628 results match your criteria caused sex-specific


Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta.

Alcohol Clin Exp Res 2021 Aug 2. Epub 2021 Aug 2.

School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.

Background: Maternal choline supplementation in rats can ameliorate specific neurological and behavioral abnormalities caused by alcohol exposure during pregnancy. We aimed to test whether choline supplementation could ameliorate fetal growth restriction and molecular changes in the placenta associated with periconceptional ethanol exposure in the rat.

Methods: Sprague-Dawley dams were given either 12. Read More

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Caloric restriction alleviates radiation injuries in a sex-dependent fashion.

FASEB J 2021 08;35(8):e21787

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Safe and effective regimens are still needed given the risk of radiation toxicity from iatrogenic irradiation. The gut microbiota plays an important role in radiation damage. Diet has emerged as a key determinant of the intestinal microbiome signature and function. Read More

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Profiling of Sexually Dimorphic Genes in Neural Cells to Identify , Whose Overexpression Causes Autism-Like Behaviors in Male Mice.

Front Cell Dev Biol 2021 6;9:669798. Epub 2021 Jul 6.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute for Neuroscience, School of Medicine, Xiamen University, Xiamen, China.

Many neurological disorders exhibit sex differences and sex-specific therapeutic responses. Unfortunately, significant amounts of studies investigating molecular and cellular mechanisms underlying these neurological disorders use primary cell cultures with undetermined sexes; and this may be a source for contradictory results among different studies and impair the validity of study conclusion. Herein, we comprehensively compared sexual dimorphism of gene expression in primary neurons, astrocytes, and microglia derived from neonatal mouse brains. Read More

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Identification of genetic variants for blood insulin level in sex-stratified Korean population and evaluation of the causal relationship between blood insulin level and polycystic ovary syndrome.

Genes Genomics 2021 Jul 25. Epub 2021 Jul 25.

Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, 24252, Republic of Korea.

Background: Blood insulin level is an important risk factor for numerous disorders. Individual blood insulin level is known to be substantially influenced by genetic factors. Several genetic association studies identified a number of genetic variants for blood insulin level, but none of them was from a sex-stratified population. Read More

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Sex-specific behavioral and structural alterations caused by early-life stress in C57BL/6 and BTBR mice.

Behav Brain Res 2021 Jul 22;414:113489. Epub 2021 Jul 22.

Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.

Lately, the development of various mental illnesses, such as depression, personality disorders, and autism spectrum disorders, is often associated with traumatic events in childhood. Nonetheless, the mechanism giving rise to this predisposition is still unknown. Because the development of a disease often depends on a combination of a genetic background and environment, we decided to evaluate the effect of early-life stress on BTBR mice, which have behavioral, neuroanatomical, and physiological features of autism spectrum disorders. Read More

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Mid-pregnancy PM exposure affects sex-specific growth trajectories via ARRDC3 methylation.

Environ Res 2021 Jul 21;200:111640. Epub 2021 Jul 21.

Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Prenatal particulate matter <2.5 μm (PM) is associated with adverse birth growth. However, the longitudinal growth impacts have been little studied, and no mechanistic relationships have been described. Read More

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Effect of periodic social interaction and odour presentation of same and opposite-sex conspecifics on free-running mice.

Chronobiol Int 2021 Jul 1:1-12. Epub 2021 Jul 1.

Chronobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India.

Social interaction, a non-photic cue, plays a role in the synchronization of circadian rhythm under constant environmental conditions. However, little is known about the effect of sex-specific interaction and sex-specific odor on the free-running circadian clock of mice. Hence, in the present study, we investigated the effect of social interaction and odor presentation of same and opposite-sex conspecifics on the free-running rhythm of mice. Read More

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Identification of the differences in olfactory system between male and female oriental tobacco budworm Helicoverpa assulta.

Arch Insect Biochem Physiol 2021 Aug 30;107(4):e21829. Epub 2021 Jun 30.

College of Plant Protection, Henan Agricultural University, Zhengzhou, China.

The olfactory system of insects facilitates their search for host and mates, hence it plays an essential role for insect survival and reproduction. Insects recognize odor substances through olfactory neurons and olfactory genes. Previous studies showed that there are significant sex-specific differences in how insects identify odorant substances, especially sex pheromones. Read More

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Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats.

