11,033 results match your criteria ccs

Exercise ECG Testing and Stress Cardiac Magnetic Resonance for Risk Prediction in Patients With Chronic Coronary Syndrome.

J Cardiopulm Rehabil Prev 2021 Sep 22. Epub 2021 Sep 22.

Department of Cardiology, Hospital Clinico Universitario de Valencia, Valencia, Spain (Drs Marcos-Garces, Merenciano-Gonzalez, Gabaldon-Perez, Nuñez-Marin, Lorenzo-Hernandez, Bonanad, Racugno, Chorro, and Bodi); INCLIVA Health Research Institute, Valencia, Spain (Drs Gavara, Chorro, and Bodi, Mss Perez and De Dios, and Mr Rios-Navarro); Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain (Dr Gavara); Centro de Investigación Biomédica en Red-Cardiovascular (CIBER-CV), Madrid, Spain (Ms De Dios and Drs Chorro and Bodi); Cardiovascular Magnetic Resonance Unit, ERESA, Valencia, Spain (Drs Lopez-Lereu and Monmeneu); and Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain (Drs Chorro and Bodi).

Purpose: Vasodilator stress cardiac magnetic resonance (VS-CMR) has become crucial in the workup of patients with known or suspected chronic coronary syndrome (CCS). Whether traditional exercise ECG testing (ExECG) contributes prognostic information beyond VS-CMR is unclear.

Methods: We retrospectively included 288 patients with known or suspected CCS who had undergone ExECG and subsequent VS-CMR in our institution. Read More

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September 2021

Glioblastoma: What can we do for these patients today and what will we be able to do in the future?

Prog Brain Res 2021 12;265:99-118. Epub 2021 Aug 12.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Glioblastoma multiforme (GBM) is an extremely aggressive primary human brain tumor. The median survival of GBM patients is 15 months in case of completing the modern complex treatment protocol. Chemotherapy can help to extend the life expectancy of patients. Read More

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Cervical cancer screening programs and their context-dependent effect on inequalities in screening uptake: a dynamic interplay between public health policy and welfare state redistribution.

Int J Equity Health 2021 Sep 24;20(1):211. Epub 2021 Sep 24.

Department of Sociology, Ghent University, Korte Meer 5, 9000, Ghent, Belgium.

Background: While organized and opportunistic cervical cancer screening (CCS) programs implemented across the European Union have increased participation rates, barriers to socioeconomically deprived women remain substantial, implying high levels of inequality in CCS uptake.

Aim: This study assesses how the screening strategy (as a score based on the availability of organized population-based CCS programs), accessibility of the healthcare system (as an index of out-of-pocket expenditure as a proportion of total healthcare costs, public health expenditure as a percentage of total GDP, and general practitioner (GP) density per 10'000 inhabitants) and social protection (as a decommodification index), impact education- and income-based inequalities in CCS uptake.

Methods: A two-level design with 25-64-year-old women (N = 96'883), eligible for Pap smear screening, nested in 28 European countries, was used to analyze data from the European Health Interview Survey's second wave, using multilevel logistic regression modelling. Read More

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September 2021

Biomechanical study of two alternative methods for the treatment of vertical femoral neck fractures - A finite element analysis.

Comput Methods Programs Biomed 2021 Sep 9;211:106409. Epub 2021 Sep 9.

Dalian Medical University, Dalian 116044, Liaoning Province, China; Department of Orthopedics, Subei People's Hospital of Jiangsu Province, Yangzhou 225001, Jiangsu Province, China. Electronic address:

Background: No consensus has been reached for the treatment of vertical femoral neck fractures (vFNFs). Recently, two alternative methods were invented to treat vFNFs, one of which is a new plate with a sliding groove, which was designed as a substitution of the medial buttress locking plate to combine with cannulated compression screws (CCS) for reducing the breakage possibility of the proximal locking screw during the bone healing. Another one is the femoral neck system (FNS), which was believed with biomechanical superiority. Read More

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September 2021

Adsorption and Activation of CO2 on Nitride MXenes: Composition, Temperature, and Pressure effects.

