Gen Comp Endocrinol 2021 May 4;305:113734. Epub 2021 Feb 4.
Laboratory of Neuroendocrinology, Brain Research Institute UCLA, Box 951761, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E Young Drive E, Los Angeles, CA 90095, USA; Department of Ecology and Evolutionary Biology, University of California Los Angeles, 621 Charles E Young Drive S, Los Angeles, CA 90095, USA.
Regulation of glucocorticoids (GCs), important mediators of physiology and behavior at rest and during stress, is multi-faceted and dynamic. The 11ß hydroxysteroid dehydrogenases 11ß-HSD1 and 11ß-HSD2 catalyze the regeneration and inactivation of GCs, respectively, and provide peripheral and central control over GC actions in mammals. While these enzymes have only recently been investigated in just two songbird species, central expression patterns suggest that they may function differently in birds and mammals, and little is known about how peripheral expression regulates circulating GCs. Read More