Front Endocrinol (Lausanne) 2021 9;12:694336. Epub 2021 Jun 9.

Department of Endocrinology, Diabetes and Metabolism, Nippon Medical School, Tokyo, Japan.

Smoking during pregnancy is one of the causes of low birthweight. Ingestion of nicotine during pregnancy has various metabolic impacts on the fetus and offspring. According to the developmental origins of health and disease theory, low birthweight is a risk factor for developing various non-communicable diseases, including diabetes. Read More

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Diagnostic value of standard deviation score of log-transformed serum dehydroepiandrosterone sulfate in patients with hypothalamic-pituitary-adrenal axis insufficiency.

Endocr J 2021 Jun 23. Epub 2021 Jun 23.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion. However, it is difficult to use serum DHEA-S to diagnose hypothalamic-pituitary-adrenal (HPA) axis insufficiency due to its non-normal and highly skewed distribution. In this study, we focused on HPA insufficiency caused by hypothalamic and/or pituitary dysfunction and evaluated the usefulness of the standard deviation score of log-transformed DHEA-S (ln DHEA-S SD score), which was calculated from the established age- and sex-specific reference values. Read More

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Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus.

J Neuroinflammation 2021 Jun 21;18(1):140. Epub 2021 Jun 21.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.

Background: Obesity is characterized by a systemic inflammation and hypothalamic neuroinflammation. Systemic inflammation is caused by macrophages that infiltrate obese adipose tissues. We previously demonstrated that high-fat diet (HFD)-fed male mice exhibited peripheral macrophage infiltration into the hypothalamus, in addition to activation of resident microglia. Read More

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Isolating the Role of Corticosterone in the Hypothalamic-Pituitary-Gonadal Transcriptomic Stress Response.

Front Endocrinol (Lausanne) 2021 2;12:632060. Epub 2021 Jun 2.

Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, CA, United States.

Investigation of the negative impacts of stress on reproduction has largely centered around the effects of the adrenal steroid hormone, corticosterone (CORT), and its influence on a system of tissues vital for reproduction-the hypothalamus of the brain, the pituitary gland, and the gonads (the HPG axis). Research on the action of CORT on the HPG axis has predominated the stress and reproductive biology literature, potentially overshadowing other influential mediators. To gain a more complete understanding of how elevated CORT affects transcriptomic activity of the HPG axis, we experimentally examined its role in male and female rock doves (). Read More

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Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner.

Sci Total Environ 2021 Sep 21;788:147918. Epub 2021 May 21.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Bisphenol AF (BPAF), a kind of the ideal substitutes of Bisphenol A (BPA), has frequently been detected in environmental media and biological samples. Numerous studies have focused on the reproductive toxicity, cardiotoxicity and endocrine disrupting toxicity of BPAF. However, little evidence is available on neurodevelopmental toxicity of BPAF. Read More

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September 2021

The role of sexual dimorphism in susceptibility to SARS-CoV-2 infection, disease severity, and mortality: facts, controversies and future perspectives.

Microbes Infect 2021 Jun 12:104850. Epub 2021 Jun 12.

Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece. Electronic address:

Former studies have revealed intersex variability in immune response to infectious diseases, including Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological surveillance of the ongoing pandemic has demonstrated a male vulnerability to morbidity and mortality, despite similar infection rates between the two sexes. Divergence in the frequency of comorbidities between males and females, differences in hormonal profile, chromosomal composition and gender behavior have all been proposed as potential causative factors. Read More

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Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications.

Environ Pollut 2021 May 28;285:117471. Epub 2021 May 28.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.

Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), an alternative to brominated flame retardants, might pose an exposure risk to humans and wild animals during fetal development. Our recent study suggested that short-term TDCIPP exposure during early development caused sex-dependent behavioral alteration in adults. In the present study, multigenerational neurodevelopmental toxicity upon early-life exposure of parental zebrafish was evaluated, and the possible underlying mechanisms were further explored. Read More

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The effect of age on blood pressure response by 4-week treatment perindopril: A pooled sex-specific analysis of the EUROPA, PROGRESS, and ADVANCE trials.

Clin Transl Sci 2021 Jun 3. Epub 2021 Jun 3.

