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Betulinic acid promotes the osteogenic differentiation of human periodontal ligament stem cells by upregulating EGR1.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 13. Epub 2021 Sep 13.

Department of Stomatology, Jing'an District Institute of Dantal Diseases, Shanghai 200040, China.

Periodontitis is one of the most common chronic inflammations of the oral cavity, which eventually leads to tooth loss. Betulinic acid (BetA) is an organic acid that has anti-inflammatory effects and is derived from fruits and plants, but its effect on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) is still unclear. This study aimed to explore the effect of BetA on the osteogenic differentiation of hPDLSCs and its mechanism. Read More

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September 2021

Complex gastroschisis: a new indication for fetal surgery?

Ultrasound Obstet Gynecol 2021 Sep 1. Epub 2021 Sep 1.

Michael E. DeBakey Department of Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Gastroschisis (GS) is a congenital abdominal wall defect in which the bowel eviscerates from the abdominal cavity. It is a non-lethal isolated anomaly and its pathogenesis is hypothesized to occur as a result of two hits, i.e. Read More

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September 2021

Morphological and Functional Changes of Roof Plate Cells in Spinal Cord Development.

J Dev Biol 2021 Jul 30;9(3). Epub 2021 Jul 30.

Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Aichi, Okazaki 444-8787, Japan.

The most dorsal region, or roof plate, is the dorsal organizing center of developing spinal cord. This region is also involved in development of neural crest cells, which are the source of migratory neural crest cells. During early development of the spinal cord, roof plate cells secrete signaling molecules, such as Wnt and BMP family proteins, which regulate development of neural crest cells and dorsal spinal cord. Read More

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Modelling the impact of increase in sugar prices on dental caries in India.

Community Dent Oral Epidemiol 2021 Aug 26. Epub 2021 Aug 26.

Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: This study aims to assess the impact of raising the price of sugar and/or sugar-sweetened beverages (SSBs) on caries incidence in the Indian population.

Methods: A tooth-level decision-analytic model was developed to evaluate a change in caries increment after increasing the price of Sugar and SSBs. The transition of a tooth from a caries-free state to the state of tooth loss in both scenarios was modelled with the help of a Markov model for a time horizon of 63 years, ranging from 2021 to 2083 for the 12-year-old population cohort of India. Read More

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Multidetector Computed Tomography Findings of Acute Abdominal Intussusception Due to Peutz-Jeghers Syndrome.

Cureus 2021 Jul 15;13(7):e16401. Epub 2021 Jul 15.

Radiology, Vietnam National Cancer Hospital, Ha Noi, VNM.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant inheritance characterized by intestinal hamartomatous polyps and hyperpigmented mucocutaneous macules. Bleeding, bowel obstruction, and intussusception are the most common complications in PJS patients. Individuals are infrequently present for the first time with bowel obstruction secondary to intussusception. Read More

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Phosphaturic Mesenchymal Tumors of the Sinonasal Area and Skull Base: Experience at a Single Institution.

Ann Otol Rhinol Laryngol 2021 Aug 8:34894211037416. Epub 2021 Aug 8.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.

Objectives: Phosphaturic mesenchymal tumor (PMT) is a rare, polymorphous neoplasm with a highly variable presentation and natural history and unpredictable clinical course. The primary objective was to describe our clinical experience with and management of 4 markedly different cases of sinonasal and skull base PMT.

Methods: A retrospective case series with chart review, and relevant literature review, was performed at a tertiary academic medical center between 1998 and 2020. Read More

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species isolated from a chronic recurrent corneal ulcer.

Am J Ophthalmol Case Rep 2021 Sep 22;23:101168. Epub 2021 Jul 22.

Department of Ophthalmology, University of Washington. 325 9th Ave Box 359608, Seattle, WA, USA.

Purpose: To report a case of recurrent corneal ulcer caused by an oropharyngeal cavity pathogen.

Observations: A patient presented with recurrent corneal ulcers with hypopyon. species was eventually isolated from the corneal ulcer on bacterial polymerase chain reaction (PCR) after many negative bacterial culture attempts. Read More

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September 2021

A Review of Mechano-Biochemical Models for Testing Composite Restorations.

