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Monitoring New Symptoms After COVID-19 Infection Among Primary Care Patients in New York City.

J Am Board Fam Med 2021 Sep-Oct;34(5):1014-1016

From the Department of Population Health, NYU Grossman School of Medicine, New York, NY (KT); Internal Medicine, NYU Langone Health, New York, NY (EK); Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY (YY).

Introduction: COVID-19 affects multiple organ systems causing substantial long-term morbidity. The implications of the Post-Acute Sequelae of SARS-CoV-2 infection, particularly for primary care, remain unknown. This cross-sectional study examines new symptoms reported at primary care encounters during three post-acute follow-up intervals after initial SARS-CoV-2 infection. Read More

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Patient, Provider, and Clinic Characteristics Associated with Opioid and Non-Opioid Pain Prescriptions for Patients Receiving Low Back Imaging in Primary Care.

J Am Board Fam Med 2021 Sep-Oct;34(5):950-963

From the Department of Radiology, School of Medicine, University of Washington, Seattle, WA (LSG, KTJ, SKJ, JGJ); Clinical Learning, Evidence, and Research Center, University of Washington, Seattle, WA (LSG, ENM, JAT, KTJ, JLF, PS, SKJ, PJH, JGJ); Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA (ZAM); Department of Biostatistics, University of Washington, Seattle, WA (ENM, PJH); Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA (JAT); Department of Rehabilitation Medicine, University of Washington, Seattle, WA (JAT, JLF); Department of Radiology Mayo Clinic, Rochester, MN (DFK, PHL); Department of Radiology, Henry Ford Hospital, Detroit, MI, (BG); Kaiser Permanente Washington, Seattle, WA (KJS); Rehabilitation Care Services, VA Puget Sound Health Care System, Seattle, WA (PS); Departments of Family Medicine and Internal Medicine, Oregon Health & Science University, Portland, OR (RAD); Division of Research, Kaiser Permanente Northern California, Oakland, CA (ALA).

Background: To describe characteristics of patients, providers, and clinics associated with opioid or non-opioid pain medication prescribing patterns for patients who received lower spine imaging in primary care clinics.

Methods: In these secondary analyses of the Lumbar Imaging with Reporting of Epidemiology (LIRE) study, a randomized controlled trial conducted in 4 health systems in the United States, we evaluated characteristics associated with receipt of pain medication prescriptions. The outcomes were receipt of prescriptions for opioid or, separately, non-opioid pain medications within 90 days after imaging. Read More

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January 2021

Clinical and laboratory findings and PCR results in severe and non-severe COVID19 patients based on CURB-65 and WHO severity indices.

Virol J 2021 Sep 17;18(1):189. Epub 2021 Sep 17.

Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: The importance of clinicolaboratory characteristics of COVID-19 made us report our findings in the Alborz province according to the latest National Guideline for the diagnosis and treatment of COVID-19 in outpatients and inpatients (trial five versions, 25 March 2020) of Iran by emphasizing rRT-PCR results, clinical features, comorbidities, and other laboratory findings in patients according to the severity of the disease.

Methods: In this study, 202 patients were included, primarily of whom 164 had fulfilled the inclusion criteria. This cross-sectional, two-center study that involved 164 symptomatic adults hospitalized with the diagnosis of COVID-19 between March 5 and April 5, 2020, was performed to analyze the frequency of rRT-PCR results, distribution of comorbidities, and initial clinicolaboratory data in severe and non-severe cases, comparing the compatibility of two methods for categorizing the severity of the disease. Read More

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September 2021

Validation of the Rage Attack Questionnaire-Revised (RAQ-R) in a Mixed Psychiatric Population.

Front Psychiatry 2021 18;12:724802. Epub 2021 Aug 18.

Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.

Rage Attacks (RA) represent a clinically relevant symptom in patients with different psychiatric disorders. However, only recently the Rage Attack Questionnaire Revised (RAQ-R, 22 items, range, 0-66) has been developed as a new instrument for the assessment of RA. This study aimed to validate the RAQ-R in a large mixed psychiatric and psychosomatic sample. Read More

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Key Performance Indicators in Claims Management: Definition of a set of indicators for the evaluation of the Medico-Legal Activity.

Curr Pharm Biotechnol 2021 Sep 16. Epub 2021 Sep 16.

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, Rome, 00185. Italy.

Background: In recent decades, in the field of healthcare, awareness of the problems inherent to the quality has steadily increased. Currently, the evaluation of healthcare activities is one of the ways in which health systems regulate internal relationships and define strategic decisions.

