567 results match your criteria cbcs

Interaction of membrane-embedded cytochrome b-complexes with quinols: Classical Q-cycle and murburn model.

Cell Biochem Funct 2022 Jan 13. Epub 2022 Jan 13.

Karel de Grote University College, Antwerp University Association, Campus Hoboken, Hoboken, Belgium.

We recently proposed a diffusible reactive (oxygen) species (DRS/DROS) based function for cytochrome b complexes (CBC) and quinones (Q)/quinols (QH ) in the murburn model of bioenergetics. This proposal is in direct conflict with the classical purview of Q-cycle. Via extensive analyses of the structure-function correlations of membrane-quinones/quinols and proteins, we present qualitative and quantitative arguments to infer that the classical model cannot explain the energetics, kinetics, mechanism and probabilistic considerations. Read More

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January 2022

Systemic Effects of Photobiomodulation on Blood Components in the Treatment of Community-Acquired Pneumonia.

Photobiomodul Photomed Laser Surg 2022 Jan 20;40(1):51-58. Epub 2021 Dec 20.

Institute of Biomedical Engineering, Anhembi Morumbi University (UAM), São José dos Campos, Brazil.

The analysis of the complete blood count (CBC) of patients with community-acquired pneumonia (CAP) is an essential practice both for diagnosing the disease and for evaluating the patient's clinical evolution. It is proposed in the present study to analyze the hematological alterations resulting from photobiostimulation using near-infrared light-emitting diodes (LEDs) in patients with CAP. This was a clinical, prospective, blinded, and descriptive longitudinal study that involved 21 patients undergoing CAP treatment who were divided into two groups: LED, 11 patients who were treated with infrared LED and conventional treatment; and CON (control), 10 patients who received only conventional treatment (antibiotic therapy and physiotherapy). Read More

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January 2022

Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.

Curr Biol 2021 Dec 8. Epub 2021 Dec 8.

Institute for Ophthalmic Research, University of Tübingen, Elfriede-Aulhorn-Str. 7, 72076 Tübingen, Germany; Center for Integrative Neuroscience, University of Tübingen, Otfried-Müller-Str. 25, 72076 Tübingen, Germany. Electronic address:

In the outer plexiform layer (OPL) of the mammalian retina, cone photoreceptors (cones) provide input to more than a dozen types of cone bipolar cells (CBCs). In the mouse, this transmission is modulated by a single horizontal cell (HC) type. HCs perform global signaling within their laterally coupled network but also provide local, cone-specific feedback. Read More

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December 2021

Hematological and immunological responses to naturally occurring bovine respiratory disease in newly received beef calves in a commercial stocker farm.

J Anim Sci 2021 Dec 13. Epub 2021 Dec 13.

Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA.

The objective was to determine temporal changes in hematological and immune parameters in response to naturally occurring bovine respiratory disease (BRD) in commercially managed stocker calves. Forty newly weaned beef steers purchased from auction markets were housed at a commercial stocker operation in Crossville, TN. Blood samples, rectal temperature, and thoracic ultrasonography (TUS; 1: normal to 3: severe) were collected on days 0, 7, 14, and 21. Read More

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December 2021

Glioblastoma cytotoxicity conferred through dual disruption of endolysosomal homeostasis by Vacquinol-1.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab152. Epub 2021 Oct 15.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Background: Increased membrane trafficking is observed in numerous cancer types, including glioblastoma. Targeting the oncogenic driven acquired alterations in membrane trafficking by synthetic cationic amphiphilic small molecules has recently been shown to induce death of glioblastoma cells, although the molecular targets are unknown.

Methods: The mechanism of action of the cationic amphiphilic drug Vacquinol-1 (Vacq1)-induced cytotoxicity was investigated using cell biology, biochemistry, functional experiments, chemical biology, unbiased antibody-based post-translation modification profiling, and mass spectrometry-based chemical proteomic analysis on patient-derived glioblastoma cells. Read More

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October 2021

Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy.

