813 results match your criteria ccs common

Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State.

Front Immunol 2021 27;12:737170. Epub 2021 Aug 27.

Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

Cerebral-cardiac syndrome (CCS) refers to cardiac dysfunction following varying brain injuries. Ischemic stroke is strongly evidenced to induce CCS characterizing as arrhythmia, myocardial damage, and heart failure. CCS is attributed to be the second leading cause of death in the post-stroke stage; however, the responsible mechanisms are obscure. Read More

View Article and Full-Text PDF

Advances in Skin Tissue Bioengineering and the Challenges of Clinical Translation.

Front Surg 2021 24;8:640879. Epub 2021 Aug 24.

Skin Engineering Laboratory, Adult Burns Centre, Royal Adelaide Hospital, Adelaide, SA, Australia.

Skin tissue bioengineering is an emerging field that brings together interdisciplinary teams to promote successful translation to clinical care. Extensive deep tissue injuries, such as large burns and other major skin loss conditions, are medical indications where bioengineered skin substitutes (that restore both dermal and epidermal tissues) are being studied as alternatives. These may not only reduce mortality but also lessen morbidity to improve quality of life and functional outcome compared with the current standards of care. Read More

View Article and Full-Text PDF

Effects of ocean acidification on the growth, photosynthetic performance, and domoic acid production of the diatom Pseudo-nitzschia australis from the California Current System.

Harmful Algae 2021 Jul 19;107:102030. Epub 2021 Jul 19.

Estuary and Ocean Science Center, San Francisco State University, 3150 Paradise Drive, Tiburon, California, 94920-1205, USA. Electronic address:

Pseudo-nitzschia australis (Frenguelli), a toxigenic pennate diatom capable of producing the neurotoxin domoic acid (DA), was examined in unialgal laboratory cultures to quantify its physiological response to ocean acidification (OA) - the decline in pH resulting from increasing partial pressure of CO (pCO) in the oceans. Toxic blooms of P. australis are common in the coastal waters of eastern boundary upwelling systems (EBUS), including those of the California Current System (CCS) off the west coast of the United States where increased pCO and decreased seawater pH are well-known. Read More

View Article and Full-Text PDF

Safety of Immune Checkpoint Inhibitors in Elderly Patients: An Observational Study.

Curr Oncol 2021 Aug 25;28(5):3259-3267. Epub 2021 Aug 25.

Medical Oncology Unit, Careggi University Hospital, 50134 Florence, Italy.

Background: Immunotherapy has completely changed the treatment of solid tumors. Although immune checkpoint inhibitors (ICIs) seem to be an appealing alternative to chemotherapy, especially in elderly patients, due to a more tolerable toxicity profile, they can lead to a peculiar variety of immune-related adverse events (irAEs). However, data on tolerability and outcome of ICIs in the elderly are lacking due to poor accrual in clinical trials of these patients. Read More

View Article and Full-Text PDF

Efficacy and toxicity of SBRT in advanced hepatocellular carcinoma with portal vein tumor thrombosis - a retrospective study.

Rep Pract Oncol Radiother 2021 12;26(4):573-581. Epub 2021 Aug 12.

Department of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: The purpose of this study was to evaluate the outcome of stereotactic body radiation therapy (SBRT) in patients of unresectable hepatocellular carcinoma (HCC ) complicated with portal vein tumor thrombosis (PVTT) who are also unsuitable for other locoregional therapies.

Materials And Methods: Between May 2018 and January 2020, twenty-nine patients with advanced unresectable HCC s, treated with SBRT, were enrolled in this retrospective audit. Patients of Child status A5-B7 and with healthy liver volume, ≥ 700 ccs were treated. Read More

View Article and Full-Text PDF

An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.

Dis Model Mech 2021 Apr 23;14(4). Epub 2021 Apr 23.

Laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, INSERM UMR 1163, Imagine Institute, Paris 75015, France.

Achondroplasia (ACH), the most common form of dwarfism, is caused by a missense mutation in the gene coding for fibroblast growth factor receptor 3 (FGFR3). The resulting increase in FGFR3 signaling perturbs the proliferation and differentiation of chondrocytes (CCs), alters the process of endochondral ossification and thus reduces bone elongation. Increased FGFR3 signaling in osteoblasts (OBs) might also contribute to bone anomalies in ACH. Read More

View Article and Full-Text PDF

Coexisting Epithelioid Trophoblastic Tumor and Placental Site Trophoblastic Tumor During Asymptomatic Relapse: A Case Report and Literature Review.