Objective: The study aims to describe in detail the entire process of developing a group of Key Performance Indicators for monitoring and implementing the management of litigation due to medical liability. Read More

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September 2021

Prediction models with multiple machine learning algorithms for POPs: The calculation of PDMS-air partition coefficient from molecular descriptor.

J Hazard Mater 2021 Aug 26;423(Pt B):127037. Epub 2021 Aug 26.

School of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, Jiangsu, China.

Polydimethylsiloxane-air partition coefficient (K) is a key parameter for passive sampling to measure POPs concentrations. In this study, 13 QSPR models were developed to predict K, with two descriptor selection methods (MLR and RF) and seven algorithms (MLR, LASSO, ANN, SVM, kNN, RF and GBDT). All models were based on a data set of 244 POPs from 13 different categories. Read More

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SARS-CoV-2 infection: Initial viral load (iVL) predicts severity of illness/outcome, and declining trend of iVL in hospitalized patients corresponds with slowing of the pandemic.

PLoS One 2021 16;16(9):e0255981. Epub 2021 Sep 16.

Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, United States of America.

Background: Hospitalization of patients infected with the severe acute respiratory syndrome virus 2 (SARS-CoV-2) have remained considerable worldwide. Patients often develop severe complications and have high mortality rates. The cycle threshold (Ct) value derived from nasopharyngeal swab samples using real time polymerase chain reaction (RT-PCR) may be a useful prognostic marker in hospitalized patients with SARS-CoV-2 infection, however, its role in predicting the course of the pandemic has not been evaluated thus far. Read More

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September 2021

Systemic lupus erythematosus children in Egypt: Homeland spectrum amid the global situation.

Lupus 2021 Sep 16:9612033211043010. Epub 2021 Sep 16.

Pediatrics Department, Rheumatology and Nephrology Unit, 68789Alexandria University, Alexandria, Egypt.

Objectives: This study aims to present the manifestations of juvenile systemic lupus erythematosus (JSLE) across Egypt, to focus on age at onset and gender-driven influence on disease characteristics, and to compare findings to other countries.

Methods: The study included 404 Egyptian children with systemic lupus erythematosus (SLE) presenting to one of the specialized rheumatology centers corresponding to 13 major governorates. Juvenile cases age was ≤ 16°years at the time of recruitment. Read More

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September 2021

Reliability and Validity of the Spanish Version of the Medical Outcomes Study Pain Severity Scale in Mexican Patients With Rheumatic Diseases.

J Clin Rheumatol 2021 Sep;27(6S):S308-S315

From the Servicio de Reumatología, Hospital General Regional número 1, Delegación Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán; and Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Doctorado en Ciencias Médicas, Universidad Nacional Autónoma de Mexico, Ciudad de México, México.

Objective: To evaluate the reliability and validity of the Spanish version of the Medical Outcomes Study Pain Severity Scale (MOS-PSS) in patients with rheumatic diseases.

Methods: A cross-sectional study was carried out from January 2019 to March 2020 using a nonprobabilistic sampling of consecutive cases. The internal consistency of the scale was evaluated through the Cronbach α coefficient and by the item response theory reliability coefficient. Read More

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September 2021

Urticarial Vasculitis: A Potential Signpost for Multisystem Inflammatory Syndrome in Children.

J Cutan Pathol 2021 Sep 15. Epub 2021 Sep 15.

Section of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University, Roanoke, Virginia.

Multisystem inflammatory syndrome in children (MIS-C) is a rare and serious complication of Sars-Cov-2 infection. Dermatologic manifestations are present in the majority of patients. Skin lesions found in children with MIS-C are classified into four categories: morbilliform, reticulated, scarlatiniform, and urticarial lesions. Read More

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September 2021

Non-pharmacological measures implemented in the setting of long-term care facilities to prevent SARS-CoV-2 infections and their consequences: a rapid review.

Cochrane Database Syst Rev 2021 09 15;9:CD015085. Epub 2021 Sep 15.

Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Chair of Public Health and Health Services Research, LMU Munich, Munich, Germany.

Background: Starting in late 2019, COVID-19, caused by the novel coronavirus SARS-CoV-2, spread around the world. Long-term care facilities are at particularly high risk of outbreaks, and the burden of morbidity and mortality is very high among residents living in these facilities.

Objectives: To assess the effects of non-pharmacological measures implemented in long-term care facilities to prevent or reduce the transmission of SARS-CoV-2 infection among residents, staff, and visitors. Read More

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September 2021

Hakuna mycotic aneurysm, does not always mean "no worries".