Autophagy 2021 Nov 5:1-17. Epub 2021 Nov 5.

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.

The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. Read More

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November 2021

Paleoceanography of the northwestern Pacific across the Early-Middle Pleistocene boundary (Marine Isotope Stages 20-18).

Prog Earth Planet Sci 2021 30;8(1):29. Epub 2021 Apr 30.

Department of Earth Sciences, Ibaraki University, 2-2-1, Bunkyo, Mito, Ibaraki, 310-8512 Japan.

The fluctuating position of the boundary between the Kuroshio (warm) and Oyashio (cold) currents in the mid-latitude western North Pacific affects both heat transport and air-ocean interactions and has significant consequences for the East Asian climate. We reconstruct the paleoceanography of Marine Isotope Stages (MIS) 20-18, MIS 19 being one of the closest astronomical analogues to the present interglacial, through multiple proxies including microfossil assemblage data, planktonic foraminiferal isotopes (δO and δC), and foraminiferal Mg/Ca-based temperature records, from the Chiba composite section (CbCS) exposed on the Boso Peninsula, east-central Japan. Principal component analysis (PCA) is used to capture dominant patterns of the temporal variation in these marine records, and shows that the relative abundances of calcareous nannofossil and radiolarian taxa are consistent with the water mass types inferred from geochemical proxies. Read More

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Impact of Oncoplastic Breast Surgery on Rate of Complications, Time to Adjuvant Treatment, and Risk of Recurrence.

Breast Care (Basel) 2021 Oct 25;16(5):452-460. Epub 2020 Nov 25.

Breast Center, University Hospital of Basel, Basel, Switzerland.

Background: The aim of this study was to compare the risk of complications and recurrence between oncoplastic and conventional breast surgery.

Methods: This is a retrospective analysis of a consecutive series of 436 patients with stage I-III breast cancer who underwent surgery at the University Hospital of Basel between 2011 and 2018.

Results: The nipple/skin-sparing mastectomy (NSM/SSM) group showed significantly more delayed wound healing (32. Read More

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October 2021

Stomatocytosis in a Beagle and Australian Cattle Dog.

Vet Clin Pathol 2021 Dec 10;50(4):501-506. Epub 2021 Oct 10.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Background: Canine stomatocytosis is a well-recognized rare erythrocyte disorder characterized by nonsyndromic forms with selective erythroid involvement, syndromic forms with extra-hematologic disease, and acquired forms.

Objectives: We describe serial clinicopathologic changes in two dogs with stomatocytosis of breeds that are different from those previously reported.

Methods: Blood samples were obtained from a 12-year-old female neutered Australian Cattle Dog and a 12-year-old male neutered Beagle for hematologic and biochemical analyses, including a morphologic examination of peripheral blood films. Read More

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December 2021

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.

Cell Death Dis 2021 10 6;12(10):914. Epub 2021 Oct 6.

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.

Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irreversible collapse of the UPS, accompanied by a general accumulation of ubiquitylated proteins and caspase-dependent cell death. CBK77 caused accumulation of ubiquitin-dependent, but not ubiquitin-independent, reporter substrates of the UPS, suggesting a selective effect on ubiquitin-dependent proteolysis. Read More

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October 2021

Early crack detection using modified spectral clustering method assisted with FE analysis for distress anticipation in cement-based composites.

Sci Rep 2021 Oct 4;11(1):19685. Epub 2021 Oct 4.

Department of Mechanical Engineering, Invertis University, Bareilly, UP, 243001, India.

The present work reports an efficient way of capturing real-time crack propagation in concrete structures. The modified spectral analysis based algorithm and finite element modeling (FEM) were utilised for crack detection and quantitative analysis of crack propagation. Crack propagation was captured in cement-based composite (CBC) containing saw dust and M20 grade concrete under compressive loading using a simple and inexpensive 8-megapixel mobile phone camera. Read More

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October 2021

The evolution trend of availability of China's community-based care services and its impact on the cognitive function of elderly people: 2008-2018.

