6,059 results match your criteria caused retained


Litchi anthracnose caused by Colletotrichum karstii in Guangxi, China.

Plant Dis 2021 Apr 21. Epub 2021 Apr 21.

University of Guelph, Environmental Sciences, 50 Stone Road East, Guelph, Ontario, Canada, N1G2W1;

Litchi (Litchi chinensis Sonn.), a native fruit tree from southern China, has been planted in many subtropical and tropical countries for its fruit which are considered delicious and of medicinal value (Anderson et al. 2013). Read More

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Seasonal and altitudinal variation in Pteridium aquilinum (L.) Kuhn: frond and stand types.

Authors:
T P Atkinson

New Phytol 1989 Nov;113(3):359-365

Department of Resource and Environmental Management, University of London, Goldsmiths'College, London SEI4 6NW, UK.

The field ecology of Pteridium aquilinum (L.) Kuhn was studied through a growing season in the northern Malvern Hills. At lower altitudes, stands reached a biomass plateau by late July extending through to late September, while at higher altitudes biomass increment was delayed and curtailed by the shorter growing season. Read More

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November 1989

Seasonal uptake and allocation of phosphorus in Eriophorum vaginatum L measured by labelling with P.

New Phytol 1991 Jun;118(2):349-357

Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.

Seasonal measurements of phosphorus (P) pools in the tussock-forming sedge Eriophorum vaginatum L. indicated low annual P uptake, but pronounced fluxes of P to growing biomass from below-ground stores in spring, and a return in autumn. Additions of P to tussocks in early spring and mid summer confirmed this deduction. Read More

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Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.

PLoS Genet 2021 Apr 19;17(4):e1009457. Epub 2021 Apr 19.

Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Spatiotemporal restriction of signaling plays a critical role in animal development and tissue homeostasis. All stem and progenitor cells in newly hatched C. elegans larvae are quiescent and capable of suspending their development until sufficient food is supplied. Read More

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DNA repair in primordial follicle oocytes following cisplatin treatment.

J Assist Reprod Genet 2021 Apr 16. Epub 2021 Apr 16.

Ovarian Biology Laboratory, Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, 3800, Australia.

Purpose: Genotoxic chemotherapy and radiotherapy can cause DNA double stranded breaks (DSBs) in primordial follicle (PMF) oocytes, which then undergo apoptosis. The development of effective new fertility preservation agents has been hampered, in part, by a limited understanding of DNA repair in PMF oocytes. This study investigated the induction of classical DSB repair pathways in the follicles of wild type (WT) and apoptosis-deficient Puma mice in response to DSBs caused by the chemotherapy agent cisplatin. Read More

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SM22 Loss Contributes to Apoptosis of Vascular Smooth Muscle Cells via Macrophage-Derived circRasGEF1B.

Oxid Med Cell Longev 2021 16;2021:5564884. Epub 2021 Mar 16.

Department of Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang, Hebei 050017, China.

Vascular smooth muscle cell (VSMC) apoptosis is a major defining feature of abdominal aortic aneurysm (AAA) and mainly caused by inflammatory cell infiltration. Smooth muscle (SM) 22 prevents AAA formation through suppressing NF-B activation. However, the role of SM22 in VSMC apoptosis is controversial. Read More

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Retained iron intraocular foreign body with late onset siderotic glaucoma: a clinical challenge.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Vitreoretina Services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Siderotic glaucoma is a rare and challenging clinical scenario caused by a retained iron intraocular foreign body (IOFB), which results in irreversible vision loss. Presented here is a case of secondary open-angle glaucoma in a 36-year-old man that was refractory to maximal medical therapy. A meticulous history and careful clinical examination revealed that he had a penetrating trauma 15 years ago, a self-sealed corneal entry wound, open angles, a retained encapsulated metallic IOFB and siderosis bulbi. Read More

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First Report of Anthracnose on Pecan () Caused by in Korea.

Plant Dis 2021 Apr 15. Epub 2021 Apr 15.

National Institute of Forest Science, Division of Forest Diseases & Insect Pests, 57, Hoegi-ro, Dongdaemun-gu, Seoul, Korea (the Republic of), 02455;

In 2020, severely infected fruit of pecan, , showing distinct anthracnose symptoms were observed from pecan orchards in Uiseong (36°21'31.5"N 128°27'15.9"E) and Miryang (35°22'54. Read More

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Tedizolid Activity against a Multi-center Worldwide Collection of Staphylococcus aureus and Streptococcus pneumoniae Recovered from Patients with Pneumonia (2017-2019).

