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Mucinous Adenocarcinoma of the Appendix With Histologic Response to Neoadjuvant Chemotherapy: Review of Histologic and Clinical Spectrum of Epithelial Neoplastic Mucinous Lesions of the Appendix.

Oncology (Williston Park) 2021 Jun 23;35(6):335-340. Epub 2021 Jun 23.

Mary Lanning Healthcare, Hastings, NE.

Appendiceal mucinous neoplasms are a rare and heterogeneous group of diseases with challenging clinical management decisions. They account for less than 1% of all cancers but their incidence is on the rise. Treatment is based on their stage and histology. Read More

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A novel Veress needle mechanism that reduces overshooting after puncturing the abdominal wall.

Surg Endosc 2021 Jun 22. Epub 2021 Jun 22.

Department of BioMechanical Engineering, Faculty of Biomedical Engineering, University of Technology Delft, Mekelweg 2, 2628 CD, Delft, The Netherlands.

Background: Complications that occur in laparoscopic surgery are often associated with the initial entry into the peritoneal cavity. The literature reported incidences of Veress needle (VN) injuries of e.g. Read More

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Saliva and Serum Protein Adsorption on Chemically Modified Silica Surfaces.

J Dent Res 2021 Jun 22:220345211022273. Epub 2021 Jun 22.

Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Biomaterials, once inserted in the oral cavity, become immediately covered by a layer of adsorbed proteins that consists mostly of salivary proteins but also of plasma proteins if the biomaterial is placed close to the gingival margin or if it becomes implanted into tissue and bone. It is often this protein layer, rather than the pristine biomaterial surface, that is subsequently encountered by colonizing bacteria or attaching tissue cells. Thus, to study this important initial protein adsorption from human saliva and serum and how it might be influenced through chemical modification of the biomaterial surface, we have measured the amount of protein adsorbed and analyzed the composition of the adsorbed protein layer using gel electrophoresis and western blotting. Read More

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Zero echo time pediatric musculoskeletal magnetic resonance imaging: initial experience.

Pediatr Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Radiology, Stanford University School of Medicine, 725 Welch Road, Room 1844, Stanford, CA, 94305, USA.

Background: Projection radiography (XR) is often supplemented by both CT (to evaluate osseous structures with ionizing radiation) and MRI (for marrow and soft-tissue assessment). Zero echo time (ZTE) MR imaging produces a "CT-like" osseous contrast that might obviate CT.

Objective: This study investigated our institution's initial experience in implementing an isotropic ZTE MR imaging sequence for pediatric musculoskeletal examinations. Read More

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Extracranial non-vestibular head and neck schwannomas: a case series with the review of literature.

Braz J Otorhinolaryngol 2021 Jun 9. Epub 2021 Jun 9.

Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Department of Otorhinolaryngology & Head and Neck Surgery, Karnataka, India.

Introduction: Schwannomas are tumous that arise from Schwann cells. Schwannoma is one of the differential diagnosis for lateral neck swelling.

Objective: In this study, we aim to describe the incidence, presenting clinical features and management of extracranial, non-vestibular schwannomas of head and neck region, along with the review of the literature. Read More

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Oral submucous fibrosis presenting with histological lichenoid changes as predominant feature: Report of 5 cases and review of the literature.

J Cutan Pathol 2021 Jun 20. Epub 2021 Jun 20.

Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, Spain.

Oral submucous fibrosis (OSF) is a precancerous condition of the oral cavity associated with habitual chewing of quid, with a high incidence among populations of the Indian subcontinent and Southeast Asia. Clinically, its initial manifestation may mimic oral lichen planus or lichen sclerosus. If the habit is not halted, the mucosa gets leathery and thickened, and fibrous bands form causing significant morbidity. Read More

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Meningitis caused by in a locally advanced cervical cancer patient with pyometra: A case report.

Gynecol Oncol Rep 2021 Aug 29;37:100799. Epub 2021 May 29.

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Locally advanced cervical cancer occasionally induces pyometra, but there have been no reports of meningitis where pyometra is the cause of infection. Here, we report a case of meningitis related to pyometra during concurrent chemoradiotherapy (CCRT) in a cervical cancer patient. The patient, a 77-year-old woman, was diagnosed with Stage IIB (FIGO 2018) cervical adenocarcinoma, and CCRT was initiated. Read More

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Effect of septal deviation on nasomaxillary shape: A geometric morphometric study.

J Anat 2021 Jun 19. Epub 2021 Jun 19.

Department of Orthodontics and Dentofacial Orthopedics, Lebanese University, Beirut, Lebanon.

