adult (AYA) childhood cancer survivors (CCS) often involves their parents. Recognizing the importance of parents in the ongoing care of CCS, our study sought to identify key aspects of a successful transition for CCS from pediatric- to adult-centered care from the parent perspective.

Methods: We conducted qualitative interviews with 26 parents of CCS who were receiving care in the long-term follow-up (LTFU) clinic at a single institution. Read More

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September 2021

Effect of the Combination of Levofloxacin with Cationic Carbosilane Dendron and Peptide in the Prevention and Treatment of Biofilms.

Polymers (Basel) 2021 Jun 29;13(13). Epub 2021 Jun 29.

Department of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), Universidad de Alcala, 28805 Madrid, Spain.

Antibiotic resistance and biofilm-related infections, persistent in conventional antimicrobial treatment, are continuously increasing and represent a major health problem worldwide. Therefore, the development of new effective treatments to prevent and treat biofilm-related infections represents a crucial challenge. Unfortunately, the extensive use of antibiotics has led to an increase of resistant bacteria with the subsequent loss of effectivity of commercial antibiotics, mainly due to antibiotic resistance and the ability of some bacteria to form microbial communities in biotic or abiotic surfaces (biofilms). Read More

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Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.

Cell Commun Signal 2021 Jun 30;19(1):69. Epub 2021 Jun 30.

Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church St. SE, Minneapolis, MN, 55455, USA.

Background: Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Among various vesicles, exosomes can be detected in a wide variety of biological systems, but the regulation and biological implication of exosome secretion/uptake remains largely unclear. Read More

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Central Cord Syndrome Redefined.

Neurosurg Clin N Am 2021 Jul 7;32(3):353-363. Epub 2021 May 7.

Department of Neurosurgery, University of Arizona, Banner University Medical Center, PO Box 245070, 1501 North Campbell Avenue, Room 4303, Tucson, AZ 85724-5070, USA. Electronic address:

This article reviews the historical origins of central cord syndrome (CCS), the mechanism of injury, pathophysiology, and clinical implications. CCS is the most common form of incomplete spinal cord injury. CCS involves a spectrum of neurologic deficits preferentially affecting the hands and arms. Read More

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Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease.

Cell Commun Signal 2021 May 7;19(1):51. Epub 2021 May 7.

Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, 411008,, Pune, India.

Neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease involves abnormal aggregation and accumulation of toxic proteins aggregates. Post-translational modifications (PTMs) of the causative proteins play an important role in the etiology of disease as they could either slow down or accelerate the disease progression. Alzheimer disease is associated with the aggregation and accumulation of two major protein aggregates-intracellular neurofibrillary tangles made up of microtubule-associated protein Tau and extracellular Amyloid-β plaques. Read More

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Contamination Control Strategy: Implementation Roadmap.

Walid El Azab

PDA J Pharm Sci Technol 2021 Mar 15. Epub 2021 Mar 15.

STERIS Corporation

The article proposes an implementation roadmap of a Contamination Control Strategy (CCS) in a facility. The CCS is a culmination of an exercise to identify activities designed to prevent microorganisms, pyrogens, and particulates contamination in the product, the facility, and supporting processes used to manufacture the product. Manufacturers can formulate their contamination control strategy based on information in the quality target product profile or in the critical quality attributes, in the facility and in the processes used to manufacture and transport the product. Read More

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Thyroid Dysfunction and Thyroid Cancer in Childhood Cancer Survivors: Prevalence, Surveillance and Management.

Front Horm Res 2021 Mar 9;54:1-14. Epub 2021 Mar 9.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands,

Childhood cancer survivors (CCS) are at increased risk of developing thyroid disorders during follow-up. Radiation therapy to a field that includes the thyroid gland and 131I-meta-iodobenzylguanidine (131I-MIBG) treatment are the main risk factors for thyroid sequelae, which include decreased thyroid function, hyperthyroidism, thyroid nodules, and differentiated thyroid cancer, specifically papillary thyroid carcinoma. In addition, treatment with anti-neoplastic drugs or immunotherapy may result in thyroid dysfunction. Read More

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Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways.