Int J Gynecol Pathol 2021 Aug 16. Epub 2021 Aug 16.

Department of Obstetrics and Gynecology, Galilee Medical Centre (A.A., K.N., R.T., A.S., J.B.) The Pathology and Cytology Units, Galilee Medical Centre (H.I.C.), Nahariya Azrieli Faculty of Medicine, Bar-Ilan University, Safed (A.A., K.N., R.T., A.S., J.B., H.I.C.), Israel.

Gestational trophoblastic neoplasms are a group of trophoblastic tumors that include choriocarcinoma (CC), epithelioid trophoblastic tumors (ETTs), and placental site trophoblastic tumors (PSTTs). Mixed gestational trophoblastic neoplasms include combinations of CCs with ETTs and/or PSTTs; combinations of ETTs and PSTTs have also been described. This report describes the case of a 49-yr-old female with mixed ETT and PSTT discovered due to menstrual delay and a positive beta-human chorionic gonadotropin in serum 11 yr after normal pregnancy; it is an asymptomatic recurrence of the neoplasm after 2 yr. Read More

View Article and Full-Text PDF

Changes in the diagnosis and non-invasive treatment of chronic coronary syndromes in the last three European Society of Cardiology guidelines.

Kardiochir Torakochirurgia Pol 2021 Jun 5;18(2):105-110. Epub 2021 Jul 5.

3 Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.

One of the most common forms of ischemic heart disease is chronic coronary syndromes (CCS), formerly known as stable coronary artery disease. During the last 15 years, the European Society of Cardiology has modified the guidelines for the diagnosis and treatment of CCS three times. The aim of this study was to analyze the changes in non-invasive diagnostics and pharmacotherapy of CCS that occurred in the last three guidelines. Read More

View Article and Full-Text PDF

Galvanic Vestibular Stimulation-Based Prediction Error Decoding and Channel Optimization.

Int J Neural Syst 2021 Aug 11:2150034. Epub 2021 Aug 11.

Institute of Innovative Research, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.

A significant problem in brain-computer interface (BCI) research is decoding - obtaining required information from very weak noisy electroencephalograph signals and extracting considerable information from limited data. Traditional intention decoding methods, which obtain information from induced or spontaneous brain activity, have shortcomings in terms of performance, computational expense and usage burden. Here, a new methodology called prediction error decoding was used for motor imagery (MI) detection and compared with direct intention decoding. Read More

View Article and Full-Text PDF

Sorghum polyphenols: plant stress, human health benefits, and industrial applications.

Planta 2021 Aug 10;254(3):47. Epub 2021 Aug 10.

Department of Plant Breeding and Genetics, COA, CCS Haryana Agricultural University, Hisar, 125004, Haryana, India.

Main Conclusion: Various phenolic compounds of sorghum are effective in the management of abiotic stress (salt, nutrients) and biotic stress (caused by birds, fungi and aphids). The health and industrial application of phenolics is mainly contributed by inherent antioxidant and nutraceutical potential. In a natural environment, plant growth is affected by various biotic and abiotic stresses. Read More

View Article and Full-Text PDF

Prevalence, Characteristics and Clonal Distribution of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Following the Swine Production Stages, and Potential Risks to Humans.

Front Microbiol 2021 21;12:710747. Epub 2021 Jul 21.

College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea.

The worldwide spread of extended spectrum β-lactamase (ESBL)- and AmpC β-lactamase (AmpC)-producing poses serious threats to public health. Swine farms have been regarded as important reservoirs of ESBL/AmpC-EC. This study aimed to determine the prevalence, ESBL/AmpC types, and clonal distribution of ESBL/AmpC-EC from swine farms and analyze the difference according to the swine production stages. Read More

View Article and Full-Text PDF

Myrsinoic acid B from Myrsine coriacea reverses depressive-like behavior and brain oxidative stress in streptozotocin-diabetic rats.

Chem Biol Interact 2021 Sep 2;347:109603. Epub 2021 Aug 2.

