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Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells.

Chemosphere 2021 Jul 13;286(Pt 1):131550. Epub 2021 Jul 13.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Decabromodiphenyl ethane (DBDPE) is one of the most commonly used novel brominated flame retardants (NBFRs), and its mass production and widespread application have caused health threats to the human being. Existing studies have shown that DBDPE has hepatotoxicity. And we have found that DBDPE could change cytochrome P450 3A (CYP3A) expression levels in rat livers, whereas the mechanism is unclear. Read More

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The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis.

Biochem Pharmacol 2021 Jul 19:114691. Epub 2021 Jul 19.

Clinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, Zhejiang, China. Electronic address:

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease caused by an interaction of genetics, immune responses, and environmental factors. However, the precise pathogenesis of UC remains poorly understood. The aim of the present study was to explore the potential target genes implicated in UC and to elucidate its underlying pathogenic mechanism. Read More

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Analysis of HSPA1B (+1267A>G) Genetic Polymorphism in Patients with Vibration Disease in Combination with Metabolic Syndrome.

Bull Exp Biol Med 2021 Jul 22. Epub 2021 Jul 22.

East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia.

In 167 men with vibration syndrome (VS), allele and genotype frequencies of HSPA1B (+1267A>G) genetic polymorphism (rs1061581) were studied depending on the type of vibration exposure and on the presence or absence of metabolic syndrome (MetS). The examined subjects were divided into two groups: VS patients (n=80) and VS+MetS patients (n=87). The differences in the lipid profiles between groups were revealed against the background of the lack of distinctions in the age of patients for A/G and G/G genotypes carriers. Read More

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Land-use changes in Northern Ukraine: patterns and dynamics of illegal amber mining during 1986-2016.

Environ Monit Assess 2021 Jul 22;193(8):502. Epub 2021 Jul 22.

Center for Remote Sensing of Land Surfaces (ZFL), University of Bonn, Genscherallee 3, 53113, Bonn, Germany.

Political instability and economic crises may trigger informal, unsustainable and often illegal land use, leading to land degradation. One of the most recent and striking examples of such a phenomenon within Europe is demonstrated by the Polissia region in Northern Ukraine, famous for its amber deposits. Amid severe political disturbances and subsequent economic recession in Ukraine in 2014 and 2015, amber mining flourished in the region. Read More

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Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.

J Biomed Mater Res A 2021 Jul 22. Epub 2021 Jul 22.

Laboratory of micro- and nanostructured systems, Institute of chemistry of new materials National academy of sciences of Belarus, 36 F. Skaryna str, Minsk, 220141, Belarus.

Implant-related infection is one of the serious problems in regenerative medicine. Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings. A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly. Read More

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Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism.

J Obstet Gynaecol Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Adıyaman University School of Medicine, Adıyaman, Turkey.

Objective: The aim of this study is to investigate the histopathological and biochemical efficacy of vitamin D on oxidative damage and fibrosis in rat ovaries induced by experimental hyperthyroidism.

Methods: This study is a comparative, prospective experimental rat study. Sprague-Dawley female rats were divided into four groups. Read More

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The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial.

Urol J 2021 Jul 22:6505. Epub 2021 Jul 22.

3. Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Purpose: Tranexamic acid is a fibrinolysis suppressor that is used for a variety of bleeding control procedures such as hematuria, surgery bleeding, and trauma caused bleeding. The advantages of using the tranexamic acid are bleeding control and less need for blood transfusion.

Materials And Methods:  This double blind clinical trial was conducted on 108 patients in Imam Khomeni Hospital, Urmia, Iran 2013-14. Read More

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Urate Transporters in the Kidney: What Clinicians Need to Know.

Electrolyte Blood Press 2021 Jun 30;19(1):1-9. Epub 2021 Jun 30.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

Urate is produced in the liver by the degradation of purines from the diet and nucleotide turnover and excreted by the kidney and gut. The kidney is the major route of urate removal and has a pivotal role in the regulation of urate homeostasis. Approximately 10% of the glomerular filtered urate is excreted in the urine, and the remainder is reabsorbed by the proximal tubule. Read More

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Evaluation of Acromegaly patients with sleep disturbance related symptoms.

Pak J Med Sci 2021 Jul-Aug;37(4):1161-1165

Prof. Dr. Bulent Ciftci, Yozgat Bozok University, Medical School, Department of Chest Diseases, Yozgat Turkey.

