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Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery.

ESMO Open 2021 Jun 9;6(4):100178. Epub 2021 Jun 9.

Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France. Electronic address:

Background: Oral cavity is the most prevalent site of head and neck squamous cell carcinomas (HNSCCs). Most often diagnosed at a locally advanced stage, treatment is multimodal with surgery as the cornerstone. The aim of this study was to explore the molecular landscape of a homogenous cohort of oral cavity squamous cell carcinomas (OCSCCs), and to assess the prognostic value of tumor mutational burden (TMB), along with classical molecular and clinical parameters. Read More

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Root cause determination of intraperitoneal catheter obstructions: Insulin amyloid aggregates vs foreign body reaction.

J Control Release 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Road U3092, Storrs, CT 06269, USA. Electronic address:

Continuous intraperitoneal insulin infusion, from an implanted insulin pump connected to a catheter that delivers insulin directly to the peritoneal cavity has many clinical advantages for patients with Type 1 diabetes. However, the ongoing incidence of catheter obstructions remains a barrier to the widespread use of this therapy. To date, the root cause of these obstructions remains unknown. Read More

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In situ evaluation of 200 ppm fluoride toothpaste content trimetaphosphate, xylitol and erythritol on enamel demineralization and dental biofilm.

J Dent 2021 Jun 9:103724. Epub 2021 Jun 9.

São Paulo State University (UNESP), School of Dentistry, Araçatuba, Department of Preventive and Restorative Dentistry Rua José Bonifácio 1193 Araçatuba, SP, Zip code 16015-050, Brazil. Electronic address:

Objective: To evaluate the effect of low-fluoride (F) toothpaste and sodium trimetaphosphate (TMP) associated with xylitol and erythritol (XE) on enamel demineralization and biofilm composition.

Methods: This crossover double-blind in situ study consisted of five phases (seven days each) and 14 volunteers who wore oral appliances containing four enamel bovine blocks. The cariogenic challenge was performed by 30% sucrose solution (6x/day). Read More

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Olfactory epithelium and ontogeny of the nasal chambers in the bowhead whale (Balaena mysticetus).

Anat Rec (Hoboken) 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, USA.

In a species of baleen whale, we identify olfactory epithelium that suggests a functional sense of smell and document the ontogeny of the surrounding olfactory anatomy. Whales must surface to breathe, thereby providing an opportunity to detect airborne odorants. Although many toothed whales (odontocetes) lack olfactory anatomy, baleen whales (mysticetes) have retained theirs. Read More

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MMP-7 affects peritoneal ultrafiltration associated with elevated aquaporin-1 expression via MAPK/ERK pathway in peritoneal mesothelial cells.

J Cell Mol Med 2021 Jun 11. Epub 2021 Jun 11.

Division of Nephrology, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long-term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal membrane. Matrix metalloproteinases (MMPs) function in the extracellular environment of cells and mediate extracellular matrix turnover during peritoneal membrane homeostasis. Read More

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Influence of maternal postpartum depression on children's toothbrushing frequency.

Community Dent Oral Epidemiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthodontics and Speech Therapy for Craniofacial Anomalies, Tohoku University Hospital, Sendai, Japan.

Objectives: Daily toothbrushing behaviour is very effective for the prevention of early childhood dental caries (ECC), but is mostly dependent upon parental management. Intrapersonal association between lower toothbrushing frequency and depression is well known; however, the impact of maternal postpartum depression on child toothbrushing behaviour within the mother-child dyad remains unknown. The aim of this study was to determine the association between the prevalence of maternal postpartum depression and lower toothbrushing frequency in children aged two years. Read More

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Oral health of overweight and obese children and adolescents: a comparative study with a multivariate analysis of risk indicators.

Eur Arch Paediatr Dent 2021 Jun 11. Epub 2021 Jun 11.

First Department of Pediatrics, Medical School, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, 1 Thivon Str, Goudi, 11527, Athens, Greece.

Purpose: The aim of this study was to investigate the oral health status of overweight and obese children compared to normal weight children and to explore the effect of risk indicators, including stress, on the oral health of the children.

Methods: For this cross-sectional study, 7-15-year-old children were enrolled: divided into a group of overweight and obese and a group of normal weight children. Parent-reported questionnaires were used to for data collection demographic data, children's medical and developmental history, brushing frequency and dietary habits. Read More

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Current status of surgical treatment of Boerhaave's syndrome.