Int J Infect Dis 2021 Apr 12. Epub 2021 Apr 12.

JMI Laboratories, North Liberty, Iowa, USA.

Objectives: The antimicrobial activity of tedizolid and comparators was evaluated against a large worldwide collection of Staphylococcus aureus and Streptococcus pneumoniae isolates recovered from patients with pneumonia.

Methods: Clinical isolates were collected from patients in 96 medical centers in the Asia-Pacific, Europe, Latin America, and United States during 2017-2019 and tested for susceptibility by reference broth microdilution.

Results: The most active agents against S. Read More

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Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.

PLoS Negl Trop Dis 2021 Apr 15;15(4):e0009339. Epub 2021 Apr 15.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.

Background: Scrub typhus is a neglected tropical disease that threatens more than one billion people. If antibiotic therapy is delayed, often due to mis- or late diagnosis, the case fatality rate can increase considerably. Scrub typhus is caused by the obligate intracellular bacterium, Orientia tsutsugamushi, which invades phagocytes and endothelial cells in vivo and diverse tissue culture cell types in vitro. Read More

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Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

Cell Stem Cell 2021 Apr 8. Epub 2021 Apr 8.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Oncode Institute, Jaarbeursplein 6, 3521 AL Utrecht, the Netherlands; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address:

Cervical cancer is a common gynecological malignancy often caused by high-risk human papillomavirus. There is a paucity of human-derived culture systems to study the cervical epithelium and the cancers derived thereof. Here we describe a long-term culturing protocol for ecto- and endocervical epithelia that generates 3D organoids that stably recapitulate the two tissues of origin. Read More

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Silicon induces metallochaperone-driven Cd binding to the cell wall and restores redox status through elevated glutathione in Cd-toxic sugar beet.

Physiol Plant 2021 Apr 13. Epub 2021 Apr 13.

Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Cheonan, Republic of Korea.

Cadmium (Cd) is toxic; however, whether silicon (Si) alleviates Cd toxicity was never studied in sugar beet. The study was conducted on two weeks old sugar beet cultivated in the presence or absence of Cd (10 μM CdSO ) and Si (1 mM Na SiO ) in hydroponic conditions. The morphological impairment and cellular damages observed in sugar beet upon Cd toxicity were entirely reversed due to Si. Read More

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Properties of degradable polyhydroxyalkanoates with different monomer compositions.

Int J Biol Macromol 2021 Apr 6;182:98-114. Epub 2021 Apr 6.

Siberian Federal University, 79 Svobodnyi av., Krasnoyarsk 660041, Russia; Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS", 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.

Purpose: To synthesize and investigate polyhydroxyalkanoates (PHAs) with different monomer composition and percentages and polymer films prepared from them.

Results: Various PHAs: homopolymer poly-3-hydroxybutyrate P(3HB) and 2-, 3-, and 4-component copolymers comprising various combinations of 3-hydroxybutyrate (3HB), 3-hydroxyvalerate (3HV), 4-hydroxybutyrate (4HB), and 3-hydroxyhexanoate (3HHx) monomers were synthesized under specialized conditions. Relationships were found between the monomer composition of PHAs and their molecular-weight and thermal properties and degree of crystallinity. Read More

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Identification of chemical and pharmacological chaperones for correction of trafficking- deficient mutant CNGA3 channels.

Mol Pharmacol 2021 Apr 7. Epub 2021 Apr 7.

Institute for Ophthalmic Research, Molecular Genetics Laboratory, Germany

Trafficking deficiency caused by missense mutations is a well-known phenomenon occurring for mutant, misfolded proteins. Typically, the misfolded protein is retained by the protein quality control system and degraded by the endoplasmic reticulum-associated protein degradation pathway and thus does not reach its destination although residual function of the protein may be preserved. Chemical and pharmacological chaperones can improve the targeting of trafficking-deficient proteins and thus may be promising candidates for therapeutic applications. Read More

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Biochemical and synergistic properties of a novel alpha-amylase from Chinese nong-flavor Daqu.

Microb Cell Fact 2021 Apr 7;20(1):80. Epub 2021 Apr 7.

CAS Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, No. 9 Section 4, Renmin Nan Road, Chengdu, 610041, Sichuan, People's Republic of China.

Background: Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have been analyzed with crude protein for total liquefying power and saccharifying power of Daqu. Therefore, the complex enzymatic system present in Daqu has not been completely characterized. Read More

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Cascading effects of composts and cover crops on soil chemistry, bacterial communities and the survival of foodborne pathogens.

