280 results match your criteria caused hpt


Sub-chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin-like growth factor axis.

Environ Toxicol 2021 Jun 15;36(6):1195-1205. Epub 2021 Mar 15.

College of Fisheries, Huazhong Agricultural University, Wuhan, China.

In this study, healthy Wuchang bream (Megalobrama amblycephala) juveniles were exposed to 0, 5, 10, 20 and 30 mg/L total ammonia nitrogen for 30 days to elucidate toxic effects and mechanisms of ammonia on growth performance involved with the regulation of growth hormone/insulin-like growth factor (GH/IGF) and hypothalamic-pituitary-thyroid (HPT) axes. Our results showed that the increasing total ammonia nitrogen concentrations caused dose-depend decreases in the weight gain and specific growth rate but increases in the food conversion ratio and mortality in juvenile bream, indicating growth inhibitory effects induced by ammonia. Concurrently, GH, IGF-1 at protein and mRNA levels were significantly decreased in ammonia exposure groups (p < . Read More

View Article and Full-Text PDF

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence.

Front Immunol 2021 26;12:606860. Epub 2021 Feb 26.

Section of Internal Medicine and Endocrinological and Metabolic Sciences, Department of Medicine, University of Perugia, Perugia, Italy.

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator () gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage to multimolecular complexes involved in the initiation and post-initiation events of tissue-specific antigen-encoding gene transcription. Read More

View Article and Full-Text PDF
February 2021

Familial Hyperparathyroidism.

Front Endocrinol (Lausanne) 2021 25;12:623667. Epub 2021 Feb 25.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.

Regulation of the serum calcium level in humans is achieved by the endocrine action of parathyroid glands working in concert with vitamin D and a set of critical target cells and tissues including osteoblasts, osteoclasts, the renal tubules, and the small intestine. The parathyroid glands, small highly vascularized endocrine organs located behind the thyroid gland, secrete parathyroid hormone (PTH) into the systemic circulation as is needed to keep the serum free calcium concentration within a tight physiologic range. Primary hyperparathyroidism (HPT), a disorder of mineral metabolism usually associated with abnormally elevated serum calcium, results from the uncontrolled release of PTH from one or several abnormal parathyroid glands. Read More

View Article and Full-Text PDF
February 2021

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis.

Mol Med Rep 2021 Apr 2;23(4). Epub 2021 Mar 2.

Department of Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.

Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and causes serious pollution in the ecological environment. As previously reported, exposure to DEHP may cause thyroid dysfunction of the hypothalamic‑pituitary‑thyroid (HPT) axis. However, the underlying role of DEHP remains to be elucidated. Read More

View Article and Full-Text PDF

Lateral Heel Pain Caused by Impingement of Hypertrophic Peroneal Tubercle and Os Peroneum.

Case Rep Orthop 2021 8;2021:6621539. Epub 2021 Jan 8.

Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Hypertrophic peroneal tubercle (HPT) is an overgrowth of the peroneal tubercle located on the lateral aspect of the hindfoot, which could cause tenosynovitis of the peroneus longus tendon. Os peroneum (OP) is an accessory ossicle that exists in the peroneus longus tendon at the lateral aspect of the calcaneocuboid joint. Both HPT and OP can cause lateral foot pain and occasionally require surgical treatment. Read More

View Article and Full-Text PDF
January 2021

Surgical treatment of haemophilic pseudotumor with severe bone destruction: a case report.

Mod Rheumatol Case Rep 2021 Feb 18:1-7. Epub 2021 Feb 18.

Department of Joint Surgery, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Haemophilia is an X-linked congenital bleeding disorder caused by a deficiency of factor VIII/IX. Patients with haemophilia (PWH) experience spontaneous bleeding into joints and muscles. Recurrent joint bleeds result in painful and disabling haemophilic multi-arthropathy characteristic of elbows, knees and ankles. Read More

View Article and Full-Text PDF
February 2021

PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.

Sci Total Environ 2021 Feb 20;757:143727. Epub 2020 Nov 20.

NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, China. Electronic address:

Cypermethrin (CYP), a broad-spectrum pyrethroid insecticide is extensively used. CYP is also considered as a potential endocrine disruptor with the thyroid-disturbing property. Protein kinase C alpha (PKCα) is a pleiotropic signal transduction molecule that functions crucially in thyroid hormone (TH) homeostasis and thyroid functions. Read More

View Article and Full-Text PDF
February 2021

A case of temporary metastatic pulmonary calcification in a patient with hyperparathyroidism on peritoneal dialysis.

Clin Nephrol 2021 Mar;95(3):161-165

Introduction: Ectopic calcification is associated with secondary hyperparathyroidism (HPT) in patients with end-stage renal failure (ESRD). Metastatic pulmonary calcification (MPC) is another rare type of ectopic calcification, and there are a few reports on MPC in dialysis patients.