J Gen Physiol 2021 04;153(4)

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

Voltage-dependent sodium (Nav) current in adrenal chromaffin cells (CCs) is rapidly inactivating and tetrodotoxin (TTX)-sensitive. The fractional availability of CC Nav current has been implicated in regulation of action potential (AP) frequency and the occurrence of slow-wave burst firing. Here, through recordings of Nav current in rat CCs, primarily in adrenal medullary slices, we describe unique inactivation properties of CC Nav inactivation that help define AP firing rates in CCs. Read More

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Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer's disease.

Cell Commun Signal 2021 02 24;19(1):28. Epub 2021 Feb 24.

Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune, 411008, India.

Alzheimer's disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathological protein in neurodegenerative diseases, Tau and amyloid-β contribute to the disrupted microglial signaling pathways, actin cytoskeleton, and cellular receptor expression. The important secondary messenger lipids i. Read More

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February 2021

A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β impact breast cancer cell extravasation.

Lab Chip 2021 03 1;21(6):1061-1072. Epub 2021 Feb 1.

Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900 Lugano, Switzerland.

During metastatic progression multiple players establish competitive mechanisms, whereby cancer cells (CCs) are exposed to both pro- and anti-metastatic stimuli. The early metastatic niche (EMN) is a transient microenvironment which forms in the circulation during CC dissemination. EMN is characterized by the crosstalk among CCs, platelets, leukocytes and endothelial cells (ECs), increasing CC ability to extravasate and colonize secondary tissues. Read More

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Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency.

J Cancer Surviv 2021 Jan 19. Epub 2021 Jan 19.

Department of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Malmo, Sweden.

Purpose: Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals' health and mental life. Read More

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January 2021

Three distinct mechanisms, Notch instructive, permissive, and independent, regulate the expression of two different pericardial genes to specify cardiac cell subtypes.

PLoS One 2020 27;15(10):e0241191. Epub 2020 Oct 27.

Department of Biology, Indiana State University, Terre Haute, Indiana, United States of America.

The development of a complex organ involves the specification and differentiation of diverse cell types constituting that organ. Two major cell subtypes, contractile cardial cells (CCs) and nephrocytic pericardial cells (PCs), comprise the Drosophila heart. Binding sites for Suppressor of Hairless [Su(H)], an integral transcription factor in the Notch signaling pathway, are enriched in the enhancers of PC-specific genes. Read More

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December 2020

Combustion in the future: The importance of chemistry.

Proc Combust Inst 2020 Sep 25. Epub 2020 Sep 25.

Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.

Combustion involves chemical reactions that are often highly exothermic. Combustion systems utilize the energy of chemical compounds released during this reactive process for transportation, to generate electric power, or to provide heat for various applications. Chemistry and combustion are interlinked in several ways. Read More

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September 2020

Uncertainty Estimations for Collision Cross Section Determination via Uniform Field Drift Tube-Ion Mobility-Mass Spectrometry.

J Am Soc Mass Spectrom 2020 Oct 1;31(10):2102-2110. Epub 2020 Sep 1.

Institute of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, Vienna 1190, Austria.

Uniform field drift tube ion mobility-mass spectrometry (DTIM-MS) has emerged as a valuable tool for a range of analytical applications. In focus here are standardized collisional cross section values from DTIM-MS (CCS) as a candidate identification point for various analytical workflows. Of critical importance in establishing this parameter as a valid identification point is a rugged estimation of uncertainties according to the procedures used for their derivation. Read More

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October 2020

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.

Cell Commun Signal 2020 08 18;18(1):129. Epub 2020 Aug 18.

Cellular Communication Laboratory, Program of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Independencia, 838-0453, Santiago, Chile.

Background: Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the surface of astrocytes to induce cell migration. Despite a well-described role of Syndecan-4 during cell movement, information is scarce regarding specific Syndecan-4 partners involved in Thy-1/CD90-stimulated cell migration. Read More

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The role of Wnt/β-catenin-lin28a/let-7 axis in embryo implantation competency and epithelial-mesenchymal transition (EMT).

Cell Commun Signal 2020 07 11;18(1):108. Epub 2020 Jul 11.