Int J Equity Health 2021 09 8;20(1):203. Epub 2021 Sep 8.

Institute of Income Distribution and Public Finance, Zhongnan University of Economics and Law, Room 130 in the Wenqin Building, No. 182 Nanhu Road, Donghu New Technology Development Zone, Wuhan, 430073, China.

Background: To address the challenge of the aging population, community-based care services (CBCS) have been developed rapidly in China as a new way of satisfying the needs of elderly people. Few studies have described the evolution trend of availability of CBCS in rural and urban areas and evaluated their effectiveness. This study aims to show the availability of China's CBCS and further analyze the effect of the CBCS on the cognitive function of elderly people. Read More

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September 2021

The monocyte-to-lymphocyte ratio: Sex-specific differences in the tuberculosis disease spectrum, diagnostic indices and defining normal ranges.

PLoS One 2021 30;16(8):e0247745. Epub 2021 Aug 30.

Department of Respiratory Medicine, Homerton University Hospital, London, United Kingdom.

Background: The monocyte-to-lymphocyte ratio (MLR) has been advocated as a biomarker in tuberculosis. Our objective was to evaluate its clinical value and associations.

Methods: Blood counts, inflammatory markers and clinical parameters were measured in patients with and those screened for tuberculosis. Read More

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November 2021

Spatiotemporal Change and the Natural-Human Driving Processes of a Megacity's Coastal Blue Carbon Storage.

Int J Environ Res Public Health 2021 08 23;18(16). Epub 2021 Aug 23.

School of Design & China Institute for Urban Governance, Shanghai Jiao Tong University, Shanghai 200240, China.

Coastal blue carbon storage (CBCS) plays a key role in addressing global climate change and realizing regional carbon neutrality. Although blue carbon has been studied for some years, there is little understanding of the influence of a megacity's complex natural and human-driven processes on CBCS. Taking the Shanghai coastal area as an example, this study investigated the spatiotemporal change in CBCS using the InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) model during 1990-2015, and analyzed the response of the CBCS to a megacity's complex natural- and human-driven processes through a land use/land cover transition matrix and hierarchical clustering. Read More

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Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques.

Animals (Basel) 2021 Aug 12;11(8). Epub 2021 Aug 12.

Oregon National Primate Research Center, Division of Reproductive and Developmental Sciences, Oregon Health & Science University, Beaverton, OR 97006, USA.

Collaborative semen collection in monkeys is a valuable tool in research, animal collection management, and conservation efforts. To obtain samples, monkeys are often restrained in open restraint chairs (ORC) with the "pole and collar" technique. While commonly used, this restraint is not tolerated by all individuals; some become anxious or aggressive towards the poles and people. Read More

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Neonatal Reference Intervals for the Complete Blood Count Parameters MicroR and HYPO-He: Sensitivity Beyond the Red Cell Indices for Identifying Microcytic and Hypochromic Disorders.

J Pediatr 2021 12 10;239:95-100.e2. Epub 2021 Aug 10.

Division of Neonatology, University of Utah Health, Salt Lake City, UT; Division of Hematology/Oncology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT; Center for Iron and Heme Disorders, University of Utah Health, Salt Lake City, UT; Women and Newborns Clinical Program, Intermountain Healthcare, Salt Lake City, UT.

Objective: To create neonatal reference intervals for the MicroR and HYPO-He complete blood count (CBC) parameters and to test whether these parameters are sensitive early markers of disease at early stages of microcytic/hypochromic disorders while the CBC indices are still normal.

Study Design: We retrospectively collected the CBC parameters MicroR and HYPO-He, along with the standard CBC parameters, from infants aged 0-90 days at Intermountain Healthcare hospitals using Sysmex hematology analyzers. We created reference intervals for these parameters by excluding values from neonates with proven microcytic disorders (ie, iron deficiency or alpha thalassemia) from the dataset. Read More

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December 2021

An Overview on Collagen and Gelatin-Based Cryogels: Fabrication, Classification, Properties and Biomedical Applications.