J Dent Res 2021 Sep 7;100(10):1030-1038. Epub 2021 Aug 7.

Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.

Due to the severe mechano-biochemical conditions in the oral cavity, many dental restorations will degrade and eventually fail. For teeth restored with resin composite, the major modes of failure are secondary caries and fracture of the tooth or restoration. While clinical studies can answer some of the more practical questions, such as the rate of failure, fundamental understanding on the failure mechanism can be obtained from laboratory studies using simplified models more effectively. Read More

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September 2021

Molecular vibrational polariton: Its dynamics and potentials in novel chemistry and quantum technology.

Authors:
Bo Xiang Wei Xiong

J Chem Phys 2021 Aug;155(5):050901

Materials Science and Engineering Program, UC San Diego, San Diego, California 92093, USA.

Molecular vibrational polaritons, a hybridized quasiparticle formed by the strong coupling between molecular vibrational modes and photon cavity modes, have attracted tremendous attention in the chemical physics community due to their peculiar influence on chemical reactions. At the same time, the half-photon half-matter characteristics of polaritons make them suitable to possess properties from both sides and lead to new features that are useful for photonic and quantum technology applications. To eventually use polaritons for chemical and quantum applications, it is critical to understand their dynamics. Read More

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Antibody-functionalized theranostic protein nanoparticles for the synergistic deep red fluorescence imaging and multimodal therapy of ovarian cancer.

Biomater Sci 2021 Sep 14;9(18):6183-6202. Epub 2021 Sep 14.

Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania.

Among women, ovarian cancer is the fifth most frequent type of cancer, and despite benefiting from current standard treatment plans, 90% of patients relapse in the subsequent 18 months and, eventually, perish. As a result, embracing nanotechnological advancements in the field of medical science, researchers working in the areas of cancer therapy and imaging are looking for the next breakthrough treatment strategy to ensure lower cancer recurrence rates and improved outcomes for patients. Herein, we design a novel phototheranostic agent with optical features in the biological window of the electromagnetic spectrum encapsulating a newly synthesized phthalocyanine dye within biocompatible protein nanoparticles, allowing the targeted fluorescence imaging and synergistic dual therapy of ovarian cancer. Read More

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September 2021

A Large Intrathoracic Hiatal Hernia as a Cause of Complete Heart Block.

Case Rep Cardiol 2021 9;2021:6697016. Epub 2021 Jul 9.

Department of Internal Medicine, Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, Florida, USA.

Hiatal hernia is a not uncommon anatomic disorder resulting in portions of the bowel occupying space in the thoracic cavity. There are a number of antecedent risk factors including obesity but not hiatal hernias resulting in symptoms. When symptoms do occur, they can include chest pain, nausea, abdominal pain, and gastroesophageal reflux. Read More

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Resonant Stimulated Photorefractive Scattering.

Phys Rev Lett 2021 Jul;127(3):033902

Institute for Photonics and Advanced Sensing (IPAS) and The School of Physical Sciences, The University of Adelaide, Adelaide 5005, Australia.

We present the first observations, and a complete theoretical explanation, of stimulated photorefractive scattering in a high- Q crystalline cavity. The standing-wave light field in the cavity induces an ultranarrow and long-lived Bragg grating through the photorefractive effect. The spatial phase of the grating is automatically matched to that of the standing wave. Read More

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Medical management of endometriosis.

Minerva Obstet Gynecol 2021 Jul 15. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT, USA.

Introduction: Endometriosis is a benign gynecologic disorder that is defined as functional endometrial tissue outside of the uterine cavity. It is an estrogen-dependent, inflammatory disease that leads to symptoms of pelvic pain, dysmenorrhea, dyspareunia, and infertility, occurring in 6-10% of reproductive aged women. The severity of the disease ranges from asymptomatic to debilitating symptoms that have a major impact on women's lives. Read More

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Spatial distribution of proteins and metabolites in developing wheat grain and their differential regulatory response during the grain filling process.

Plant J 2021 Aug 14;107(3):669-687. Epub 2021 Aug 14.

Department of Functional and Evolutionary Ecology, Molecular Systems Biology Lab (MOSYS), University of Vienna, Althanstrasse 14, Vienna, A-1090, Austria.