Esophagus 2021 Jun 11. Epub 2021 Jun 11.

Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Surgical treatment is usually required for Boerhaave's syndrome (post-emetic esophageal perforation), and the technique should be chosen based on the local infection status and patient's general condition. This study was performed to examine the current status of surgical treatment of Boerhaave's syndrome in Japan.

Methods: Ninety-five patients with Boerhaave's syndrome who underwent surgical treatment from January 2010 to December 2015, obtained from a national survey were retrospectively analyzed. Read More

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Mechanisms for the Sour Taste.

Handb Exp Pharmacol 2021 Jun 12. Epub 2021 Jun 12.

Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

Sour, the taste of acids, provides important sensory information to prevent the ingestion of unripe, spoiled, or fermented foods. In mammals, acids elicit disgust and pain by simultaneously activating taste and somatosensory neurons innervating the oral cavity. Early researchers detected electrical activity in taste nerves upon presenting acids to the tongue, establishing this as the bona fide sour taste. Read More

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Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.

Dysphagia 2021 Jun 11. Epub 2021 Jun 11.

Cancer Late Effects Research Unit (CASTLE), Department of Oncology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

The diagnosis and treatment of head and neck cancer (HNC) can have substantial impact on swallowing function, nutritional balance, physical function and quality of life (QoL). Early initiated swallowing exercises are hypothesized to improve swallowing function in HNC patients. The aim was to investigate the effects of swallowing exercises and progressive resistance training (PRT) during radiotherapy on swallowing function, physical function and QoL in patients with pharynx-, larynx-, oral cavity cancer or unknown primary compared to usual care. Read More

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Oral mucositis in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation in relation to the conditioning used prior to transplantation.

Ann Hematol 2021 Jun 12. Epub 2021 Jun 12.

Department of Gerodontology and Oral Pathology, Poznan University of Medical Sciences, Bukowska 70, 60-812, Poznań, Poland.

This study was designed to investigate the frequency and severity of oral mucositis in patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation, in relation to the type of conditioning used. Eighty patients diagnosed with acute myeloid leukemia were assigned to two groups based on the conditioning regimen used before transplantation. The intensity of oral inflammatory lesions induced by chemotherapy (oral mucositis) was evaluated according to a 5-point scale recommended by World Health Organization. Read More

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Cavity-forming, chamber-like cardioids derived from hPSCs.

Authors:
Andrew Robson

Nat Rev Cardiol 2021 Jun 11. Epub 2021 Jun 11.

Nature Reviews Cardiology, .

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COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells.

Oncogene 2021 Jun 11. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence tumor development and migration into the peritoneal cavity. Collagen type XI alpha 1 (COL11A1) is overexpressed in CAFs; therefore this study examines its role during CAF activation in epithelial ovarian cancer (EOC). Coculturing human ovarian fibroblasts (HOFs) with high COL11A1-expressing EOC cells or exposure to the conditioned medium of these cells prompted the expression of COL11A1 and CAF phenotypes. Read More

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Defect and strain engineering of monolayer WSe enables site-controlled single-photon emission up to 150 K.

Nat Commun 2021 Jun 11;12(1):3585. Epub 2021 Jun 11.

Department of Electrical and Computer Engineering, University of California, Santa Barbara, CA, USA.

In recent years, quantum-dot-like single-photon emitters in atomically thin van der Waals materials have become a promising platform for future on-chip scalable quantum light sources with unique advantages over existing technologies, notably the potential for site-specific engineering. However, the required cryogenic temperatures for the functionality of these sources has been an inhibitor of their full potential. Existing methods to create emitters in 2D materials face fundamental challenges in extending the working temperature while maintaining the emitter's fabrication yield and purity. Read More

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Dynamic control of Purcell enhanced emission of erbium ions in nanoparticles.

Nat Commun 2021 Jun 11;12(1):3570. Epub 2021 Jun 11.

ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.

The interaction of single quantum emitters with an optical cavity enables the realization of efficient spin-photon interfaces, an essential resource for quantum networks. The dynamical control of the spontaneous emission rate of quantum emitters in cavities has important implications in quantum technologies, e.g. Read More

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Superabsorbent polymer balls as foreign bodies in the nasal cavities of children: our clinical experience.

BMC Pediatr 2021 Jun 11;21(1):273. Epub 2021 Jun 11.

Department of Otorhinolaryngology, Shenzhen Children's Hospital, 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.