Ann Med Surg (Lond) 2021 Sep 4;69:102798. Epub 2021 Sep 4.

Department of Nephrology, Icahn School of Medicine at Mount Sinai Hospital (Elmhurst Hospital Center) NY, USA.

, an easily missed and commonly disregarded Viridians strep species, is usually written off as a culture contaminant, but has been implicated as a rare cause of bacterial endocarditis with serious complications. It is a normal commensal microorganism of the mouth and gut, is usually harmless and even demonstrates anti-inflammatory properties. However, the literature about the complications of a bacteremia remains unclear. Read More

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September 2021

Menopause Is Associated with Coronary Artery Calcium Score: Results from the ELSA-Brasil.

J Womens Health (Larchmt) 2021 Sep 14. Epub 2021 Sep 14.

Department of Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.

Menopause and aging deteriorate the metabolic profile, but little is known about how they independently contribute to structural changes in coronary arteries. We compared a broad cardiometabolic risk profile of women according to their menopausal status and investigated if menopause is associated with presence of coronary artery calcium (CAC) in the ELSA-Brasil. All participants, except perimenopausal women, who had menopause <40 years or from non-natural causes or reported use of hormone therapy were included. Read More

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September 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.

Nat Commun 2021 Sep 13;12(1):5395. Epub 2021 Sep 13.

Department I for Internal Medicine and Centre for Integrated Oncology, University of Cologne, Cologne, Germany.

Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform a multi-platform molecular characterization. We identify major subgroups characterized by genomic instability (GI) or activation of epithelial-mesenchymal-transition (EMT)-like programs, which subdivide into non-inflammatory and inflammatory subtypes. Read More

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September 2021

Influence of Ethnicities and Skin Color Variations in Different Populations: A Review.

Skin Pharmacol Physiol 2021 Aug 5. Epub 2021 Aug 5.

Department of Internal Medicine, Adam-Vital Hospital, Dubai, United Arab Emirates.

Background: In the world scientific tradition, skin color is the primary physical characteristic used to divide humans into groups. Human skin has a wide range of tones and colors, which can be seen in a wide range of demographic populations. Many factors influence the color of people's skin, but the pigment melanin is by far the most important. Read More

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Nurses' experiences of using restraint in neurosurgical care - A qualitative interview study.

J Clin Nurs 2021 Sep 12. Epub 2021 Sep 12.

Department of Neurosurgery, Heart, Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden.

Aim And Objectives: To describe nurses' experiences of using restraint in neurosurgical care.

Background: Despite reports of negative consequences, and conflicts with key values in healthcare, restraint measures are still practised in somatic healthcare worldwide. When using restraint, basic principles of nursing collide, creating dilemmas known to be perceived as difficult for many nurses. Read More

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September 2021

Effectiveness of TI-RADS and ATA classifications for predicting malignancy of thyroid nodules.

Adv Clin Exp Med 2021 Sep 9. Epub 2021 Sep 9.

Department of Endocrinology and Metabolism, Gaziantep Liv Hospital, Turkey.

Background: Thyroid cancer is one of the most common cancers and is especially common in young patients. Therefore, effective recognition and treatment of thyroid cancer are essential for patient survival.

Objectives: To compare the effectiveness of standard guidelines for predicting thyroid malignancy. Read More

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September 2021

Validity and Reliability of The Student Refractive Error and Eyeglasses Questionnaire-Revised Version in Myopic Children.

Optom Vis Sci 2021 Sep 9. Epub 2021 Sep 9.

University of Arizona College of Pharmacy, Tucson, Arizona (SM), National Institute for Health Research Moorfields Biomedical Research Centre, London, United Kingdom (AD-N), Public Health Community, Environment & Policy Department, University of Arizona, Tucson, Arizona (MC), Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, Arizona (MS), Department of Optometry & Visual Science, School of Health Sciences, Hadassah Academic College, Jerusalem, Israel (SB), Private Practice, London, United Kingdom (IA), Private Practice, Biggleswade, Bedfordshire, United Kingdom (AL), Private Practice, Luton, Bedfordshire, United Kingdom (DC), Private Practice, Stotfold, Hitchin, United Kingdom (PA), City University, London, United Kingdom (RW), University of Arizona College of Pharmacy, Tucson, Arizona (TW).

Significance: Multiple vision-related quality of life (VRQoL) instruments exist, but questionnaires designed specifically for myopic children that are appropriate for assessing the impact of refractive error are rare.

Purpose: To assess the validity and reliability of the Student Refractive Error and Eyeglasses Questionnaire - Revised (SREEQ-R) in school-aged children with myopia in United Kingdom, UK.