Background And Objectives: It is known that the prevalence of obstructive sleep apnea (OSA) is increased in acromegaly. Craniofacial anomalies, macroglossia, and thickening of the laryngeal wall caused by the increase in soft tissue in these patients lead to OSA. Also, the increase in growth hormone can trigger central apnea by causing a decrease in respiratory drive. Read More

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January 2021

The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory.

Front Psychol 2021 5;12:617814. Epub 2021 Jul 5.

Department of Animal Environment and Health, Section of Anthrozoology and Applied Ethology, Swedish University of Agricultural Sciences, Skara, Sweden.

Ever more research results demonstrate that human health and wellbeing are positively affected by stays in and/or exposure to natural areas, which leads, among other things, to a reduction in high stress levels. However, according to the studies, these natural areas must meet certain qualities. The qualities that are considered to be most health promoting are those that humans perceive in a positive way. Read More

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Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis.

Sci Rep 2021 Jul 21;11(1):14886. Epub 2021 Jul 21.

Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

In heart failure (HF) caused by hypertension, the myocyte size increases, and the cardiac wall thickens. A low-molecular-weight compound called ICG001 impedes β-catenin-mediated gene transcription, thereby protecting both the heart and kidney. However, the HF-preventive mechanisms of ICG001 remain unclear. Read More

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The pyriproxyfen metabolite, 4'-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection.

Environ Pollut 2021 Jul 13:117654. Epub 2021 Jul 13.

Laboratory Molecular Physiology and Adaptation, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Department Adaptations of Life, F-75005, Paris, France. Electronic address:

North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused by the Zika virus (ZIKV). ZIKV requires the neural RNA-binding protein Musashi-1 to replicate. Thyroid hormone (TH) represses MSI1. Read More

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Effects of nano- or microplastic exposure combined with arsenic on soil bacterial, fungal, and protistan communities.

Chemosphere 2021 Oct 26;281:130998. Epub 2021 May 26.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

The soil protistan community makes important contributions to the ecological functions of soil. However, our knowledge of the effects of pollutants, especially plastic particles, on the soil protistan community is still very limited compared to our knowledge on other soil microbes, such as bacterial and fungi. In this study, we revealed the effects of combined and single pollution caused by arsenic (As) and microplastics/nanoplastics (MPs/NPs) on bacterial, fungal and protistan communities. Read More

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October 2021

Effect of relationships among clinical mastitis incidence, reproductive performance, and culling rate on the lifetime of dairy cows at Hiroshima University Farm.

Anim Sci J 2021 Dec;92(1):e13591

Japan International Research Center for Agricultural Sciences, Tsukuba, Japan.

Farm managers' decision to cull dairy cows is based on the cows' milk production, history of disorder(s), and reproductive performance, each of which affects dairy cows' lifetime (herd life and productive lifespan). We investigated the relationships among the incidence of clinical mastitis (CM), the reproductive performance, and the culling rate. We also assessed the effects of these relationships on the lifetimes of dairy cows, using the records made before and after the introduction of an automatic milking system (AMS) at Hiroshima University Farm. Read More

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December 2021

Lassa fever amidst the COVID-19 Pandemic in Africa: A rising concern, Efforts, Challenges and Future recommendations.

J Med Virol 2021 Jul 21. Epub 2021 Jul 21.

School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B152TT, UK.

Lassa fever, caused by the Lassa virus of the Arenaviruses family, is a re-emerging public health concern that has led to 300,000 infections and 5,000 deaths annually in Africa. Highly prevalent in Sierra Leone, Liberia, Guinea, Nigeria, Côte d'lvoire, Ghana, Togo, and Benin, patients infected with the virus can manifest with cough, sore throat, headache, nausea, and vomiting among other symptoms. Coexisting with the COVID-19 pandemic and its impacts, cases of Lassa fever in the African population have been reported to decrease due to hesitancy in visiting clinics that leads to unreported cases - all contributing to a silent outbreak in West Africa. Read More

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Indoor NH3 variation and its relationship with outdoor NH3 in urban Beijing.

Indoor Air 2021 Jul 21. Epub 2021 Jul 21.

Institute of Atmospheric Composition, Chinese Academy of Meteorological Sciences, Beijing, China.