Grain filling and grain development are essential biological processes in the plant's life cycle, eventually contributing to the final seed yield and quality in all cereal crops. Studies of how the different wheat (Triticum aestivum L.) grain components contribute to the overall development of the seed are very scarce. Read More

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Mechanisms for the Sour Taste.

Handb Exp Pharmacol 2021 Jun 12. Epub 2021 Jun 12.

Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

Sour, the taste of acids, provides important sensory information to prevent the ingestion of unripe, spoiled, or fermented foods. In mammals, acids elicit disgust and pain by simultaneously activating taste and somatosensory neurons innervating the oral cavity. Early researchers detected electrical activity in taste nerves upon presenting acids to the tongue, establishing this as the bona fide sour taste. Read More

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A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.

Elife 2021 Jun 11;10. Epub 2021 Jun 11.

The School of Medicine, Nankai University, Tianjin, China.

Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Read More

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Introduction of a Handmade Vacuum-Assisted Sponge Drain for the Treatment of Anastomotic Leakage After Low Anterior Rectal Resection.

Ann Coloproctol 2021 Jun 10. Epub 2021 Jun 10.

Disivion of Colorectal Surgery, Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Anastomotic leakage, a known major postoperative complication, potentially leads to readmission, reoperation, and increased mortality rates in patients, such as rectal cancer patients following a low anterior resection (LAR). Currently, vacuum-assisted closure, as featured by B-Braun (B-Braun Medical B.V. Read More

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"Migratory Kerato osteomyelitis" - A refractory lesion of the mandible: A pathologist's and surgeon's dilemma!!

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S61-S67. Epub 2021 Mar 19.

Army Dental Centre (R&R), New Delhi, India.

A 62 year old female patient presented with a chief complaint of non healing extraction socket in the lower left back teeth region. She underwent extraction of 37 at a private clinic following which an ulceroinfiltrative lesion developed at operated side. Multiple biopsies from the lesion were inconclusive. Read More

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Responses and coping methods of different testicular cell types to heat stress: overview and perspectives.

Biosci Rep 2021 Jun;41(6)

College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.

To facilitate temperature adjustments, the testicles are located outside the body cavity. In most mammals, the temperature of the testes is lower than the body temperature to ensure the normal progression of spermatogenesis. Rising temperatures affect spermatogenesis and eventually lead to a decline in male fertility or even infertility. Read More

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Biology of sinus floor augmentation with an autograft versus a bone graft substitute in a preclinical in vivo experimental model.

Clin Oral Implants Res 2021 Aug 14;32(8):916-927. Epub 2021 Jun 14.

Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Palo Alto, CA, USA.

Objectives: Compared to autografts, bone graft substitutes are slower to consolidate. If we understood why, this might open strategies to accelerate new bone formation and thus shorten the time to implant placement. In this study, we aimed at comparing autologous bone graft with a bovine bone graft substitute in a preclinical sinus lift model. Read More

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Optomechanical engineering of quasi-continuous-wave background in mode-locked fiber laser.

Opt Express 2021 May;29(10):14452-14466

Noise-like quasi-continuous-wave background (qCWB) in a mode-locked fiber laser mediates various multi-pulse dynamics via long-range inter-pulse interactions. This raises a possibility to control multi-pulse phenomena through manipulation of the qCWB, while it has been rarely studied yet. Here, we investigate the qCWB engineering by imposing optomechanically induced impulsive intensity modulations on the qCWB. Read More

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A rare case of numerous hydatid cysts in the pleural cavity without extrapleural involvement.

Ann Med Surg (Lond) 2021 May 13;65:102290. Epub 2021 Apr 13.

Department of Thoracic Surgery, Al-moassat Hospital, Damascus, Syrian Arab Republic.

Introduction: and importance: The Echinococcus Granulosus, an endemic parasite in several parts of the world which causes hydatid disease. Human acts as an intermediate host and gets infected by eating parasitic eggs. As it is well known, lungs and liver are the most commonly involved organs in this disease. Read More

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Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Department of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, Korea.