Chemphyschem 2021 Sep 23. Epub 2021 Sep 23.

University of Barcelona: Universitat de Barcelona, Material Science and Physical Chemistry, SPAIN.

The interaction of CO 2 with nitride MXenes of different thickness is investigated using periodic density functional theory-based calculations and kinetic simulations carried out in the framework of transition state theory, the ultimate goal being predicting their possible use in Carbon Capture and Storage (CCS). We consider the basal (0001) surface plane of nitride MXenes with M n +1 N n ( n = 1-3; M = Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W) stoichiometry and also compare to equivalent results for extended (001) and (111) surfaces of the bulk rock-salt transition metal nitride compounds. The present results show that the composition of MXenes has a marked influence on the CO 2 -philicity of these substrates, whereas the thickness effect is, in general, small, but not negligible. Read More

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September 2021

Group B streptococcal infections in infants in Iceland: clinical and microbiological factors.

J Med Microbiol 2021 Sep;70(9)

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Group B streptococcus (GBS) is a leading cause of invasive neonatal infections. These have been divided into early-onset disease (EOD; <7 days) and late-onset disease (LOD; 7-89 days), with different GBS clonal complexes (CCs) associated with different disease presentations. Different GBS CCs are associated with timing of infection (EOD or LOD) and clinical presentation (sepsis, meningitis or pneumonia). Read More

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September 2021

Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells.

Front Cell Dev Biol 2021 6;9:735684. Epub 2021 Sep 6.

The State Key Laboratory of Medicinal Chemical Biology, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, China.

Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS patients undergoing ovarian stimulation have more oocytes; however, the poor quality of oocytes leads to lower fertilization and implantation rates, decreased pregnancy rates, and increased miscarriage rates. The complex molecular mechanisms underlying PCOS and the poor quality of oocytes remain to be elucidated. Read More

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September 2021

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.

Cell Commun Signal 2021 Sep 22;19(1):96. Epub 2021 Sep 22.

Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery, University of Miami, 1600 NW 10th Ave, Miami, FL, 33136, USA.

Background: Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Complex Kinase (NACK), INT activates Notch1 target genes by driving RNA polymerase II (RNAPII)-dependent transcription, leading to tumorigenesis. Read More

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September 2021

Evaluation of different vagus nerve stimulation anatomical targets in the ear by vagus evoked potential responses.

Brain Behav 2021 Sep 22:e2343. Epub 2021 Sep 22.

Biomedical Research Centre of the Government of Navarre, Pamplona, Spain.

Background: Electrical auricular vagus nerve stimulation (taVNS) is an emerging therapy. Stimuli are transported to brainstem nuclei, whereby its multiple projections reach to many subcortical and cortical areas, thus allowing the neuromodulation of several systemic physiological processes. We aim to define the best auricular target for taVNS through vagus somatosensory evoked potential (VSEP) elicited stimulating different auricular areas with different electrode sizes. Read More

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September 2021

Systematic Review of Substance Use Measurement Tools in Adolescent and Young Adult Childhood Cancer Survivors.

J Adolesc Young Adult Oncol 2021 Sep 22. Epub 2021 Sep 22.

Division of Behavioral Medicine & Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Substance use among adolescents and young adults (AYAs) is associated with an increased risk of poor physical and mental health outcomes. For AYA childhood cancer survivors (CCSs), substance use may also increase their likelihood of experiencing late effects. As a result, professional organizations recommend that AYA CCSs be regularly screened for risk behaviors, including substance use. Read More

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September 2021

HPV vaccination, information sources, and acculturation among Chinese college students aged 18-26 in the United States.

Res Nurs Health 2021 Sep 21. Epub 2021 Sep 21.

Department of Mathematics and Statistics, University of Nevada-Reno, Reno, Nevada, USA.