Online measurements of indoor and outdoor ammonia (NH ) were conducted at a university building in Haidian District, Beijing, to investigate their variation characteristics, indoor-outdoor differences, influencing factors, and possible contribution of indoor NH to atmospheric NH . Indoor NH3 mixing ratios varied greatly among the rooms of the same building. Indoor NH mixing ratio peaked at 1. Read More

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Gallic acid mitigates LPS-induced inflammatory response via suppressing NF-κB signalling pathway in IPEC-J2 cells.

J Anim Physiol Anim Nutr (Berl) 2021 Jul 20. Epub 2021 Jul 20.

Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.

Gallic acid is a phenolic compound that exhibits antibacterial, antioxidative and anti-inflammatory functions. In a previous study, we found that dietary supplementation with gallic acid decreased incidence of diarrhoea and protected intestinal integrity in weaning piglets. However, the underlying mechanism remains unclear. Read More

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Stopping-power ratios for electron beams used in total skin electron therapy.

Authors:
George X Ding

Med Phys 2021 Jul 21. Epub 2021 Jul 21.

Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Purpose: The electron beams for total skin electron therapy (TSET) are often degraded by a scatter plate in addition to extended distances. For electron dosimetry both the AAPM TG-51 and IAEA TRS-398 recommend use of two formulas developed by Burns et al [Med. Phys. Read More

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Optimization of scintillator-reflector optical interfaces for the LUT Davis model.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Department of Biomedical Engineering, University of California Davis, Davis, CA, United States of America.

Purpose: Designing and optimizing scintillator-based gamma detector using Monte Carlo simulation is of great importance in nuclear medicine and high energy physics. In scintillation detectors, understanding the light transport in the scintillator and the light collection by the photodetector plays a crucial role in achieving high performance. Thus, accurately modeling them is critical. Read More

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Pilot Study on Neonatal Screening for Methylmalonic Acidemia Caused by Defects in the Adenosylcobalamin Synthesis Pathway and Homocystinuria Caused by Defects in Homocysteine Remethylation.

Int J Neonatal Screen 2021 Jul 7;7(3). Epub 2021 Jul 7.

Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8551, Japan.

Neonatal screening (NS) for methylmalonic acidemia uses propionylcarnitine (C3) as a primary index, which is insufficiently sensitive at detecting methylmalonic acidemia caused by defects in the adenosylcobalamin synthesis pathway. Moreover, homocystinuria from cystathionine β-synthase deficiency is screened by detecting hypermethioninemia, but methionine levels decrease in homocystinuria caused by defects in homocysteine remethylation. To establish NS detection of methylmalonic acidemia and homocystinuria of these subtypes, we evaluated the utility of indices (1) C3 ≥ 3. Read More

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The Effects of Exergaming on Sensory Reweighting and Mediolateral Stability of Women Aged Over 60: Usability Study.

JMIR Serious Games 2021 Jul 21;9(3):e27884. Epub 2021 Jul 21.

Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.

Background: Older adults tend to experience difficulties in switching quickly between various reliable sensory inputs, which ultimately may contribute to an increased risk of falls and injuries. Sideward falls are the most frequent cause of hip fractures among older adults. Recently, exergame programs have been confirmed as beneficial tools for enhancing postural control, which can reduce the risk of falls. Read More

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Research on the improvement of oxidative stress in rats with high-altitude pulmonary hypertension through the participation of irbesartan in regulating intestinal flora.

Eur Rev Med Pharmacol Sci 2021 Jul;25(13):4540-4553

College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, China.

Objective: High-altitude pulmonary hypertension (HAPH) is one of the diseases with higher occurrence among people living in plateau areas. The possible mechanism of angiotensin II receptor 1 inhibitor irbesartan in improving HAPH was explored from the perspective of intestinal bacterial flora in this study.

Materials And Methods: A HAPH rat model was established under simulated high-altitude hypobaric hypoxia. Read More

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A meta-analysis of the combined effects of elevated carbon dioxide and chronic warming on plant %N, protein content and N-uptake rate.

AoB Plants 2021 Aug 25;13(4):plab031. Epub 2021 May 25.

Agricultural Research Service, United States Department of Agriculture, Toledo, OH 43606, USA.

Elevated CO (eCO) and high temperatures are known to affect plant nitrogen (N) metabolism. Though the combined effects of eCO and chronic warming on plant N relations have been studied in some detail, a comprehensive statistical review on this topic is lacking. This meta-analysis examined the effects of eCO plus warming on shoot and root %N, tissue protein concentration (root, shoot and grain) and N-uptake rate. Read More

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Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans.