Methods: Community optometrists in UK invited children up to the age of 18 years presenting for an eye examination with current or previous reported use of eyeglasses for myopia to complete the SREEQ-R, which consists of 20 specific items divided into two sections each with 3 response categories. Read More

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September 2021

Measurement properties of grimace scales for pain assessment in non-human mammals: a systematic review.

Pain 2021 Sep 9. Epub 2021 Sep 9.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC - Canada.

Abstract: Facial expressions of pain have been identified in several animal species. The aim of this systematic review was to provide evidence on the measurement properties of grimace scales for pain assessment. The protocol was registered (SyRF#21-Nov-2019) and the study is reported according to the PRISMA guidelines. Read More

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September 2021

Phenotypic traits of individuals in a long-term colony of Anopheles (Nyssorhynchus) aquasalis (Diptera: Culicidae) show variable susceptibility to Plasmodium and suggest cryptic speciation.

Acta Trop 2021 Sep 9:106129. Epub 2021 Sep 9.

Laboratory of Medical Entomology, Institute René Rachou, Oswaldo Cruz Foundation, Minas Gerais, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil; Institute of Clinical Research Borborema, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil; Graduation Program in Tropical Medicine, Amazonas State University, Manaus, AM, Brazil; Foundation of Tropical Medicine Dr. Heitor Vieira Dourado, Manaus, AM, Brazil; Institute Leônidas and Maria Deane, Oswaldo Cruz Foundation, FIOCRUZ, Manaus, AM, Brazil. Electronic address:

Anopheles aquasalis is an important malaria vector in coastal regions of South America and islands of the Caribbean. In its original description, the species was divided into two varieties, based on the scaling patterns of their hind-tarsomere 2. Specimens from our 25-year established colony, used for Plasmodium experimental infections, still exhibit both scaling tarsomere patterns. Read More

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September 2021

Prognostic value of NT-proBNP and CA125 across glomerular filtration rate categories in acute heart failure.

Eur J Intern Med 2021 Sep 7. Epub 2021 Sep 7.

Cardiology Department, Hospital Clínico Universitario de Valencia, Universitat de Valencia, INCLIVA, Valencia, Spain; CIBER Cardiovascular, Madrid, Spain. Electronic address:

Background: This study aimed to evaluate whether glomerular filtration rate (eGFR) during admission modifies the predictive value of plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP) and carbohydrate antigen 125 (CA125) in patients hospitalized for acute heart failure (AHF).

Methods: We retrospectively evaluated 4595 patients consecutively discharged after admission for AHF at three tertiary-care hospitals from January 2008 through October 2019. To investigate the effect of kidney function on the association of NT-proBNP and CA125 with 1-year mortality (all-cause and cardiovascular mortality), we stratified patients according to four eGFR categories: <30 mL•min•1. Read More

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September 2021

Relation classification via BERT with piecewise convolution and focal loss.

PLoS One 2021 10;16(9):e0257092. Epub 2021 Sep 10.

State Grid Information and Telecommunication Branch, Beijing, China.

Recent relation extraction models' architecture are evolved from the shallow neural networks to natural language model, such as convolutional neural networks or recurrent neural networks to Bert. However, these methods did not consider the semantic information in the sequence or the distance dependence problem, the internal semantic information may contain the useful knowledge which can help relation classification. Focus on these problems, this paper proposed a BERT-based relation classification method. Read More

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September 2021

Characterizing phenotypic abnormalities associated with high-risk individuals developing lung cancer using electronic health records from the All of Us researcher workbench.

J Am Med Inform Assoc 2021 Sep 10. Epub 2021 Sep 10.

Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, Minnesota, USA.

Objective: The study sought to test the feasibility of conducting a phenome-wide association study to characterize phenotypic abnormalities associated with individuals at high risk for lung cancer using electronic health records.

Materials And Methods: We used the beta release of the All of Us Researcher Workbench with clinical and survey data from a population of 225 000 subjects. We identified 3 cohorts of individuals at high risk to develop lung cancer based on (1) the 2013 U. Read More

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September 2021

Testing the febrile response of snakes inoculated with Ophidiomyces ophidiicola, the causative agent of snake fungal disease.

J Therm Biol 2021 Aug 3;100:103065. Epub 2021 Aug 3.

Tennessee Technological University, Department of Biology, 1 William L Jones Dr, Cookeville, TN, 38505, USA; Southeastern Louisiana University, Department of Biological Sciences, Hammond, LA, 70402, USA.