Department of Obstetrics and Gynaecology, Laboratory Block, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China.

Background: The pre-implantation embryo in a competent status and post-implantation fully differentiation of the inner cell mass (ICM) and trophectoderm (TE) are prerequisites of successful implantation. Type I embryonic epithelial-mesenchymal transition (EMT) involves in these processes. A high level of the mir-let-7 family was found in the dormant mouse embryo of implantation failure in our previous study. Read More

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β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.

Cell Commun Signal 2020 06 16;18(1):93. Epub 2020 Jun 16.

Rush University Medical Center, Department of Microbial Pathogens and Immunity, Rush University Medical College, 1735 W. Harrison Street, 614 Cohn, Chicago, IL, 60612, USA.

Background: The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF family of transcription factors (TCF1, TCF3, TCF4, LEF1) to regulate gene expression. IL-6 is a key cytokine involved in inflammation and is particularly a hallmark of inflammation in the brain. Read More

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The molecular mechanisms of copper metabolism and its roles in human diseases.

Pflugers Arch 2020 10 7;472(10):1415-1429. Epub 2020 Jun 7.

Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.

Copper is an essential element in cells; it can act as either a recipient or a donor of electrons, participating in various reactions. However, an excess of copper ions in cells is detrimental as these copper ions can generate free radicals and increase oxidative stress. In multicellular organisms, copper metabolism involves uptake, distribution, sequestration, and excretion, at both the cellular and systemic levels. Read More

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October 2020

CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.

Cell Commun Signal 2020 05 27;18(1):80. Epub 2020 May 27.

Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Room R2034 - 351 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada.

Background: Circulatory iron is a hazardous biometal. Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF). Different organs acquire iron from the systemic circulation through a tightly regulated mechanism at the blood-tissue interface which involves receptor-mediated internalization of TF. Read More

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Applications of Mass Spectrometry in the Onset of Amyloid Fibril Formation: Focus on the Analysis of Early-Stage Oligomers.

Front Chem 2020 5;8:324. Epub 2020 May 5.

Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing, China.

Amyloid fibril formation is a hallmark of diverse neurodegenerative and metabolic diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and type 2 diabetes mellitus (T2DM). Conventional diagnosis is based on the appearance of fibrils or plaques, while neglects the role of early-stage oligomers in the disease progression. Recent studies have uncovered that it is the early-stage oligomer, rather than the mature fibril, that greatly contributes cytotoxicity. Read More

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Highly efficient colorimetric CO sensors for monitoring CO leakage from carbon capture and storage sites.

Sci Total Environ 2020 Aug 19;729:138786. Epub 2020 Apr 19.

Department of Environmental Engineering, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Carbon capture and storage (CCS) technology used for reducing anthropogenic CO emissions involves the capture of CO from industrial sources and its injection into geological sinks, such as oil reservoirs and abandoned gas fields. To ensure environmental and public safety in implementing CCS technology, efficient CO-monitoring technology must be developed to detect potential CO leakage from CCS sites. Conventional CO sensors used for monitoring CCS sites are typically high in cost and require professional staff for maintenance. Read More

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AKT2 deficiency impairs formation of the BCR signalosome.

Cell Commun Signal 2020 04 6;18(1):56. Epub 2020 Apr 6.

Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China.

Background: AKT2 is one of the key molecules that involves in the insulin-induced signaling and the development of cancer. In B cells, the function of AKT2 is unclear.

Methods: In this study, we used AKT2 knockout mice model to study the role of AKT2 in BCR signaling and B cell differentiation. Read More

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Does the ion mobility resolving power as provided by commercially available ion mobility quadrupole time-of-flight mass spectrometry instruments permit the unambiguous identification of small molecules in complex matrices?

Anal Chim Acta 2020 Apr 17;1107:113-126. Epub 2020 Feb 17.

Official Food Control Authority of the Canton of Zurich, Fehrenstrasse 15, 8032, Zürich, Switzerland.