Polymers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

Department of Biomass and Leather Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China.

Decades of research into cryogels have resulted in the development of many types of cryogels for various applications. Collagen and gelatin possess nontoxicity, intrinsic gel-forming ability and physicochemical properties, and excellent biocompatibility and biodegradability, making them very desirable candidates for the fabrication of cryogels. Collagen-based cryogels (CBCs) and gelatin-based cryogels (GBCs) have been successfully applied as three-dimensional substrates for cell culture and have shown promise for biomedical use. Read More

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Morphopathological and molecular morphometric characterization of var. causing a novel sheath spot disease of maize in India.

Plant Dis 2021 Jul 14. Epub 2021 Jul 14.

Indian Agricultural Research Institute, 28802, Division of Plant Pathology, New Delhi, Delhi, India;

Maize brown sheath spot (MBSS), a new disease of maize, was discovered while surveying for maize leaf and sheath blight diseases in the Indian states of Assam, Jharkhand, Meghalaya, Manipur, and Odisha. Maize is the third most important cereal after rice and wheat in India. Unlike banded leaf and sheath blight (BLSB) disease caused by , MBSS symptoms on maize were discrete and limited to sheaths only. Read More

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Conflict monitoring and adaptation to affective stimuli as a function of ageing.

Cogn Process 2021 Nov 1;22(4):675-690. Epub 2021 Jul 1.

Centre of Behavioural and Cognitive Sciences, University of Allahabad, Allahabad, Uttar Pradesh, 211002, India.

The current study investigated whether preference for positive affect would be observed in the context of a higher order control process with increasing age given the premise of affective prioritization with ageing. The study examined how affect interacted with cognitive control mechanisms across young, middle-aged and older adults. Conflict monitoring and adaptation for affective stimuli was examined with a face-word Stroop task using happy and fearful facial expressions. Read More

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November 2021

A Comprehensive Review on the Utilization of Recycled Waste Fibers in Cement-Based Composites.

Materials (Basel) 2021 Jun 29;14(13). Epub 2021 Jun 29.

Guangxi Engineering and Technology Center for Utilization of Industrial Waste Residue in Building Materials, Guilin 541004, China.

Ecological problems such as natural resource depletion and massive quantities of waste for disposal are now guiding progressive civilization towards sustainable construction. The reduction of natural resources and the discarding of debris into open landfills are the two main environmental concerns. As a result, managing these solid wastes is a major challenge worldwide. Read More

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Erythrogram Patterns in Dogs with Chronic Kidney Disease.

Vet Sci 2021 Jun 30;8(7). Epub 2021 Jun 30.

Department of Veterinary Science, University of Pisa, 56122 San Piero a Grado (Pisa), Italy.

Anemia is considered a common finding in dogs with chronic kidney disease (CKD), typically as normochromic, normocytic, and non-regenerative. Although anemia can occur at any CKD IRIS (International Renal Interest Society) stage, its severity is related with the loss of kidney function. The aim of the present study was to retrospectively evaluate quantitative and morphological abnormalities of the erythrogram in dogs at different CKD IRIS stages. Read More

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Second invasive breast cancers in patients treated with breast-conserving therapy.

Eur J Surg Oncol 2021 10 10;47(10):2492-2498. Epub 2021 Jun 10.

Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: Second breast cancers after breast-conserving therapy (BCT) include ipsilateral breast tumor recurrence (IBTR) and metachronous contralateral breast cancer (CBC). Each IBTR is further classified as true recurrence (TR) or new primary tumor (NP). We aim to compare survival outcomes of TR, NP and CBC, and explore the optimal treatments. Read More

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October 2021

Identification, characterization, and lipid profiling of microalgae sp. NC1, isolated from coal mine effluent with potential for biofuel production.

Biotechnol Rep (Amst) 2021 Jun 24;30:e00621. Epub 2021 Apr 24.

Department of Environmental Science & Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, 826004, India.