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral-gut barrier. Read More

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Effects of three commercial toothpastes incorporating "chitosan, casein phosphopeptide-amorphous calcium phosphate, sodium monofluorophosphate, and sodium fluoride" on remineralization of incipient enamel caries in the primary dentition: A preliminary study.

Dent Res J (Isfahan) 2020 Nov-Dec;17(6):433-438. Epub 2020 Dec 10.

Private Practice, Tehran, Iran.

Background: Given the importance of primary dental caries, assessment of new preventive/therapeutic materials is necessary. In light of the scarcity of such studies on the role of new agents in primary dentition, this study assessed the efficacy of three commercial toothpastes with different ingredients on remineralization of early caries in the primary dentition.

Materials And Methods: Thirty-nine intact primary canines were used in this experimental study. Read More

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December 2020

Comparison of staining potential of silver diamine fluoride versus silver diamine fluoride and potassium iodide under tooth-colored restorations: An study.

J Indian Soc Pedod Prev Dent 2021 Jan-Mar;39(1):47-52

Department of Pedodontics and Preventive Dentistry, Government Dental College and Hospital, Hyderabad, Telangana, India.

Background: Silver diamine fluoride (SDF) is one of the effectual cariostatic agents widely used in minimal intervention dentistry. However, the major drawback of SDF is dark staining after its application.

Aim: In the present study, the staining of 38% SDF alone and 38% SDF and potassium iodide (KI) was compared after restoration with glass-ionomer cement (GIC) and resin composite using ImageJ software. Read More

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Interstitial Hypertension Suppresses Escape of Human Breast Tumor Cells Convection of Interstitial Fluid.

Cell Mol Bioeng 2021 Apr 9;14(2):147-159. Epub 2020 Nov 9.

Department of Chemical and Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, Princeton, NJ 08544 USA.

Introduction: Interstitial hypertension, a rise in interstitial fluid pressure, is a common feature of many solid tumors as they progress to an invasive state. It is currently unclear whether this elevated pressure alters the probability that tumor cells eventually escape into a neighboring blood or lymphatic vessel.

Methods: In this study, we analyze the escape of MDA-MB-231 human breast tumor cells from a ~3-mm-long preformed aggregate into a 120-m-diameter empty cavity in a micromolded type I collagen gel. Read More

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Ameloblastic fibrosarcoma of the maxilla with EGFR exon 20 insertions: Relevance of whole-exome sequencing in molecular understanding and therapeutic proposals for rare cancers.

Auris Nasus Larynx 2021 Apr 15. Epub 2021 Apr 15.

Department of Diagnostic Pathology, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Kyoto 606-8507, Japan.

Ameloblastic fibrosarcoma (AFS) is the most common odontogenic sarcoma, but the incidence is relatively low, and its molecular biology is poorly understood. We experienced a young female patient with a rapidly growing soft tissue tumor of the left maxilla, which eventually occupied the left side of the oral cavity. Histologically, the tumor mainly consisted of a proliferation of atypical spindle to polygonal cells without any specific differentiation, but a small number of benign odontogenic epithelial foci mainly in the tumor periphery were also noted; thus, a diagnosis of AFS was made. Read More

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[Effects of antimicrobial peptide GH12 on the morphology and composition of cariogenic three-species biofilm].

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Apr;39(2):188-194

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Objectives: To evaluate the effects of antimicrobial peptide GH12 designed on the structure, morphology, and composition of a cariogenic three-species biofilm.

Methods: The cariogenic three-species biofilm consis-ted of the cariogenic () and commensal bacteria () and (). The biofilm was treated using GH12 (2, 4, and 8 mg·L), and untreated biofilm was used as the control. Read More

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The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.

Neurosci Lett 2021 05 1;753:135865. Epub 2021 Apr 1.

Neuropsychopharmacology Division, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India. Electronic address:

Parkinson disease (PD) is a progressive movement functionality disorder resulting in tremor and inability to execute voluntary functions combined with the preponderant non-motor disturbances encompassing constipation and gastrointestinal irritation. Despite continued research, the pathogenesis of PD is not yet clear. The available class of drugs for effective symptomatic management of PD includes a combination of levodopa and carbidopa. Read More

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