J Appl Microbiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Wildlife, Fish, and Conservation Biology, University of California, Davis, Davis, CA, USA.

Aims: Recent foodborne disease outbreaks have caused farmers to re-evaluate their practices. In particular, concern that soil amendments could introduce foodborne pathogens onto farms and promote their survival in soils has led farmers to reduce or eliminate the application of animal-based composts. However, organic amendments (such as composts and cover crops) could bolster food safety by increasing soil microbial diversity and activity, which can act as competitors or antagonists and reduce pathogen survival. Read More

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Negative effect of ectoparasite burdens on the condition factor from farmed tilapia Oreochromis niloticus in the Yucatan, Mexico.

Vet Parasitol 2021 Apr 24;292:109393. Epub 2021 Feb 24.

Laboratorios de Parasitología y Pesquerías, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad Mérida, Antigua Carretera a Progreso km 6, C.P. 97310, Mérida, Yucatan, Mexico. Electronic address:

Nile tilapia (Oreochromis niloticus Linnaeus, 1758) is one of the most important aquaculture species in the world, and, when introduced, the ectoparasites of Nile tilapia have followed. Currently, farmers worldwide consider these ectoparasites harmless, but intensities can reach up to 1000 individuals per fish in tropical regions. In this cross-sectional study, we used the condition factor to estimate the potential effects of low (45 ± 31 ectoparasites per fish) and high (295 ± 191) ectoparasitic burdens across 28 tilapia farms and included the analysis of the effects of 44 management and environmental variable from the farms. Read More

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Organic Acids as Sanitizers for Natamycin and other Fungicides in Postharvest Recirculating Application Systems for Citrus.

Plant Dis 2021 Apr 6. Epub 2021 Apr 6.

University of California, Plant Pathgology, Riverside, Riverside, California, United States, 92521;

Natamycin is a new postharvest biofungicide for citrus and some other fruit crops in the United States that can be effectively used in recycling drench or flooder treatments. These types of applications necessitate sanitation of the fungicide solution to ensure that it remains free from contamination by bacteria that potentially are human pathogens. In in vitro experiments, heated (48°C) citric acid (1,100 μg/ml or 2,200 μg/ml) amended with sodium dodecylbenzensulfonate (SDBS; 55 μg/ml or 110 μg/ml, respectively) significantly reduced viability of E. Read More

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An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication.

bioRxiv 2021 Mar 31. Epub 2021 Mar 31.

All coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in non-structural protein 3 (nsp3) which binds and hydrolyzes ADP-ribose covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent virulence factor, there is still a limited understanding of its cellular roles during infection. Currently, most of the information regarding the role of CoV Mac1 during infection is based on a single point mutant of a highly conserved asparagine-to-alanine mutation, which is known to largely eliminate Mac1 ADP-ribosylhydrolase activity. Read More

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Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury.

Biomaterials 2021 Mar 22;272:120766. Epub 2021 Mar 22.

Department of Biological Systems Engineering, University of Nebraska - Lincoln, 200LW Chase Hall, Lincoln, NE, 68583, USA. Electronic address:

The secondary phase of traumatic brain injury (TBI) is partly caused by the release of excess reactive oxygen species (ROS) from the primary injury. However, there are currently no therapies that have been shown to reduce the secondary spread of injury beyond the primary insult. Nanoparticles offer the ability to rapidly accumulate and be retained in injured brain for improved target engagement. Read More

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Shorter distal forelimbs benefit bipedal walking and running mechanics: Implications for hominin forelimb evolution.

Am J Phys Anthropol 2021 Apr 5. Epub 2021 Apr 5.

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Objectives: Brachial index is a skeletal ratio that describes the relative length of the distal forelimb. Over the course of hominin evolution, a shift toward smaller brachial indices occurred. First, Pleistocene australopiths yield values between extant chimpanzees and humans, with further evolution in Pliocene Homo to the modern human range. Read More

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Mechanical Pull-Out Test of a New Hybrid Fixture-Abutment Connection: An In Vitro Study.

Materials (Basel) 2021 Mar 22;14(6). Epub 2021 Mar 22.

Department of Innovative Technologies in Medicine and Dentistry, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.

Implant abutment connection was described among the main causes of peri-implant bone resorption. The aim of this in vitro study was to test the coupling capacity, the surface modification of a new hybrid connection and the influence of repeated connection activations caused during the main clinical and laboratory phases. A total of 40 implant-abutment screw retained systems with 10°-conical and internal hexagon connection were tested. Read More

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Highly Efficient Methylene Blue Dye Removal by Nickel Molybdate Nanosorbent.