Nasal cavities in their primitive stage communicate with the oral cavity until the 8th week of intrauterine life where the posterior palate initiates its development. Hence, starting from the initial growth phases, a significant connection lays between the nasal structures and the maxillary bone and witnessing key functional roles, among which the respiration. Proper nasal breathing has been proven to be a crucial factor for the maturity of the craniofacial complex, and obstruction of the respiratory airway due to nasal septum deviation can generate clinically significant reduction of the nasal airflow. Read More

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Role of indocyanine green combined with radiotracer-Technetium 99 m in neck surgery for primary and recurrent head and neck cancer: preliminary results of a tertiary cancer center.

Eur Arch Otorhinolaryngol 2021 Jun 19. Epub 2021 Jun 19.

Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: Neck dissection (ND), whether therapeutic or elective, is an essential component of the treatment of head and neck squamous cell carcinoma (HNSCC). Due to altered anatomy and fibrosis caused by initial treatments, surgeons face challenges during salvage ND. A combination of Technetium-99 m and indocyanine green (ICG) previously used in the sentinel lymph node (SLN) biopsy for oral cavity cancers, may be useful in different types of neck surgeries. Read More

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Delayed pseudoaneurysm formation of the carotid artery following the oral cavity injury in a child: A case report.

World J Clin Cases 2021 Jun;9(16):4104-4109

Department ofSurgery, Jeonbuk National University Hospital, Jeonju 54907, South Korea.

Background: An impalement injury of the oral cavity is a common traumatic injury in children. In most cases, it is not accompanied by sequelae, but if foreign body residues are not found due to a minor injury, they may result in inflammatory responses and delayed vascular injuries in the surrounding tissues. Without early diagnosis and appropriate initial management, residual foreign bodies can cause serious complications and even mortality in some cases. Read More

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Effect of treatment time on performance of nano-encapsulated fluoride dentifrices for remineralization of initial carious lesions: an in vitro study.

Acta Odontol Latinoam 2021 Apr;34(1):56-62

Universidade Federal da Paraíba, Faculdade de Odontologia, Departamento de Clínica e Odontologia Social, Disciplina de Cariologia, João Pessoa, Brasil.

The aim of this in vitro study was to evaluate the influence of treatment time on the remineralization performance of nanoencapsulated fluoride dentifrices on initial carious lesions. Ninety-six human enamel samples were allocated to eight groups (n = 12): 50% NanoF + 50% free NaF, 100% NanoF, 100% NaF (positive control), and placebo (negative control), using two different treatment times (one and five minutes) for each dentifrice tested. After the carious lesion induction, the specimens were submitted to a pH remineralizing cycling model for seven days. Read More

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A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation.

Am J Case Rep 2021 Jun 15;22:e931156. Epub 2021 Jun 15.

Division of Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia.

BACKGROUND Gestational trophoblastic disease (GTD) is a spectrum of disorders consisting of premalignant (ie, complete [CHM] and partial hydatidiform moles [PHM]) and malignant conditions (ie, invasive moles, choriocarcinoma, placental site trophoblastic tumors, and epithelioid trophoblastic tumor). If GTD persists after initial treatment and has persistent elevated beta human chorionic gonadotropin (ß-hCG), it is referred to as post-molar gestational trophoblastic neoplasia (pGTN). To date, there is no detailed information regarding how fast invasive moles can develop from CHM. Read More

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Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries.

Cochrane Database Syst Rev 2021 Jun 14;6:CD014546. Epub 2021 Jun 14.

Dundee Dental School, University of Dundee, Dundee, UK.

Background: The detection and diagnosis of caries at the initial (non-cavitated) and moderate (enamel) levels of severity is fundamental to achieving and maintaining good oral health and prevention of oral diseases. An increasing array of methods of early caries detection have been proposed that could potentially support traditional methods of detection and diagnosis. Earlier identification of disease could afford patients the opportunity of less invasive treatment with less destruction of tooth tissue, reduce the need for treatment with aerosol-generating procedures, and potentially result in a reduced cost of care to the patient and to healthcare services. Read More

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Gastric and Large Colon Impactions Combined With Aggressive Enteral Fluid Therapy May Predispose to Large Colon Volvulus: 4 Cases.

J Equine Vet Sci 2021 Jul 18;102:103617. Epub 2021 Apr 18.

Department of Veterinary Sciences, University of Turin, Italy.

To resolve large colon impactions, frequent enteral administration of large volumes of water (8-10 liters in a 500 kg horse) has been suggested. Furthermore, in large colon volvulus, the simultaneous presence of gastric impaction has been described as a possible predisposing factor. To describe the clinical and surgical features of horses with large colon volvulus associated with aggressive enteral fluid therapy performed to resolve an initial large colon impaction. Read More

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Self-assembling ferritin-dendrimer nanoparticles for targeted delivery of nucleic acids to myeloid leukemia cells.

J Nanobiotechnology 2021 Jun 9;19(1):172. Epub 2021 Jun 9.

Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Background: In recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Archaeoglobus fulgidus ferritin is particularly interesting due to its unique ability to assemble-disassemble under very mild conditions. Recently this ferritin was engineered to get a chimeric protein targeted to human CD71 receptor, typically overexpressed in cancer cells. Read More

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NMR resonance assignments of the PR-10 allergens Act c 8 and Act d 8 from golden and green kiwifruit.

Biomol NMR Assign 2021 Jun 9. Epub 2021 Jun 9.

Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.

Kiwifruits have become one of the most common food sources triggering allergic reactions. In patients suffering from birch pollen related food allergy, reactions result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1, followed by immunological cross-reactivity to structurally homologous proteins in kiwifruit. Clinical symptoms range from scratching and itching of the oral cavity to more severe immunological reactions such as rhino conjunctivitis. Read More

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The effect of Remin Pro on the microhardness of initial enamel lesions in primary teeth: An study.

Dent Res J (Isfahan) 2021 17;18:16. Epub 2021 Mar 17.

Department of Pediatric Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: Remineralization is currently considered a treatment option for many clinicians. The present study was conducted to compare the effect of three remineralizing agents on microhardness of initial caries lesions in primary teeth.

Materials And Methods: In this study, 96 enamel samples were prepared. Read More

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Nonrestorative treatment of initial caries lesion in primary teeth: a systematic review and network meta-analysis.

Acta Odontol Scand 2021 Jun 8:1-8. Epub 2021 Jun 8.

Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Sao Paulo, São Paulo, SP, Brazil.

Objective: To identify the best available approach to avoid initial caries lesions progression in primary teeth.

Materials And Methods: Search was performed in MEDLINE/Pubmed, Web of Science, Embase and CENTRAL databases until March 2021. Studies compared treatment options to avoid the initial caries lesion progression with at least 12 months of follow-up were included. Read More

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EWSR1-WT1 gene fusions in neoplasms other than desmoplastic small round cell tumor: a report of three unusual tumors involving the female genital tract and review of the literature.

Mod Pathol 2021 Jun 7. Epub 2021 Jun 7.

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Desmoplastic small round cell tumor (DSRCT) is a high-grade round cell sarcoma that typically arises in the abdominopelvic cavity of young males, co-expresses keratins and desmin, and carries a pathognomonic EWSR1-WT1 gene fusion. The EWSR1-WT1 gene fusion is generally considered specific for DSRCT, although there are two reports of this fusion in tumors otherwise lacking features of DSRCT. We report three female genital tract tumors with EWSR1-WT1 fusions but showing morphologic and immunohistochemical features incompatible with DSRCT. Read More

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Spontaneous Rupture of Empyema Necessitans in the Emergency Department.

Cureus 2021 May 3;13(5):e14822. Epub 2021 May 3.

Emergency Medicine, California University of Science and Medicine, Colton, USA.

An empyema necessitans is a rare complication of a collection of purulent material in the pleural space that spreads outside of the pleural cavity and involves the soft tissues of the chest wall. Due to compression forces created by the size of the collection of empyema in the chest cavity, patients are usually symptomatic and present with severe dyspnea. Chest X-ray or ultrasound of the chest cavity are the ideal screening tools to visualize the empyema and followed by computerized tomography scan of the chest to confirm the presence and extent of the pathology. Read More

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Skull Base Primary Ewing Sarcoma: A Radiological Experience of a Rare Disease in an Atypical Location.

Am J Case Rep 2021 Jun 5;22:e930384. Epub 2021 Jun 5.

Department of Radiology, School of Medical Sciences, University of Science Malaysia, Kota Bharu, Malaysia.

BACKGROUND Ewing sarcoma and primitive neuroectodermal tumor are rare tumors grouped under the spectrum of the Ewing sarcoma family of tumors. These highly malignant tumors involve the bones and commonly occur in children. Ewing sarcoma of the skull bone accounts for only 1% of all Ewing sarcomas, with primary skull base Ewing sarcoma occurring in less than 1% of cases. Read More

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[Dental management of head and neck irradiated patients].

P Piret P A Coucke

Rev Med Liege 2021 May;76(5-6):554-558

Service de Radiothérapie, CHU Liège, Belgique.

The oncological management of head and neck tumours is well known and standardized. Radiotherapy is one of the effective tools. However, it induces major changes in healthy tissues: teeth, gums, mucous membranes, salivary glands and bones. Read More

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Risk factors for the presence of residual disease in women after partial mastectomy for invasive breast cancer: A single institution experience.

Surg Oncol 2021 Jun 25;37:101608. Epub 2021 May 25.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: We hypothesize that in addition to specimen margin widths other clinical variables may help predict the presence of residual disease in the lumpectomy bed.