Centro de Ciências da Saúde, CCS, Programa de Pós-Graduação Em Ciências Farmacêuticas/UNIVALI, Rua Uruguai 458, Centro, CEP: 88302-202, Itajaí, SC, Brazil.

Aims: Major depressive disorder (MDD) affects approximately 322 million people worldwide and is a common comorbidity in patients with diabetes mellitus (DM). A possible pathophysiological mechanism correlating both diseases is the increased oxidative stress in brain regions due to hyperglycemia. Myrsine coriacea (Primulaceae) is popularly known as "capororoca" and studies have been shown that this plant exhibits several pharmacological properties attributed to myrsinoic acid A (MAA) and B (MAB). Read More

View Article and Full-Text PDF
September 2021

Clinical Acupoint Selection for the Treatment of Functional Constipation by Massage and Acupuncture Based on Smart Medical Big Data Analysis.

J Healthc Eng 2021 16;2021:9930412. Epub 2021 Jul 16.

Chinese Massage Department, The Affiliated Hospital of Shandong University of TCM, Jinan 250014, Shandong, China.

With the development of society and economy, people's lifestyle and eating habits have undergone great changes, such as spending a long time behind desks, sitting for a long time, drinking and staying up late, and emotional depression; functional constipation, a disease of the digestive system, has changed. It is extremely common, and the age of onset is gradually decreasing. The development of the medical and health industry is also accompanied by the rapid development of technologies such as the Internet of Things, big data, and artificial intelligence, which penetrates into all aspects of the medical and health field and has entered the stage of smart medical care. Read More

View Article and Full-Text PDF

Cellular level response of the bivalve Limecola balthica to seawater acidification due to potential CO leakage from a sub-seabed storage site in the southern Baltic Sea: TiTank experiment at representative hydrostatic pressure.

Sci Total Environ 2021 Nov 24;794:148593. Epub 2021 Jun 24.

University of Gdańsk, Faculty of Oceanography and Geography, Institute of Oceanography, Al. Piłsudskiego 46, 81-378 Gdynia, Poland.

Understanding of biological responses of marine fauna to seawater acidification due to potential CO leakage from sub-seabed storage sites has improved recently, providing support to CCS environmental risk assessment. Physiological responses of benthic organisms to ambient hypercapnia have been previously investigated but rarely at the cellular level, particularly in areas of less common geochemical and ecological conditions such as brackish water and/or reduced oxygen levels. In this study, CO-related responses of oxygen-dependent, antioxidant and detoxification systems as well as markers of neurotoxicity and acid-base balance in the Baltic clam Limecola balthica from the Baltic Sea were quantified in 50-day experiments. Read More

View Article and Full-Text PDF
November 2021

Same Day Surgical Intervention Dramatically Minimizes Complication Occurrence and Optimizes Perioperative Outcomes for Central Cord Syndrome.

Clin Spine Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY Department of Pediatric Neurosurgery, UT Southwestern Medical Center, Dallas, TX Department of Neurologic Surgery, University of Michigan, Ann Arbor, MI Department of Orthopaedic Surgery, University of Calgary, Calgary, AB, Canada Department of Neurological Surgery Montefiore Medical Center/Albert Einstein College of Medicine Bronx, NY Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD Deparment of Orthopedic Surgery, SUNY Downstate, New York, NY.

Study Design: This was a retrospective cohort study.

Objective: The aim of this study was to investigate associations between time to surgical intervention and outcomes for central cord syndrome (CCS) patients.

Background: As surgery is increasingly recommended for patients with neurological deterioration CCS, it is important to investigate the relationship between time to surgery and outcomes. Read More

View Article and Full-Text PDF

Relation of the Number of Cardiovascular Conditions and Short-term Symptom Improvement After Percutaneous Coronary Intervention for Stable Angina Pectoris.

Am J Cardiol 2021 09 17;155:1-8. Epub 2021 Jul 17.

Harvard Medical School, Boston, Massachusetts; Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Division of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Electronic address:

With aging of the population, cardiovascular conditions (CC) are increasingly common in individuals undergoing PCI for stable angina pectoris (AP). It is unknown if the overall burden of CCs associates with diminished symptom improvement after PCI for stable AP. We prospectively administered validated surveys assessing AP, dyspnea, and depression to patients undergoing PCI for stable AP at our institution, 2016-2018. Read More

View Article and Full-Text PDF
September 2021

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial.

