Thromb Haemost 2015 May 26;113(5):916-30. Epub 2015 Feb 26.
Matteo Nicola Dario Di Minno, MD, Department of Clinical Medicine and Surgery, Federico II University, Via S. Pansini 5, 80131 Napoli, Italy, Tel./Fax: +39 081 7462060, E-mail:
We performed a systematic review with meta-analysis and meta-regression of literature studies evaluating the impact of rheumatoid arthritis (RA) on common carotid artery intima-media thickness (CCA-IMT) and on the prevalence of carotid plaques. Studies evaluating the relationship between RA and markers of cardiovascular (CV) risk (CCA-IMT and prevalence of carotid plaques) were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. A total of 59 studies (4,317 RA patients and 3,606 controls) were included in the final analysis, 51 studies with data on CCA-IMT (52 data-sets on 3,600 RA patients and 3,020 controls) and 35 studies reporting on the prevalence of carotid plaques (2,859 RA patients and 2,303 controls). Read More