Snake Fungal Disease (SFD) negatively impacts wild snake populations in the eastern United States and Europe. Ophidiomyces ophidiicola causes SFD and manifests clinically by the formation of heterophilic granulomas around the mouth and eyes, weight loss, impaired vision, and sometimes death. Field observations have documented early seasonal basking behaviors in severely infected snakes, potentially suggesting induction of a behavioral febrile response to combat the mycosis. Read More

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Moderate Altitude Residence Reduces Male Colorectal and Female Breast Cancer Mortality More Than Incidence: Therapeutic Implications?

Cancers (Basel) 2021 Sep 1;13(17). Epub 2021 Sep 1.

Department of Sport Science, University of Innsbruck, A-6020 Innsbruck, Austria.

Background: Living at moderate altitude may be associated with health benefits, including reduced mortality from male colorectal and female breast cancer. We aimed to determine altitude-dependent incidence and mortality rates of those cancers and put them in the context of altitude-associated lifestyle differences.

Methods: Incidence cases and deaths of male colorectal cancer ( = 17,712 and 7462) and female breast cancer ( = 33,803 and 9147) from altitude categories between 250 to about 2000 m were extracted from official Austrian registries across 10 years (2008-2017). Read More

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September 2021

SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study.

Int J Epidemiol 2021 Sep 8. Epub 2021 Sep 8.

Department of Epidemiology, Regional Public Health Laboratory Kennemerland, Haarlem, The Netherlands.

Background: Describing the SARS-CoV-2 viral-load distribution in different patient groups and age categories.

Methods: All results from first nasopharyngeal (NP) and oropharyngeal (OP) swabs from unique patients tested via SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) collected between 1 January and 1 December 2020 predominantly in the Public Health Services regions Kennemerland and Hollands Noorden, province of North Holland, the Netherlands, were included in this study. SARS-CoV-2 PCR crossing-point (Cp)-values were used to estimate viral loads. Read More

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September 2021

The Effects of Frequency, Variability, and Co-occurrence on Category Formation in Neural Systems.

J Cogn Neurosci 2021 Jul;33(8):1397-1412

Indiana University, Bloomington.

Objects are grouped into categories through a complex combination of statistical and structural regularities. We sought to better understand the neural responses to the structural features of object categories that result from implicit learning. Adult participants were exposed to 32 object categories that contained three structural properties: frequency, variability, and co-occurrences, during an implicit learning task. Read More

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Treatment of Circadian Rhythm Sleep-Wake Disorders.

Curr Neuropharmacol 2021 Sep 7. Epub 2021 Sep 7.

Department of Neurology (Sleep Disorders), the Affiliated Chaohu Hospital of Anhui Medical University, Hefei 238000, Anhui Province. China.

Circadian rhythm sleep-wake disorders (CRSWDs) are a distinct class of sleep disorders caused by alterations to the circadian time-keeping system, its entrainment mechanisms, or a mismatch between the endogenous circadian rhythm and the external environment. The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment. CRSWDs are easily mistaken for insomnia or early waking up, resulting in inappropriate treatment. Read More

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September 2021

Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study.

PLoS Med 2021 Sep 7;18(9):e1003739. Epub 2021 Sep 7.

TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Among people living with HIV (PLHIV), more flexible and sensitive tuberculosis (TB) screening tools capable of detecting both symptomatic and subclinical active TB are needed to (1) reduce morbidity and mortality from undiagnosed TB; (2) facilitate scale-up of tuberculosis preventive therapy (TPT) while reducing inappropriate prescription of TPT to PLHIV with subclinical active TB; and (3) allow for differentiated HIV-TB care.

Methods And Findings: We used Botswana XPRES trial data for adult HIV clinic enrollees collected during 2012 to 2015 to develop a parsimonious multivariable prognostic model for active prevalent TB using both logistic regression and random forest machine learning approaches. A clinical score was derived by rescaling final model coefficients. Read More

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September 2021

Goals and outcomes of hospitalised older people: does the current hospital care match the needs of older people?

Intern Med J 2021 Sep 6. Epub 2021 Sep 6.

Department of Internal Medicin, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Background: Due to the rising number of acutely hospitalised older people in the coming years, there is increased interest in tailoring care to the individual goals and preferences of patients in order to reach patient-centered care.

Aims: This study aimed to investigate the goals of older hospitalised patients and the extent to which these goals were reached during hospitalisation.

Methods: A single centre prospective cohort study was performed in the Netherlands between December 2017 and January 2018. Read More

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September 2021