Quadrupole based mass spectrometry based detection has experienced enormous improvements in terms of sensitivity over the last centuries. This development has not been equally matched with improvements in selectivity. Hence, the use of unit mass based MS/MS transitions or high resolution (HRMS) based extracted ion chromatograms is gradually becoming insufficient in the field of high sensitivity multi-residue analysis (e. Read More

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Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.

Cell Commun Signal 2020 Jan 27;18(1):12. Epub 2020 Jan 27.

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership for Molecular Medicine, University of Oslo, P.O. Box 1137, Blindern, N-0318, Oslo, Norway.

Background: Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more insight into these mechanisms, the ER stressor thapsigargin (Tg) is an instrumental experimental tool. Additionally, Tg forms the basis for analog prodrugs designed for cell killing in targeted cancer therapy. Read More

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January 2020

Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.

Cell Commun Signal 2020 01 15;18(1). Epub 2020 Jan 15.

Department of Rehabilitation Medicine, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang, Liaoning, 110001, People's Republic of China.

Background: Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bone mass homeostasis. Our group prior demonstrated that activation of CNR2 signaling promoted osteogenic differentiation of bone marrow derived mesenchymal stem cells in vitro. Read More

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January 2020

Liquid chromatography-ion mobility spectrometry-mass spectrometry analysis of multiple classes of steroid hormone isomers in a mixture.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jan 16;1137:121941. Epub 2019 Dec 16.

Department of Chemistry, University of Nebraska - Lincoln, Lincoln, NE 68588-0304, USA; Nebraska Center for Integrated Biomolecular Communication, University of Nebraska - Lincoln, Lincoln, NE 68588-0304, USA. Electronic address:

Methods for the analysis of steroids have long been of interest due to the multiple uses for such methods in medical applications, sports monitoring, and environmental science. The analysis of steroids involves inherent analytical hurdles due to their low biological concentrations, poor ionization efficiencies, and frequent occurrence of isomerism. One analytical technique that has been recently applied to steroid analysis is ion mobility spectrometry (IMS). Read More

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January 2020

Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract.

Cell Commun Signal 2019 10 21;17(1):131. Epub 2019 Oct 21.

Department of Pathology, Saint Louis University, 1100 South Grand Boulevard, St. Louis, MO, 63104, USA.

Background: Metabolic reprogramming is one of the hallmarks of cancer which favours rapid energy production, biosynthetic capabilities and therapy resistance. In our previous study, we showed bitter melon extract (BME) prevents carcinogen induced mouse oral cancer. RNA sequence analysis from mouse tongue revealed a significant modulation in "Metabolic Process" by altering glycolysis and lipid metabolic pathways in BME fed group as compared to cancer group. Read More

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October 2019

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.

Cell Commun Signal 2019 09 18;17(1):120. Epub 2019 Sep 18.

Department of Urology, Upstate Cancer Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York, 13210, USA.

Background: Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer but the role of ABI1 in EMT is not clear.

Methods: To investigate the molecular mechanism by which loss of ABI1 contributes to tumor progression, we disrupted the ABI1 gene in the benign prostate epithelial RWPE-1 cell line and determined its phenotype. Read More

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September 2019

Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence.

Mol Hum Reprod 2019 11;25(11):684-694

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, Japan.

Advanced glycation end products (AGEs) affect the follicular microenvironment. The close relationship between AGEs, proinflammatory cytokine production and activation of the unfolded protein response (UPR), which involves activating transcription factor 4 (ATF4), is crucial for regulation of various cellular functions. We examined whether accumulation of AGEs in follicles was associated with proinflammatory cytokine production and activation of the UPR in granulosa cells and decreased oocyte developmental competence. Read More

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November 2019

Embryology of the Cardiac Conduction System Relevant to Arrhythmias.

Card Electrophysiol Clin 2019 09 11;11(3):409-420. Epub 2019 Jul 11.

Cardiovascular Sciences, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK.

Embryogenesis of the heart involves the complex cellular differentiation of slow-conducting primary myocardium into the rapidly conducting chamber myocardium of the adult. However, small areas of relatively undifferentiated cells remain to form components of the adult cardiac conduction system (CCS) and nodal tissues. Further investigation has revealed additional areas of nodal-like tissues outside of the established CCS. Read More

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September 2019