Objective: To summarize the clinical diagnosis and treatment of superabsorbent polymer balls as nasal foreign bodies in children.

Methods: We retrospectively analysed the clinical data concerning 12 cases of superabsorbent polymer balls as nasal foreign bodies in children and summarized the corresponding clinical features, methods of diagnoses and treatment, and prognoses.

Results: Twelve children with superabsorbent polymer balls as foreign bodies in their nasal cavities presented with relatively severe symptoms, such as congestion, runny nose, and nasal swelling. Read More

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Evaluation of fully automated a priori MCO treatment planning in VMAT for head-and-neck cancer.

Phys Med 2021 Jun 8;87:31-38. Epub 2021 Jun 8.

Centre Léon Bérard, 28 rue Laennec 69373, LYON Cedex 08, France.

Purpose: Automated planning techniques aim to reduce manual planning time and inter-operator variability without compromising the plan quality which is particularly challenging for head-and-neck (HN) cancer radiotherapy. The objective of this study was to evaluate the performance of an a priori-multicriteria plan optimization algorithm on a cohort of HN patients.

Methods: A total of 14 nasopharyngeal carcinoma (upper-HN) and 14 "middle-lower indications" (lower-HN) previously treated in our institution were enrolled in this study. Read More

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3 Tesla MRI in diagnosis and follow up of children with pneumonia.

Clin Imaging 2021 Jun 1;79:213-218. Epub 2021 Jun 1.

Ondokuz Mayis University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Samsun, Turkey.

Purpose: To investigate the utilization of 3-Tesla (3 T) magnetic resonance imaging (MRI) in detection of pulmonary abnormalities in children with pneumonia.

Materials And Methods: Forty-seven children with pneumonia prospectively underwent 3 T thoracic MRI and posteroanterior (PA) chest radiography (CR). Of these, 15 patients also underwent contrast-enhanced thorax computed tomography (CT) or high-resolution CT (HRCT). Read More

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An atomic model for the human septin hexamer by cryo-EM.

J Mol Biol 2021 Jun 8:167096. Epub 2021 Jun 8.

São Carlos Institute of Physics, USP, São Carlos, SP, Brazil.

In order to form functional filaments, human septins must assemble into hetero-oligomeric rod-like particles which polymerize end-to-end. The rules governing the assembly of these particles and the subsequent filaments are incompletely understood. Although crystallographic approaches have been successful in studying the separate components of the system, there has been difficulty in obtaining high resolution structures of the full particle. Read More

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Tim-4 cavity-resident macrophages impair anti-tumor CD8 T cell immunity.

Cancer Cell 2021 May 29. Epub 2021 May 29.

Departments of Surgery and Pathology, Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after ICB therapy. Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced numbers of CD8 T cells with tumor-reactive features in pleural effusions and peritoneal ascites from patients with cancer. Read More

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The effect of the combined use of silver diamine fluoride and potassium iodide in disrupting the plaque biofilm microbiome and alleviating tooth discoloration: A systematic review.

PLoS One 2021 11;16(6):e0252734. Epub 2021 Jun 11.

Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Silver diamine fluoride (SDF) is used in minimally invasive dentistry for arresting dental caries. However, discoloration of teeth is a significant side effect that has limited the use of SDF. Hence, the application of potassium iodide (KI) following SDF has been proposed to ameliorate the staining. Read More

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Development of LaCaMnO materials for Bezaktiv Blue removal in aqueous media.

Water Sci Technol 2021 Jun;83(11):2793-2808

Graduate program in Chemical Engineering, Federal University of Sergipe, Av. Marechal Rondon, Rosa Elze, São Cristóvão, SE 49100-000, Brazil.

In this work, mixed oxides of LaCaMnO perovskite type (x = 0, 0.5 and 1.0) were synthesized through modified proteic method using collagen and calcination process at 700 °C/2 h in order to remove the commercial textile dye Bezaktiv Blue S-MAX from water. Read More

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Rotational Spectrum and Molecular Structures of the Binary Aggregates of 1,1,1,3,3,3-Hexafluoro-2-propanol with Ne and Ar.

J Phys Chem A 2021 Jun 11. Epub 2021 Jun 11.

Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2, Canada.

The structures and binding topologies of two binary van der Waals complexes 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)···Ne and ···Ar were investigated. The rotational spectra of these two complexes including several isotopic species containing Ne, Ne, Ar, C, and hydroxyl D were measured using a chirped pulse Fourier transform microwave spectrometer and a cavity-based Fourier transform microwave spectrometer. While HFIP was shown to exist in both the and configurations based on previous reports, the rare gas atom is predicted to attach to HFIP in several different binding topologies, leading to a total of nine possible structural isomers for each complex. Read More

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CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells.