Case Presentation: We report the case of a 52-year-old woman admitted with general fatigue and appetite loss, who was on peritoneal dialysis (PD) for 7 years. Read More

View Article and Full-Text PDF

Treatment of pathological fractures due to brown tumours in a patient with hyperparathyroidism and lack of parafibromin expression - A case report.

Trauma Case Rep 2020 Dec 14;30:100367. Epub 2020 Oct 14.

Department of Orthopaedics and Traumatology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.

Brown tumours, known also as osteitis fibrosa cystica, are benign osteolytic lesions found in 5-15% of patients with hyperparathyroidism, and commonly located in mandibles, the shafts of long bones, the pelvis or ribs. As they compromise bone strength, pathological fractures can be a typical effect of their presence; but given the complex nature of the disease process in this case, such fractures require an interdisciplinary approach directed at orthopaedic treatment, plus management of the underlying hyperparathyroidism. In this paper, we present the case of a 36-year-old female patient with bilateral anophthalmia, hyperparathyroidism and nephrolithiasis, in whom a fall led to her sustaining a pathological fracture of the proximal third of the femoral shaft in the place of an osteolytic lesion, as well as second pathological fracture of the left patella also changed by multiple examples of such lesions. Read More

View Article and Full-Text PDF
December 2020

Ten-year use of recombinant parathyroid hormone for the treatment of hypoparathyroidism in a boy with partial Jacobsen syndrome.

Pediatr Endocrinol Diabetes Metab 2021 ;27(1):57-61

Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pediatric hypoparathyroidism (HPT) is caused by inherited or acquired defects involving the synthesis or secretion of PTH, resistance to PTH action, or inappropriate regulation of PTH. Several syndromes such as DiGeorge syndrome, HDR (hypoparathyroidism, sensorineural deafness and renal dysplasia) syndrome, HRD (hypoparathyroidism, retardation, and dysmorphism) syndrome, Kenny-Caffey syndrome etc. may have associated HPT. Read More

View Article and Full-Text PDF
January 2021

Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease.

JAMA Netw Open 2020 10 1;3(10):e2019169. Epub 2020 Oct 1.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Importance: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis affecting multiple organs and commonly caused by somatic pathogenic variants in BRAF V600E and mitogen-activated protein kinase genes. Clinical features of ECD result from histiocytic involvement of various tissues; while endocrine involvement in ECD occurs frequently, the prevalence of central or primary hypothyroidism has not been thoroughly investigated.

Objective: To assess hypothalamus-pituitary-thyroid (HPT) dysfunction in patients with ECD. Read More

View Article and Full-Text PDF
October 2020

Brown tumor complicating end-stage kidney disease.

Clin Nephrol Case Stud 2020 12;8:72-79. Epub 2020 Oct 12.

Department of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Baylor University Medical Center, Dallas, TX, USA.

Longstanding, severe hyperparathyroidism (HPT) can lead to the formation of "brown tumors". A brown tumor is a radiolucent bone lesion that is locally destructive; it is not a neoplasm, but rather a stromal mass consisting of fibrous tissue, poorly mineralized woven bone, and supporting vasculature. These tumors are a rare complication of advanced primary or secondary HPT. Read More

View Article and Full-Text PDF
October 2020

Easing of lockdown measures in Nigeria: Implications for the healthcare system.

Health Policy Technol 2020 Dec 15;9(4):399-404. Epub 2020 Sep 15.

Crown-Hill University, P.O Box, 1605 Eiyenkorin, Kwara State, Nigeria.

The year 2020 was ushered in with a historical novel virus (COVID-19) pandemic in a manner that the world has never witnessed before. The human-to-human transmission rates of the virus are not only alarming and worrisome but also, the respiratory dysfunction and unwavering deaths it caused have risen global concerns. We employ the daily situation data on reported cases of COVID-19 to explicate the implications of the lockdown lifting in Nigeria using both qualitative and descriptive statistics. Read More

View Article and Full-Text PDF
December 2020

Fast deployment of COVID-19 disinfectant from common ethanol of gas stations in Brazil.

Health Policy Technol 2020 Sep 24;9(3):384-390. Epub 2020 Jul 24.

Department of Electrical and Computer Engineering, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC28223-0001, United States.

Objectives: Coronavirus COVID-19 is spreading very fast in Brazil, requiring innovative strategies for the fast deployment of disinfectants. Panic in population triggered by COVID-19 has caused a shortage of alcohol-based hand sanitizers and disinfectants in many cities of Brazil. Despite the governmental reaction against the outbreak, a risk of shortage of disinfectants still exists. Read More

View Article and Full-Text PDF
September 2020

[Acquired factor V inhibitor].