Department of Internal Medicine, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Previous studies showed that postmenopausal women are more likely to have poorly controlled hypertension than men of the same age. Whether this is caused by inadequate treatment or poor response to antihypertensive agents remains unknown. The aim of this study is to analyze treatment response to the most potent renin angiotensin aldosterone system (RAAS) inhibitor perindopril in different age categories in women and men. Read More

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Favipiravir (T-705) Protects IFNAR Mice against Lethal Zika Virus Infection in a Sex-Dependent Manner.

Microorganisms 2021 May 29;9(6). Epub 2021 May 29.

Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

Zika virus (ZIKV), a member of the family, is an important human pathogen that has caused epidemics in Africa, Southeast Asia, and the Americas. No licensed treatments for ZIKV disease are currently available. Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) and ribavirin (1-(β-D-Ribofuranosyl)-1-1,2,4-triazole-3-carboxamide) are nucleoside analogs that have exhibited antiviral activity against a broad spectrum of RNA viruses, including some flaviviruses. Read More

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Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice.

Metabolites 2021 May 20;11(5). Epub 2021 May 20.

Tennessee Valley Health System, Veterans Affairs, Nashville, TN 37212, USA.

Mechanisms of sex differences in hypertriglyceridemia remain poorly understood. Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid, glucose, and lipid metabolism. SHP also regulates transcriptional activity of sex hormone receptors and may mediate sex differences in triglyceride (TG) metabolism. Read More

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Effect of sex chromosomes versus hormones in neonatal lung injury.

JCI Insight 2021 Jul 8;6(13). Epub 2021 Jul 8.

Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.

The main mechanisms underlying sexually dimorphic outcomes in neonatal lung injury are unknown. We tested the hypothesis that hormone- or sex chromosome-mediated mechanisms interact with hyperoxia exposure to impact injury and repair in the neonatal lung. To distinguish sex differences caused by gonadal hormones versus sex chromosome complement (XX versus XY), we used the Four Core Genotypes (FCG) mice and exposed them to hyperoxia (95% FiO2, P1-P4: saccular stage) or room air. Read More

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Plastin 3 in health and disease: a matter of balance.

Cell Mol Life Sci 2021 Jul 23;78(13):5275-5301. Epub 2021 May 23.

Institute of Human Genetics, University of Cologne, Kerpener Str. 34, 50931, Cologne, Germany.

For a long time, PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a rather inconspicuous protein, involved in F-actin-binding and -bundling. However, in recent years, a plethora of discoveries have turned PLS3 into a highly interesting protein involved in many cellular processes, signaling pathways, and diseases. PLS3 is localized on the X-chromosome, but shows sex-specific, inter-individual and tissue-specific expression variability pointing towards skewed X-inactivation. Read More

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Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.

Mol Reprod Dev 2021 06 18;88(6):437-458. Epub 2021 May 18.

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Genomic imprinting is important for mammalian development and its dysregulation can cause various developmental defects and diseases. The study evaluated the effects of different dietary combinations of folic acid and B12 on epigenetic regulation of IGF2R and KCNQ1OT1 ncRNA in C57BL/6 mice model. Female mice were fed diets with nine combinations of folic acid and B12 for 4 weeks. Read More

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Anthropogenic underwater vibrations are sensed and stressful for the shore crab Carcinus maenas.

Environ Pollut 2021 Apr 16;285:117148. Epub 2021 Apr 16.

Biosciences, College of Life and Environmental Sciences, Hatherly Laboratories, University of Exeter, Stocker Road, Exeter, EX4 4PS, UK; Departamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Casilla 160-C, Concepción, Chile; Instituto Milenio de Oceanografía (IMO), Universidad de Concepción, Chile. Electronic address:

Acoustic pollution in aquatic environments has increased with adverse effects on many aquatic organisms. However, little work has been done considering the effects of the vibratory component of acoustic stimuli, which can be transmitted in the substrate and propagated into the aquatic medium. Benthic marine organisms, including many invertebrates, are capable of sensing seabed vibration, yet the responses they trigger on organism have received little attention. Read More

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G protein-coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex-specific manner?

Br J Pharmacol 2021 May 4. Epub 2021 May 4.

Department of Physiology, Anatomy and Microbiology and Centre for Cardiovascular Biology and Disease Research, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia.