An autoflocculating microalgal strain was isolated from coal mine effluent wastewater which was named as sp. NC1 after morphological and molecularly characterization. Further analysis of internal transcribed spacer 2 (ITS2) and compensatory base changes (CBCs) showed it does not belong to the clade comprising . Read More

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Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?

Breast Cancer (Dove Med Press) 2021 12;13:299-310. Epub 2021 May 12.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy.

BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered radio sensitivity of mutated cancer cells, mastectomy has always been advised in most patients with BC linked to TSGs mutations in order to avoid or minimize the use of adjuvant radiotherapy (ART). Whether ART is safe or not in these carriers is still debated. Read More

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Combination of optimized tissue engineering bone implantation with heel-strike like mechanical loading to repair segmental bone defect in New Zealand rabbits.

Cell Tissue Res 2021 Sep 8;385(3):639-658. Epub 2021 May 8.

Department of Orthopedic Surgery, 909th Hospital of People's Liberation Army, Affiliated Southeast Hospital of Xiamen University, 269 Zhanghua Middle Road, Fujian Province, 363000, Zhangzhou, People's Republic of China.

In this study, effects of combining optimized tissue engineering bone (TEB) implantation with heel-strike like mechanical loading to repair segmental bone defect in New Zealand rabbits were investigated. Physiological characteristics of bone marrow mesenchymal stem cells (BMMSCs), compact bone cells (CBCs), and bone marrow and compact bone coculture cells (BMMSC-CBCs) were compared to select the optimal seed cells for optimized TEB construction. Rabbits with segmental bone defects were treated in different ways (cancellous bone scaffold for group A, cancellous bone scaffold and mechanical loading for group B, optimized TEB for group C, optimized TEB and mechanical loading for group D, n = 4), and the bone repair were compared. Read More

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September 2021

The effectiveness of mammography surveillance after treatment of primary breast cancer: A single centre retrospective cohort study.

Ann Med Surg (Lond) 2021 May 9;65:102272. Epub 2021 Apr 9.

Norwich Medical School, University of East Anglia. Norwich Research Park, Norwich, NR4 7TJ, UK.

Introduction: There is a little evidence that routine follow-up of patients treated for early breast cancer (BC) to detect ibsilateral breast tumour recurrence (IBTR), or contralateral breast cancer (CBC), is either effective or offers any mortality benefits. We report our experience of following patients with early BC for recurrences and new primaries in order to determine the role of mammogram surveillance.

Methods: Single centre, retrospective primary observational study was designed. Read More

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Complete Blood Count Score Model Predicts Inferior Prognosis in Primary Central Nervous System Lymphoma.

Front Oncol 2021 26;11:618694. Epub 2021 Mar 26.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.

Background: Primary central nervous system lymphoma (PCNSL), an aggressive type of non-Hodgkin lymphoma, has a poor prognosis. Currently available prognostic scoring systems are inadequate. We therefore aimed to investigate the predictive values of complete blood counts (CBCs) in PCNSL. Read More

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Integrating biology and access to care in addressing breast cancer disparities: 25 years' research experience in the Carolina Breast Cancer Study.

Curr Breast Cancer Rep 2020 Sep 14;12(3):149-160. Epub 2020 May 14.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.

Purpose Of Review: To review research on breast cancer mortality disparities, emphasizing research conducted in the Carolina Breast Cancer Study, with a focus on challenges and opportunities for integration of tumor biology and access characteristics across the cancer care continuum.

Recent Findings: Black women experience higher mortality following breast cancer diagnosis, despite lower incidence compared to white women. Biological factors, such as stage at diagnosis and breast cancer subtypes, play a role in these disparities. Read More

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September 2020

Compensatory Base Changes Reveal Sexual Incompatibility among Members of the Sensu Lato (Diptera: Culicidae) Species Complex in Sri Lanka.

Life (Basel) 2021 Mar 8;11(3). Epub 2021 Mar 8.

Center for Biotechnology, Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda 10250, Sri Lanka.

The mosquito sensu lato (s.l.) is a major secondary vector of malaria in Sri Lanka. Read More

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