Sci Rep 2021 Jul 20;11(1):14796. Epub 2021 Jul 20.

Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope Pb as a tracer. Read More

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Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds.

J Voice 2021 Jul 17. Epub 2021 Jul 17.

Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objectives: Local injection of glucocorticoids (GCs) into the vocal folds has been used for treating the vocal fold lesions. While the positive effects on vocal fold nodules, polyps, or scarring have been clinically reported, some concern remains around the potential adverse effects such as vocal fold atrophy, and the mechanisms remain unclear. The present study examined the histology and gene expression of locally injected GC into the vocal folds in rats. Read More

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Artificial hyperventilation normalizes haemodynamics and arterial oxygen content in hypoxic rats.

Anaesthesiol Intensive Ther 2021 Jul 21. Epub 2021 Jul 21.

Department of Critical Care Medicine, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Introduction: Although humans are capable of enduring critically low levels of oxygen, many hypoxaemic patients die despite aggressive therapies. Mimicking the physiological hyperventilation necessary to survive extreme hypoxic conditions could minimize the derangements caused by acute hypoxic-hypoxia. The objective of this study was to measure the haemodynamic-biochemical response to artificially induced hyperventilation in hypoxic rats. Read More

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Deoxygenation reduces growth rates and increases assimilation of essential trace metals in gilthead seabream (Sparus aurata).

Environ Pollut 2021 Jul 13;288:117786. Epub 2021 Jul 13.

International Atomic Energy Agency, 4a Quai Antoine 1er, 98000, Monaco.

The widespread decline in oceanic dissolved oxygen (DO), known as deoxygenation, is a threat to many marine ecosystems, and fish are considered one of the more vulnerable marine organisms. While food intake and growth rates in some fish can be reduced under hypoxic conditions (DO ~ 60 μmol kg), the dietary transfer of essential metals remains unclear. In this context, we investigated the influence of DO on the dietary acquisition of two essential metals (Zn and Mn) in the commercially important gilthead seabream (Sparus aurata) using radiotracer techniques. Read More

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Angiogenesis effects of 4-methoxy benzyl alcohol on cerebral ischemia-reperfusion injury via regulation of VEGF-Ang/Tie2 balance.

Can J Physiol Pharmacol 2021 Jul 20. Epub 2021 Jul 20.

Yunnan University of Traditional Chinese Medicine, 177554, Department of Pharmacology, Kunming, China, 650500;

Introduction: Angiogenesis facilitates the formation of microvascular networks and promotes neurological deficit recovery after cerebral ischemia-reperfusion injury (CIRI). This study investigated the angiogenesis effects of 4-methoxy benzyl alcohol (4-MA) on CIRI.

Methods: The angiogenesis effects of 4-MA and the potential underlying mechanisms were assessed based on a middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and a hind limb ischemic (HLI) mouse model. Read More

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Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma.

Clin Transl Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Rd, Shanghai, 201203, China.

Purpose: Elongation factor Tu GTP-binding domain containing 2 (EFTUD2) is an essential constituent of U5 small nuclear ribonucleoproteins (snRNPs) and plays a crucial role in spliceosome activation and cancer. The mechanism of EFTUD2 on carcinogenesis and development of liver cancer still need further study.

Methods: Bioinformatic analysis was performed to find differential expressed genes and related pathways. Read More

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Long-term decrease in Asian monsoon rainfall and abrupt climate change events over the past 6,700 years.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, N-0316 Oslo, Norway

Asian summer monsoon (ASM) variability and its long-term ecological and societal impacts extending back to Neolithic times are poorly understood due to a lack of high-resolution climate proxy data. Here, we present a precisely dated and well-calibrated tree-ring stable isotope chronology from the Tibetan Plateau with 1- to 5-y resolution that reflects high- to low-frequency ASM variability from 4680 BCE to 2011 CE. Superimposed on a persistent drying trend since the mid-Holocene, a rapid decrease in moisture availability between ∼2000 and ∼1500 BCE caused a dry hydroclimatic regime from ∼1675 to ∼1185 BCE, with mean precipitation estimated at 42 ± 4% and 5 ± 2% lower than during the mid-Holocene and the instrumental period, respectively. Read More

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