Methods: Patients with Stage I-III invasive breast cancer (BC) who underwent partial mastectomy (PM) and re-excision from July 2010-June 2015 were retrospectively reviewed. Bivariate analyses were conducted using two-sample t-tests for continuous variables and Fisher's Exact tests for categorical variables. Read More

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The Effect of Er:YAG Lasers on the Reduction of Aerosol Formation for Dental Workers.

Materials (Basel) 2021 May 26;14(11). Epub 2021 May 26.

Laser Laboratory, Department of Oral Surgery, Wroclaw Medical University, 50-425 Wroclaw, Poland.

Infection prevention in dental practice plays a major role, especially during the COVID-19 pandemic. This study aimed to measure the quantity of aerosol released during various dental procedures (caries and prosthetic treatment, debonding of orthodontic brackets, root canal irrigation) while employing the Er:YAG lasers combined with a high-volume evacuator, HVE or salivary ejector, SE. The mandibular second premolar was extracted due to standard orthodontic therapy and placed in a dental manikin, to simulate typical treatment conditions. Read More

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Translation of c-Met Targeted Image-Guided Surgery Solutions in Oral Cavity Cancer-Initial Proof of Concept Data.

Cancers (Basel) 2021 May 28;13(11). Epub 2021 May 28.

Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.

Intraoperative tumor identification (extension/margins/metastases) via receptor-specific targeting is one of the ultimate promises of fluorescence-guided surgery. The translation of fluorescent tracers that enable tumor visualization forms a critical component in the realization of this approach. Ex vivo assessment of surgical specimens after topical tracer application could help provide an intermediate step between preclinical evaluation and first-in-human trials. Read More

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Asymptotic Entanglement Sudden Death in Two Atoms with Dipole-Dipole and Ising Interactions Coupled to a Radiation Field at Non-Zero Detuning.

Entropy (Basel) 2021 May 18;23(5). Epub 2021 May 18.

Department of Physics, University of Hamburg, 22589 Hamburg, Germany.

We investigate the time evolution and asymptotic behavior of a system of two two-level atoms (qubits) interacting off-resonance with a single mode radiation field. The two atoms are coupled to each other through dipole-dipole as well as Ising interactions. An exact analytic solution for the system dynamics that spans the entire phase space is provided. Read More

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Characterization of a Two-Photon Quantum Battery: Initial Conditions, Stability and Work Extraction.

Entropy (Basel) 2021 May 14;23(5). Epub 2021 May 14.

Dipartimento di Fisica, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.

We consider a quantum battery that is based on a two-level system coupled with a cavity radiation by means of a two-photon interaction. Various figures of merit, such as stored energy, average charging power, energy fluctuations, and extractable work are investigated, considering, as possible initial conditions for the cavity, a Fock state, a coherent state, and a squeezed state. We show that the first state leads to better performances for the battery. Read More

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Salivary Pellicle Modification with Grape-seed Extract: In Vitro Study on the Effect on Bacterial Adhesion and Biofilm Formation.

Oral Health Prev Dent 2021 Jan;19(1):301-309

Purpose: Grape-seed extract (GSE) contains polyphenols that readily adhere to proteins and modify the acquired enamel pellicle (AEP). The first step in biofilm formation is bacterial adhesion to the AEP-covered enamel. The aim of this in vitro study was to test whether AEP modification with GSE, fluoride (F-), or their combination (GSE+F-) modulates bacterial adhesion, biofilm metabolism and composition, or cariogenic demineralisation of the enamel. Read More

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January 2021

Numerical Investigation of Coal and Gas Outbursts under Different In Situ Stresses and Gas Pressures and the Physical Characteristics of Coal.

ACS Omega 2021 May 11;6(20):13260-13274. Epub 2021 May 11.

State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China.

The coal and gas outbursts are recognized as a worldwide difficulty, and there is still ample research space in this field, especially on the mechanical mechanism of outbursts. The main purpose of this paper is to attempt to reveal the outburst mechanism as fully as possible from the point of view of mechanics. In this paper, a mechanical model on coal and gas outbursts including the governing equations of gas desorption-seepage, the stress state in the coal sample, and the criteria of coal sample failure and outburst evolution is put forward according to the porous media seepage theory and elastic theory. Read More

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Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature.

Int J Dent 2021 18;2021:6648082. Epub 2021 May 18.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

The pathogenic mechanism of SARS-CoV-2 infection is unclear, and its symptoms vary in different patients. Initial reports of COVID-19 concentrated on pulmonary issues, but with time, additional features such as hyposmia/anosmia, dysgeusia, and skin lesions were added to the list of COVID-19 symptoms. There have been an increasing number of reports on oral cavity lesions in individuals with COVID-19, which might be relevant considering that this location is one of the first sites coming into contact with the virus and that it contains the SARS-CoV-2 receptor. Read More

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