Human papillomavirus (HPV) vaccination behaviors among Chinese college students (CCS) in the United States are affected by social determinants of health. Using a self-report questionnaire and a snowball sampling technique, this cross-sectional study investigated (a) HPV vaccination practices; (b) primary social networking platforms and preferred means of receiving HPV information; and (c) the influence of acculturation on HPV vaccination, HPV information sources, and social networking use among 213 CCS aged 18-26 in the United States. About half (50. Read More

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September 2021

Stress cardiac magnetic resonance for mortality prediction and decision-making: registry of 2496 elderly patients with chronic coronary syndrome.

Rev Esp Cardiol (Engl Ed) 2021 Sep 18. Epub 2021 Sep 18.

Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Valencia, Spain; Instituto de Investigación Sanitaria del Hospital Clínico de Valencia (INCLIVA), Valencia, Spain; Departamento de Medicina, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. Electronic address:

Introduction And Objectives: The management of elderly patients with chronic coronary syndrome (CCS) is challenging. We explored the prognostic value and usefulness for decision-making of ischemic burden determined by vasodilator stress cardiac magnetic resonance (CMR) imaging in elderly patients with known or suspected CCS.

Methods: The study group comprised 2496 patients older than 70 years who underwent vasodilator stress CMR for known or suspected CCS. Read More

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September 2021

Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease.

Oxid Med Cell Longev 2021 2;2021:2531062. Epub 2021 Sep 2.

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Diabetic type 2 patients compared to nondiabetic patients exhibit an increased risk of developing diabetic kidney disease (DKD), the leading cause of end-stage renal disease. Hyperglycemia, hypertension, oxidative stress (OS), and genetic background are some of the mechanisms and pathways implicated in DKD pathogenesis. However, data on OS pathway susceptibility genes show limited success and conflicting or inconclusive results. Read More

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September 2021

Delineation of genotype × environment interaction for identification of stable genotypes for tillering phase drought stress tolerance in sugarcane.

Sci Rep 2021 Sep 20;11(1):18649. Epub 2021 Sep 20.

Division of Crop Improvement, ICAR-Sugarcane Breeding Institute, Coimbatore, India.

Sugarcane is a trans-seasonal long-duration crop and tillering phase (60-150 days) is the most sensitive phase for moisture stress, causing significant reduction in biomass accumulation. The study focussed to assess the Genotype × Environment Interaction (GEI) for tillering phase moisture stress and to identify the stable genotypes in sugarcane. The study dealt with 14 drought tolerant genotypes and two standards (Co 86032 and CoM 0265) which were evaluated in two plant and one ratoon trials at four locations in Maharashtra, India. Read More

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September 2021

Preliminary Evaluation of a New Orthotic for Patellofemoral and Multicompartment Knee Osteoarthritis.

Rehabil Res Pract 2021 6;2021:5923721. Epub 2021 Sep 6.

Spring Loaded Technology, Halifax, Canada.

Purpose: Traditional knee osteoarthritis (OA) braces are usually indicated for a minority of patients with knee OA, as they are only suitable for those with unicompartmental disease affecting the tibiofemoral joint. A new assistive brace design is intended for use in a wider range of knee OA patients with heterogeneous symptoms characteristic of patellofemoral, tibiofemoral, or multicompartmental knee OA. The purpose of this case series was to explore whether the use of this novel "tricompartment offloader" (TCO) brace was associated with clinically relevant improvements in pain and function. Read More

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September 2021

The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: a systematic literature review.

Neurosci Biobehav Rev 2021 Sep 16. Epub 2021 Sep 16.

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; South London & Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, London, United Kingdom.

The relaxin-3/RXFP3 system is one of several neuropeptidergic systems putatively implicated in regulating the behavioural alterations that characterise clinical depression and anxiety, making it a potential target for clinical translation. Accordingly, this systematic review identified published reports on the role of relaxin-3/RXFP3 signalling in these neuropsychiatric disorders and their behavioural endophenotypes, evaluating evidence from animal and human studies to ascertain any relationship. We searched PubMed, EMBASE, PsycINFO and Google Scholar databases up to February 2021, finding 609 relevant records. Read More

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September 2021

Genetic diversity of Listeria monocytogenes isolated from ready-to-eat food products in retail in Poland.