Molecules 2021 Mar 4;26(5). Epub 2021 Mar 4.

Chemistry Department, College of Science, Taibah University, Al-Madinah Al-Munawwarah 30002, Saudi Arabia.

Removing methylene blue (MB) dye from aqueous solutions was examined by the use of nickel molybdate (α-NiMoO) as an adsorbent produced by an uncomplicated, rapid, and cost-effective method. Different results were produced by varying different parameters such as the pH, the adsorbent dose, the temperature, the contact time, and the initial dye concentration. Adsorbent dose and pH had a major removal effect on MB. Read More

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Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation.

Stem Cell Res 2021 Mar 22;53:102306. Epub 2021 Mar 22.

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Autosomal dominant polycystic kidney disease (ADPKD) is one of the common genetic kidney disorders that are caused by mutations in PKD1 or PKD2 gene. In this report, the MUi026-A human induced pluripotent stem cell (hiPSC) line was established from the skin fibroblasts of a female ADPKD patient who had the PKD1 mutation with c.5878C > T. Read More

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Higher throughput drug screening for rare respiratory diseases: Readthrough therapy in primary ciliary dyskinesia.

Eur Respir J 2021 Apr 1. Epub 2021 Apr 1.

Respiratory, Critical Care & Anesthesia, UCL Great Ormond Street Institute of Child Health, London, UK

Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is a particular problem for primary ciliary dyskinesia (PCD), a rare genetic disease caused by mutations in genes that adversely affect ciliary movement and consequently mucociliary transport. Primary cell culture of basal epithelial cells from nasal brush biopsies, followed by ciliated differentiation at air-liquid interface (ALI) has proven to be a useful tool in PCD diagnostics but the technique's broader utility, including in pre-clinical PCD research, has been restricted by the limited number of basal cells that it is possible to expand from such biopsies. Read More

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Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription.

EMBO J 2021 Apr 1:e105464. Epub 2021 Apr 1.

European Institute of Oncology (IEO) - IRCCS, Milan, Italy.

Eukaryotic transcription factors recognize specific DNA sequence motifs, but are also endowed with generic, non-specific DNA-binding activity. How these binding modes are integrated to determine select transcriptional outputs remains unresolved. We addressed this question by site-directed mutagenesis of the Myc transcription factor. Read More

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Posttraumatic Endophthalmitis: Clinical Characteristics and Antibiotic Susceptibilities.

J Ophthalmol 2021 17;2021:6634179. Epub 2021 Mar 17.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou 510060, China.

Purpose: To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes of patients with posttraumatic endophthalmitis caused by .

Methods: In this retrospective, noncomparative case series, the medical records of eyes with culture-proven endophthalmitis treated from January 2016 to December 2019 at a referral center were reviewed. Clinical features, antibiotic susceptibilities, and visual outcomes were assessed. Read More

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Self-Structural Healing of Encapsulated Perovskite Microcrystals for Improved Optical and Thermal Stability.

Adv Mater 2021 Mar 31:e2100466. Epub 2021 Mar 31.

State Key Laboratory of High Power Semiconductor Lasers, School of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, P. R. China.

Perovskite materials and their optoelectronic devices have attracted intensive attentions in recent years. However, it is difficult to further improve the performance of perovskite devices due to the poor stability and the intrinsic deep level trap states (DLTS), which are caused by surface dangling bonds and grain boundaries. Herein, the CH NH PbBr perovskite microcrystal is encapsulated by a dense Al O layer to form a microenvironment. Read More

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Job loss and mental health during the COVID-19 lockdown: Evidence from South Africa.

PLoS One 2021 30;16(3):e0249352. Epub 2021 Mar 30.

School of Economics and Finance, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: Existing literature on how employment loss affects depression has struggled to address potential endogeneity bias caused by reverse causality. The COVID-19 pandemic offers a unique natural experiment because the source of unemployment is very likely to be exogenous to the individual. This study assessed the effect of job loss and job furlough on the mental health of individuals in South Africa during the COVID-19 pandemic. Read More

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Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions.

Proc Natl Acad Sci U S A 2021 Apr;118(14)

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

Genetic screens can identify synthetic lethal (SL) interactions and uncover potential anticancer therapeutic targets. However, most SL screens have utilized knockout or knockdown approaches that do not accurately mimic chemical inhibition of a target protein. Here, we test whether missense mutations can be utilized as a model for a type of protein inhibition that creates a dominant gain-of-function cytotoxicity. Read More

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