Rinsho Ketsueki 2020 ;61(7):791-798

Department of Hematology, Kanazawa University Hospital.

Since acquired factor V inhibitor (FV-INH) has been first reported in Germany in 1955, about 200 cases have been recorded globally. The incidence of FV-INH is extremely low, with a rate of 0.023-0. Read More

View Article and Full-Text PDF
September 2020

Changes in porcine cauda epididymal fluid proteome by disrupting the HPT axis: Unveiling potential mechanisms of male infertility.

Mol Reprod Dev 2020 09 4;87(9):952-965. Epub 2020 Aug 4.

Laboratório de Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Rio Grande do Sul, Brazil.

Male infertility or subfertility is frequently associated with disruption of the hypothalamic-pituitary-testis axis events, like secondary hypogonadism. However, little is known how this condition affects the proteomic composition of the epididymal fluid. In the present study, we evaluated the proteomic changes in the cauda epididymal fluid (CEF) in a swine model of secondary hypogonadism induced by anti-GnRH immunization using multidimensional protein identification technology. Read More

View Article and Full-Text PDF
September 2020

Surgical Treatment of Primary Hyperparathyroidism: Which Therapy to Whom?

Sisli Etfal Hastan Tip Bul 2019 27;53(3):201-214. Epub 2019 Aug 27.

Department of General Surgery, Health Sciences University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Primary hyperparathyroidism (pHPT) is characterized by an increase in the levels of PTH and Ca, or one of these (Ca, PTH) as a result of a dysregulation of calcium (Ca) metabolism due to inappropriate excess parathyroid hormone (PTH) autonomously produced from one or more than one parathyroid glands. Ninety to 95% of pHPT is a sporadic type, which is not associated with the familial history and other endocrine organ tumors, and 5-10% of it is hereditary. While 80-85% of pHPT arises from a single parathyroid adenoma, 4-5% is caused by a double adenoma, 10-15% by multigland hyperplasia and less than 1% by parathyroid cancer. Read More

View Article and Full-Text PDF

Thyroid disruption and developmental toxicity caused by Cd in Schizopygopsis younghusbandi larvae.

Comp Biochem Physiol C Toxicol Pharmacol 2020 Sep 25;235:108783. Epub 2020 Apr 25.

Fishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of the Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

In recent years, the adverse effects of cadmium (Cd) on aquatic systems have attracted much attention because Cd can induce endocrine disorders and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in native fish in Lhasa are still unclear. In the present study, Schizopygopsis younghusbandi larvae were exposed to Cd (0. Read More

View Article and Full-Text PDF
September 2020

Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae.

Toxicol Appl Pharmacol 2020 05 12;394:114957. Epub 2020 Mar 12.

Fishery Resources and Environmental Science Experimental Station of The Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

The adverse effects of triphenyltin (TPT) on aquatic systems have attracted much attention because TPT is widely used and prevalent in aquatic environments. Here, zebrafish embryos/larvae were exposed to TPT (0, 0.039, 0. Read More

View Article and Full-Text PDF

Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1.

Acta Pharm Sin B 2020 Mar 22;10(3):383-398. Epub 2019 Jun 22.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Read More

View Article and Full-Text PDF

The comparison of transcriptomic response of green microalga Chlorella sorokiniana exposure to environmentally relevant concentration of cadmium(II) and 4-n-nonylphenol.

Environ Geochem Health 2020 Sep 5;42(9):2881-2894. Epub 2020 Feb 5.

School of Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.

The transcriptomic response of green microalga Chlorella sorokiniana exposure to environmentally relevant concentration of cadmium(II) (Cd) and 4-n-nonylphenol (4-n-NP) was compared in the present study. Cd and 4-n-NP exposure showed a similar pattern of dys-regulated pathways. The photosystem was affected due to suppression of chlorophyll biosynthesis via down-regulation of Mg-protoporphyrin IX chelatase subunit ChlD (CHLD) and divinyl chlorophyllide a 8-vinyl-reductase (DVR) in Cd group and via down-regulation of DVR in 4-n-NP group. Read More

View Article and Full-Text PDF
September 2020

HIGH RISK OF PARATHYROID CARCINOMA AND GENETIC SCREENING IN THE FIRST DIAGNOSED ROMANIAN FAMILY WITH HYPERPARATHYROIDISM-JAW TUMOR SYNDROME AND A GERMLINE MUTATION OF THE CDC73 GENE.

Acta Endocrinol (Buchar) 2019 Jul-Sep;15(3):398-403

University of Florence - FirmoLab, Department of Surgery and Translational Medicine, Florence, Italy.

Context: Hyperparathyroidism-jaw tumour (HPT-JT) syndrome is a rare autosomal dominant cause of familial hyperparathyroidism associated with ossifying fibromas (OF) of the maxillofacial bones and increased risk of parathyroid carcinoma, caused by inactivating germline mutation of the cell division cycle 73 (CDC73) gene.