Int J Food Microbiol 2021 Sep 9;358:109397. Epub 2021 Sep 9.

Department of Food Safety, National Institute of Public Health NIH - National Research Institute, Warsaw, Poland.

The study describes the characterization of Listeria monocytogenes isolated from the general 2017-2019 national official control and monitoring sampling program. A total of 60,928 of ready-to-eat (RTE) food products were collected in retail in Poland, while the number of L. monocytogenes contaminated samples was 67 (0. Read More

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September 2021

Prevalence and multilocus sequence typing of Clostridium perfringens isolated from retail chicken products and diseased chickens in Tai'an region, China.

Vet Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong Agricultural University, China.

Background: Clostridium perfringens is an important zoonotic microorganism, which can cause diseases in animals and humans under suitable conditions. Contamination of C. perfringens in chicken products has been reported worldwide, but the genetic diversity and relationship of isolates were seldom analyzed. Read More

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September 2021

The long-running issues of tuberculosis.

Lancet Glob Health 2021 10;9(10):e1339-e1340

Post-Graduation Program in Medical Clinics, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

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October 2021

Initial in-human experience with the conveyor cardiovascular system for the delivery of large profile transcatheter valve devices.

Catheter Cardiovasc Interv 2021 Sep 17. Epub 2021 Sep 17.

Cardiovascular Masters Consortium, Durham, North Carolina, USA.

Objectives: To determine the safety and efficacy of the conveyor cardiovascular system (CCS) to facilitate the delivery of large profile transcatheter valve devices.

Background: Transcatheter valve devices rely on force provided by the operator to be delivered to their intended position. This delivery may be challenging in a variety of anatomic scenarios. Read More

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September 2021

The core qualities and competencies of the intensive and critical care nurse, a meta-ethnography.

J Adv Nurs 2021 Sep 17. Epub 2021 Sep 17.

Faculty of Health and Social Sciences, Department of Nursing and Health Sciences, University of South-Eastern Norway, Kongsberg, Norway.

Aim: To develop a conceptual framework of the core qualities and competencies of the intensive and critical care nurse based on the experiences of intensive care patients, their relatives and the intensive and critical care nurses.

Design: Meta-ethnography.

Data Sources: A comprehensive, systematic search in seven databases supplemented with hand, citation and reference search. Read More

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September 2021

Network pharmacology study on the mechanism of Qiangzhifang in the treatment of panic disorder.

Ann Transl Med 2021 Aug;9(16):1350

Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Background: Panic disorder (PD) is a kind of mental illness characterized by the symptom of recurring panic attacks. Qiangzhifang (QZF) is a novel decoction developed by Professor Zhaojun Yan based on a unique system of syndrome differentiation and clinical experience. It has achieved remarkable results after long-term clinical practice, but its mechanism of action is still unclear. Read More

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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

Cell Commun Signal 2021 Sep 16;19(1):95. Epub 2021 Sep 16.

Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.

Background: Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily proteins. We have shown that classic Ras proteins promote proliferation and survival, but not migration, in malignant peripheral nerve sheath tumor (MPNST) cells. Read More

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September 2021

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling.

Cell Commun Signal 2021 Sep 16;19(1):94. Epub 2021 Sep 16.

Institute of Biology, Department of Systems Biology, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an essential mediator of pro- and anti-inflammatory processes. Dysregulated IL-6-induced intracellular JAK/STAT signalling is associated with severe inflammatory and proliferative diseases. Read More

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September 2021

Phylogenetic analysis and population structure of Pseudomonas alloputida.

Genomics 2021 Sep 13;113(6):3762-3773. Epub 2021 Sep 13.

Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil. Electronic address:

The Pseudomonas putida group comprises strains with biotechnological and clinical relevance. P. alloputida was proposed as a new species and highlighted the misclassification of P. Read More

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September 2021

Methodologies to measure the coverage of vitamin A supplementation: a systematic review.

J Nutr Sci 2021;10:e68. Epub 2021 Aug 27.

Nutrition Section, UNICEF Headquarters, New York, USA.

Countries are increasingly transitioning from event-based vitamin A supplementation (VAS) distribution to delivery through routine health system contacts, shifting also to administrative, electronic-based monitoring tools, a process that brings certain limitations affecting the quality of administrative VAS coverage. At present, there is no standardised methodology for measuring the coverage of VAS delivered through routine health services. To address this gap, we conducted a systematic review of the literature to identify and recommend methods to measure VAS coverage, with the aim of providing guidance to countries on the collection of consistent data for planning, monitoring and evaluating VAS programmes integrated into routine health systems. Read More

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Association between apolipoprotein B/A1 ratio and coronary plaque vulnerability in patients with atherosclerotic cardiovascular disease: an intravascular optical coherence tomography study.

Cardiovasc Diabetol 2021 Sep 15;20(1):188. Epub 2021 Sep 15.

Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xiwulu 157#, Xi'an, 710004, Shaanxi, China.

Background: Apolipoprotein (Apo) A1 and Apo B are strongly associated with the risk of atherosclerotic cardiovascular disease (ASCVD). However, the relationship between the Apo B/A1 ratio and the morphology of coronary vulnerable plaques has not been fully elucidated in patients with ASCVD.

Methods: A total of 320 patients with ASCVD undergoing percutaneous coronary intervention were enrolled and assigned into acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) group. Read More

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September 2021

Cancer derived exosomes induce macrophages immunosuppressive polarization to promote bladder cancer progression.

Cell Commun Signal 2021 Sep 14;19(1):93. Epub 2021 Sep 14.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Background: Exosomes mediated crosstalk between tumor cells and other stromal cells including tumor associated macrophages plays an essential role in reprogramming tumor microenvironment (TME) to facilitate tumor progression. However, the mechanism of tumor derived exosomes promotes bladder cancer progression have not been defined.

Methods: Exosomes were extracted from bladder cancer cells MB49 conditioned medium by ultracentrifugation. Read More

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September 2021

Spatiotemporal differences in climate change impacts on vegetation cover in China from 1982 to 2015.

Environ Sci Pollut Res Int 2021 Sep 13. Epub 2021 Sep 13.

Qingdao Engineering Research Center for Rural Environment, College of Resources and Environment, Qingdao Agricultural University, Qingdao, 266109, Shandong, China.

The impacts of climate change on vegetation cover in different regions in China are not entirely clear because of the interference of non-climatic factors, such as human activity. This study aims to analyze the spatiotemporal differences in climate impacts qualitatively and quantitatively by applying trend, correlation, and multiple linear regression (MLR) analyses to the data of Normalized Difference Vegetation Index (NDVI) and two climatic factors (air temperature and precipitation) during 1982-2015 in China. The MLR equation linking two climatic variables with NDVI was used to identify the NDVI trend caused by climate change. Read More

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September 2021

Optimization of a liquid chromatography-ion mobility-high resolution mass spectrometry platform for untargeted lipidomics and application to HepaRG cell extracts.

Talanta 2021 Dec 17;235:122808. Epub 2021 Aug 17.

University of Antwerp, Toxicological Centre, Universiteitsplein 1, 2610, Antwerp, Belgium. Electronic address:

Analytical methods to evaluate the lipidome of biological samples need to provide high data quality to ensure comprehensive profiling and reliable structural elucidation. In this perspective, liquid chromatography-high resolution mass spectrometry (LC-HRMS) is the state-of-the-art technique for lipidomic analysis of biological samples. There are thousands of lipids in most biological samples, and therefore separation methods before introduction to the mass spectrometer is key for relative quantitation and identification. Read More

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December 2021