Trials 2021 Jul 19;22(1):466. Epub 2021 Jul 19.

Cardiovascular Department, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, China.

Background: Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Read More

View Article and Full-Text PDF

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.

Obes Rev 2021 Jul 13. Epub 2021 Jul 13.

Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.

Childhood cancer survivors (CCS) are at increased risk to develop metabolic syndrome (MetS), diabetes, and cardiovascular disease. Common criteria underestimate adiposity and possibly underdiagnose MetS, particularly after abdominal radiotherapy. A systematic literature review and meta-analysis on the diagnostic and predictive value of nine newer MetS related biomarkers (adiponectin, leptin, uric acid, hsCRP, TNF-alpha, IL-1, IL-6, apolipoprotein B (apoB), and lipoprotein(a) [lp(a)]) in survivors and adult non-cancer survivors was performed by searching PubMed and Embase. Read More

View Article and Full-Text PDF

The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury.

Cell Commun Signal 2021 Jul 13;19(1):76. Epub 2021 Jul 13.

Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Anshan Road NO.154, Tianjin, 300052, China.

Hypoxia is a pathological condition common to many diseases, although multiple organ injuries induced by hypoxia are often overlooked. There is increasing evidence to suggest that the hypoxic environment may activate innate immune cells and suppress adaptive immunity, further stimulating inflammation and inhibiting immunosurveillance. We found that dysfunctional immune regulation may aggravate hypoxia-induced tissue damage and contribute to secondary injury. Read More

View Article and Full-Text PDF

Penicillin susceptibility among invasive MSSA infections: a multicentre study in 16 Spanish hospitals.

J Antimicrob Chemother 2021 Sep;76(10):2519-2527

Área Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.

Objectives: To determine the prevalence of penicillin susceptibility among MSSA causing bloodstream infections (BSIs) in 16 Spanish hospitals and to characterize the penicillin-susceptible MSSA (MSSA-PENS) isolates.

Methods: A total of 1011 Staphylococcus aureus isolates were collected from blood cultures in 16 Spanish hospitals during 2018-19 (6-12 months) and their susceptibility to 18 antimicrobials was determined. The MSSA-PENS isolates were selected and examined by PCR to determine the presence of the blaZ gene, other resistance genes and the genes lukF/lukS-PV, eta, etb and tst. Read More

View Article and Full-Text PDF
September 2021

Adolescent and young adult childhood cancer survivors' preferences for screening and education of sexual function.

Pediatr Blood Cancer 2021 Jul 10:e29229. Epub 2021 Jul 10.

Adult & Child Consortium for Health Outcomes Research & Delivery Science (ACCORDS), University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Sexual dysfunction (SD) is a common yet underrecognized concern among childhood cancer survivors (CCS). CCS who are now adolescent and young adult (AYA-CCS) identify SD as an unmet need. This study sought to explore AYA-CCS preferences on how, when, where, and by whom SD-focused communication should occur. Read More

View Article and Full-Text PDF

Comparative Study: Impacts of Ca and Mg Salts on Iron Oxygen Carriers in Chemical Looping Combustion of Biomass.

ACS Omega 2021 Jun 16;6(25):16649-16660. Epub 2021 Jun 16.

Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

Chemical looping combustion (CLC) is one of the most promising methods for carbon capture and storage (CCS). An oxygen carrier, i.e. Read More

View Article and Full-Text PDF

Identifying Potential Neoantigens for Cervical Cancer Immunotherapy Using Comprehensive Genomic Variation Profiling of Cervical Intraepithelial Neoplasia and Cervical Cancer.

Front Oncol 2021 17;11:672386. Epub 2021 Jun 17.

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Cervical cancer (CC) is one of the most common gynecological malignant tumors. The 5-year survival rate remains poor for the advanced and metastatic cervical cancer for the lack of effective treatments. Immunotherapy plays an important role in clinical tumor therapy. Read More

View Article and Full-Text PDF

Predicting differential ion mobility behaviour using machine learning.

Analyst 2021 Jul;146(15):4737-4743

Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada. and Waterloo Institute for Nanotechnology, University of 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada and WaterMine Innovation, Inc., Waterloo, Ontario N0B 2T0, Canada and Centre for Eye and Vision Research, Hong Kong Science Park, New Territories, 999077, Hong Kong.