Objective: To report the first Romanian family with HPT-JT and genetic screening of CDC73 gene.

Subjects And Methods: Mutational analysis of the CDC73 gene and genetic screening of the family of a proband with HPT-JT. Read More

View Article and Full-Text PDF
February 2020

OVARIAN GRANULOSA CELL TUMOR IN A PATIENT WITH A PATHOGENIC VARIANT IN THE GENE (HYPERPARATHYROIDISM-JAW TUMOR SYNDROME).

AACE Clin Case Rep 2019 May-Jun;5(3):e222-e225. Epub 2019 Apr 25.

Objective: To report a patient with the hyperparathyroidism-jaw tumor syndrome (HPT-JT) who was found to have a rare ovarian tumor (granulosa cell tumor [GCT]). HPT-JT is caused by pathogenic variants in the gene and results in primary hyperparathyroidism (PHPT), benign fibro-osseous jaw tumors, benign or malignant renal tumors and cysts, and benign or malignant uterine tumors. We believe this is the first reported case of HPT-JT and GCT. Read More

View Article and Full-Text PDF

A complex case of brown tumors as initial manifestation of primary hyperparathyroidism in a young female.

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):477

Department of Oral Pathology and Microbiology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.

Brown tumor is one of the lesions that develop in patients with hyperparathyroidism (HPT) and represents the terminal stages of bone remodeling process. Any of the skeletal bones can be affected including the craniomaxillofacial ones. Many a times, brown tumor was detected after a final diagnosis of HPT is made. Read More

View Article and Full-Text PDF
January 2020

Clinical Features, Treatment, and Surveillance of Hyperparathyroidism-Jaw Tumor Syndrome: An Up-to-Date and Review of the Literature.

Int J Endocrinol 2019 18;2019:1761030. Epub 2019 Dec 18.

Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 () gene that encodes the parafibromin, a 531-amino acid protein with antiproliferative activity. Primary hyperparathyroidism is the main finding of HPT-JT syndrome, usually caused by a single-gland parathyroid involvement (80% of cases), at variance with other variants of hereditary hyperparathyroidism, in which a multiglandular involvement is more frequent. Read More

View Article and Full-Text PDF
December 2019

Huge brown tumor of the rib in an unlocatable hyperparathyroidism patient with "self-recovered" serum calcium and parathyroid hormone: A case report.

World J Clin Cases 2019 Dec;7(24):4321-4326

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: The brown tumor is a kind of complication of hyperparathyroidism (HPT). The ultimate therapy usually is the resolution of HPT. We herein report an unlocatable HPT patient who received resection of a huge brown tumor of the rib, and experienced "self-recovery" of serum calcium and parathyroid hormone. Read More

View Article and Full-Text PDF
December 2019

Somatosensory changes in Chinese patients after coronectomy vs. total extraction of mandibular third molar: a prospective study.

Clin Oral Investig 2020 Sep 18;24(9):3017-3028. Epub 2019 Dec 18.

Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.

Objectives: This study aimed to quantitatively compare the somatosensory function changes of inferior alveolar nerve (IAN) after mandibular third molar extraction with a surgery protocol of coronectomy, as opposed to the conventional method.

Materials And Methods: Patients with a lower third molar directly contacting IAN were recruited and assigned either to a test group (coronectomy group) or a control group (conventional extraction). A standardized quantitative sensory testing (QST) battery was performed for four times: one week before surgery and the second, seventh, and 28th days after surgery. Read More

View Article and Full-Text PDF
September 2020

Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex.

Ecotoxicol Environ Saf 2020 Jan 6;188:109912. Epub 2019 Nov 6.

University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic. Electronic address:

Synthetic progestins are emerging contaminants of the aquatic environment with endocrine disrupting potential. The main aim of the present study was to investigate the effects of the synthetic progestins gestodene, and drospirenone on sex differentiation in common carp (Cyprinus carpio) by histological analysis. To gain insights into the mechanisms behind the observations from the in vivo experiment on sex differentiation, we analyzed expression of genes involved in hypothalamus-pituitary-gonad (HPG) and hypothalamus-pituitary-thyroid (HPT) axes, histology of hepatopancreas, and in vitro bioassays. Read More

View Article and Full-Text PDF
January 2020

Does health plan type influence receipt of an annual influenza vaccination?

J Epidemiol Community Health 2020 01 19;74(1):57-63. Epub 2019 Oct 19.

Population Health, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA

Background: The influenza virus caused 48.8 million people to fall ill and 79 400 deaths during the 2017-2018 influenza season, yet less than 50% of US adults receive an annual flu vaccination (AFV). Having health insurance coverage influences whether individuals receive an AFV. Read More

View Article and Full-Text PDF
January 2020