As an agonist of the classical nuclear receptors, estrogen receptor-α and -β (NR3A1/2), estrogen has been assumed to inhibit the development of cardiovascular disease in premenopausal women. Indeed, reduced levels of estrogen after menopause are believed to contribute to accelerated morbidity and mortality rates in women. However, estrogen replacement therapy has variable effects on cardiovascular risk in postmenopausal women, including increased serious adverse events. Read More

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EDCs Reorganize Brain-Behavior Phenotypic Relationships in Rats.

J Endocr Soc 2021 May 18;5(5):bvab021. Epub 2021 Feb 18.

Institute for Neuroscience, The University of Texas at Austin, Austin, TX, 78712, USA.

All species, including humans, are exposed to endocrine-disrupting chemicals (EDCs). Previous experiments have shown behavioral deficits caused by EDCs that have implications for social competence and sexual selection. The neuromolecular mechanisms for these behavioral changes induced by EDCs have not been thoroughly explored. Read More

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Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan.

Sci Rep 2021 Apr 26;11(1):8899. Epub 2021 Apr 26.

School of Public Health, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.

Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60. Read More

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Harvest is associated with the disruption of social and fine-scale genetic structure among matrilines of a solitary large carnivore.

Evol Appl 2021 Apr 14;14(4):1023-1035. Epub 2020 Dec 14.

Department of Natural Sciences and Environmental Health University of South-Eastern Norway Telemark Norway.

Harvest can disrupt wildlife populations by removing adults with naturally high survival. This can reshape sociospatial structure, genetic composition, fitness, and potentially affect evolution. Genetic tools can detect changes in local, fine-scale genetic structure (FGS) and assess the interplay between harvest-caused social and FGS in populations. Read More

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STAT3 but Not ERK2 Is a Crucial Mediator Against Diet-Induced Obesity via VMH Neurons.

Diabetes 2021 Jul 21;70(7):1498-1507. Epub 2021 Apr 21.

Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions in ventromedial hypothalamic (VMH) neurons. However, little is known about the intracellular mechanisms involved in these effects. To assess the role of the STAT3 and ERK2 signaling in neurons that express the steroidogenic factor 1 (SF1) in the VMH in energy homeostasis, we used cre-lox technology to generate male and female mice with specific disruption of STAT3 or ERK2 in SF1 neurons of the VMH. Read More

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Acute stress reveals different impacts in male and female Zdhhc7-deficient mice.

Brain Struct Funct 2021 Jun 20;226(5):1613-1626. Epub 2021 Apr 20.

Department of Mental Health, University of Münster, Münster, Germany.

Numerous processes of neuronal development and synaptic plasticity in the brain rely on the palmitoyl acyltransferase ZDHHC7, as it palmitoylates various synaptic and extrasynaptic proteins such as neural cell adhesion molecule (NCAM) or gamma-aminobutyric acid (GABA) receptors. In addition, ZDHHC7 palmitoylates sex steroid hormone receptors and is, therefore, indirectly linked to mental disorders that often occur because of or in conjunction with stress. In this work, we investigated how ZDHHC7 affects stress responses in mice. Read More

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Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):22

Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Decatur, Georgia, United States.

Purpose: Light is a salient cue that can influence neurodevelopment and the immune system. Light exposure out of sync with the endogenous clock causes circadian disruption and chronic disease. Environmental light exposure may contribute to developmental programming of metabolic and neurological systems but has been largely overlooked in Developmental Origins of Health and Disease (DOHaD) research. Read More

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SEX DIFFERENCES IN THE PHYSICAL PERFORMANCE, PHYSIOLOGICAL, AND PSYCHO-COGNITIVE RESPONSES TO MILITARY OPERATIONAL STRESS.

Eur J Sport Sci 2021 Apr 10:1-34. Epub 2021 Apr 10.

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory & Warrior Human Performance Research Center, University of Pittsburgh, United States.

Combat roles are physically demanding and expose service personnel to operational stressors such as high levels of physical activity, restricted nutrient intake, sleep loss, psychological stress, and environmental extremes. Women have recently integrated into combat roles, but our knowledge of the physical, physiological, and psycho-cognitive responses to these operational stressors in women is limited. The aim of this narrative review was to evaluate the evidence for sex-specific physical, physiological, and psycho-cognitive responses to real, and simulated, military operational stress. Read More

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