Although there has been a surge in popularity of differential mobility spectrometry (DMS) within analytical workflows, determining separation conditions within the DMS parameter space still requires manual optimization. A means of accurately predicting differential ion mobility would benefit practitioners by significantly reducing the time associated with method development. Here, we report a machine learning (ML) approach that predicts dispersion curves in an N2 environment, which are the compensation voltages (CVs) required for optimal ion transmission across a range of separation voltages (SVs) between 1500 to 4000 V. Read More

View Article and Full-Text PDF

Novel Sequence Types of of Different Origin Obtained in the Republic of Serbia.

Microorganisms 2021 Jun 12;9(6). Epub 2021 Jun 12.

Federal Research Center for Virology and Microbiology, Branch in Saratov, 410028 Saratov, Russia.

, the causative agent of listeriosis, is amongst the major food-borne pathogens in the world that affect mammal species, including humans. This microorganism has been associated with both sporadic episodes and large outbreaks of human listeriosis worldwide, with high mortality rates. In this study, the main sequence types (STs) and clonal complexes (CCs) were investigated in all of the 13 strains originating from different sources in the Republic of Serbia in 2004-2019 and that were available in the BIGSdb-Lm database. Read More

View Article and Full-Text PDF

Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors.

Oncogene 2021 Aug 30;40(32):5095-5104. Epub 2021 Jun 30.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Chromosomal translocations constitute driver mutations in solid tumors and leukemias. The mechanisms of how related or even identical gene fusions drive the pathogenesis of various tumor types remain elusive. One remarkable example is the presence of EWSR1 fusions with CREB1 and ATF1, members of the CREB family of transcription factors, in a variety of sarcomas, carcinomas and mesotheliomas. Read More

View Article and Full-Text PDF

Can you hear us now? The impact of health-care utilization by rare disease patients in the United States.

Genet Med 2021 Jun 28. Epub 2021 Jun 28.

Advocate Aurora Health, Advocate Aurora Research Institute, Milwaukee, WI, USA.

Purpose: The vast majority of rare diseases (RDs) are complex, disabling, and life-threatening conditions with a genetic origin. RD patients face significant health challenges and limited treatments, yet the extent of their impact within health care is not well known. One direct method to gauge the disease burden of RDs is their overall cost and utilization within health-care systems. Read More

View Article and Full-Text PDF

Genomic epidemiology of methicillin-resistant and -susceptible Staphylococcus aureus from bloodstream infections.

BMC Infect Dis 2021 Jun 21;21(1):589. Epub 2021 Jun 21.

Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, 12222, USA.

Background: Bloodstream infections due to Staphylococcus aureus cause significant patient morbidity and mortality worldwide. Of major concern is the emergence and spread of methicillin-resistant S. aureus (MRSA) in bloodstream infections, which are associated with therapeutic failure and increased mortality. Read More

View Article and Full-Text PDF

Potentially Inappropriate Medication and Associated Factors Among Older Patients with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China.

Clin Interv Aging 2021 9;16:1047-1056. Epub 2021 Jun 9.

Department of Pharmacy, Peking University People's Hospital, Beijing, People's Republic of China.

Purpose: Medication therapy is crucial in the management of chronic coronary syndrome (CCS). The use of potentially inappropriate medications (PIMs) contributes to poor outcomes in older patients, making it a major public health concern. However, few studies are available on PIMs use in older Chinese CCS patients. Read More

View Article and Full-Text PDF

Disease Prevalence, Comorbid Conditions, and Medication Utilization Among Patients with Schizophrenia in the United States.

CNS Spectr 2021 04;26(2):157

Epidemiologic Research & Methods, LLC, Atlanta, GA, USA.

Objective: Disease prevalence, comorbid conditions, and pharmacological treatments were examined in a large population of US commercial- or Medicaid-insured individuals with schizophrenia.

Methods: This retrospective, cross-sectional claims analysis sourced data from the IBM MarketScan Commercial and Medicare Supplemental Databases and the Multi-state Medicaid Database (01Jan2009 to 30Jun2016). Cases were defined by =1 diagnostic claim (ICD-9-CM/ICD-10-CM) for schizophrenia during the study period. Read More

View Article and Full-Text PDF