Clin Exp Metastasis 2021 Jun 11. Epub 2021 Jun 11.

Section of Surgery, Department of Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.

Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antagonist or integrin-αV-antibody. Read More

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[Aluminium release of glitter particles in removable orthodontic appliances].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Jun 11. Epub 2021 Jun 11.

Oralmedizinische Technologie, Zentrum für Zahn‑, Mund- und Kieferheilkunde, Medizinische Fakultät, Universitätsklinikum Bonn (AöR), Universität Bonn, Bonn, Deutschland.

Background And Aim: In order to support children's compliance with orthodontic treatment, glitter particles containing aluminium (Al) are often embedded in the acrylic of removable appliances. When worn for up to 16 h daily for 2-3 years, it can be assumed that Al ions diffuse into saliva over time. The aim of this study was to investigate the release of Al ions from the acrylic using different orthodontic wires. Read More

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[Use of fluorides for caries prevention].

Authors:
Ulrich Schiffner

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Jun 11. Epub 2021 Jun 11.

Zentrum für Zahn‑, Mund- und Kieferheilkunde, Poliklinik für Parodontologie, Präventive Zahnmedizin und Zahnerhaltung, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

For a few decades, a decrease in the caries burden in all age groups has been observed in Germany. The regular use of fluoride preparations is described as the main reason for the caries decline. It is well established that topical fluoride application directly to the tooth surfaces in the oral cavity, in particular fluoride-containing toothpastes and fluoride varnishes, is responsible for the decline. Read More

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Clinical and Radiographic Evaluation of Modified Transalveolar Two-Step Osteotome-Mediated Localized Maxillary Sinus Elevation: A Retrospective Computed Tomography Study with a 3-Year Follow-up.

Int J Oral Maxillofac Implants 2021 May-Jun;36(3):553-560

Purpose: This study aimed to report a practicable and noninvasive two-stage technique for sinus elevation and delayed implant insertion in the augmented site with residual bone height down to 3 mm or even lower.

Materials And Methods: The surgical technique employed a two-stage process for rehabilitation of posterior maxillary single-tooth edentulous areas, involving, in the first step, transcrestal maxillary sinus floor augmentation with a collagen sponge to fill the intrabony cavity resulting from the detachment of the sinus membrane; the second step consisted of another indirect sinus floor elevation using magnetoelectric surgery with immediate implant placement and no grafting material. Changes in bone height were evaluated by a comparison of the computed tomography scans acquired before treatment and after surgery (at 3 months and 5 years of the survey). Read More

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A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.

Elife 2021 Jun 11;10. Epub 2021 Jun 11.

The School of Medicine, Nankai University, Tianjin, China.

Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Read More

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Extremely Broadband Stochastic Resonance of Light and Enhanced Energy Harvesting Enabled by Memory Effects in the Nonlinear Response.

Phys Rev Lett 2021 May;126(21):213901

Center for Nanophotonics, AMOLF, Science Park 104, 1098 XG Amsterdam, Netherlands.

We report the first observation of non-Markovian stochastic resonance (SR), and we discover that memory effects in the nonlinearity extremely enlarge the SR bandwidth. Our experimental system is an oil-filled microcavity which, driven by a continuous wave laser, has memory in its nonlinear optical response. Modulating the cavity length while adding noise to the driving laser, we observe a peak in the transmitted signal-to-noise ratio as a function of the noise variance. Read More

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Synthesis and Characterization of Methacrylate-Functionalized Betulin Derivatives as Antibacterial Comonomer for Dental Restorative Resins.

ACS Biomater Sci Eng 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Secondary caries is the primary cause of composite restoration failures, resulting from marginal leakage and bacterial accumulation in the oral environment. Antibacterial dental composites, especially antibacterial monomers, have emerged as a promising strategy to inhibit secondary caries, which is pivotal to prolonging the lifespan of dental restorations. In this work, monomethacrylate- and dimethacrylate-functionalized betulin derivatives (MBet and MBet) were synthesized via an esterification reaction and served as antibacterial comonomers to develop novel dental resin formulations, in which MBet and MBet were incorporated to partially or completely replace bisphenol A glycerolate dimethacrylate (Bis-GMA). Read More

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